Glycyrrhetinic acid

Glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. Glycyrrhetinic acid is associated with abnormalities such as Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency, Hypertensive disease, Mineralocorticoid Excess Syndrome, Apparent and Syndrome. The involved functions are known as Signal, Muscle Contraction, Pressure- physical agent, Agent and Metabolic Inhibition. Glycyrrhetinic acid often locates in Protoplasm, Body tissue, Muscle, Connexon and Extracellular. The associated genes with Glycyrrhetinic acid are SLC33A1 gene, GJB1 gene, RNU1-1 gene, HADHA gene and RNU1-4 gene. The related lipids are Steroids, Saponin, Octanols, Heptanol and amyrin.

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Introduction

To understand associated biological information of Glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Glycyrrhetinic acid?

Glycyrrhetinic acid is suspected in Hypertensive disease, Kozlowski Celermajer Tink syndrome, Hypernatremia, Leishmaniasis, Visceral, Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Glycyrrhetinic acid

PubChem Associated disorders and diseases

What pathways are associated with Glycyrrhetinic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Glycyrrhetinic acid?

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What functions are associated with Glycyrrhetinic acid?


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What lipids are associated with Glycyrrhetinic acid?

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What genes are associated with Glycyrrhetinic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Glycyrrhetinic acid

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Authors Title Published Journal PubMed Link
Lin J et al. Development of Salvianolic acid B-Tanshinone II A-Glycyrrhetinic acid compound liposomes: formulation optimization and its effects on proliferation of hepatic stellate cells. 2014 Int J Pharm pmid:24374609
Kuzma-Kuzniarska M et al. Functional assessment of gap junctions in monolayer and three-dimensional cultures of human tendon cells using fluorescence recovery after photobleaching. 2014 J Biomed Opt pmid:24390370
Cheng M et al. Optimized synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and their characteristics. 2014 Int J Nanomedicine pmid:24493926
Hou J et al. A novel approach for fluorescent visualization of glycyrrhetic acid on a cell with a quantum dot. 2014 Biochemistry Mosc. pmid:24512660
Jayasooriya RG et al. 18β-Glycyrrhetinic acid suppresses TNF-α induced matrix metalloproteinase-9 and vascular endothelial growth factor by suppressing the Akt-dependent NF-κB pathway. 2014 Toxicol In Vitro pmid:24613819
Chu Y et al. Preparation and in vitro evaluation of glycyrrhetinic acid-modified curcumin-loaded nanostructured lipid carriers. 2014 Molecules pmid:24566313
Ghosh D et al. Dual-energy precursor and nuclear erythroid-related factor 2 activator treatment additively improve redox glutathione levels and neuron survival in aging and Alzheimer mouse neurons upstream of reactive oxygen species. 2014 Neurobiol. Aging pmid:23954169
Akopian A et al. Gap junction-mediated death of retinal neurons is connexin and insult specific: a potential target for neuroprotection. 2014 J. Neurosci. pmid:25100592
Kim YJ et al. Prevention of cisplatin-induced ototoxicity by the inhibition of gap junctional intercellular communication in auditory cells. 2014 Cell. Mol. Life Sci. pmid:24623558
Yang YA et al. Synthesis, molecular docking and biological evaluation of glycyrrhizin analogs as anticancer agents targeting EGFR. 2014 Molecules pmid:24853453
Li X et al. Inhibitory effects of herbal constituents on P-glycoprotein in vitro and in vivo: herb-drug interactions mediated via P-gp. 2014 Toxicol. Appl. Pharmacol. pmid:24380838
Tang WJ et al. Synthesis and discovery of 18α-GAMG as anticancer agent in vitro and in vivo via down expression of protein p65. 2014 Sci Rep pmid:25407586
Tang ZH et al. Glycyrrhetinic Acid triggers a protective autophagy by activation of extracellular regulated protein kinases in hepatocellular carcinoma cells. 2014 J. Agric. Food Chem. pmid:25403108
Yuan R et al. Self-assembled nanoparticles of glycyrrhetic acid-modified pullulan as a novel carrier of curcumin. 2014 Molecules pmid:25170951
Muller B et al. Glycyrrhetinic acid reverses the lipopolysaccharide-induced hypocontractility to noradrenaline in rat aorta: implications to septic shock. 2014 J. Pharmacol. Sci. pmid:25141925
Fujita K et al. Mutual enhancement of differentiation of osteoblasts and osteocytes occurs through direct cell-cell contact. 2014 J. Cell. Biochem. pmid:25043105
Hendricks JM et al. Differential induction of isolated lymphoid follicles in the gut by 18β-glycyrrhetinic acid. 2014 PLoS ONE pmid:24992099
Li JY et al. Glycyrrhizic acid in the treatment of liver diseases: literature review. 2014 Biomed Res Int pmid:24963489
Makino T 3-Monoglucuronyl glycyrrhretinic acid is a possible marker compound related to licorice-induced pseudoaldosteronism. 2014 Biol. Pharm. Bull. pmid:24882402
Zhang W et al. [Inhibitory effect of 18β-glycyrrhetinic acid on KCl- and PE-induced constriction of rat renal interlobar artery in vitro]. 2014 Sheng Li Xue Bao pmid:24777410