| MeSH term | MeSH ID | Detail |
|---|---|---|
| Edema | D004487 | 152 associated lipids |
| Ear Diseases | D004427 | 7 associated lipids |
Total
2
Glycyrrhetinic acid
Glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. Glycyrrhetinic acid is associated with abnormalities such as Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency, Hypertensive disease, Mineralocorticoid Excess Syndrome, Apparent and Syndrome. The involved functions are known as Signal, Muscle Contraction, Pressure- physical agent, Agent and Metabolic Inhibition. Glycyrrhetinic acid often locates in Protoplasm, Body tissue, Muscle, Connexon and Extracellular. The associated genes with Glycyrrhetinic acid are SLC33A1 gene, GJB1 gene, RNU1-1 gene, HADHA gene and RNU1-4 gene. The related lipids are Steroids, Saponin, Octanols, Heptanol and amyrin.
Cross Reference
Introduction
To understand associated biological information of Glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Glycyrrhetinic acid?
Glycyrrhetinic acid is suspected in Hypertensive disease, Kozlowski Celermajer Tink syndrome, Hypernatremia, Leishmaniasis, Visceral, Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Glycyrrhetinic acid
PubChem Associated disorders and diseases
What pathways are associated with Glycyrrhetinic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Glycyrrhetinic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Glycyrrhetinic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Glycyrrhetinic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Glycyrrhetinic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Glycyrrhetinic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Glycyrrhetinic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Guo BH et al. | HPLC assay and pharmacokinetics and tissue distribution study of glycyrrhetinic acid liposomes modified with galactosylated lipid. | 2012 | J Liposome Res | pmid:22313057 |
| Coutinho AE et al. | 11β-Hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in mice. | 2012 | Endocrinology | pmid:22067318 |
| Ishida T et al. | Inhibitory effects of glycyrrhetinic Acid on DNA polymerase and inflammatory activities. | 2012 | Evid Based Complement Alternat Med | pmid:21785649 |
| Nafisi S et al. | Study on the interaction of glycyrrhizin and glycyrrhetinic acid with RNA. | 2012 | J. Photochem. Photobiol. B, Biol. | pmid:22513095 |
| Wang LJ et al. | Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22520261 |
| Couteau C et al. | Influence of certain ingredients on the SPF determined in vivo. | 2012 | Arch. Dermatol. Res. | pmid:22707250 |
| Wang XH et al. | In vitro evaluation of polymeric micelles based on hydrophobically-modified sulfated chitosan as a carrier of doxorubicin. | 2012 | J Mater Sci Mater Med | pmid:22538726 |
| Zhao X et al. | Optimization on condition of glycyrrhetinic acid liposome by RSM and the research of its immunological activity. | 2012 | Int. J. Biol. Macromol. | pmid:22584079 |
| Matsumoto T et al. | The anti-ulcer agent, irsogladine, increases insulin secretion by MIN6 cells. | 2012 | Eur. J. Pharmacol. | pmid:22542662 |
| Asakawa C et al. | Utilization of [11C]phosgene for radiosynthesis of N-(2-{3-[3,5-bis(trifluoromethyl)]phenyl[11C]ureido}ethyl)glycyrrhetinamide, an inhibitory agent for proteasome and kinase in tumors. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22546673 |
| Csuk R et al. | Conversions at C-30 of glycyrrhetinic acid and their impact on antitumor activity. | 2012 | Arch. Pharm. (Weinheim) | pmid:21997717 |
| Niger C et al. | ERK acts in parallel to PKCδ to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts. | 2012 | Am. J. Physiol., Cell Physiol. | pmid:22277757 |
| Cao S et al. | [Effect of oral administration of glycyrrhetinic acid on six metal elements in rat serum]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22667150 |
| Li L et al. | Myoendothelial coupling is unidirectional in guinea pig spiral modiolar arteries. | 2012 | Microvasc. Res. | pmid:22580342 |
| Gao J et al. | Facile synthesis of triterpenoid saponins bearing β-Glu/Gal-(1→3)-β-GluA methyl ester and their cytotoxic activities. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22406153 |
| Yang JC et al. | 18β-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway. | 2012 | Mol. Cell. Biochem. | pmid:22865487 |
| Wen J et al. | UPLC-MS/MS determination of paeoniflorin, naringin, naringenin and glycyrrhetinic acid in rat plasma and its application to a pharmacokinetic study after oral administration of Si-Ni-San decoction. | 2012 | J Pharm Biomed Anal | pmid:22521636 |
| Sharma G et al. | 18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells. | 2012 | J. Cell. Physiol. | pmid:21732363 |
| Shi Q et al. | Glycyrrhetic acid synergistically enhances β₂-adrenergic receptor-Gs signaling by changing the location of Gαs in lipid rafts. | 2012 | PLoS ONE | pmid:23028680 |
| Guo BH et al. | Preparation and characterization of galactose-modified liposomes by a nonaqueous enzymatic reaction. | 2011 | J Liposome Res | pmid:21545336 |
| Haddock RE et al. | Diet-induced obesity impairs endothelium-derived hyperpolarization via altered potassium channel signaling mechanisms. | 2011 | PLoS ONE | pmid:21283658 |
| Li XL et al. | Antioxidant status and immune activity of glycyrrhizin in allergic rhinitis mice. | 2011 | Int J Mol Sci | pmid:21541033 |
| Witkamp RF | Current and future drug targets in weight management. | 2011 | Pharm. Res. | pmid:21181547 |
| Wyrwoll CS et al. | 11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress. | 2011 | Front Neuroendocrinol | pmid:21144857 |
| Csuk R et al. | Synthesis and antitumor activity of ring A modified glycyrrhetinic acid derivatives. | 2011 | Eur J Med Chem | pmid:21959232 |
| Lin KW et al. | 18β-Glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells. | 2011 | Bioorg. Med. Chem. | pmid:21696969 |
| Harahap IS et al. | Herbal Medicine Containing Licorice May Be Contraindicated for a Patient with an HSD11B2 Mutation. | 2011 | Evid Based Complement Alternat Med | pmid:20007258 |
| Popovich DG et al. | Ginseng (Panax quinquefolius) and Licorice (Glycyrrhiza uralensis) Root Extract Combinations Increase Hepatocarcinoma Cell (Hep-G2) Viability. | 2011 | Evid Based Complement Alternat Med | pmid:19617200 |
| Desforges B et al. | Gap junctions favor normal rat kidney epithelial cell adaptation to chronic hypertonicity. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21677260 |
| Sun W et al. | Design, synthesis, and sustained-release property of 1,3-cyclic propanyl phosphate ester of 18β-glycyrrhetinic acid. | 2011 | Chem Biol Drug Des | pmid:21244638 |
| Kratschmar DV et al. | Characterization of activity and binding mode of glycyrrhetinic acid derivatives inhibiting 11β-hydroxysteroid dehydrogenase type 2. | 2011 | J. Steroid Biochem. Mol. Biol. | pmid:21236343 |
| Piao H et al. | Effects of connexin-mimetic peptides on perfusion pressure in response to phenylephrine in isolated, perfused rat kidneys. | 2011 | Clin. Exp. Nephrol. | pmid:21153751 |
| Scott LM et al. | Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21193311 |
| Kong X et al. | Roles of phytochemicals in amino acid nutrition. | 2011 | Front Biosci (Schol Ed) | pmid:21196382 |
| Sasseville D et al. | Allergic contact dermatitis caused by glycyrrhetinic acid and castor oil. | 2011 | Contact Derm. | pmid:21272025 |
| Kim SJ et al. | Therapeutic effects of connexin inhibitors on detrusor overactivity induced by bladder outlet obstruction in rats. | 2011 | Urology | pmid:21820587 |
| Wang CY et al. | Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions. | 2011 | J. Agric. Food Chem. | pmid:21644799 |
| Delacour H et al. | [The old man and the syrup]. | 2011 | Pathol. Biol. | pmid:19896293 |
| Ma KT et al. | [18β-glycyrrhetinic acid inhibits outward current of vascular smooth muscle cells of arterioles]. | 2011 | Sheng Li Xue Bao | pmid:22193450 |
| Ukil A et al. | Curative effect of 18β-glycyrrhetinic acid in experimental visceral leishmaniasis depends on phosphatase-dependent modulation of cellular MAP kinases. | 2011 | PLoS ONE | pmid:22194991 |
| Zhang C et al. | Antitumor activity of drug loaded glycyrrhetinic acid modified alginate nanoparticles on mice bearing orthotopic liver tumor. | 2011 | J Control Release | pmid:22195787 |
| Tian Q et al. | Understanding the role of the C3-hydroxyl group in glycyrrhetinic acid on liver targeting. | 2011 | J Control Release | pmid:22195881 |
| Upur H et al. | Inhibition of Cell Growth and Cellular Protein, DNA and RNA Synthesis in Human Hepatoma (HepG2) Cells by Ethanol Extract of Abnormal Savda Munziq of Traditional Uighur Medicine. | 2011 | Evid Based Complement Alternat Med | pmid:18955370 |
| Veratti E et al. | 18beta-glycyrrhetinic acid and glabridin prevent oxidative DNA fragmentation in UVB-irradiated human keratinocyte cultures. | 2011 | Anticancer Res. | pmid:21737643 |
| Chen Q et al. | Identification and quantification of oleanolic acid and ursolic acid in Chinese herbs by liquid chromatography-ion trap mass spectrometry. | 2011 | Biomed. Chromatogr. | pmid:21465498 |
| Akasaka Y et al. | Glycyrrhetinic acid prevents cutaneous scratching behavior in mice elicited by substance P or PAR-2 agonist. | 2011 | Eur. J. Pharmacol. | pmid:21925497 |
| Tao Y et al. | [Expression of 11β-hydroxysteroid dehydrogenase type 2 in lymphoblastic cells and its relationship with glucocorticoid sensitivity]. | 2011 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:21362233 |
| Logashenko EB et al. | Synthesis and pro-apoptotic activity of novel glycyrrhetinic acid derivatives. | 2011 | Chembiochem | pmid:21328513 |
| Matsuzaki Y et al. | [Alternative therapies for hepatitis C: UDCA and SNMC]. | 2011 | Nippon Rinsho | pmid:22096928 |
| Jeong HJ et al. | C-kit binding properties of hesperidin (a major component of KMP6) as a potential anti-allergic agent. | 2011 | PLoS ONE | pmid:21559359 |