| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinogenesis | D063646 | 3 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee JS et al. | Two new triterpenes from the Rhizome of Dryopteris crassirhizoma, and inhibitory activities of its constituents on human immunodeficiency virus-1 protease. | 2008 | Chem. Pharm. Bull. | pmid:18451564 |
| Kiran MS et al. | Modulation of angiogenic factors by ursolic acid. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18448068 |
| pmid:18446772 | ||||
| Shen YM et al. | [Effect of ursolic acid on proliferation and apoptosis of hepatic stellate cells in vitro]. | 2008 | Zhonghua Gan Zang Bing Za Zhi | pmid:18423155 |
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| Chen CC et al. | Fructus Corni suppresses hepatic gluconeogenesis related gene transcription, enhances glucose responsiveness of pancreatic beta-cells, and prevents toxin induced beta-cell death. | 2008 | J Ethnopharmacol | pmid:18400427 |
| Chadalapaka G et al. | Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18359628 |
| pmid:18335336 | ||||
| Lin YL et al. | [Study on fingerprint spectrum of loquat leaf by HPLC]. | 2007 | Zhong Yao Cai | pmid:18300490 |
| Kim JM et al. | Aldose-reductase- and protein-glycation-inhibitory principles from the whole plant of Duchesnea chrysantha. | 2008 | Chem. Biodivers. | pmid:18293434 |
| Bonaccorsi I et al. | Endogenous reverse transcriptase as a mediator of ursolic acid's anti-proliferative and differentiating effects in human cancer cell lines. | 2008 | Cancer Lett. | pmid:18282657 |
| Ramos AA et al. | Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells: evaluation by the comet assay. | 2008 | Toxicol. Lett. | pmid:18276086 |
| Tanachatchairatana T et al. | Antimycobacterial activity of cinnamate-based esters of the triterpenes betulinic, oleanolic and ursolic acids. | 2008 | Chem. Pharm. Bull. | pmid:18239308 |
| Ikeda Y et al. | Ursolic acid: an anti- and pro-inflammatory triterpenoid. | 2008 | Mol Nutr Food Res | pmid:18203131 |
| Gnoatto SC et al. | Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition. | 2008 | Eur J Med Chem | pmid:18192087 |
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| Duval RE et al. | Differential involvement of mitochondria during ursolic acid-induced apoptotic process in HaCaT and M4Beu cells. | 2008 | Oncol. Rep. | pmid:18097588 |
| Jovel EM et al. | Bioactivity-guided isolation of the active compounds from Rosa nutkana and quantitative analysis of ascorbic acid by HPLC. | 2007 | Can. J. Physiol. Pharmacol. | pmid:18066132 |
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| pmid:18058608 | ||||
| pmid:18000679 | ||||
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| Gnoatto SC et al. | Pharmacomodulation on the 3-acetylursolic acid skeleton: Design, synthesis, and biological evaluation of novel N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-O-acetylursolamide derivatives as antimalarial agents. | 2008 | Bioorg. Med. Chem. | pmid:17967541 |
| Pathak AK et al. | Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. | 2007 | Mol. Cancer Res. | pmid:17855663 |
| Liu XS and Jiang J | Induction of apoptosis and regulation of the MAPK pathway by ursolic acid in human leukemia K562 cells. | 2007 | Planta Med. | pmid:17764066 |
| Lim SW et al. | Simultaneous effect of ursolic acid and oleanolic acid on epidermal permeability barrier function and epidermal keratinocyte differentiation via peroxisome proliferator-activated receptor-alpha. | 2007 | J. Dermatol. | pmid:17727365 |
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| Lu J et al. | Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. | 2007 | Biochem. Pharmacol. | pmid:17692828 |
| pmid:17678936 | ||||
| Huang L et al. | [Studies on chemical constituents of Patrinia villosa]. | 2007 | Zhong Yao Cai | pmid:17674792 |
| Santos Rosa C et al. | Antihistaminic and antieicosanoid effects of oleanolic and ursolic acid fraction from Helichrysum picardii. | 2007 | Pharmazie | pmid:17663195 |
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| pmid:17638339 | ||||
| Chen JC et al. | Inhibition of Escherichia coli heat-labile enterotoxin-induced diarrhea by Chaenomeles speciosa. | 2007 | J Ethnopharmacol | pmid:17624704 |
| pmid:17616904 | ||||
| Andersson D et al. | Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats. | 2008 | J. Cancer Res. Clin. Oncol. | pmid:17605045 |
| Kress CL et al. | Triterpenoids display single agent anti-tumor activity in a transgenic mouse model of chronic lymphocytic leukemia and small B cell lymphoma. | 2007 | PLoS ONE | pmid:17593960 |
| Tatsuzaki J et al. | Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents. | 2007 | Bioorg. Med. Chem. | pmid:17591444 |
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| Vidya SM et al. | Evaluation of hepatoprotective activity of Clerodendrum serratum L. | 2007 | Indian J. Exp. Biol. | pmid:17585689 |
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| Li YL et al. | [Studies on chemical constituents from Serissa serissoides]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17583202 |
| Sagar SM et al. | Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 2. | 2006 | Curr Oncol | pmid:17576449 |
| Duan WD et al. | [Chemical constituents from the flower of Paulownia fortunei( seem. ) Hemsl]. | 2007 | Zhong Yao Cai | pmid:17571764 |
| pmid:17570616 | ||||
| Horiuchi K et al. | Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE). | 2007 | Biol. Pharm. Bull. | pmid:17541170 |
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| Huang L et al. | Use of liquid chromatography-atmospheric pressure chemical ionization-ion trap mass spectrometry for identification of oleanolic acid and ursolic acid in Anoectochilus roxburghii (wall.) Lindl. | 2007 | J Mass Spectrom | pmid:17535010 |
| pmid:17533651 | ||||
| Oh CJ et al. | Ursolic acid regulates high glucose-induced apoptosis. | 2007 | Free Radic. Res. | pmid:17516235 |
| Kassi E et al. | Ursolic acid, a naturally occurring triterpenoid, demonstrates anticancer activity on human prostate cancer cells. | 2007 | J. Cancer Res. Clin. Oncol. | pmid:17516089 |
| pmid:17507178 | ||||
| pmid:17488026 | ||||
| Steinkamp-Fenske K et al. | Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells. | 2007 | Atherosclerosis | pmid:17481637 |
| Saimaru H et al. | Production of triterpene acids by cell suspension cultures of Olea europaea. | 2007 | Chem. Pharm. Bull. | pmid:17473469 |
| Rosas LV et al. | In vitro evaluation of the cytotoxic and trypanocidal activities of Ampelozizyphus amazonicus (Rhamnaceae). | 2007 | Braz. J. Med. Biol. Res. | pmid:17464428 |
| Nataraju A et al. | Group IIA secretory PLA2 inhibition by ursolic acid: a potent anti-inflammatory molecule. | 2007 | Curr Top Med Chem | pmid:17456043 |
| Nangia-Makker P et al. | Inhibition of breast tumor growth and angiogenesis by a medicinal herb: Ocimum gratissimum. | 2007 | Int. J. Cancer | pmid:17437270 |
| Huang Y et al. | Effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf on inflammatory cytokine and mediator induction from alveolar macrophages of chronic bronchitic rats. | 2007 | Inflamm. Res. | pmid:17431744 |
| Ikeda Y et al. | Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36. | 2007 | J. Immunol. | pmid:17404266 |
| Ko KM and Leung HY | Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. | 2007 | Chin Med | pmid:17386115 |
| Zhou C et al. | Determination of oleanolic acid, ursolic acid and amygdalin in the flower of Eriobotrya japonica Lindl. by HPLC. | 2007 | Biomed. Chromatogr. | pmid:17385800 |
| Gao X et al. | Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling. | 2007 | J. Neurooncol. | pmid:17361329 |
| Wu JY et al. | [Chemical constituents of the non-alkaloid fraction of Uncaria macrophylla]. | 2007 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:17355944 |
| Lai MY et al. | Up-regulation of matrix metalloproteinase family gene involvement in ursolic acid-induced human lung non-small carcinoma cell apoptosis. | 2007 Jan-Feb | Anticancer Res. | pmid:17352226 |
| Moghaddam FM et al. | Chemical Constituents of Dichloromethane Extract of Cultivated Satureja khuzistanica. | 2007 | Evid Based Complement Alternat Med | pmid:17342246 |
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| pmid:17311714 | ||||
| Ali MS et al. | Ursolic acid: a potent inhibitor of superoxides produced in the cellular system. | 2007 | Phytother Res | pmid:17295383 |
| Jedinák A et al. | Antiprotease and antimetastatic activity of ursolic acid isolated from Salvia officinalis. | 2006 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:17294686 |
| pmid:17291738 | ||||
| pmid:17288440 | ||||
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| Heo HJ et al. | Carbenoxolone and triterpenoids inhibited mucin secretion from airway epithelial cells. | 2007 | Phytother Res | pmid:17262888 |
| Taviano MF et al. | Ursolic acid plays a role in Nepeta sibthorpii Bentham CNS depressing effects. | 2007 | Phytother Res | pmid:17236171 |
| Achiwa Y et al. | Regulation of the phosphatidylinositol 3-kinase-Akt and the mitogen-activated protein kinase pathways by ursolic acid in human endometrial cancer cells. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17213663 |
| Jung SH et al. | Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator. | 2007 | Biochem. J. | pmid:17201692 |
| pmid:17193306 | ||||
| pmid:17191931 | ||||
| Yim EK et al. | Antiproliferative and antiviral mechanisms of ursolic acid and dexamethasone in cervical carcinoma cell lines. | 2006 Nov-Dec | Int. J. Gynecol. Cancer | pmid:17177841 |
| Slamenová D et al. | Reduction of DNA-damaging effects of anti-HIV drug 3'-azido-3'-dideoxythymidine on human cells by ursolic acid and lignin biopolymer. | 2006 | Neoplasma | pmid:17167716 |
| Song LL et al. | [Determination of ursolic acid of Liuwei Dihuangwan simulation samples by NIR]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17165581 |
| pmid:17163944 | ||||
| Dufour D et al. | Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius. | 2007 | J Ethnopharmacol | pmid:17156957 |
| Yang P et al. | Determination of free isomeric oleanolic acid and ursolic acid in Pterocephalus hookeri by capillary zone electrophoresis. | 2007 | J Pharm Biomed Anal | pmid:17141445 |
| Vareed SK et al. | Lipid peroxidation, cyclooxygenase enzyme and tumor cell proliferation inhibitory compounds in Cornus kousa fruits. | 2007 | Phytomedicine | pmid:17084606 |
| Leite JP et al. | Trypanocidal activity of triterpenes from Arrabidaea triplinervia and derivatives. | 2006 | Biol. Pharm. Bull. | pmid:17077535 |
| Senthil S et al. | Isomers (oleanolic and ursolic acids) differ in their protective effect against isoproterenol-induced myocardial ischemia in rats. | 2007 | Int. J. Cardiol. | pmid:17052790 |
| He X and Liu RH | Cranberry phytochemicals: Isolation, structure elucidation, and their antiproliferative and antioxidant activities. | 2006 | J. Agric. Food Chem. | pmid:16968064 |
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| Ovesná Z et al. | Protective effects of ursolic acid and oleanolic acid in leukemic cells. | 2006 | Mutat. Res. | pmid:16831451 |
| Ma X et al. | [Determination of ursolic acid in Ledum palustre L. by RP-HPLC]. | 2006 | Se Pu | pmid:16830480 |
| Zhang W et al. | Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake. | 2006 | Biochim. Biophys. Acta | pmid:16828971 |