| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinogenesis | D063646 | 3 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Arapitsas P et al. | A metabolomic approach to the study of wine micro-oxygenation. | 2012 | PLoS ONE | pmid:22662221 |
| Li BX et al. | [Ursolic acid activates chloride channels and decreases cell volume in poorly differentiated nasopharyngeal carcinoma cells]. | 2012 | Sheng Li Xue Bao | pmid:23258331 |
| Orhan IE | Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential. | 2012 | Evid Based Complement Alternat Med | pmid:22666298 |
| Joffry SM et al. | Melastoma malabathricum (L.) Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A Review. | 2012 | Evid Based Complement Alternat Med | pmid:22242040 |
| Perera PK and Li Y | Functional herbal food ingredients used in type 2 diabetes mellitus. | 2012 | Pharmacogn Rev | pmid:22654403 |
| Liu M et al. | Chemical constituents of the ethyl acetate extract of Belamcanda chinensis (L.) DC roots and their antitumor activities. | 2012 | Molecules | pmid:22627971 |
| Liu YQ et al. | Retigeric acid B exhibits antitumor activity through suppression of nuclear factor-κB signaling in prostate cancer cells in vitro and in vivo. | 2012 | PLoS ONE | pmid:22666431 |
| Quave CL et al. | Ellagic acid derivatives from Rubus ulmifolius inhibit Staphylococcus aureus biofilm formation and improve response to antibiotics. | 2012 | PLoS ONE | pmid:22242149 |
| Gohari AR et al. | Evaluation of the cytotoxicity of Satureja spicigera and its main compounds. | 2012 | ScientificWorldJournal | pmid:22623883 |
| Masuda M et al. | Matrix metalloproteinase-1 inhibitory activities of Morinda citrifolia seed extract and its constituents in UVA-irradiated human dermal fibroblasts. | 2012 | Biol. Pharm. Bull. | pmid:22293351 |
| Murakami A and Ohnishi K | Target molecules of food phytochemicals: food science bound for the next dimension. | 2012 | Food Funct | pmid:22377900 |
| Tang LI et al. | Screening of anti-dengue activity in methanolic extracts of medicinal plants. | 2012 | BMC Complement Altern Med | pmid:22244370 |
| González-Trujano ME et al. | Spasmolytic and antinociceptive activities of ursolic acid and acacetin identified in Agastache mexicana. | 2012 | Planta Med. | pmid:22473340 |
| Kurek A et al. | Modulation of antibiotic resistance in bacterial pathogens by oleanolic acid and ursolic acid. | 2012 | Phytomedicine | pmid:22341643 |
| Gao N et al. | Ursolic acid induces apoptosis in human leukaemia cells and exhibits anti-leukaemic activity in nude mice through the PKB pathway. | 2012 | Br. J. Pharmacol. | pmid:21950524 |
| Liu YW et al. | Bioactive diterpenes from Callicarpa longissima. | 2012 | J. Nat. Prod. | pmid:22429052 |
| Zeng G et al. | Ursolic acid inhibits T-cell activation through modulating nuclear factor-κ B signaling. | 2012 | Chin J Integr Med | pmid:21994027 |
| Zhang YH et al. | A new inositol derivative from Prenanthes macrophylla. | 2012 | J Asian Nat Prod Res | pmid:22296160 |
| Shin IS et al. | Ursolic acid reduces prostate size and dihydrotestosterone level in a rat model of benign prostatic hyperplasia. | 2012 | Food Chem. Toxicol. | pmid:22266360 |
| Kalani K et al. | Pharmacophore, QSAR, and ADME based semisynthesis and in vitro evaluation of ursolic acid analogs for anticancer activity. | 2012 | J Mol Model | pmid:22271093 |
| Teixeira T et al. | Molluscicidal activity of crude water and hexane extracts of Hypericum species to snails (Radix peregra). | 2012 | Environ. Toxicol. Chem. | pmid:22170085 |
| Choi YH et al. | Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22940448 |
| He X et al. | In vitro and in vivo antimammary tumor activities and mechanisms of the apple total triterpenoids. | 2012 | J. Agric. Food Chem. | pmid:22924395 |
| Machado DG et al. | Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: evidence for the involvement of the dopaminergic system. | 2012 | Pharmacol. Biochem. Behav. | pmid:22940588 |
| Kazmi I et al. | Antiepileptic potential of ursolic acid stearoyl glucoside by GABA receptor stimulation. | 2012 | CNS Neurosci Ther | pmid:22943148 |
| Leal AS et al. | Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells. | 2012 | Bioorg. Med. Chem. | pmid:22959527 |
| Hong SY et al. | Protective effects of the key compounds isolated from Corni fructus against β-amyloid-induced neurotoxicity in PC12 cells. | 2012 | Molecules | pmid:22964500 |
| Zhong Y et al. | Preparation and evaluation of liposome-encapsulated codrug LMX. | 2012 | Int J Pharm | pmid:22981689 |
| Shin SW et al. | Autophagy inhibition enhances ursolic acid-induced apoptosis in PC3 cells. | 2012 | Biochim. Biophys. Acta | pmid:22178132 |
| Berrington D and Lall N | Anticancer Activity of Certain Herbs and Spices on the Cervical Epithelial Carcinoma (HeLa) Cell Line. | 2012 | Evid Based Complement Alternat Med | pmid:22649474 |
| Koh SJ et al. | Sensitization of ionizing radiation-induced apoptosis by ursolic acid. | 2012 | Free Radic. Res. | pmid:22239065 |
| Kunkel SD et al. | Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease. | 2012 | PLoS ONE | pmid:22745735 |
| Wang L et al. | [Effects of ursolic acid in ameliorating insulin resistance in liver of KKAy mice via peroxisome proliferator-activated receptors α and γ]. | 2012 | Zhong Xi Yi Jie He Xue Bao | pmid:22805086 |
| Massaoka MH et al. | Jacaranone induces apoptosis in melanoma cells via ROS-mediated downregulation of Akt and p38 MAPK activation and displays antitumor activity in vivo. | 2012 | PLoS ONE | pmid:22701695 |
| Gu G et al. | Oldenlandia diffusa extracts exert antiproliferative and apoptotic effects on human breast cancer cells through ERα/Sp1-mediated p53 activation. | 2012 | J. Cell. Physiol. | pmid:22213398 |
| Wilkinson K and El Khoury J | Microglial scavenger receptors and their roles in the pathogenesis of Alzheimer's disease. | 2012 | Int J Alzheimers Dis | pmid:22666621 |
| Ma T et al. | Human papillomavirus type 18 E6 and E7 genes integrate into human hepatoma derived cell line Hep G2. | 2012 | PLoS ONE | pmid:22655088 |
| Debprasad C et al. | Inhibition of NO(2), PGE(2), TNF-α, and iNOS EXpression by Shorea robusta L.: An Ethnomedicine Used for Anti-Inflammatory and Analgesic Activity. | 2012 | Evid Based Complement Alternat Med | pmid:22649472 |
| Mooi LY et al. | Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22799301 |
| Feldman M et al. | Cranberry proanthocyanidins inhibit the adherence properties of Candida albicans and cytokine secretion by oral epithelial cells. | 2012 | BMC Complement Altern Med | pmid:22248145 |
| Katsuyama M et al. | Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme. | 2012 | J Clin Biochem Nutr | pmid:22247596 |
| Bonkhoff H | Factors implicated in radiation therapy failure and radiosensitization of prostate cancer. | 2012 | Prostate Cancer | pmid:22229096 |
| Sun G et al. | A new triterpene from the plant of uncaria macrophylla. | 2012 | Molecules | pmid:22222909 |
| Saxena RC et al. | Efficacy of an Extract of Ocimum tenuiflorum (OciBest) in the Management of General Stress: A Double-Blind, Placebo-Controlled Study. | 2012 | Evid Based Complement Alternat Med | pmid:21977056 |
| Chang CL et al. | Phytochemical characteristics, free radical scavenging activities, and neuroprotection of five medicinal plant extracts. | 2012 | Evid Based Complement Alternat Med | pmid:21845204 |
| Gao J et al. | Facile synthesis of triterpenoid saponins bearing β-Glu/Gal-(1→3)-β-GluA methyl ester and their cytotoxic activities. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22406153 |
| Youn K and Jun M | Inhibitory effects of key compounds isolated from Corni fructus on BACE1 Activity. | 2012 | Phytother Res | pmid:22407769 |
| Figueiredo VC and Nader GA | Ursolic acid directly promotes protein accretion in myotubes but does not affect myoblast proliferation. | 2012 | Cell Biochem. Funct. | pmid:22411156 |
| Liu W et al. | Ursolic acid inhibits cigarette smoke extract-induced human bronchial epithelial cell injury and prevents development of lung cancer. | 2012 | Molecules | pmid:22858837 |
| Crown PL et al. | Ritual Black Drink consumption at Cahokia. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22869743 |
| Radhiga T et al. | Effect of ursolic acid on cardiac marker enzymes, lipid profile and macroscopic enzyme mapping assay in isoproterenol-induced myocardial ischemic rats. | 2012 | Food Chem. Toxicol. | pmid:22898613 |
| Li D et al. | [Effects of ursolic acid on c-Cbl-associated protein expression in 3T3-L1 adipocytes with insulin resistance]. | 2012 | Zhong Xi Yi Jie He Xue Bao | pmid:22883405 |
| Prasad S et al. | Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine. | 2012 | Clin. Cancer Res. | pmid:22832932 |
| Liu Y et al. | Study on the noncovalent interactions of saikosaponins and cytochrome c by electrospray ionization mass spectrometry. | 2012 | Rapid Commun. Mass Spectrom. | pmid:22368050 |
| Radhiga T et al. | Effect of ursolic acid treatment on apoptosis and DNA damage in isoproterenol-induced myocardial infarction. | 2012 | Biochimie | pmid:22289617 |
| BershteÄn LM | [Ursolic acid as antitumor agent and inductor of PTEN and brown fat]. | 2012 | Vopr Onkol | pmid:23600297 |
| Conserva LM and Ferreira JC | Borreria and Spermacoce species (Rubiaceae): A review of their ethnomedicinal properties, chemical constituents, and biological activities. | 2012 | Pharmacogn Rev | pmid:22654404 |
| Baliga MS and Kurian PJ | Ixora coccinea Linn.: traditional uses, phytochemistry and pharmacology. | 2012 | Chin J Integr Med | pmid:22231708 |
| Wang J et al. | 55-week treatment of mice with the unani and ayurvedic medicine pomegranate flower ameliorates ageing-associated insulin resistance and skin abnormalities. | 2012 | Evid Based Complement Alternat Med | pmid:22253646 |
| Xia EQ et al. | Ultrasound-assisted extraction of oleanolic acid and ursolic acid from Ligustrum lucidum Ait. | 2012 | Ultrason Sonochem | pmid:22197019 |
| Maurya A et al. | QSAR, docking and in vivo studies for immunomodulatory activity of isolated triterpenoids from Eucalyptus tereticornis and Gentiana kurroo. | 2012 | Eur J Pharm Sci | pmid:22659375 |
| e Silva Mde L et al. | Bioactive oleanane, lupane and ursane triterpene acid derivatives. | 2012 | Molecules | pmid:23075816 |
| Zhou C et al. | Molecular cloning and expression of squalene synthase and 2,3-oxidosqualene cyclase genes in persimmon (Diospyros kaki L.) fruits. | 2012 | Mol. Biol. Rep. | pmid:21573791 |
| Multhoff G and Radons J | Radiation, inflammation, and immune responses in cancer. | 2012 | Front Oncol | pmid:22675673 |
| de Oliveira Eloy J et al. | Solid dispersion of ursolic acid in Gelucire 50/13: a strategy to enhance drug release and trypanocidal activity. | 2012 | AAPS PharmSciTech | pmid:23070562 |
| Cui Y et al. | New diterpene furanoids from the Antarctic lichen Huea sp. | 2012 | Bioorg. Med. Chem. Lett. | pmid:23141910 |
| Peixoto MP et al. | LC-UV assay method and UPLC/Q-TOF-MS characterisation of saponins from Ilex paraguariensis A. St. Hil. (mate) unripe fruits. | 2012 Jul-Aug | Phytochem Anal | pmid:22105927 |
| Lee YH et al. | Modulation of photochemical damage in normal and malignant cells by naturally occurring compounds. | 2012 Nov-Dec | Photochem. Photobiol. | pmid:22486439 |
| Yang YC et al. | Optimisation of an ultrasound-assisted extraction followed by RP-HPLC separation for the simultaneous determination of oleanolic acid, ursolic acid and oridonin content in Rabdosia rubescens. | 2012 Nov-Dec | Phytochem Anal | pmid:22706975 |
| Lin J et al. | Ursolic acid promotes colorectal cancer cell apoptosis and inhibits cell proliferation via modulation of multiple signaling pathways. | 2013 | Int. J. Oncol. | pmid:23900560 |
| Yang JJ et al. | [Study on the effect of ursolic acid (UA) on the myocardial fibrosis of experimental diabetic mice]. | 2013 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:24175562 |
| Kong L et al. | Oleanolic acid and ursolic acid: novel hepatitis C virus antivirals that inhibit NS5B activity. | 2013 | Antiviral Res. | pmid:23422646 |
| Nam H and Kim MM | Ursolic acid induces apoptosis of SW480 cells via p53 activation. | 2013 | Food Chem. Toxicol. | pmid:24071474 |
| Lin J et al. | Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways. | 2013 | Int. J. Oncol. | pmid:24042330 |
| Saraswati S et al. | Ursolic acid inhibits tumor angiogenesis and induces apoptosis through mitochondrial-dependent pathway in Ehrlich ascites carcinoma tumor. | 2013 | Chem. Biol. Interact. | pmid:24051192 |
| Wang W et al. | Ursolic acid inhibits the growth of colon cancer-initiating cells by targeting STAT3. | 2013 | Anticancer Res. | pmid:24122993 |
| Feng L et al. | Inhibition of human neutrophil elastase by pentacyclic triterpenes. | 2013 | PLoS ONE | pmid:24376583 |
| Gai L et al. | Ursolic acid induces apoptosis via Akt/NF-κB signaling suppression in T24 human bladder cancer cells. | 2013 | Mol Med Rep | pmid:23483134 |
| Park JH et al. | Inhibition of Wnt/β-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells. | 2013 | Pharmacol Rep | pmid:24399733 |
| Chen Y et al. | Optimisation of potassium chloride nutrition for proper growth, physiological development and bioactive component production in Prunella vulgaris L. | 2013 | PLoS ONE | pmid:23874390 |
| Zhai B et al. | Antimalarial evaluation of the chemical constituents of hairy root culture of Bixa orellana L. | 2013 | Molecules | pmid:24406786 |
| Kowalczyk MC et al. | Effects of combined phytochemicals on skin tumorigenesis in SENCAR mice. | 2013 | Int. J. Oncol. | pmid:23835587 |
| Junco JJ et al. | Resveratrol and P-glycoprotein inhibitors enhance the anti-skin cancer effects of ursolic acid. | 2013 | Mol. Cancer Res. | pmid:24072817 |
| Zhang P et al. | Ursolic acid inhibits acid sphingomyelinase in intestinal cells. | 2013 | Phytother Res | pmid:22511398 |
| Yu F et al. | Functional characterization of amyrin synthase involved in ursolic acid biosynthesis in Catharanthus roseus leaf epidermis. | 2013 | Phytochemistry | pmid:22652241 |
| Jiménez-Arellanes A et al. | Ursolic and oleanolic acids as antimicrobial and immunomodulatory compounds for tuberculosis treatment. | 2013 | BMC Complement Altern Med | pmid:24098949 |
| Rao AR et al. | In vitro and in vivo inhibitory activities of four Indian medicinal plant extracts and their major components on rat aldose reductase and generation of advanced glycation endproducts. | 2013 | Phytother Res | pmid:22826152 |
| Li L et al. | Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice. | 2013 | Brain Res. | pmid:23276496 |
| Son HS et al. | Activation of AMP-activated protein kinase and phosphorylation of glycogen synthase kinase3 β mediate ursolic acid induced apoptosis in HepG2 liver cancer cells. | 2013 | Phytother Res | pmid:23325562 |
| Zhu Z et al. | A phase I pharmacokinetic study of ursolic acid nanoliposomes in healthy volunteers and patients with advanced solid tumors. | 2013 | Int J Nanomedicine | pmid:23319864 |
| Saifudin A et al. | Sesquiterpenes from the rhizomes of Curcuma heyneana. | 2013 | J. Nat. Prod. | pmid:23387824 |
| Zhang H et al. | Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2). | 2013 | Int J Pharm | pmid:23194884 |
| Dorota W et al. | Effect of asiatic and ursolic acids on morphology, hydrophobicity, and adhesion of UPECs to uroepithelial cells. | 2013 | Folia Microbiol. (Praha) | pmid:23132656 |
| Wang XH et al. | Evaluation of toxicity and single-dose pharmacokinetics of intravenous ursolic acid liposomes in healthy adult volunteers and patients with advanced solid tumors. | 2013 | Expert Opin Drug Metab Toxicol | pmid:23134084 |
| Liu K et al. | Ursolic acid inhibits epithelial-mesenchymal transition by suppressing the expression of astrocyte-elevated gene-1 in human nonsmall cell lung cancer A549 cells. | 2013 | Anticancer Drugs | pmid:23511428 |
| Wu DM et al. | Ursolic acid improves domoic acid-induced cognitive deficits in mice. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23707761 |
| Caligiani A et al. | A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients. | 2013 | Food Chem | pmid:23122121 |
| Leng S et al. | Ursolic acid promotes cancer cell death by inducing Atg5-dependent autophagy. | 2013 | Int. J. Cancer | pmid:23737395 |
| Wang J et al. | Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells. | 2013 | PLoS ONE | pmid:23737956 |
| Zhao C et al. | Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells. | 2013 | Autophagy | pmid:23182854 |