| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinogenesis | D063646 | 3 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li R et al. | The influence of cosolvent on the complexation of HP-beta-cyclodextrins with oleanolic acid and ursolic acid. | 2009 | AAPS PharmSciTech | pmid:19834815 |
| Zheng RX et al. | Chemical constituents from the fruits of Hippophae rhamnoides. | 2009 | Nat. Prod. Res. | pmid:19809919 |
| Ichikawa T et al. | Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes. | 2009 | PLoS ONE | pmid:20027226 |
| Yasukawa K et al. | Anti-tumor promoters phenolics and triterpenoid from Hippophae rhamnoides. | 2009 | Fitoterapia | pmid:19535023 |
| Kim J et al. | Anti-lipase and lipolytic activities of ursolic acid isolated from the roots of Actinidia arguta. | 2009 | Arch. Pharm. Res. | pmid:19641878 |
| Liu M et al. | Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma. | 2009 | Fitoterapia | pmid:19446614 |
| Kontogianni VG et al. | Rapid and novel discrimination and quantification of oleanolic and ursolic acids in complex plant extracts using two-dimensional nuclear magnetic resonance spectroscopy-Comparison with HPLC methods. | 2009 | Anal. Chim. Acta | pmid:19216877 |
| da Silva Filho AA et al. | In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae). | 2009 | Fitoterapia | pmid:19540316 |
| Seo C et al. | Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19362837 |
| Tu HY et al. | Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species. | 2009 | Bioorg. Med. Chem. | pmid:19758808 |
| Shan JZ et al. | Ursolic acid inhibits proliferation and induces apoptosis of HT-29 colon cancer cells by inhibiting the EGFR/MAPK pathway. | 2009 | J Zhejiang Univ Sci B | pmid:19735099 |
| Ma CM et al. | Triterpenes from Cynomorium songaricium--analysis of HCV protease inhibitory activity, quantification, and content change under the influence of heating. | 2009 | J Nat Med | pmid:18600299 |
| Jang SM et al. | Ursolic acid enhances the cellular immune system and pancreatic beta-cell function in streptozotocin-induced diabetic mice fed a high-fat diet. | 2009 | Int. Immunopharmacol. | pmid:19013541 |
| Meng YQ et al. | The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation of their preliminary mechanism of action. | 2009 | Bioorg. Med. Chem. | pmid:19091579 |
| Kassi E et al. | Ursolic acid triggers apoptosis and Bcl-2 downregulation in MCF-7 breast cancer cells. | 2009 | Cancer Invest. | pmid:19440893 |
| Pérez Gutiérrez RM et al. | Hypoglycemic activity of constituents from Astianthus viminalis in normal and streptozotocin-induced diabetic mice. | 2009 | J Nat Med | pmid:19484331 |
| Kowalczyk MC et al. | Differential effects of several phytochemicals and their derivatives on murine keratinocytes in vitro and in vivo: implications for skin cancer prevention. | 2009 | Carcinogenesis | pmid:19329757 |
| Zhang YX et al. | Phosphorylation of Bcl-2 and activation of caspase-3 via the c-Jun N-terminal kinase pathway in ursolic acid-induced DU145 cells apoptosis. | 2009 | Biochimie | pmid:19545597 |
| Cristians S et al. | Hypoglycemic activity of extracts and compounds from the leaves of Hintonia standleyana and H. latiflora: potential alternatives to the use of the stem bark of these species. | 2009 | J. Nat. Prod. | pmid:19140696 |
| Yu HH et al. | Protective effect of ursolic acid from Cornus officinalis on the hydrogen peroxide-induced damage of HEI-OC1 auditory cells. | 2009 | Am. J. Chin. Med. | pmid:19655411 |
| Yao Z et al. | [Triterpenoids from leaves of Ilex cornuta]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19639785 |
| Lee JH et al. | Gardenia jasminoides Ellis ethanol extract and its constituents reduce the risks of gastritis and reverse gastric lesions in rats. | 2009 | Food Chem. Toxicol. | pmid:19425231 |
| MartÃn R et al. | Natural triterpenic diols promote apoptosis in astrocytoma cells through ROS-mediated mitochondrial depolarization and JNK activation. | 2009 | PLoS ONE | pmid:19543395 |
| Hoang DM et al. | Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19846295 |
| Zhang P et al. | Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. | 2009 | J. Nat. Prod. | pmid:19642687 |
| Chen IH et al. | Cytotoxic triterpenoids from the stems of Microtropis japonica. | 2009 | J. Nat. Prod. | pmid:19534471 |
| Puangpraphant S and de Mejia EG | Saponins in yerba mate tea ( Ilex paraguariensis A. St.-Hil) and quercetin synergistically inhibit iNOS and COX-2 in lipopolysaccharide-induced macrophages through NFkappaB pathways. | 2009 | J. Agric. Food Chem. | pmid:19807157 |
| Wu PK et al. | Oleanolic acid isolated from Oldenlandia diffusa exhibits a unique growth inhibitory effect against ras-transformed fibroblasts. | 2009 | Life Sci. | pmid:19433096 |
| Gayathri R et al. | Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats. | 2009 | Asian Pac. J. Cancer Prev. | pmid:20104993 |
| Lavhale MS et al. | A novel triterpenoid isolated from the root bark of Ailanthus excelsa Roxb (Tree of Heaven), AECHL-1 as a potential anti-cancer agent. | 2009 | PLoS ONE | pmid:19399188 |
| Wang X et al. | Effects of ursolic acid on the proliferation and apoptosis of human ovarian cancer cells. | 2009 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:20037823 |
| Acda MN | Toxicity, tunneling and feeding behavior of the termite, Coptotermes vastator, in sand treated with oil of the physic nut, Jatropha curcas. | 2009 | J. Insect Sci. | pmid:20053119 |
| Yang JD et al. | Lysis of Microcystis aeruginosa with extracts from Chinese medicinal herbs. | 2009 | Int J Mol Sci | pmid:19865537 |
| Li J et al. | Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. | 2009 | J. Nat. Prod. | pmid:19555121 |
| Grange PA et al. | Production of superoxide anions by keratinocytes initiates P. acnes-induced inflammation of the skin. | 2009 | PLoS Pathog. | pmid:19629174 |
| Matsumoto RL et al. | Effects of maté tea intake on ex vivo LDL peroxidation induced by three different pathways. | 2009 | Nutrients | pmid:22253965 |
| Abdullah NH et al. | Methyl 3-acet-oxy-3-dehydroxy-ursolate. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21577529 |
| Awang K et al. | Methyl 3-dehydr-oxy-3-oxoursolate. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21577528 |
| Kawano M et al. | Anti-inflammatory and analgesic components from "hierba santa," a traditional medicine in Peru. | 2009 | J Nat Med | pmid:19067116 |
| Ramadan MA et al. | Chemical composition of the stem bark and leaves of Ficus pandurata Hance. | 2009 | Nat. Prod. Res. | pmid:19731141 |
| Ali S et al. | Mutiniside, new antioxidant phenolic glucoside from Abutilon muticum. | 2009 | J Asian Nat Prod Res | pmid:19504389 |
| Jäger S et al. | Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts. | 2009 | Molecules | pmid:19513002 |
| Awad R et al. | Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity. | 2009 | Phytother Res | pmid:19165747 |
| Lee SU et al. | Anabolic activity of ursolic acid in bone: Stimulating osteoblast differentiation in vitro and inducing new bone formation in vivo. | 2008 Nov-Dec | Pharmacol. Res. | pmid:18822379 |
| Gnoatto SC et al. | Synthesis and preliminary evaluation of new ursolic and oleanolic acids derivatives as antileishmanial agents. | 2008 | J Enzyme Inhib Med Chem | pmid:18608757 |
| Cunha WR et al. | Hypoglicemic effect of Leandra lacunosa in normal and alloxan-induced diabetic rats. | 2008 | Fitoterapia | pmid:18538949 |
| Yu XH et al. | [Study on ursolic acid extraction rate by ultramicro smashing and conventional smashing from leaves of Paulownia fortunei]. | 2008 | Zhong Yao Cai | pmid:19230417 |
| Ramachandran S and Prasad NR | Effect of ursolic acid, a triterpenoid antioxidant, on ultraviolet-B radiation-induced cytotoxicity, lipid peroxidation and DNA damage in human lymphocytes. | 2008 | Chem. Biol. Interact. | pmid:18793624 |
| Ahmad M et al. | Urease inhibitor from Datisca cannabina linn. | 2008 | J Enzyme Inhib Med Chem | pmid:18569344 |
| Raphael TJ and Kuttan G | Effect of naturally occurring triterpenoids ursolic acid and glycyrrhizic acid on the cell-mediated immune responses of metastatic tumor-bearing animals. | 2008 | Immunopharmacol Immunotoxicol | pmid:18569082 |