| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinogenesis | D063646 | 3 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nataraju A et al. | Group IIA secretory PLA2 inhibition by ursolic acid: a potent anti-inflammatory molecule. | 2007 | Curr Top Med Chem | pmid:17456043 |
| Grudniak AM et al. | Oleanolic and ursolic acids influence affect the expression of the cysteine regulon and the stress response in Escherichia coli. | 2011 | Curr. Microbiol. | pmid:21221969 |
| Samadi N et al. | Comparative antibacterial efficacy of endemic satureja khuzistanica jamzad essential oil, sodium hypochlorite and chlorhexidine gluconate solutions as root canal irrigations. | 2011 | Dent Res J (Isfahan) | pmid:22132012 |
| Akiyama M | The roles of ABCA12 in keratinocyte differentiation and lipid barrier formation in the epidermis. | 2011 | Dermatoendocrinol | pmid:21695020 |
| PokrovskiÄ AG et al. | [Immunomodulating activity of ursolic acid derivatives]. | 1999 | Dokl. Akad. Nauk. | pmid:10613250 |
| Bacanlı M et al. | The antioxidant, cytotoxic, and antigenotoxic effects of galangin, puerarin, and ursolic acid in mammalian cells. | 2017 | Drug Chem Toxicol | pmid:27461151 |
| Wu S et al. | Ursolic acid sensitizes cisplatin-resistant HepG2/DDP cells to cisplatin via inhibiting Nrf2/ARE pathway. | 2016 | Drug Des Devel Ther | pmid:27822011 |
| Wang Y et al. | Ursolic acid reduces the metalloprotease/anti-metalloprotease imbalance in cerebral ischemia and reperfusion injury. | 2016 | Drug Des Devel Ther | pmid:27274199 |
| He W et al. | A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver. | 2015 | Drug Des Devel Ther | pmid:26347199 |
| Zhou XJ et al. | Preparation and body distribution of freeze-dried powder of ursolic acid phospholipid nanoparticles. | 2009 | Drug Dev Ind Pharm | pmid:18798089 |
| Wapling J et al. | Targeting human immunodeficiency virus type 1 assembly, maturation and budding. | 2007 | Drug Target Insights | pmid:21901072 |
| Teixeira T et al. | Molluscicidal activity of crude water and hexane extracts of Hypericum species to snails (Radix peregra). | 2012 | Environ. Toxicol. Chem. | pmid:22170085 |
| Zeller I et al. | Inhibition of cell surface expression of endothelial adhesion molecules by ursolic acid prevents intimal hyperplasia of venous bypass grafts in rats. | 2012 | Eur J Cardiothorac Surg | pmid:22551965 |
| Hua WJ et al. | The influence of herbal medicine ursolic acid on the uptake of rosuvastatin mediated by OATP1B1*1a and *5. | 2014 | Eur J Drug Metab Pharmacokinet | pmid:24736980 |
| Hua WJ et al. | Transepithelial transport of rosuvastatin and effect of ursolic acid on its transport in Caco-2 monolayers. | 2012 | Eur J Drug Metab Pharmacokinet | pmid:22562361 |
| Wen JH and Xiong YQ | The effect of herbal medicine danshensu and ursolic acid on pharmacokinetics of rosuvastatin in rats. | 2011 | Eur J Drug Metab Pharmacokinet | pmid:21717139 |
| Chen H et al. | Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agents. | 2015 | Eur J Med Chem | pmid:25617694 |
| Sun LP et al. | Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors. | 2011 | Eur J Med Chem | pmid:21680062 |
| Shao JW et al. | In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives. | 2011 | Eur J Med Chem | pmid:21514015 |
| Ma CM et al. | The cytotoxic activity of ursolic acid derivatives. | 2005 | Eur J Med Chem | pmid:15922841 |
| Gnoatto SC et al. | Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition. | 2008 | Eur J Med Chem | pmid:18192087 |
| Rashid S et al. | Synthesis and biological evaluation of ursolic acid-triazolyl derivatives as potential anti-cancer agents. | 2013 | Eur J Med Chem | pmid:23811086 |
| Mendes VIS et al. | Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells. | 2016 | Eur J Med Chem | pmid:27484517 |
| Liu MC et al. | Synthesis and cytotoxicity of novel ursolic acid derivatives containing an acyl piperazine moiety. | 2012 | Eur J Med Chem | pmid:23124210 |
| Siewert B et al. | The chemical and biological potential of C ring modified triterpenoids. | 2014 | Eur J Med Chem | pmid:24361521 |
| Wang YL et al. | Effects of artesunate and ursolic acid on hyperlipidemia and its complications in rabbit. | 2013 | Eur J Pharm Sci | pmid:23954455 |
| Lv YY et al. | Ursolic acid suppresses IL-6 induced C-reactive protein expression in HepG2 and protects HUVECs from injury induced by CRP. | 2012 | Eur J Pharm Sci | pmid:22108347 |
| Zhong Y et al. | Synthesis, stability and pharmacological evaluation of a novel codrug consisting of lamivudine and ursolic acid. | 2012 | Eur J Pharm Sci | pmid:22085635 |
| Maurya A et al. | QSAR, docking and in vivo studies for immunomodulatory activity of isolated triterpenoids from Eucalyptus tereticornis and Gentiana kurroo. | 2012 | Eur J Pharm Sci | pmid:22659375 |
| Cui HZ et al. | Ursolic acid increases the secretion of atrial natriuretic peptide in isolated perfused beating rabbit atria. | 2011 | Eur. J. Pharmacol. | pmid:21122803 |
| Kim SH et al. | Ursolic acid, a potential PPARγ agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of allergic asthma. | 2013 | Eur. J. Pharmacol. | pmid:23201068 |
| Jung TY et al. | Ursolic acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFN-gamma by CD4+ naïve T cells. | 2010 | Eur. J. Pharmacol. | pmid:20599915 |
| Wang ZH et al. | Anti-glycative effects of oleanolic acid and ursolic acid in kidney of diabetic mice. | 2010 | Eur. J. Pharmacol. | pmid:19917277 |
| Soo Lee Y et al. | Inhibition of ultraviolet-A-modulated signaling pathways by asiatic acid and ursolic acid in HaCaT human keratinocytes. | 2003 | Eur. J. Pharmacol. | pmid:12969763 |
| Máñez S et al. | Effect of selected triterpenoids on chronic dermal inflammation. | 1997 | Eur. J. Pharmacol. | pmid:9346335 |
| Colla AR et al. | Anxiolytic-like effects of ursolic acid in mice. | 2015 | Eur. J. Pharmacol. | pmid:25861934 |
| Moghaddam FM et al. | Chemical Constituents of Dichloromethane Extract of Cultivated Satureja khuzistanica. | 2007 | Evid Based Complement Alternat Med | pmid:17342246 |
| Wen KC et al. | Inhibitory Effects of Terminalia catappa on UVB-Induced Photodamage in Fibroblast Cell Line. | 2011 | Evid Based Complement Alternat Med | pmid:20981325 |
| Arora R et al. | Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud. | 2011 | Evid Based Complement Alternat Med | pmid:20976081 |
| Chiou JF et al. | A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging. | 2011 | Evid Based Complement Alternat Med | pmid:21785640 |
| Lin Y et al. | Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters. | 2011 | Evid Based Complement Alternat Med | pmid:19228775 |
| Berrington D and Lall N | Anticancer Activity of Certain Herbs and Spices on the Cervical Epithelial Carcinoma (HeLa) Cell Line. | 2012 | Evid Based Complement Alternat Med | pmid:22649474 |
| Ismail M et al. | Antibacterial, Antifungal, Cytotoxic, Phytotoxic, Insecticidal, and Enzyme Inhibitory Activities of Geranium wallichianum. | 2012 | Evid Based Complement Alternat Med | pmid:23049606 |
| Bei WJ et al. | Lipid-regulating effect of traditional chinese medicine: mechanisms of actions. | 2012 | Evid Based Complement Alternat Med | pmid:22611438 |
| Debprasad C et al. | Inhibition of NO(2), PGE(2), TNF-α, and iNOS EXpression by Shorea robusta L.: An Ethnomedicine Used for Anti-Inflammatory and Analgesic Activity. | 2012 | Evid Based Complement Alternat Med | pmid:22649472 |
| Lan YH et al. | Activations of Both Extrinsic and Intrinsic Pathways in HCT 116 Human Colorectal Cancer Cells Contribute to Apoptosis through p53-Mediated ATM/Fas Signaling by Emilia sonchifolia Extract, a Folklore Medicinal Plant. | 2012 | Evid Based Complement Alternat Med | pmid:22474491 |
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| Ansarullah S et al. | Influence of Oreocnide integrifolia (Gaud.) Miq on IRS-1, Akt and Glut-4 in Fat-Fed C57BL/6J Type 2 Diabetes Mouse Model. | 2011 | Evid Based Complement Alternat Med | pmid:21785636 |
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| Kaur M and Goel RK | Anti-Convulsant Activity of Boerhaavia diffusa: Plausible Role of Calcium Channel Antagonism. | 2011 | Evid Based Complement Alternat Med | pmid:19948752 |