MeSH term | MeSH ID | Detail |
---|---|---|
Carcinogenesis | D063646 | 3 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Dermatitis, Contact | D003877 | 59 associated lipids |
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with ursolic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinogenesis | D063646 | 3 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Dermatitis, Contact | D003877 | 59 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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LE MEN J and POURRAT H | [The presence of ursolic acid in the leaves of Vinca minor L., Nerium oleander L. and Salvia officinalis L]. | 1952 | Ann Pharm Fr | pmid:14953076 |
JANOT MM et al. | [Study of a deposit of crystals from a fluid extract of Salvia officinalis]. | 1952 | Ann Pharm Fr | pmid:12986502 |
LE MEN J and POURRAT H | [Distribution of ursolic acid in the Apocynaceae]. | 1953 | Ann Pharm Fr | pmid:13092702 |
WU BY and PARKS LM | Oleanolic acid from cranberries. | 1953 | J Am Pharm Assoc Am Pharm Assoc (Baltim) | pmid:13096399 |
WU BY and PARKS LM | Chemical studies on ursolic acid. | 1953 | J Am Pharm Assoc Am Pharm Assoc (Baltim) | pmid:13096400 |
POURRAT H and LE MEN J | [Ursolic acid: distribution of ursolic acid in labiate plants]. | 1953 | Ann Pharm Fr | pmid:13058228 |
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POURRAT H et al. | [Ursolic acid; distribution of ursolic acid in Oleaceae]. | 1954 | Ann Pharm Fr | pmid:13171723 |
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LE MEN J and POURRAT H | [Distribution of ursolic acid in the leaves of various Rosaceae; ursolic acid. V..]. | 1955 | Ann Pharm Fr | pmid:14388439 |
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Ohigashi H et al. | Search for possible antitumor promoters by inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation; ursolic acid and oleanolic acid from an anti-inflammatory Chinese medicinal plant, Glechoma hederaceae L. | 1986 | Cancer Lett. | pmid:3006912 |
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Najid A et al. | Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL60 leukemic cells. | 1992 | FEBS Lett. | pmid:1544497 |
Simon A et al. | Inhibition of lipoxygenase activity and HL60 leukemic cell proliferation by ursolic acid isolated from heather flowers (Calluna vulgaris). | 1992 | Biochim. Biophys. Acta | pmid:1567909 |
Varanda EM et al. | Effect of ursolic acid from epicuticular waxes of Jacaranda decurrens on Schizaphis graminum. | 1992 | J. Nat. Prod. | pmid:1522421 |
Takechi M and Tanaka Y | Structure-activity relationships of synthetic methyl ursolate glycosides. | 1993 | Phytochemistry | pmid:7764145 |
Niikawa M et al. | Isolation of substances from glossy privet (Ligustrum lucidum Ait.) inhibiting the mutagenicity of benzo[a]pyrene in bacteria. | 1993 | Mutat. Res. | pmid:7690454 |
Richards RM et al. | Antibacterial activity of compounds from Rubus pinfaensis. | 1994 | Planta Med. | pmid:7997480 |
Huang MT et al. | Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. | 1994 | Cancer Res. | pmid:8306331 |
Sohn KH et al. | Anti-angiogenic activity of triterpene acids. | 1995 | Cancer Lett. | pmid:7543366 |
Liu J | Pharmacology of oleanolic acid and ursolic acid. | 1995 | J Ethnopharmacol | pmid:8847885 |
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Quéré L et al. | Triterpenes as potential dimerization inhibitors of HIV-1 protease. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8967903 |
Singletary K et al. | Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. | 1996 | Cancer Lett. | pmid:8640744 |
Cha HJ et al. | Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells. | 1996 | Cancer Res. | pmid:8625299 |
Xu HX et al. | Anti-HIV triterpene acids from Geum japonicum. | 1996 | J. Nat. Prod. | pmid:8759159 |
Es-saady D et al. | Inhibitory effect of ursolic acid on B16 proliferation through cell cycle arrest. | 1996 | Cancer Lett. | pmid:8844972 |
Tan GT et al. | Natural-product inhibitors of human DNA ligase I. | 1996 | Biochem. J. | pmid:8615799 |
Es-Saady D et al. | MCF-7 cell cycle arrested at G1 through ursolic acid, and increased reduction of tetrazolium salts. | 1996 Jan-Feb | Anticancer Res. | pmid:8615658 |
Hsu HY et al. | Effects of oleanolic acid and ursolic acid on inhibiting tumor growth and enhancing the recovery of hematopoietic system postirradiation in mice. | 1997 | Cancer Lett. | pmid:9022122 |
Baek JH et al. | Intracellular Ca2+ release mediates ursolic acid-induced apoptosis in human leukemic HL-60 cells. | 1997 | Int. J. Cancer | pmid:9398053 |
Máñez S et al. | Effect of selected triterpenoids on chronic dermal inflammation. | 1997 | Eur. J. Pharmacol. | pmid:9346335 |
Tu P et al. | [Fat soluble constituents of the leaves of Vaccinium bracteatum Thunb]. | 1997 | Zhongguo Zhong Yao Za Zhi | pmid:11038902 |
Ringbom T et al. | Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis. | 1998 | J. Nat. Prod. | pmid:9784154 |
Suh N et al. | Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages. | 1998 | Cancer Res. | pmid:9485026 |
Farina C et al. | Synthesis and anti-ulcer activity of new derivatives of glycyrrhetic, oleanolic and ursolic acids. | 1998 | Farmaco | pmid:9543723 |
Cha HJ et al. | Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells. | 1998 | Oncogene | pmid:9488041 |
Kim DW et al. | Growth inhibitory activities of kalopanaxsaponins A and I against human pathogenic fungi. | 1998 | Arch. Pharm. Res. | pmid:9868538 |
Huang H et al. | [Chemical constituents in the stem and leaf of Isodon oresbius]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11243153 |
Zhou F et al. | [Chemical constituents of the stem and root of Syzygium buxifolium Hook. Et Arn]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11596235 |
Ding H et al. | [Quantitative determination of ursolic acid in Herba cynomorii by ultraviolet spectrophotometry]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11596256 |
Paik KJ et al. | Induction of differentiation of the cultured rat mammary epithelial cells by triterpene acids. | 1998 | Arch. Pharm. Res. | pmid:9875466 |
Zheng X et al. | [Chemical studies on Pyrrosia gralla (Gies.) Ching]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11596269 |
Kashiwada Y et al. | Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids. | 1998 | J. Nat. Prod. | pmid:9748372 |
Steele JC et al. | In vitro and in vivo evaluation of betulinic acid as an antimalarial. | 1999 | Phytother Res | pmid:10190183 |
Haraguchi H et al. | Antimicrobial triterpenes from Ilex integra and the mechanism of antifungal action. | 1999 | Phytother Res | pmid:10190191 |
Min BS et al. | Inhibitory effect of triterpenes from Crataegus pinatifida on HIV-I protease. | 1999 | Planta Med. | pmid:10364847 |
Jeong TS et al. | Chitin synthase II inhibitory activity of ursolic acid, isolated from Crataegus pinnatifida. | 1999 | Planta Med. | pmid:10232075 |
Huang J et al. | [Experimental study on apoptosis induced by ursolic acid isolated from asparagus in HL-60 cells]. | 1999 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11783246 |
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Pérez-Camino MC and Cert A | Quantitative determination of hydroxy pentacyclic triterpene acids in vegetable oils. | 1999 | J. Agric. Food Chem. | pmid:10564016 |
Kitani K et al. | Pharmacological modifications of endogenous antioxidant enzymes with special reference to the effects of deprenyl: a possible antioxidant strategy. | 1999 | Mech. Ageing Dev. | pmid:10656538 |
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Kashiwada Y et al. | Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives. | 2000 | J. Nat. Prod. | pmid:11141100 |
Kim YK et al. | Cytotoxic triterpenes from stem bark of Physocarpus intermedius. | 2000 | Planta Med. | pmid:10909277 |
Syrovets T et al. | Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIalpha. | 2000 | Mol. Pharmacol. | pmid:10860928 |
Lauthier F et al. | Ursolic acid triggers calcium-dependent apoptosis in human Daudi cells. | 2000 | Anticancer Drugs | pmid:11129737 |
Yarosh DB et al. | Liposomal ursolic acid (merotaine) increases ceramides and collagen in human skin. | 2000 | Horm. Res. | pmid:11595826 |
Subbaramaiah K et al. | Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. | 2000 | Cancer Res. | pmid:10811116 |
Xu XZ and Tian X | [Studies on chemical components of Gentiana tizuensis Franch. (I)]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12512438 |
Yang J et al. | [Studies on constituents in Uncaria macrophylla Wall]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12515211 |
Saraswat B et al. | Ursolic acid isolated from Eucalyptus tereticornis protects against ethanol toxicity in isolated rat hepatocytes. | 2000 | Phytother Res | pmid:10815008 |
Min BS et al. | Cytotoxic triterpenes from Crataegus pinnatifida. | 2000 | Arch. Pharm. Res. | pmid:10836742 |
Akbarsha MA et al. | Retention of cytoplasmic droplet by rat cauda epididymal spermatozoa after treatment with cytotoxic and xenobiotic agents. | 2000 | J. Reprod. Fertil. | pmid:11058454 |
Choi YH et al. | Induction of apoptosis by ursolic acid through activation of caspases and down-regulation of c-IAPs in human prostate epithelial cells. | 2000 | Int. J. Oncol. | pmid:10938399 |
Kim DK et al. | Apoptotic activity of ursolic acid may correlate with the inhibition of initiation of DNA replication. | 2000 | Int. J. Cancer | pmid:10925354 |
Choi BM et al. | Cyclic adenosine monophosphate inhibits ursolic acid-induced apoptosis via activation of protein kinase A in human leukaemic HL-60 cells. | 2000 | Pharmacol. Toxicol. | pmid:10728914 |
Hollósy F et al. | Cytostatic, cytotoxic and protein tyrosine kinase inhibitory activity of ursolic acid in A431 human tumor cells. | 2000 Nov-Dec | Anticancer Res. | pmid:11205305 |
Upadhyay RK et al. | Eclalbatin, a triterpene saponin from Eclipta alba. | 2001 | J Asian Nat Prod Res | pmid:11491397 |
Ismaili H et al. | Topical anti-inflammatory activity of Thymus willdenowii. | 2001 | J. Pharm. Pharmacol. | pmid:11804395 |
Cantrell CL et al. | Antimycobacterial plant terpenoids. | 2001 | Planta Med. | pmid:11731906 |
Novotný L et al. | Ursolic acid: an anti-tumorigenic and chemopreventive activity. Minireview. | 2001 | Neoplasma | pmid:11712672 |
Rios MY et al. | Sterols, triterpenes and biflavonoids of Viburnum jucundum and cytotoxic activity of ursolic acid. | 2001 | Planta Med. | pmid:11582553 |
Martin-Aragón S et al. | Pharmacological modification of endogenous antioxidant enzymes by ursolic acid on tetrachloride-induced liver damage in rats and primary cultures of rat hepatocytes. | 2001 | Exp. Toxicol. Pathol. | pmid:11484840 |
You HJ et al. | Ursolic acid enhances nitric oxide and tumor necrosis factor-alpha production via nuclear factor-kappaB activation in the resting macrophages. | 2001 | FEBS Lett. | pmid:11741581 |
Baricevic D et al. | Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid. | 2001 | J Ethnopharmacol | pmid:11297842 |
Chung YK et al. | Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase. | 2001 | Mol. Cells | pmid:11355692 |
Wen ZM and Xu LX | [Isolation and elucidation of chemical constituents of Shandanshaoyao Decoction(I)]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12528509 |
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Martinet A et al. | NMR and LC-MSn characterisation of two minor saponins from Ilex paraguariensis. | 2001 Jan-Feb | Phytochem Anal | pmid:11704961 |
Lee I et al. | Ursolic acid-induced changes in tumor growth, O2 consumption, and tumor interstitial fluid pressure. | 2001 Jul-Aug | Anticancer Res. | pmid:11724362 |
Ahumada C et al. | Influence of the parasite Viscum cruciatum Sieber on the chemical constituents of Crataegus monogyna Jacq. | 2001 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:11837662 |
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Hollósy F et al. | Activation of caspase-3 protease during the process of ursolic acid and its derivative-induced apoptosis. | 2001 Sep-Oct | Anticancer Res. | pmid:11848513 |
Jiang B et al. | Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata. | 2002 | Planta Med. | pmid:12391557 |
Pires VS et al. | Triterpenes and saponins from Ilex psammophila. | 2002 | Nat Prod Lett | pmid:12462345 |