| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinogenesis | D063646 | 3 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xue YM et al. | [Determination of ursolic acid of Sambucus adnata]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:24010309 |
| Mazumder K et al. | Cytotoxic activity of ursolic acid derivatives obtained by isolation and oxidative derivatization. | 2013 | Molecules | pmid:23896618 |
| Ogasawara R et al. | Ursolic acid stimulates mTORC1 signaling after resistance exercise in rat skeletal muscle. | 2013 | Am. J. Physiol. Endocrinol. Metab. | pmid:23900420 |
| Lin J et al. | Ursolic acid promotes colorectal cancer cell apoptosis and inhibits cell proliferation via modulation of multiple signaling pathways. | 2013 | Int. J. Oncol. | pmid:23900560 |
| Yang JJ et al. | [Study on the effect of ursolic acid (UA) on the myocardial fibrosis of experimental diabetic mice]. | 2013 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:24175562 |
| Kong L et al. | Oleanolic acid and ursolic acid: novel hepatitis C virus antivirals that inhibit NS5B activity. | 2013 | Antiviral Res. | pmid:23422646 |
| Nam H and Kim MM | Ursolic acid induces apoptosis of SW480 cells via p53 activation. | 2013 | Food Chem. Toxicol. | pmid:24071474 |
| Lin J et al. | Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways. | 2013 | Int. J. Oncol. | pmid:24042330 |
| Saraswati S et al. | Ursolic acid inhibits tumor angiogenesis and induces apoptosis through mitochondrial-dependent pathway in Ehrlich ascites carcinoma tumor. | 2013 | Chem. Biol. Interact. | pmid:24051192 |
| Wang W et al. | Ursolic acid inhibits the growth of colon cancer-initiating cells by targeting STAT3. | 2013 | Anticancer Res. | pmid:24122993 |
| Wang YL et al. | Effects of artesunate and ursolic acid on hyperlipidemia and its complications in rabbit. | 2013 | Eur J Pharm Sci | pmid:23954455 |
| Achiwa Y et al. | Effect of ursolic acid on MAPK in cyclin D1 signaling and RING-type E3 ligase (SCF E3s) in two endometrial cancer cell lines. | 2013 | Nutr Cancer | pmid:24083669 |
| da Silva Ferreira D et al. | In vivo activity of ursolic and oleanolic acids during the acute phase of Trypanosoma cruzi infection. | 2013 | Exp. Parasitol. | pmid:23648663 |
| Wu L et al. | Processing technology investigation of loquat (Eriobotrya japonica) leaf by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry combined with chemometrics. | 2013 | PLoS ONE | pmid:23667702 |
| Zhai B et al. | Antimalarial evaluation of the chemical constituents of hairy root culture of Bixa orellana L. | 2013 | Molecules | pmid:24406786 |
| Çulhaoğlu B et al. | Bioactive constituents of Salvia chrysophylla Stapf. | 2013 | Nat. Prod. Res. | pmid:23126495 |
| Kowalczyk MC et al. | Effects of combined phytochemicals on skin tumorigenesis in SENCAR mice. | 2013 | Int. J. Oncol. | pmid:23835587 |
| Kim SH et al. | Ursolic acid, a potential PPARγ agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of allergic asthma. | 2013 | Eur. J. Pharmacol. | pmid:23201068 |
| Zheng QY et al. | Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells. | 2013 | Cell. Signal. | pmid:23000344 |
| Zhang P et al. | Ursolic acid inhibits acid sphingomyelinase in intestinal cells. | 2013 | Phytother Res | pmid:22511398 |
| Verma SC et al. | Microwave-assisted extraction and rapid isolation of ursolic acid from the leaves of Eucalyptus × hybrida Maiden and its quantification using HPLC-diode array technique. | 2013 | J Sep Sci | pmid:23471897 |
| Shanmugam MK et al. | Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies. | 2013 | Biochem. Pharmacol. | pmid:23499879 |
| Rashid S et al. | Synthesis and biological evaluation of ursolic acid-triazolyl derivatives as potential anti-cancer agents. | 2013 | Eur J Med Chem | pmid:23811086 |
| Shin SW and Park JW | Ursolic acid sensitizes prostate cancer cells to TRAIL-mediated apoptosis. | 2013 | Biochim. Biophys. Acta | pmid:23247106 |
| da Silva GN et al. | Two series of new semisynthetic triterpene derivatives: differences in anti-malarial activity, cytotoxicity and mechanism of action. | 2013 | Malar. J. | pmid:23497003 |
| Chen X et al. | Ursolic acid attenuates lipopolysaccharide-induced acute lung injury in a mouse model. | 2013 | Immunotherapy | pmid:23256797 |
| Li L et al. | Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice. | 2013 | Brain Res. | pmid:23276496 |
| Son HS et al. | Activation of AMP-activated protein kinase and phosphorylation of glycogen synthase kinase3 β mediate ursolic acid induced apoptosis in HepG2 liver cancer cells. | 2013 | Phytother Res | pmid:23325562 |
| Zhu Z et al. | A phase I pharmacokinetic study of ursolic acid nanoliposomes in healthy volunteers and patients with advanced solid tumors. | 2013 | Int J Nanomedicine | pmid:23319864 |
| Saifudin A et al. | Sesquiterpenes from the rhizomes of Curcuma heyneana. | 2013 | J. Nat. Prod. | pmid:23387824 |
| Zhang H et al. | Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2). | 2013 | Int J Pharm | pmid:23194884 |
| Caligiani A et al. | A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients. | 2013 | Food Chem | pmid:23122121 |
| Shih WL et al. | Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model. | 2013 | Mol. Carcinog. | pmid:22549898 |
| Zhang ZF et al. | Two new ursolic acid saponins from Morina nepalensis var. alba Hand-Mazz. | 2013 | Nat. Prod. Res. | pmid:23962075 |
| Yu ZL and Zeng WC | Antioxidant, antibrowning, and cytoprotective activities of Ligustrum robustum (Rxob.) Blume extract. | 2013 | J. Food Sci. | pmid:23924383 |
| Verano J et al. | Ursolic acid from Agastache mexicana aerial parts produces antinociceptive activity involving TRPV1 receptors, cGMP and a serotonergic synergism. | 2013 | Pharmacol. Biochem. Behav. | pmid:23932918 |
| Lee YH et al. | Modulation of photochemical damage in normal and malignant cells by naturally occurring compounds. | 2012 Nov-Dec | Photochem. Photobiol. | pmid:22486439 |
| Yang YC et al. | Optimisation of an ultrasound-assisted extraction followed by RP-HPLC separation for the simultaneous determination of oleanolic acid, ursolic acid and oridonin content in Rabdosia rubescens. | 2012 Nov-Dec | Phytochem Anal | pmid:22706975 |
| Peixoto MP et al. | LC-UV assay method and UPLC/Q-TOF-MS characterisation of saponins from Ilex paraguariensis A. St. Hil. (mate) unripe fruits. | 2012 Jul-Aug | Phytochem Anal | pmid:22105927 |
| Silva LL et al. | Effects of Lecythis pisonis Camb. (Lecythidaceae) in a mouse model of pruritus. | 2012 | J Ethnopharmacol | pmid:22063727 |
| Rivero-Chan BE et al. | Rapid access to ketones related to oleanolic and ursolic acids. | 2012 | Nat. Prod. Res. | pmid:21859373 |
| Kim SH et al. | Effects of Corni fructus on ovalbumin-induced airway inflammation and airway hyper-responsiveness in a mouse model of allergic asthma. | 2012 | J Inflamm (Lond) | pmid:22439901 |
| Limami Y et al. | The P2Y2/Src/p38/COX-2 pathway is involved in the resistance to ursolic acid-induced apoptosis in colorectal and prostate cancer cells. | 2012 | Biochimie | pmid:22521508 |
| Ismail M et al. | Antibacterial, Antifungal, Cytotoxic, Phytotoxic, Insecticidal, and Enzyme Inhibitory Activities of Geranium wallichianum. | 2012 | Evid Based Complement Alternat Med | pmid:23049606 |
| Xiang M et al. | Attenuation of aortic injury by ursolic acid through RAGE-Nox-NFκB pathway in streptozocin-induced diabetic rats. | 2012 | Arch. Pharm. Res. | pmid:22644855 |
| Katsargyris A et al. | Cranberry as promising natural source of potential anticancer agents: current evidence and future perspectives. | 2012 | Anticancer Agents Med Chem | pmid:22043998 |
| Liu MC et al. | Synthesis and cytotoxicity of novel ursolic acid derivatives containing an acyl piperazine moiety. | 2012 | Eur J Med Chem | pmid:23124210 |
| Innocente AM et al. | Synthesis and antiplasmodial activity of betulinic acid and ursolic acid analogues. | 2012 | Molecules | pmid:23085651 |
| Wong KC et al. | Chemical constituents and antibacterial activity of Melastoma malabathricum L. | 2012 | Nat. Prod. Res. | pmid:21834640 |
| Huang L et al. | Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus. | 2012 | Planta | pmid:22837051 |