MeSH term | MeSH ID | Detail |
---|---|---|
Carcinogenesis | D063646 | 3 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Dermatitis, Contact | D003877 | 59 associated lipids |
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with ursolic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinogenesis | D063646 | 3 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Dermatitis, Contact | D003877 | 59 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Arora R et al. | Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud. | 2011 | Evid Based Complement Alternat Med | pmid:20976081 |
Shen D et al. | A rapid LC/MS/MS method for the analysis of nonvolatile antiinflammatory agents from Mentha spp. | 2011 | J. Food Sci. | pmid:22417488 |
Abdureyim S et al. | Anti-inflammatory, immunomodulatory, and heme oxygenase-1 inhibitory activities of ravan napas, a formulation of uighur traditional medicine, in a rat model of allergic asthma. | 2011 | Evid Based Complement Alternat Med | pmid:20953388 |
Sonnet P and Mullié C | In vitro antimalarial activity of ICL670: a further proof of the correlation between inhibition of β-hematin formation and of peroxidative degradation of hemin. | 2011 | Exp. Parasitol. | pmid:21295029 |
Chen Q et al. | Development of a liquid chromatography-mass spectrometry method for the determination of ursolic acid in rat plasma and tissue: application to the pharmacokinetic and tissue distribution study. | 2011 | Anal Bioanal Chem | pmid:21249342 |
Limami Y et al. | HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death. | 2011 | Biochimie | pmid:21251952 |
Patel DK et al. | Pedalium murex Linn.: an overview of its phytopharmacological aspects. | 2011 | Asian Pac J Trop Med | pmid:21967701 |
Prasad S et al. | Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK. | 2011 | J. Biol. Chem. | pmid:21156789 |
Wang X et al. | Ursolic acid ameliorates hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells. | 2011 | J. Hepatol. | pmid:21168456 |
Xia Y et al. | Quantitation of ursolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry and its pharmacokinetic study. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21169069 |
Xu T et al. | Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein. | 2011 | J. Biol. Chem. | pmid:21566134 |
Minaiyan M et al. | Effects of extract and essential oil of Rosmarinus officinalis L. on TNBS-induced colitis in rats. | 2011 | Res Pharm Sci | pmid:22049274 |
Filocamo A et al. | Norfloxacin and ursolic acid: in vitro association and postantibiotic effect against Staphylococcus aureus. | 2011 | Lett. Appl. Microbiol. | pmid:21609344 |
Rao VS et al. | Ursolic acid, a pentacyclic triterpene from Sambucus australis, prevents abdominal adiposity in mice fed a high-fat diet. | 2011 | J Med Food | pmid:21612453 |
Pinon A et al. | A novel form of melanoma apoptosis resistance: melanogenesis up-regulation in apoptotic B16-F0 cells delays ursolic acid-triggered cell death. | 2011 | Exp. Cell Res. | pmid:21565187 |
Chung PY et al. | Synergistic antimicrobial activity between pentacyclic triterpenoids and antibiotics against Staphylococcus aureus strains. | 2011 | Ann. Clin. Microbiol. Antimicrob. | pmid:21658242 |
Reyes-Zurita FJ et al. | The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism. | 2011 | BMC Cancer | pmid:21524306 |
Bitencourt MA et al. | Aqueous and methanolic extracts of Caulerpa mexicana suppress cell migration and ear edema induced by inflammatory agents. | 2011 | Mar Drugs | pmid:21892348 |
Zhang XH and Zhu X | [The newest progress of the pharmacology of prunol]. | 2011 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:22013813 |
Wójciak-Kosior M et al. | The effect of ursolic and oleanolic acids on human skin fibroblast cells. | 2011 | Folia Histochem. Cytobiol. | pmid:22252762 |
Tannock LR | Ursolic acid effect on atherosclerosis: apples and apples, or apples and oranges? | 2011 | Atherosclerosis | pmid:21993411 |
Martin C et al. | How can research on plants contribute to promoting human health? | 2011 | Plant Cell | pmid:21586682 |
Sun Z et al. | Identification and determination of carboxylic acids in food samples using 2-(2-(anthracen-10-yl)-1H-phenanthro[9,10-d]imidazol-1-yl)ethyl 4-methylbenzenesulfonate (APIETS) as labeling reagent by HPLC with FLD and APCI/MS. | 2011 | Talanta | pmid:21726743 |
Xu X et al. | Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway. | 2011 | J. Exp. Clin. Cancer Res. | pmid:21447176 |
Kang KS et al. | Effect of intraperitoneal injection of curcumin on food intake in a goldfish model. | 2011 | J. Mol. Neurosci. | pmid:20514526 |
Muñoz O et al. | Chemical study and anti-inflammatory, analgesic and antioxidant activities of the leaves of Aristotelia chilensis (Mol.) Stuntz, Elaeocarpaceae. | 2011 | J. Pharm. Pharmacol. | pmid:21585384 |
Li G et al. | Highly sensitive and selective pre-column derivatization high-performance liquid chromatography approach for rapid determination of triterpenes oleanolic and ursolic acids and application to Swertia species: optimization of triterpenic acids extraction and pre-column derivatization using response surface methodology. | 2011 | Anal. Chim. Acta | pmid:21334488 |
Cho K et al. | Oleanolic acid and ursolic acid derived from Cornus officinalis Sieb. et Zucc. suppress epidermal growth factor- and phorbol ester-induced MUC5AC mucin production and gene expression from human airway epithelial cells. | 2011 | Phytother Res | pmid:21442679 |
Aslan M et al. | Effect of Gentiana olivieri on experimental epilepsy models. | 2011 | Pharmacogn Mag | pmid:22262939 |
Xia EQ et al. | Microwave-assisted extraction of oleanolic acid and ursolic acid from Ligustrum lucidum Ait. | 2011 | Int J Mol Sci | pmid:21954361 |
Alshawsh MA et al. | Hepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in Rats. | 2011 | Evid Based Complement Alternat Med | pmid:21647311 |
Wakchaure D et al. | Hepatoprotective activity of Symplocos racemosa bark on carbon tetrachloride-induced hepatic damage in rats. | 2011 | J Ayurveda Integr Med | pmid:22022156 |
Anusha M et al. | Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats. | 2011 | Indian J Pharmacol | pmid:22022001 |
Zhang HE et al. | [Optimization of supercritical fluid extraction of ursolic acid from follum eriobotryae by response surface methodology]. | 2011 | Zhong Yao Cai | pmid:22372151 |
Zhong Y et al. | Carb-oxy-methyl ursolate monohydrate. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:21523096 |
Chen Q et al. | Identification and quantification of oleanolic acid and ursolic acid in Chinese herbs by liquid chromatography-ion trap mass spectrometry. | 2011 | Biomed. Chromatogr. | pmid:21465498 |
Moneriz C et al. | Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages. | 2011 | Malar. J. | pmid:21477369 |
Truong NB et al. | Antituberculosis cycloartane triterpenoids from Radermachera boniana. | 2011 | J. Nat. Prod. | pmid:21469696 |
Mohan L et al. | Evaluation of the Anxiolytic Activity of NR-ANX-C (a Polyherbal Formulation) in Ethanol Withdrawal-Induced Anxiety Behavior in Rats. | 2011 | Evid Based Complement Alternat Med | pmid:20953426 |
Kim E et al. | Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes. | 2011 | Planta Med. | pmid:20717876 |
Fu SB et al. | Multihydroxylation of ursolic acid by Pestalotiopsis microspora isolated from the medicinal plant Huperzia serrata. | 2011 | Fitoterapia | pmid:21767617 |
Chen Y et al. | [Preparation and transdermal diffusion of ursolic acid ethosomes]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21809568 |
Annan K et al. | Acaricidal effect of an isolate from Hoslundia opposita vahl against Amblyomma variegatum (Acari: Ixodidae). | 2011 | Pharmacognosy Res | pmid:22022167 |
Li GL et al. | Development of a new HPLC method with precolumn fluorescent derivatization for rapid, selective and sensitive detection of triterpenic acids in fruits. | 2011 | J. Agric. Food Chem. | pmid:21388126 |
Wilkinson K et al. | A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36. | 2011 | J. Biol. Chem. | pmid:21835916 |
Shabrova EV et al. | Insights into the molecular mechanisms of the anti-atherogenic actions of flavonoids in normal and obese mice. | 2011 | PLoS ONE | pmid:22016761 |
Fu SB et al. | Biotransformation of ursolic acid by an endophytic fungus from medicinal plant Huperzia serrata. | 2011 | Chem. Pharm. Bull. | pmid:21881267 |
Kim KH et al. | Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells. | 2011 | Arch. Pharm. Res. | pmid:21910059 |
Jilani K et al. | Triggering of erythrocyte cell membrane scrambling by ursolic acid. | 2011 | J. Nat. Prod. | pmid:21923134 |
Wang X et al. | Ursolic acid inhibits proliferation and induces apoptosis of cancer cells in vitro and in vivo. | 2011 | J. Biomed. Biotechnol. | pmid:21716649 |
Frontana-Uribe BA et al. | A new languidulane diterpenoid from Salvia mexicana var. mexicana. | 2011 | Molecules | pmid:22019574 |
Wen JH and Xiong YQ | The effect of herbal medicine danshensu and ursolic acid on pharmacokinetics of rosuvastatin in rats. | 2011 | Eur J Drug Metab Pharmacokinet | pmid:21717139 |
Pareek TK et al. | Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis. | 2011 | Sci Rep | pmid:22355716 |
Sasaki T et al. | Chemical constituents from Sambucus adnata and their protein-tyrosine phosphatase 1B inhibitory activities. | 2011 | Chem. Pharm. Bull. | pmid:22041077 |
Brendolise C et al. | An unusual plant triterpene synthase with predominant α-amyrin-producing activity identified by characterizing oxidosqualene cyclases from Malus × domestica. | 2011 | FEBS J. | pmid:21575133 |
Huang SS et al. | Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice. | 2011 | Evid Based Complement Alternat Med | pmid:21584194 |
Beg S et al. | Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives. | 2011 | Pharmacogn Rev | pmid:22279370 |
Bayer M et al. | Photoprotection against UVAR: effective triterpenoids require a lipid raft stabilizing chemical structure. | 2011 | Exp. Dermatol. | pmid:21824200 |
Hsu CL et al. | Antioxidant and anti-inflammatory effects of Orthosiphon aristatus and its bioactive compounds. | 2010 | J. Agric. Food Chem. | pmid:20095565 |
Wang P et al. | Synthesis and cytotoxic activity of the N-acetylglucosamine-bearing triterpenoid saponins. | 2010 | Carbohydr. Res. | pmid:20116049 |
Genet C et al. | Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. | 2010 | J. Med. Chem. | pmid:19911773 |
Yu YX et al. | Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway. | 2010 | Chin. Med. J. | pmid:20819578 |
Lee AW et al. | Ursolic acid induces allograft inflammatory factor-1 expression via a nitric oxide-related mechanism and increases neovascularization. | 2010 | J. Agric. Food Chem. | pmid:21070071 |
Zhang HP and Tao L | [Studies on the chemical constituents of Buddleja albiflora (II)]. | 2010 | Zhong Yao Cai | pmid:21049618 |
De Angel RE et al. | Antitumor effects of ursolic acid in a mouse model of postmenopausal breast cancer. | 2010 | Nutr Cancer | pmid:21058195 |
Purnima A et al. | Antiinflammatory, Analgesic and Antipyretic Activities of Mimusops elengi Linn. | 2010 | Indian J Pharm Sci | pmid:21218059 |
Ashok P et al. | Antiurolithiatic and antioxidant activity of Mimusops elengi on ethylene glycol-induced urolithiasis in rats. | 2010 | Indian J Pharmacol | pmid:21189910 |
Wu CR et al. | Triterpenoid contents and anti-inflammatory properties of the methanol extracts of ligustrum species leaves. | 2010 | Molecules | pmid:21187813 |
Nsonde Ntandou GF et al. | Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts. | 2010 | J Ethnopharmacol | pmid:19799981 |
Prajapati MS et al. | Leucas aspera: A review. | 2010 | Pharmacogn Rev | pmid:22228946 |
Lu J et al. | Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-κB pathway activation. | 2010 | Cereb. Cortex | pmid:20133359 |
Kwon SH et al. | Apoptotic action of ursolic acid isolated from Corni fructus in RC-58T/h/SA#4 primary human prostate cancer cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20943386 |
Singh SK et al. | Molluscicides from some common medicinal plants of eastern Uttar Pradesh, India. | 2010 | J Appl Toxicol | pmid:19943357 |
Lan K et al. | Simple quality assessment approach for herbal extracts using high performance liquid chromatography-UV based metabolomics platform. | 2010 | J Chromatogr A | pmid:20045112 |
Lee JY et al. | Effects of hydroxy pentacyclic triterpene acids from Forsythia viridissima on asthmatic responses to ovalbumin challenge in conscious guinea pigs. | 2010 | Biol. Pharm. Bull. | pmid:20118545 |
Uprety Y et al. | Indigenous use and bio-efficacy of medicinal plants in the Rasuwa District, Central Nepal. | 2010 | J Ethnobiol Ethnomed | pmid:20102631 |
Kunwar RM et al. | Traditional herbal medicine in far-west Nepal: a pharmacological appraisal. | 2010 | J Ethnobiol Ethnomed | pmid:21144003 |
Wu Q et al. | Antiviral flavonoids from Mosla scabra. | 2010 | Fitoterapia | pmid:20006976 |
Ferreira Dda S et al. | Trypanocidal activity and acute toxicity assessment of triterpene acids. | 2010 | Parasitol. Res. | pmid:20140451 |
Stanojković TP et al. | Cytotoxic and cell cycle effects induced by two herbal extracts on human cervix carcinoma and human breast cancer cell lines. | 2010 | J Med Food | pmid:20170382 |
Rollinger JM et al. | 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches. | 2010 | Bioorg. Med. Chem. | pmid:20100662 |
Zhang YX et al. | Ursolic acid overcomes Bcl-2-mediated resistance to apoptosis in prostate cancer cells involving activation of JNK-induced Bcl-2 phosphorylation and degradation. | 2010 | J. Cell. Biochem. | pmid:20052671 |
Liu Y et al. | Evaluation of inhibition of fatty acid synthase by ursolic acid: positive cooperation mechanism. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20074555 |
Suanarunsawat T et al. | Antioxidant Activity and Lipid-Lowering Effect of Essential Oils Extracted from Ocimum sanctum L. Leaves in Rats Fed with a High Cholesterol Diet. | 2010 | J Clin Biochem Nutr | pmid:20104265 |
Mullié C et al. | Inhibitory effect of ursolic acid derivatives on hydrogen peroxide- and glutathione-mediated degradation of hemin: a possible additional mechanism of action for antimalarial activity. | 2010 | Exp. Parasitol. | pmid:20109452 |
Ramos AA et al. | Protective effects of ursolic acid and luteolin against oxidative DNA damage include enhancement of DNA repair in Caco-2 cells. | 2010 | Mutat. Res. | pmid:20659486 |
Ghosh P et al. | Triterpenoids from Psidium guajava with Biocidal Activity. | 2010 | Indian J Pharm Sci | pmid:21218065 |
Annegowda HV et al. | Influence of sonication on the phenolic content and antioxidant activity of Terminalia catappa L. leaves. | 2010 | Pharmacognosy Res | pmid:21713141 |
Wang ZH et al. | Anti-glycative effects of oleanolic acid and ursolic acid in kidney of diabetic mice. | 2010 | Eur. J. Pharmacol. | pmid:19917277 |
Kurek A et al. | Oleanolic acid and ursolic acid affect peptidoglycan metabolism in Listeria monocytogenes. | 2010 | Antonie Van Leeuwenhoek | pmid:19894138 |
Yan SL et al. | Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines. | 2010 | Toxicol In Vitro | pmid:20005942 |
Yang EJ et al. | Acanthopanax koreanum fruit waste inhibits lipopolysaccharide-induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages. | 2010 | J. Biomed. Biotechnol. | pmid:20368786 |
Kaur G et al. | Exploring the potential effect of Ocimum sanctum in vincristine-induced neuropathic pain in rats. | 2010 | J Brachial Plex Peripher Nerve Inj | pmid:20181005 |
Dai Z et al. | Pomegranate extract inhibits the proliferation and viability of MMTV-Wnt-1 mouse mammary cancer stem cells in vitro. | 2010 | Oncol. Rep. | pmid:20811693 |
Nabekura T et al. | Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals. | 2010 | Pharmacol. Res. | pmid:19944162 |
Cunha WR et al. | Evaluation of the antibacterial activity of the methylene chloride extract of Miconia ligustroides, isolated triterpene acids, and ursolic acid derivatives. | 2010 | Pharm Biol | pmid:20645834 |
Musabayane CT et al. | Synergistic antihyperglycemic effects between plant-derived oleanolic acid and insulin in streptozotocin-induced diabetic rats. | 2010 | Ren Fail | pmid:20662697 |
Kuigoua GM et al. | Minor secondary metabolic products from the stem bark of Plumeria rubra Linn. displaying antimicrobial activities. | 2010 | Planta Med. | pmid:19937550 |
Ganbold M et al. | Cytotoxicity and bioavailability studies on a decoction of Oldenlandia diffusa and its fractions separated by HPLC. | 2010 | J Ethnopharmacol | pmid:20633624 |
Singh M et al. | Anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. leaves. | 2010 | Pharmacognosy Res | pmid:21713140 |