| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinogenesis | D063646 | 3 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cui HZ et al. | Ursolic acid increases the secretion of atrial natriuretic peptide in isolated perfused beating rabbit atria. | 2011 | Eur. J. Pharmacol. | pmid:21122803 |
| Kunkel SD et al. | mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass. | 2011 | Cell Metab. | pmid:21641545 |
| Liobikas J et al. | Uncoupling and antioxidant effects of ursolic acid in isolated rat heart mitochondria. | 2011 | J. Nat. Prod. | pmid:21648406 |
| Lu J et al. | Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice. | 2011 | Brain Behav. Immun. | pmid:21708244 |
| Messner B et al. | Ursolic acid causes DNA-damage, p53-mediated, mitochondria- and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo. | 2011 | Atherosclerosis | pmid:21703625 |
| Sun LP et al. | Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors. | 2011 | Eur J Med Chem | pmid:21680062 |
| Shen D et al. | A rapid LC/MS/MS method for the analysis of nonvolatile antiinflammatory agents from Mentha spp. | 2011 | J. Food Sci. | pmid:22417488 |
| Abdureyim S et al. | Anti-inflammatory, immunomodulatory, and heme oxygenase-1 inhibitory activities of ravan napas, a formulation of uighur traditional medicine, in a rat model of allergic asthma. | 2011 | Evid Based Complement Alternat Med | pmid:20953388 |
| Patel DK et al. | Pedalium murex Linn.: an overview of its phytopharmacological aspects. | 2011 | Asian Pac J Trop Med | pmid:21967701 |
| Chung PY et al. | Synergistic antimicrobial activity between pentacyclic triterpenoids and antibiotics against Staphylococcus aureus strains. | 2011 | Ann. Clin. Microbiol. Antimicrob. | pmid:21658242 |
| Reyes-Zurita FJ et al. | The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism. | 2011 | BMC Cancer | pmid:21524306 |
| Bitencourt MA et al. | Aqueous and methanolic extracts of Caulerpa mexicana suppress cell migration and ear edema induced by inflammatory agents. | 2011 | Mar Drugs | pmid:21892348 |
| Zhang XH and Zhu X | [The newest progress of the pharmacology of prunol]. | 2011 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:22013813 |
| Wójciak-Kosior M et al. | The effect of ursolic and oleanolic acids on human skin fibroblast cells. | 2011 | Folia Histochem. Cytobiol. | pmid:22252762 |
| Tannock LR | Ursolic acid effect on atherosclerosis: apples and apples, or apples and oranges? | 2011 | Atherosclerosis | pmid:21993411 |
| Martin C et al. | How can research on plants contribute to promoting human health? | 2011 | Plant Cell | pmid:21586682 |
| Sun Z et al. | Identification and determination of carboxylic acids in food samples using 2-(2-(anthracen-10-yl)-1H-phenanthro[9,10-d]imidazol-1-yl)ethyl 4-methylbenzenesulfonate (APIETS) as labeling reagent by HPLC with FLD and APCI/MS. | 2011 | Talanta | pmid:21726743 |
| Xu X et al. | Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway. | 2011 | J. Exp. Clin. Cancer Res. | pmid:21447176 |
| Muñoz O et al. | Chemical study and anti-inflammatory, analgesic and antioxidant activities of the leaves of Aristotelia chilensis (Mol.) Stuntz, Elaeocarpaceae. | 2011 | J. Pharm. Pharmacol. | pmid:21585384 |
| Li G et al. | Highly sensitive and selective pre-column derivatization high-performance liquid chromatography approach for rapid determination of triterpenes oleanolic and ursolic acids and application to Swertia species: optimization of triterpenic acids extraction and pre-column derivatization using response surface methodology. | 2011 | Anal. Chim. Acta | pmid:21334488 |
| Cho K et al. | Oleanolic acid and ursolic acid derived from Cornus officinalis Sieb. et Zucc. suppress epidermal growth factor- and phorbol ester-induced MUC5AC mucin production and gene expression from human airway epithelial cells. | 2011 | Phytother Res | pmid:21442679 |
| Aslan M et al. | Effect of Gentiana olivieri on experimental epilepsy models. | 2011 | Pharmacogn Mag | pmid:22262939 |
| Xia EQ et al. | Microwave-assisted extraction of oleanolic acid and ursolic acid from Ligustrum lucidum Ait. | 2011 | Int J Mol Sci | pmid:21954361 |
| Alshawsh MA et al. | Hepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in Rats. | 2011 | Evid Based Complement Alternat Med | pmid:21647311 |
| Wakchaure D et al. | Hepatoprotective activity of Symplocos racemosa bark on carbon tetrachloride-induced hepatic damage in rats. | 2011 | J Ayurveda Integr Med | pmid:22022156 |
| Anusha M et al. | Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats. | 2011 | Indian J Pharmacol | pmid:22022001 |
| Zhong Y et al. | Carb-oxy-methyl ursolate monohydrate. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:21523096 |
| Chen Q et al. | Identification and quantification of oleanolic acid and ursolic acid in Chinese herbs by liquid chromatography-ion trap mass spectrometry. | 2011 | Biomed. Chromatogr. | pmid:21465498 |
| Moneriz C et al. | Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages. | 2011 | Malar. J. | pmid:21477369 |
| Truong NB et al. | Antituberculosis cycloartane triterpenoids from Radermachera boniana. | 2011 | J. Nat. Prod. | pmid:21469696 |
| Mohan L et al. | Evaluation of the Anxiolytic Activity of NR-ANX-C (a Polyherbal Formulation) in Ethanol Withdrawal-Induced Anxiety Behavior in Rats. | 2011 | Evid Based Complement Alternat Med | pmid:20953426 |
| Kim E et al. | Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes. | 2011 | Planta Med. | pmid:20717876 |
| Fu SB et al. | Multihydroxylation of ursolic acid by Pestalotiopsis microspora isolated from the medicinal plant Huperzia serrata. | 2011 | Fitoterapia | pmid:21767617 |
| Chen Y et al. | [Preparation and transdermal diffusion of ursolic acid ethosomes]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21809568 |
| Annan K et al. | Acaricidal effect of an isolate from Hoslundia opposita vahl against Amblyomma variegatum (Acari: Ixodidae). | 2011 | Pharmacognosy Res | pmid:22022167 |
| Li GL et al. | Development of a new HPLC method with precolumn fluorescent derivatization for rapid, selective and sensitive detection of triterpenic acids in fruits. | 2011 | J. Agric. Food Chem. | pmid:21388126 |
| Wilkinson K et al. | A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36. | 2011 | J. Biol. Chem. | pmid:21835916 |
| Shabrova EV et al. | Insights into the molecular mechanisms of the anti-atherogenic actions of flavonoids in normal and obese mice. | 2011 | PLoS ONE | pmid:22016761 |
| Fu SB et al. | Biotransformation of ursolic acid by an endophytic fungus from medicinal plant Huperzia serrata. | 2011 | Chem. Pharm. Bull. | pmid:21881267 |
| Kim KH et al. | Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells. | 2011 | Arch. Pharm. Res. | pmid:21910059 |
| Jilani K et al. | Triggering of erythrocyte cell membrane scrambling by ursolic acid. | 2011 | J. Nat. Prod. | pmid:21923134 |
| Wang X et al. | Ursolic acid inhibits proliferation and induces apoptosis of cancer cells in vitro and in vivo. | 2011 | J. Biomed. Biotechnol. | pmid:21716649 |
| Frontana-Uribe BA et al. | A new languidulane diterpenoid from Salvia mexicana var. mexicana. | 2011 | Molecules | pmid:22019574 |
| Wen JH and Xiong YQ | The effect of herbal medicine danshensu and ursolic acid on pharmacokinetics of rosuvastatin in rats. | 2011 | Eur J Drug Metab Pharmacokinet | pmid:21717139 |
| Pareek TK et al. | Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis. | 2011 | Sci Rep | pmid:22355716 |
| Sasaki T et al. | Chemical constituents from Sambucus adnata and their protein-tyrosine phosphatase 1B inhibitory activities. | 2011 | Chem. Pharm. Bull. | pmid:22041077 |
| Brendolise C et al. | An unusual plant triterpene synthase with predominant α-amyrin-producing activity identified by characterizing oxidosqualene cyclases from Malus × domestica. | 2011 | FEBS J. | pmid:21575133 |
| Huang SS et al. | Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice. | 2011 | Evid Based Complement Alternat Med | pmid:21584194 |
| Beg S et al. | Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives. | 2011 | Pharmacogn Rev | pmid:22279370 |
| Bayer M et al. | Photoprotection against UVAR: effective triterpenoids require a lipid raft stabilizing chemical structure. | 2011 | Exp. Dermatol. | pmid:21824200 |