MeSH term | MeSH ID | Detail |
---|---|---|
Dermatitis, Contact | D003877 | 59 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with ursolic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Dermatitis, Contact | D003877 | 59 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Junco JJ et al. | Ursolic acid and resveratrol synergize with chloroquine to reduce melanoma cell viability. | 2015 | Melanoma Res. | pmid:25647735 |
Song J et al. | Development and characterisation of ursolic acid nanocrystals without stabiliser having improved dissolution rate and in vitro anticancer activity. | 2014 | AAPS PharmSciTech | pmid:24022345 |
Wu P et al. | Effects of ursolic acid derivatives on Caco-2 cells and their alleviating role in streptozocin-induced type 2 diabetic rats. | 2014 | Molecules | pmid:25153871 |
Baek SY et al. | Ursolic acid ameliorates autoimmune arthritis via suppression of Th17 and B cell differentiation. | 2014 | Acta Pharmacol. Sin. | pmid:25087995 |
Qin N et al. | RNA-Seq-based transcriptome analysis of methicillin-resistant Staphylococcus aureus biofilm inhibition by ursolic acid and resveratrol. | 2014 | Sci Rep | pmid:24970710 |
Fu HJ et al. | Tryptophan hydroxylase 1 (Tph-1)-targeted bone anabolic agents for osteoporosis. | 2014 | J. Med. Chem. | pmid:24844139 |
Innocente AM et al. | Anti-Trichomonas vaginalis activity from triterpenoid derivatives. | 2014 | Parasitol. Res. | pmid:24880238 |
Yoon JH et al. | p-Coumaric acid and ursolic acid from Corni fructus attenuated β-amyloid(25-35)-induced toxicity through regulation of the NF-κB signaling pathway in PC12 cells. | 2014 | J. Agric. Food Chem. | pmid:24815946 |
Zhao CH et al. | Inhibition of human enterovirus 71 replication by pentacyclic triterpenes and their novel synthetic derivatives. | 2014 | Chem. Pharm. Bull. | pmid:25087628 |
Kurek A et al. | The effect of oleanolic and ursolic acids on the hemolytic properties and biofilm formation of Listeria monocytogenes. | 2014 | Pol. J. Microbiol. | pmid:25033658 |