| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Innocente A et al. | Synthesis of isosteric triterpenoid derivatives and antifungal activity. | 2014 | Chem Biol Drug Des | pmid:24138556 |
| Yamamoto ES et al. | Treatment with triterpenic fraction purified from Baccharis uncinella leaves inhibits Leishmania (Leishmania) amazonensis spreading and improves Th1 immune response in infected mice. | 2014 | Parasitol. Res. | pmid:24173812 |
| Yang JJ et al. | [Study on the effect of ursolic acid (UA) on the myocardial fibrosis of experimental diabetic mice]. | 2013 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:24175562 |
| Tang Q et al. | Mitochondrial translocation of cofilin-1 promotes apoptosis of gastric cancer BGC-823 cells induced by ursolic acid. | 2014 | Tumour Biol. | pmid:24197982 |
| Nguyen PH et al. | Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity. | 2013 | J. Nat. Prod. | pmid:24224843 |
| Kim HY et al. | Accentuation of ursolic acid on muscarinic receptor-induced ANP secretion in beating rabbit atria. | 2014 | Life Sci. | pmid:24334003 |
| Fabri RL et al. | Anti-inflammatory and antioxidative effects of the methanolic extract of the aerial parts of Mitracarpus frigidus in established animal models. | 2014 | J. Pharm. Pharmacol. | pmid:24350832 |
| Siewert B et al. | The chemical and biological potential of C ring modified triterpenoids. | 2014 | Eur J Med Chem | pmid:24361521 |
| Zang LL et al. | Research progress of ursolic acid's anti-tumor actions. | 2014 | Chin J Integr Med | pmid:24374755 |
| Lee YH et al. | Ursolic acid differentially modulates apoptosis in skin melanoma and retinal pigment epithelial cells exposed to UV-VIS broadband radiation. | 2014 | Apoptosis | pmid:24375173 |
| Feng L et al. | Inhibition of human neutrophil elastase by pentacyclic triterpenes. | 2013 | PLoS ONE | pmid:24376583 |
| Yang Y et al. | Ursolic acid prevents endoplasmic reticulum stress-mediated apoptosis induced by heat stress in mouse cardiac myocytes. | 2014 | J. Mol. Cell. Cardiol. | pmid:24389342 |
| Wang CM et al. | The role of pentacyclic triterpenoids in the allelopathic effects of Alstonia scholaris. | 2014 | J. Chem. Ecol. | pmid:24390624 |
| Xue C et al. | Powerful protection against renal ischemia reperfusion injury by T cell-specific NF-κB inhibition. | 2014 | Transplantation | pmid:24398854 |
| Park JH et al. | Inhibition of Wnt/β-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells. | 2013 | Pharmacol Rep | pmid:24399733 |
| Zhai B et al. | Antimalarial evaluation of the chemical constituents of hairy root culture of Bixa orellana L. | 2013 | Molecules | pmid:24406786 |
| Ma D et al. | Crucial role of heme oxygenase-1 in the sensitivity of acute myeloid leukemia cell line Kasumi-1 to ursolic acid. | 2014 | Anticancer Drugs | pmid:24413389 |
| Déciga-Campos M et al. | Isobolographic analysis of the antinociceptive interaction between ursolic acid and diclofenac or tramadol in mice. | 2014 | Planta Med. | pmid:24431012 |
| Way TD et al. | Chemical constituents of Rhododendron formosanum show pronounced growth inhibitory effect on non-small-cell lung carcinoma cells. | 2014 | J. Agric. Food Chem. | pmid:24447325 |
| do Nascimento PG et al. | Antibacterial and antioxidant activities of ursolic acid and derivatives. | 2013 | Molecules | pmid:24451251 |
| Chen J et al. | Ursolic Acid-enriched herba cynomorii extract induces mitochondrial uncoupling and glutathione redox cycling through mitochondrial reactive oxygen species generation: protection against menadione cytotoxicity in h9c2 cells. | 2014 | Molecules | pmid:24473214 |
| Deng L et al. | Ursolic acid induces U937 cells differentiation by PI3K/Akt pathway activation. | 2014 | Chin J Nat Med | pmid:24484591 |
| Li S et al. | Therapeutic role of ursolic acid on ameliorating hepatic steatosis and improving metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease rats. | 2014 | PLoS ONE | pmid:24489777 |
| Ullevig SL et al. | Ursolic acid protects monocytes against metabolic stress-induced priming and dysfunction by preventing the induction of Nox4. | 2014 | Redox Biol | pmid:24494201 |
| Yang G et al. | In vitro and in vivo antitumor effects of folate-targeted ursolic acid stealth liposome. | 2014 | J. Agric. Food Chem. | pmid:24528163 |
| Peng W et al. | Bioavailability and activity of natural food additive triterpenoids as influenced by protein. | 2014 | J. Agric. Food Chem. | pmid:24548018 |
| Kim JH et al. | Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of β-catenin degradation. | 2014 | Food Chem. Toxicol. | pmid:24566423 |
| Han YY et al. | Oleanolic acid and ursolic acid inhibit proliferation in transformed rat hepatic oval cells. | 2014 | World J. Gastroenterol. | pmid:24574810 |
| pmid:24623716 | ||||
| Liu L et al. | Inhibition of HepG2 cell proliferation by ursolic acid and polysaccharides via the downregulation of cyclooxygenase-2. | 2014 | Mol Med Rep | pmid:24638056 |
| pmid:24660684 | ||||
| pmid:24682498 | ||||
| pmid:24697659 | ||||
| pmid:24727148 | ||||
| Hua WJ et al. | The influence of herbal medicine ursolic acid on the uptake of rosuvastatin mediated by OATP1B1*1a and *5. | 2014 | Eur J Drug Metab Pharmacokinet | pmid:24736980 |
| Ou X et al. | Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome. | 2014 | PLoS ONE | pmid:24740400 |
| pmid:24740831 | ||||
| Soica C et al. | The synergistic biologic activity of oleanolic and ursolic acids in complex with hydroxypropyl-γ-cyclodextrin. | 2014 | Molecules | pmid:24747649 |
| pmid:24753088 | ||||
| Jia WW et al. | [Inducing effects of ursolic acid on Jurkat cell apoptosis and its mechanisms]. | 2014 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:24762997 |
| Shen S et al. | Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress. | 2014 | Chem. Biol. Interact. | pmid:24802810 |
| pmid:24813878 | ||||
| Yoon JH et al. | p-Coumaric acid and ursolic acid from Corni fructus attenuated β-amyloid(25-35)-induced toxicity through regulation of the NF-κB signaling pathway in PC12 cells. | 2014 | J. Agric. Food Chem. | pmid:24815946 |
| Fu HJ et al. | Tryptophan hydroxylase 1 (Tph-1)-targeted bone anabolic agents for osteoporosis. | 2014 | J. Med. Chem. | pmid:24844139 |
| pmid:24880019 | ||||
| Innocente AM et al. | Anti-Trichomonas vaginalis activity from triterpenoid derivatives. | 2014 | Parasitol. Res. | pmid:24880238 |
| Li Y et al. | Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and suppression of ERK1/2 MAPK in HeLa cells. | 2014 | J. Pharmacol. Sci. | pmid:24881958 |
| Colla AR et al. | Serotonergic and noradrenergic systems are implicated in the antidepressant-like effect of ursolic acid in mice. | 2014 | Pharmacol. Biochem. Behav. | pmid:24887451 |
| Fabri RL et al. | Chromatographic fingerprint analysis and effects of the medicinal plant species Mitracarpus frigidus on adult Schistosoma mansoni worms. | 2014 | Biomed Res Int | pmid:24901000 |
| pmid:24915424 | ||||
| Micota B et al. | Leonurus cardiaca L. herb--a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis. | 2014 | Acta Biochim. Pol. | pmid:24918490 |
| pmid:24956202 | ||||
| Qin N et al. | RNA-Seq-based transcriptome analysis of methicillin-resistant Staphylococcus aureus biofilm inhibition by ursolic acid and resveratrol. | 2014 | Sci Rep | pmid:24970710 |
| Chun J et al. | Ursolic acid inhibits nuclear factor-κB signaling in intestinal epithelial cells and macrophages, and attenuates experimental colitis in mice. | 2014 | Life Sci. | pmid:24992474 |
| pmid:25009078 | ||||
| pmid:25026072 | ||||
| pmid:25026340 | ||||
| Kurek A et al. | The effect of oleanolic and ursolic acids on the hemolytic properties and biofilm formation of Listeria monocytogenes. | 2014 | Pol. J. Microbiol. | pmid:25033658 |
| Gao R et al. | Simultaneous determination of oleanolic acid, ursolic acid, quercetin and apigenin in Swertia mussotii Franch by capillary zone electrophoresis with running buffer modifier. | 2015 | Biomed. Chromatogr. | pmid:25042239 |
| Lee J et al. | Effects of ursolic acid on glucose metabolism, the polyol pathway and dyslipidemia in non-obese type 2 diabetic mice. | 2014 | Indian J. Exp. Biol. | pmid:25059036 |
| Jia YY et al. | [Comparative analysis of ursolic acid in Crataegus pinnatifida Bge. var. major N.E. Br. before and after processing]. | 1989 | Zhongguo Zhong Yao Za Zhi | pmid:2508668 |
| Zhao CH et al. | Inhibition of human enterovirus 71 replication by pentacyclic triterpenes and their novel synthetic derivatives. | 2014 | Chem. Pharm. Bull. | pmid:25087628 |
| Baek SY et al. | Ursolic acid ameliorates autoimmune arthritis via suppression of Th17 and B cell differentiation. | 2014 | Acta Pharmacol. Sin. | pmid:25087995 |
| Kim HI et al. | Inhibition of estrogen signaling through depletion of estrogen receptor alpha by ursolic acid and betulinic acid from Prunella vulgaris var. lilacina. | 2014 | Biochem. Biophys. Res. Commun. | pmid:25088993 |
| Lu CC et al. | Ursolic acid triggers nonprogrammed death (necrosis) in human glioblastoma multiforme DBTRG-05MG cells through MPT pore opening and ATP decline. | 2014 | Mol Nutr Food Res | pmid:25131308 |
| pmid:25149666 | ||||
| Wu P et al. | Effects of ursolic acid derivatives on Caco-2 cells and their alleviating role in streptozocin-induced type 2 diabetic rats. | 2014 | Molecules | pmid:25153871 |
| pmid:25167761 | ||||
| pmid:25168399 | ||||
| Chen J et al. | A new synthetic ursolic acid derivative IUA with anti-tumor efficacy against osteosarcoma cells via inhibition of JNK signaling pathway. | 2014 | Cell. Physiol. Biochem. | pmid:25171517 |
| pmid:25179815 | ||||
| Zhang W et al. | Review on anti-tumor effect of triterpene acid compounds. | 2014 | J Cancer Res Ther | pmid:25207885 |
| pmid:25213465 | ||||
| pmid:25217706 | ||||
| pmid:25227714 | ||||
| pmid:25230943 | ||||
| Castro AJ et al. | The mechanism of action of ursolic acid as insulin secretagogue and insulinomimetic is mediated by cross-talk between calcium and kinases to regulate glucose balance. | 2015 | Biochim. Biophys. Acta | pmid:25312987 |
| He Y et al. | Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes. | 2014 | PLoS ONE | pmid:25329874 |
| Flasiński M et al. | Incorporation of pentacyclic triterpenes into mitochondrial membrane--studies on the interactions in model 2D lipid systems. | 2014 | J Phys Chem B | pmid:25358079 |
| Hwang TL et al. | Ursolic acid inhibits superoxide production in activated neutrophils and attenuates trauma-hemorrhage shock-induced organ injury in rats. | 2014 | PLoS ONE | pmid:25360589 |
| Kalani K et al. | In vitro, in silico and in vivo studies of ursolic acid as an anti-filarial agent. | 2014 | PLoS ONE | pmid:25375886 |
| Podder B et al. | Ursolic Acid Activates Intracellular Killing Effect of Macrophages During Mycobacterium tuberculosis Infection. | 2015 | J. Microbiol. Biotechnol. | pmid:25406534 |
| pmid:25418615 | ||||
| Broniatowski M et al. | Studies of the interactions of ursane-type bioactive terpenes with the model of Escherichia coli inner membrane-Langmuir monolayer approach. | 2015 | Biochim. Biophys. Acta | pmid:25450351 |
| Hu Z et al. | Ursolic acid improves survival and attenuates lung injury in septic rats induced by cecal ligation and puncture. | 2015 | J. Surg. Res. | pmid:25454976 |
| pmid:25459994 | ||||
| pmid:25466266 | ||||
| pmid:25476148 | ||||
| Lopes SC et al. | Ursolic acid incorporation does not prevent the formation of a non-lamellar phase in pH-sensitive and long-circulating liposomes. | 2014 | Langmuir | pmid:25490253 |
| pmid:25491337 | ||||
| pmid:25515785 | ||||
| Li R et al. | Ursolic acid promotes apoptosis of SGC-7901 gastric cancer cells through ROCK/PTEN mediated mitochondrial translocation of cofilin-1. | 2014 | Asian Pac. J. Cancer Prev. | pmid:25520072 |
| pmid:25522955 | ||||
| pmid:25529824 | ||||
| pmid:25537271 | ||||
| pmid:25547067 | ||||
| pmid:25550074 | ||||
| pmid:25559759 | ||||
| pmid:25569287 | ||||
| Ding YJ et al. | Nephroprotective role of resveratrol and ursolic Acid in aristolochic Acid intoxicated zebrafish. | 2015 | Toxins (Basel) | pmid:25590276 |