| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee CJ et al. | Effects of ursolic acid, betulin and sulfur-containing compounds on mucin release from airway goblet cells. | 2004 | Planta Med. | pmid:15643543 |
| Jeong HG et al. | Involvement of cytokines in the hepatic expression of metallothionein by ursolic acid. | 2005 | Toxicol. Lett. | pmid:15649620 |
| Zhang G et al. | Determination of oleanolic acid and ursolic acid in cornel by cyclodextrin-modified micellar electrokinetic chromatography. | 2005 | Biomed. Chromatogr. | pmid:15654724 |
| Xiang W et al. | Four new prenylated isoflavonoids in Tadehagi triquetrum. | 2005 | J. Agric. Food Chem. | pmid:15656660 |
| pmid:15659827 | ||||
| Simon A et al. | Inhibition of lipoxygenase activity and HL60 leukemic cell proliferation by ursolic acid isolated from heather flowers (Calluna vulgaris). | 1992 | Biochim. Biophys. Acta | pmid:1567909 |
| pmid:15694457 | ||||
| Miceli N et al. | Anti-inflammatory activity of extract and fractions from Nepeta sibthorpii Bentham. | 2005 | J Ethnopharmacol | pmid:15707763 |
| Fu L et al. | Three new triterpenes from Nerium oleander and biological activity of the isolated compounds. | 2005 | J. Nat. Prod. | pmid:15730243 |
| Miyazawa M et al. | Suppression of the SOS-inducing activity of mutagenic heterocyclic amine, Trp-P-1, by triterpenoid from Uncaria sinensis in the Salmonella typhimurium TA1535/pSK1002 Umu test. | 2005 | J. Agric. Food Chem. | pmid:15769173 |
| pmid:15771880 | ||||
| Chattopadhyay D et al. | A potent sperm motility-inhibiting activity of bioflavonoids from an ethnomedicine of Onge, Alstonia macrophylla Wall ex A. DC, leaf extract. | 2005 | Contraception | pmid:15854639 |
| Pozo M et al. | Ursolic acid inhibits neointima formation in the rat carotid artery injury model. | 2006 | Atherosclerosis | pmid:15922347 |
| Ma CM et al. | The cytotoxic activity of ursolic acid derivatives. | 2005 | Eur J Med Chem | pmid:15922841 |
| Yim EK et al. | Proteomic analysis of ursolic acid-induced apoptosis in cervical carcinoma cells. | 2006 | Cancer Lett. | pmid:15925442 |
| Usia T et al. | Cytochrome P450 2D6 (CYP2D6) inhibitory constituents of Catharanthus roseus. | 2005 | Biol. Pharm. Bull. | pmid:15930738 |
| Liao Q et al. | LC-MS determination and pharmacokinetic studies of ursolic acid in rat plasma after administration of the traditional chinese medicinal preparation Lu-Ying extract. | 2005 | Yakugaku Zasshi | pmid:15930819 |
| Yuan G and Yi Y | [Studies on chemical constituents of the roots of Salacia hainanensis]. | 2005 | Zhong Yao Cai | pmid:15934239 |
| Gören AC et al. | DNA damaging activities of methanol extract of Ajuga postii and iridoid glucoside reptoside. | 2005 | Nat. Prod. Res. | pmid:15938192 |
| pmid:15975734 |