| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Basappa M et al. | Novel delta2-isoxazolines as group II phospholipase A2 inhibitors. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15203142 |
| Chadalapaka G et al. | Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18359628 |
| Kwon SH et al. | Apoptotic action of ursolic acid isolated from Corni fructus in RC-58T/h/SA#4 primary human prostate cancer cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20943386 |
| Kazakova OB et al. | Betulin and ursolic acid synthetic derivatives as inhibitors of Papilloma virus. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20558062 |
| Hoang DM et al. | Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19846295 |
| Bibi N et al. | In vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicum. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20542692 |
| Choi YH et al. | Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22940448 |
| Bai KK et al. | Synthesis and evaluation of ursolic acid derivatives as potent cytotoxic agents. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22370266 |
| Gao J et al. | Facile synthesis of triterpenoid saponins bearing β-Glu/Gal-(1→3)-β-GluA methyl ester and their cytotoxic activities. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22406153 |
| Hwang JS et al. | Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22079762 |
| Cui Y et al. | New diterpene furanoids from the Antarctic lichen Huea sp. | 2012 | Bioorg. Med. Chem. Lett. | pmid:23141910 |
| Banno N et al. | Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. | 2004 | Biosci. Biotechnol. Biochem. | pmid:14745168 |
| Ikeda Y et al. | Ursolic acid enhances cyclooxygenases and tumor necrosis factor-alpha expression in mouse skin. | 2006 | Biosci. Biotechnol. Biochem. | pmid:16636478 |
| Achiwa Y et al. | Regulation of the phosphatidylinositol 3-kinase-Akt and the mitogen-activated protein kinase pathways by ursolic acid in human endometrial cancer cells. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17213663 |
| Feria-Romero I et al. | Induced accumulation of oleanolic acid and ursolic acid in cell suspension cultures of Uncaria tomentosa. | 2005 | Biotechnol. Lett. | pmid:16086245 |
| Bolta Z et al. | Biomass segregation in sage cell suspension culture. | 2003 | Biotechnol. Lett. | pmid:12882308 |
| Reyes-Zurita FJ et al. | The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism. | 2011 | BMC Cancer | pmid:21524306 |
| Holy J et al. | Disruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarine. | 2006 | BMC Cell Biol. | pmid:16512916 |
| Tang LI et al. | Screening of anti-dengue activity in methanolic extracts of medicinal plants. | 2012 | BMC Complement Altern Med | pmid:22244370 |
| Feldman M et al. | Cranberry proanthocyanidins inhibit the adherence properties of Candida albicans and cytokine secretion by oral epithelial cells. | 2012 | BMC Complement Altern Med | pmid:22248145 |
| Jiménez-Arellanes A et al. | Ursolic and oleanolic acids as antimicrobial and immunomodulatory compounds for tuberculosis treatment. | 2013 | BMC Complement Altern Med | pmid:24098949 |
| Kuete V et al. | Antimicrobial activities of the methanol extract, fractions and compounds from Ficus polita Vahl. (Moraceae). | 2011 | BMC Complement Altern Med | pmid:21269424 |
| Assob JC et al. | Antimicrobial and toxicological activities of five medicinal plant species from Cameroon traditional medicine. | 2011 | BMC Complement Altern Med | pmid:21867554 |
| Neurath AR et al. | Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide. | 2004 | BMC Infect. Dis. | pmid:15485580 |
| Arbab AS et al. | MRI to assess chemoprevention in transgenic adenocarcinoma of mouse prostate (TRAMP). | 2011 | BMC Med Imaging | pmid:22165848 |
| Gao N et al. | Ursolic acid induces apoptosis in human leukaemia cells and exhibits anti-leukaemic activity in nude mice through the PKB pathway. | 2012 | Br. J. Pharmacol. | pmid:21950524 |
| Lu J et al. | Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice. | 2011 | Brain Behav. Immun. | pmid:21708244 |
| Li L et al. | Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice. | 2013 | Brain Res. | pmid:23276496 |
| Rosas LV et al. | In vitro evaluation of the cytotoxic and trypanocidal activities of Ampelozizyphus amazonicus (Rhamnaceae). | 2007 | Braz. J. Med. Biol. Res. | pmid:17464428 |
| Park SN et al. | Oleanolic acid and ursolic acid inhibit peptidoglycan biosynthesis in Streptococcus mutans UA159. | 2015 | Braz. J. Microbiol. | pmid:26273281 |
| Jovel EM et al. | Bioactivity-guided isolation of the active compounds from Rosa nutkana and quantitative analysis of ascorbic acid by HPLC. | 2007 | Can. J. Physiol. Pharmacol. | pmid:18066132 |
| Kassi E et al. | Ursolic acid triggers apoptosis and Bcl-2 downregulation in MCF-7 breast cancer cells. | 2009 | Cancer Invest. | pmid:19440893 |
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| Yim EK et al. | Proteomic analysis of ursolic acid-induced apoptosis in cervical carcinoma cells. | 2006 | Cancer Lett. | pmid:15925442 |
| Tokuda H et al. | Inhibitory effects of ursolic and oleanolic acid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. | 1986 | Cancer Lett. | pmid:3802058 |
| Hsu HY et al. | Effects of oleanolic acid and ursolic acid on inhibiting tumor growth and enhancing the recovery of hematopoietic system postirradiation in mice. | 1997 | Cancer Lett. | pmid:9022122 |
| Singletary K et al. | Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. | 1996 | Cancer Lett. | pmid:8640744 |
| Es-saady D et al. | Inhibitory effect of ursolic acid on B16 proliferation through cell cycle arrest. | 1996 | Cancer Lett. | pmid:8844972 |
| Yang L et al. | Ursolic acid induces doxorubicin-resistant HepG2 cell death via the release of apoptosis-inducing factor. | 2010 | Cancer Lett. | pmid:20630652 |
| Dorai T and Aggarwal BB | Role of chemopreventive agents in cancer therapy. | 2004 | Cancer Lett. | pmid:15488631 |
| Ohigashi H et al. | Search for possible antitumor promoters by inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation; ursolic acid and oleanolic acid from an anti-inflammatory Chinese medicinal plant, Glechoma hederaceae L. | 1986 | Cancer Lett. | pmid:3006912 |
| Xavier CP et al. | Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells. | 2009 | Cancer Lett. | pmid:19344998 |
| Cho J et al. | Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate. | 2015 | Cancer Prev Res (Phila) | pmid:26100520 |
| Suh N et al. | Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages. | 1998 | Cancer Res. | pmid:9485026 |
| Cha HJ et al. | Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells. | 1996 | Cancer Res. | pmid:8625299 |
| Huang MT et al. | Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. | 1994 | Cancer Res. | pmid:8306331 |
| Subbaramaiah K et al. | Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. | 2000 | Cancer Res. | pmid:10811116 |
| Das B et al. | A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma. | 2005 | Cancer Res. | pmid:16103078 |
| Shishodia S et al. | Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. | 2003 | Cancer Res. | pmid:12907607 |