MeSH term | MeSH ID | Detail |
---|---|---|
Dermatitis, Contact | D003877 | 59 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with ursolic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Dermatitis, Contact | D003877 | 59 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Çulhaoğlu B et al. | Bioactive constituents of Salvia chrysophylla Stapf. | 2013 | Nat. Prod. Res. | pmid:23126495 |
Zhang ZF et al. | Two new ursolic acid saponins from Morina nepalensis var. alba Hand-Mazz. | 2013 | Nat. Prod. Res. | pmid:23962075 |
Slamenová D et al. | Reduction of DNA-damaging effects of anti-HIV drug 3'-azido-3'-dideoxythymidine on human cells by ursolic acid and lignin biopolymer. | 2006 | Neoplasma | pmid:17167716 |
Novotný L et al. | Ursolic acid: an anti-tumorigenic and chemopreventive activity. Minireview. | 2001 | Neoplasma | pmid:11712672 |
Wang YJ et al. | Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways. | 2011 | Neurobiol Learn Mem | pmid:21496491 |
Shih YH et al. | Ursolic acid protects hippocampal neurons against kainate-induced excitotoxicity in rats. | 2004 | Neurosci. Lett. | pmid:15193771 |
Yealland G et al. | Rescue of mitochondrial function in parkin-mutant fibroblasts using drug loaded PMPC-PDPA polymersomes and tubular polymersomes. | 2016 | Neurosci. Lett. | pmid:27412236 |
De Angel RE et al. | Antitumor effects of ursolic acid in a mouse model of postmenopausal breast cancer. | 2010 | Nutr Cancer | pmid:21058195 |
Achiwa Y et al. | Effect of ursolic acid on MAPK in cyclin D1 signaling and RING-type E3 ligase (SCF E3s) in two endometrial cancer cell lines. | 2013 | Nutr Cancer | pmid:24083669 |
Sung B et al. | Cancer cell signaling pathways targeted by spice-derived nutraceuticals. | 2012 | Nutr Cancer | pmid:22149093 |
Banihani S et al. | Pomegranate and type 2 diabetes. | 2013 | Nutr Res | pmid:23684435 |
Kim MJ et al. | Effects of freeze-dried cranberry powder on serum lipids and inflammatory markers in lipopolysaccharide treated rats fed an atherogenic diet. | 2011 | Nutr Res Pract | pmid:22125677 |
Matsumoto RL et al. | Effects of maté tea intake on ex vivo LDL peroxidation induced by three different pathways. | 2009 | Nutrients | pmid:22253965 |
Cha HJ et al. | Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells. | 1998 | Oncogene | pmid:9488041 |
Achiwa Y et al. | Ursolic acid induces Bax-dependent apoptosis through the caspase-3 pathway in endometrial cancer SNG-II cells. | 2005 | Oncol. Rep. | pmid:15583801 |
Achiwa Y et al. | Molecular mechanism of ursolic acid induced apoptosis in poorly differentiated endometrial cancer HEC108 cells. | 2005 | Oncol. Rep. | pmid:16012738 |
Duval RE et al. | Differential involvement of mitochondria during ursolic acid-induced apoptotic process in HaCaT and M4Beu cells. | 2008 | Oncol. Rep. | pmid:18097588 |
Li J et al. | Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant human pancreatic cancer via the JNK and PI3K/Akt/NF-κB pathways. | 2012 | Oncol. Rep. | pmid:22641480 |
Dai Z et al. | Pomegranate extract inhibits the proliferation and viability of MMTV-Wnt-1 mouse mammary cancer stem cells in vitro. | 2010 | Oncol. Rep. | pmid:20811693 |
Cho J et al. | Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. | 2015 | Oncotarget | pmid:26513295 |
Xiang L et al. | A pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis. | 2015 | Oncotarget | pmid:25823660 |
Innocente AM et al. | Anti-Trichomonas vaginalis activity from triterpenoid derivatives. | 2014 | Parasitol. Res. | pmid:24880238 |
Ferreira Dda S et al. | Trypanocidal activity and acute toxicity assessment of triterpene acids. | 2010 | Parasitol. Res. | pmid:20140451 |
Yamamoto ES et al. | Treatment with triterpenic fraction purified from Baccharis uncinella leaves inhibits Leishmania (Leishmania) amazonensis spreading and improves Th1 immune response in infected mice. | 2014 | Parasitol. Res. | pmid:24173812 |
Passero LF et al. | Anti-leishmanial effects of purified compounds from aerial parts of Baccharis uncinella C. DC. (Asteraceae). | 2011 | Parasitol. Res. | pmid:20886232 |
BRIESKORN CH and KESKIN M | [Triterpenes in the bark, peel and leaf of Punica granatum L. 5. Knowledge of biochemistry of triterpenes]. | 1954 | Pharm Acta Helv | pmid:13236480 |
González-Chávez MM et al. | Anti-inflammatory activity of standardized dichloromethane extract of Salvia connivens on macrophages stimulated by LPS. | 2017 | Pharm Biol | pmid:28347190 |
Jin YR et al. | Ursolic acid enhances mouse liver regeneration after partial hepatectomy. | 2012 | Pharm Biol | pmid:22136205 |
Chen Y et al. | Changes in bioactive components related to the harvest time from the spicas of Prunella vulgaris. | 2012 | Pharm Biol | pmid:22686260 |
Cunha WR et al. | Evaluation of the antibacterial activity of the methylene chloride extract of Miconia ligustroides, isolated triterpene acids, and ursolic acid derivatives. | 2010 | Pharm Biol | pmid:20645834 |
Anand P et al. | Cancer is a preventable disease that requires major lifestyle changes. | 2008 | Pharm. Res. | pmid:18626751 |
Aslan M et al. | Effect of Gentiana olivieri on experimental epilepsy models. | 2011 | Pharmacogn Mag | pmid:22262939 |
Ahmed MK | 2012 - Another successful new year for Pharmacogn Mag. | 2012 | Pharmacogn Mag | pmid:22438655 |
Tang XH et al. | Preservation on calcium homeostasis is involved in mitochondrial protection of Limonium sinense against liver damage in mice. | 2010 | Pharmacogn Mag | pmid:20931078 |
Tian S et al. | Determination of oleanolic acid and ursolic acid contents in Ziziphora clinopodioides Lam. by HPLC method. | 2010 | Pharmacogn Mag | pmid:20668577 |
Prajapati MS et al. | Leucas aspera: A review. | 2010 | Pharmacogn Rev | pmid:22228946 |
Perera PK and Li Y | Functional herbal food ingredients used in type 2 diabetes mellitus. | 2012 | Pharmacogn Rev | pmid:22654403 |
Ali M and Chaudhary N | Ficus hispida Linn.: A review of its pharmacognostic and ethnomedicinal properties. | 2011 | Pharmacogn Rev | pmid:22096323 |
Conserva LM and Ferreira JC | Borreria and Spermacoce species (Rubiaceae): A review of their ethnomedicinal properties, chemical constituents, and biological activities. | 2012 | Pharmacogn Rev | pmid:22654404 |
Beg S et al. | Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives. | 2011 | Pharmacogn Rev | pmid:22279370 |
Venkateswara Rao G et al. | Chemical constituents and biological studies of Origanum vulgare Linn. | 2011 | Pharmacognosy Res | pmid:21772760 |
Lahon K and Das S | Hepatoprotective activity of Ocimum sanctum alcoholic leaf extract against paracetamol-induced liver damage in Albino rats. | 2011 | Pharmacognosy Res | pmid:21731390 |
Annegowda HV et al. | Influence of sonication on the phenolic content and antioxidant activity of Terminalia catappa L. leaves. | 2010 | Pharmacognosy Res | pmid:21713141 |
Annan K et al. | Acaricidal effect of an isolate from Hoslundia opposita vahl against Amblyomma variegatum (Acari: Ixodidae). | 2011 | Pharmacognosy Res | pmid:22022167 |
Singh M et al. | Anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. leaves. | 2010 | Pharmacognosy Res | pmid:21713140 |
Park JH et al. | Inhibition of Wnt/β-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells. | 2013 | Pharmacol Rep | pmid:24399733 |
Saravanan R and Pugalendi V | Impact of ursolic acid on chronic ethanol-induced oxidative stress in the rat heart. | 2006 Jan-Feb | Pharmacol Rep | pmid:16531629 |
Colla AR et al. | Serotonergic and noradrenergic systems are implicated in the antidepressant-like effect of ursolic acid in mice. | 2014 | Pharmacol. Biochem. Behav. | pmid:24887451 |
Machado DG et al. | Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: evidence for the involvement of the dopaminergic system. | 2012 | Pharmacol. Biochem. Behav. | pmid:22940588 |
Verano J et al. | Ursolic acid from Agastache mexicana aerial parts produces antinociceptive activity involving TRPV1 receptors, cGMP and a serotonergic synergism. | 2013 | Pharmacol. Biochem. Behav. | pmid:23932918 |
Ahmad SF et al. | Amelioration of adjuvant-induced arthritis by ursolic acid through altered Th1/Th2 cytokine production. | 2006 | Pharmacol. Res. | pmid:16406805 |
Lee SU et al. | Anabolic activity of ursolic acid in bone: Stimulating osteoblast differentiation in vitro and inducing new bone formation in vivo. | 2008 Nov-Dec | Pharmacol. Res. | pmid:18822379 |
Nabekura T et al. | Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals. | 2010 | Pharmacol. Res. | pmid:19944162 |
Choi BM et al. | Cyclic adenosine monophosphate inhibits ursolic acid-induced apoptosis via activation of protein kinase A in human leukaemic HL-60 cells. | 2000 | Pharmacol. Toxicol. | pmid:10728914 |
Qi SH et al. | Constituents of Carapa guianensis Aubl. (Meliaceae). | 2004 | Pharmazie | pmid:15248467 |
Santos Rosa C et al. | Antihistaminic and antieicosanoid effects of oleanolic and ursolic acid fraction from Helichrysum picardii. | 2007 | Pharmazie | pmid:17663195 |
Lee YH et al. | Modulation of photochemical damage in normal and malignant cells by naturally occurring compounds. | 2012 Nov-Dec | Photochem. Photobiol. | pmid:22486439 |
Yang YC et al. | Optimisation of an ultrasound-assisted extraction followed by RP-HPLC separation for the simultaneous determination of oleanolic acid, ursolic acid and oridonin content in Rabdosia rubescens. | 2012 Nov-Dec | Phytochem Anal | pmid:22706975 |
Peixoto MP et al. | LC-UV assay method and UPLC/Q-TOF-MS characterisation of saponins from Ilex paraguariensis A. St. Hil. (mate) unripe fruits. | 2012 Jul-Aug | Phytochem Anal | pmid:22105927 |
Martinet A et al. | NMR and LC-MSn characterisation of two minor saponins from Ilex paraguariensis. | 2001 Jan-Feb | Phytochem Anal | pmid:11704961 |
Jang DS et al. | Beccaridiol, an unusual 28-nortriterpenoid from the leaves of Diplectria beccariana. | 2006 | Phytochemistry | pmid:16426647 |
Kadu CA et al. | Bioactive constituents in Prunus africana: geographical variation throughout Africa and associations with environmental and genetic parameters. | 2012 | Phytochemistry | pmid:22795601 |
Takechi M and Tanaka Y | Structure-activity relationships of synthetic methyl ursolate glycosides. | 1993 | Phytochemistry | pmid:7764145 |
Huang FX et al. | Microbial transformation of ursolic acid by Syncephalastrum racemosum (Cohn) Schroter AS 3.264. | 2012 | Phytochemistry | pmid:22800913 |
Yu F et al. | Functional characterization of amyrin synthase involved in ursolic acid biosynthesis in Catharanthus roseus leaf epidermis. | 2013 | Phytochemistry | pmid:22652241 |
Cáceres-Castillo D et al. | 21beta-Hydroxy-oleanane-type triterpenes from Hippocratea excelsa. | 2008 | Phytochemistry | pmid:18061220 |
Ibarra A et al. | Effects of chronic administration of Melissa officinalis L. extract on anxiety-like reactivity and on circadian and exploratory activities in mice. | 2010 | Phytomedicine | pmid:20171069 |
Somova LI et al. | Cardiotonic and antidysrhythmic effects of oleanolic and ursolic acids, methyl maslinate and uvaol. | 2004 | Phytomedicine | pmid:15070161 |
Kurek A et al. | Modulation of antibiotic resistance in bacterial pathogens by oleanolic acid and ursolic acid. | 2012 | Phytomedicine | pmid:22341643 |
Raphael TJ and Kuttan G | Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system. | 2003 | Phytomedicine | pmid:13678231 |
Vareed SK et al. | Lipid peroxidation, cyclooxygenase enzyme and tumor cell proliferation inhibitory compounds in Cornus kousa fruits. | 2007 | Phytomedicine | pmid:17084606 |
Somova LO et al. | Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension. | 2003 | Phytomedicine | pmid:12725563 |
Takada K et al. | Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-α-induced E-selectin expression by cultured umbilical vein endothelial cells. | 2010 | Phytomedicine | pmid:20579861 |
Feuillolay C et al. | A Myrtus communis extract enriched in myrtucummulones and ursolic acid reduces resistance of Propionibacterium acnes biofilms to antibiotics used in acne vulgaris. | 2016 | Phytomedicine | pmid:26969384 |
Saaby L et al. | Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.). | 2011 | Phytother Res | pmid:20632303 |
Steele JC et al. | In vitro and in vivo evaluation of betulinic acid as an antimalarial. | 1999 | Phytother Res | pmid:10190183 |
Taviano MF et al. | Ursolic acid plays a role in Nepeta sibthorpii Bentham CNS depressing effects. | 2007 | Phytother Res | pmid:17236171 |
Park JH et al. | Antiinflammatory activity of Synurus deltoides. | 2004 | Phytother Res | pmid:15597310 |
Chandramu C et al. | Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L. | 2003 | Phytother Res | pmid:12601674 |
Lee MS and Thuong PT | Stimulation of glucose uptake by triterpenoids from Weigela subsessilis. | 2010 | Phytother Res | pmid:19548274 |
Haraguchi H et al. | Antimicrobial triterpenes from Ilex integra and the mechanism of antifungal action. | 1999 | Phytother Res | pmid:10190191 |
Cho K et al. | Oleanolic acid and ursolic acid derived from Cornus officinalis Sieb. et Zucc. suppress epidermal growth factor- and phorbol ester-induced MUC5AC mucin production and gene expression from human airway epithelial cells. | 2011 | Phytother Res | pmid:21442679 |
Jiménez A et al. | Secondary metabolites from Chamaedora tepejilote (Palmae) are active against Mycobacterium tuberculosis. | 2005 | Phytother Res | pmid:16041726 |
Zhang P et al. | Ursolic acid inhibits acid sphingomyelinase in intestinal cells. | 2013 | Phytother Res | pmid:22511398 |
Youn K and Jun M | Inhibitory effects of key compounds isolated from Corni fructus on BACE1 Activity. | 2012 | Phytother Res | pmid:22407769 |
Saaby L and Nielsen CH | Triterpene acids from rose hip powder inhibit self-antigen- and LPS-induced cytokine production and CD4⺠T-cell proliferation in human mononuclear cell cultures. | 2012 | Phytother Res | pmid:22170858 |
Heo HJ et al. | Carbenoxolone and triterpenoids inhibited mucin secretion from airway epithelial cells. | 2007 | Phytother Res | pmid:17262888 |
Rao AR et al. | In vitro and in vivo inhibitory activities of four Indian medicinal plant extracts and their major components on rat aldose reductase and generation of advanced glycation endproducts. | 2013 | Phytother Res | pmid:22826152 |
Azevedo MF et al. | Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3. | 2010 | Phytother Res | pmid:20127879 |
Ali MS et al. | Ursolic acid: a potent inhibitor of superoxides produced in the cellular system. | 2007 | Phytother Res | pmid:17295383 |
Son HS et al. | Activation of AMP-activated protein kinase and phosphorylation of glycogen synthase kinase3 β mediate ursolic acid induced apoptosis in HepG2 liver cancer cells. | 2013 | Phytother Res | pmid:23325562 |
Saraswat B et al. | Ursolic acid isolated from Eucalyptus tereticornis protects against ethanol toxicity in isolated rat hepatocytes. | 2000 | Phytother Res | pmid:10815008 |
Awad R et al. | Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity. | 2009 | Phytother Res | pmid:19165747 |
Martin C et al. | How can research on plants contribute to promoting human health? | 2011 | Plant Cell | pmid:21586682 |
Flores-Sánchez IJ et al. | Biosynthesis of sterols and triterpenes in cell suspension cultures of Uncaria tomentosa. | 2002 | Plant Cell Physiol. | pmid:12514247 |
Fukushima EO et al. | CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis. | 2011 | Plant Cell Physiol. | pmid:22039103 |
Huang L et al. | Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus. | 2012 | Planta | pmid:22837051 |
Déciga-Campos M et al. | Isobolographic analysis of the antinociceptive interaction between ursolic acid and diclofenac or tramadol in mice. | 2014 | Planta Med. | pmid:24431012 |
Gu JQ et al. | Antitubercular constituents of Valeriana laxiflora. | 2004 | Planta Med. | pmid:15229801 |
Rios MY et al. | Sterols, triterpenes and biflavonoids of Viburnum jucundum and cytotoxic activity of ursolic acid. | 2001 | Planta Med. | pmid:11582553 |