| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hsu CL et al. | Antioxidant and anti-inflammatory effects of Orthosiphon aristatus and its bioactive compounds. | 2010 | J. Agric. Food Chem. | pmid:20095565 |
| Wang P et al. | Synthesis and cytotoxic activity of the N-acetylglucosamine-bearing triterpenoid saponins. | 2010 | Carbohydr. Res. | pmid:20116049 |
| Genet C et al. | Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. | 2010 | J. Med. Chem. | pmid:19911773 |
| Zhou Y et al. | Ursolic acid inhibits early lesions of diabetic nephropathy. | 2010 | Int. J. Mol. Med. | pmid:20818497 |
| Yu YX et al. | Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway. | 2010 | Chin. Med. J. | pmid:20819578 |
| Lee AW et al. | Ursolic acid induces allograft inflammatory factor-1 expression via a nitric oxide-related mechanism and increases neovascularization. | 2010 | J. Agric. Food Chem. | pmid:21070071 |
| Zhang HP and Tao L | [Studies on the chemical constituents of Buddleja albiflora (II)]. | 2010 | Zhong Yao Cai | pmid:21049618 |
| De Angel RE et al. | Antitumor effects of ursolic acid in a mouse model of postmenopausal breast cancer. | 2010 | Nutr Cancer | pmid:21058195 |
| Purnima A et al. | Antiinflammatory, Analgesic and Antipyretic Activities of Mimusops elengi Linn. | 2010 | Indian J Pharm Sci | pmid:21218059 |
| Ashok P et al. | Antiurolithiatic and antioxidant activity of Mimusops elengi on ethylene glycol-induced urolithiasis in rats. | 2010 | Indian J Pharmacol | pmid:21189910 |
| Nsonde Ntandou GF et al. | Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts. | 2010 | J Ethnopharmacol | pmid:19799981 |
| Prajapati MS et al. | Leucas aspera: A review. | 2010 | Pharmacogn Rev | pmid:22228946 |
| Lu J et al. | Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-κB pathway activation. | 2010 | Cereb. Cortex | pmid:20133359 |
| Kwon SH et al. | Apoptotic action of ursolic acid isolated from Corni fructus in RC-58T/h/SA#4 primary human prostate cancer cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20943386 |
| Singh SK et al. | Molluscicides from some common medicinal plants of eastern Uttar Pradesh, India. | 2010 | J Appl Toxicol | pmid:19943357 |
| Lan K et al. | Simple quality assessment approach for herbal extracts using high performance liquid chromatography-UV based metabolomics platform. | 2010 | J Chromatogr A | pmid:20045112 |
| Lee JY et al. | Effects of hydroxy pentacyclic triterpene acids from Forsythia viridissima on asthmatic responses to ovalbumin challenge in conscious guinea pigs. | 2010 | Biol. Pharm. Bull. | pmid:20118545 |
| Uprety Y et al. | Indigenous use and bio-efficacy of medicinal plants in the Rasuwa District, Central Nepal. | 2010 | J Ethnobiol Ethnomed | pmid:20102631 |
| Wu Q et al. | Antiviral flavonoids from Mosla scabra. | 2010 | Fitoterapia | pmid:20006976 |
| Wu B et al. | [Apoptosis of jurkat cells induced by ursolic acid and its mechanism]. | 2010 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:20137120 |
| Ferreira Dda S et al. | Trypanocidal activity and acute toxicity assessment of triterpene acids. | 2010 | Parasitol. Res. | pmid:20140451 |
| Stanojković TP et al. | Cytotoxic and cell cycle effects induced by two herbal extracts on human cervix carcinoma and human breast cancer cell lines. | 2010 | J Med Food | pmid:20170382 |
| Rollinger JM et al. | 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches. | 2010 | Bioorg. Med. Chem. | pmid:20100662 |
| Zhang YX et al. | Ursolic acid overcomes Bcl-2-mediated resistance to apoptosis in prostate cancer cells involving activation of JNK-induced Bcl-2 phosphorylation and degradation. | 2010 | J. Cell. Biochem. | pmid:20052671 |
| Liu Y et al. | Evaluation of inhibition of fatty acid synthase by ursolic acid: positive cooperation mechanism. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20074555 |
| Suanarunsawat T et al. | Antioxidant Activity and Lipid-Lowering Effect of Essential Oils Extracted from Ocimum sanctum L. Leaves in Rats Fed with a High Cholesterol Diet. | 2010 | J Clin Biochem Nutr | pmid:20104265 |
| Mullié C et al. | Inhibitory effect of ursolic acid derivatives on hydrogen peroxide- and glutathione-mediated degradation of hemin: a possible additional mechanism of action for antimalarial activity. | 2010 | Exp. Parasitol. | pmid:20109452 |
| Ramos AA et al. | Protective effects of ursolic acid and luteolin against oxidative DNA damage include enhancement of DNA repair in Caco-2 cells. | 2010 | Mutat. Res. | pmid:20659486 |
| Ghosh P et al. | Triterpenoids from Psidium guajava with Biocidal Activity. | 2010 | Indian J Pharm Sci | pmid:21218065 |
| Wang ZH et al. | Anti-glycative effects of oleanolic acid and ursolic acid in kidney of diabetic mice. | 2010 | Eur. J. Pharmacol. | pmid:19917277 |
| Kurek A et al. | Oleanolic acid and ursolic acid affect peptidoglycan metabolism in Listeria monocytogenes. | 2010 | Antonie Van Leeuwenhoek | pmid:19894138 |
| Yan SL et al. | Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines. | 2010 | Toxicol In Vitro | pmid:20005942 |
| Gui C et al. | Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. | 2010 | Curr Chem Genomics | pmid:20448812 |
| Yang EJ et al. | Acanthopanax koreanum fruit waste inhibits lipopolysaccharide-induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages. | 2010 | J. Biomed. Biotechnol. | pmid:20368786 |
| Azevedo MF et al. | Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3. | 2010 | Phytother Res | pmid:20127879 |
| Kaur G et al. | Exploring the potential effect of Ocimum sanctum in vincristine-induced neuropathic pain in rats. | 2010 | J Brachial Plex Peripher Nerve Inj | pmid:20181005 |
| Dai Z et al. | Pomegranate extract inhibits the proliferation and viability of MMTV-Wnt-1 mouse mammary cancer stem cells in vitro. | 2010 | Oncol. Rep. | pmid:20811693 |
| Nabekura T et al. | Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals. | 2010 | Pharmacol. Res. | pmid:19944162 |
| Musabayane CT et al. | Synergistic antihyperglycemic effects between plant-derived oleanolic acid and insulin in streptozotocin-induced diabetic rats. | 2010 | Ren Fail | pmid:20662697 |
| Kuigoua GM et al. | Minor secondary metabolic products from the stem bark of Plumeria rubra Linn. displaying antimicrobial activities. | 2010 | Planta Med. | pmid:19937550 |
| Kowalczyk MC et al. | Differential effects of several phytochemicals and their derivatives on murine keratinocytes in vitro and in vivo: implications for skin cancer prevention. | 2009 | Carcinogenesis | pmid:19329757 |
| Zhang YX et al. | Phosphorylation of Bcl-2 and activation of caspase-3 via the c-Jun N-terminal kinase pathway in ursolic acid-induced DU145 cells apoptosis. | 2009 | Biochimie | pmid:19545597 |
| Yu HH et al. | Protective effect of ursolic acid from Cornus officinalis on the hydrogen peroxide-induced damage of HEI-OC1 auditory cells. | 2009 | Am. J. Chin. Med. | pmid:19655411 |
| Yao Z et al. | [Triterpenoids from leaves of Ilex cornuta]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19639785 |
| Lee JH et al. | Gardenia jasminoides Ellis ethanol extract and its constituents reduce the risks of gastritis and reverse gastric lesions in rats. | 2009 | Food Chem. Toxicol. | pmid:19425231 |
| MartÃn R et al. | Natural triterpenic diols promote apoptosis in astrocytoma cells through ROS-mediated mitochondrial depolarization and JNK activation. | 2009 | PLoS ONE | pmid:19543395 |
| Lavhale MS et al. | A novel triterpenoid isolated from the root bark of Ailanthus excelsa Roxb (Tree of Heaven), AECHL-1 as a potential anti-cancer agent. | 2009 | PLoS ONE | pmid:19399188 |
| Matsumoto RL et al. | Effects of maté tea intake on ex vivo LDL peroxidation induced by three different pathways. | 2009 | Nutrients | pmid:22253965 |
| Ramadan MA et al. | Chemical composition of the stem bark and leaves of Ficus pandurata Hance. | 2009 | Nat. Prod. Res. | pmid:19731141 |
| Jäger S et al. | Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts. | 2009 | Molecules | pmid:19513002 |