| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kanjoormana M and Kuttan G | Antiangiogenic activity of ursolic acid. | 2010 | Integr Cancer Ther | pmid:20462855 |
| Shen D et al. | LC-MS method for the simultaneous quantitation of the anti-inflammatory constituents in oregano (Origanum species). | 2010 | J. Agric. Food Chem. | pmid:20496910 |
| Xia N et al. | Prunella vulgaris L. Upregulates eNOS expression in human endothelial cells. | 2010 | Am. J. Chin. Med. | pmid:20503475 |
| Kang KS et al. | Effect of intraperitoneal injection of curcumin on food intake in a goldfish model. | 2011 | J. Mol. Neurosci. | pmid:20514526 |
| Li Y et al. | Ursolic acid stimulates lipolysis in primary-cultured rat adipocytes. | 2010 | Mol Nutr Food Res | pmid:20521271 |
| pmid:20522017 | ||||
| Chen RJ et al. | Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+ -ATPase. | 2010 | Acta Pharmacol. Sin. | pmid:20523340 |
| Bibi N et al. | In vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicum. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20542692 |
| Kazakova OB et al. | Betulin and ursolic acid synthetic derivatives as inhibitors of Papilloma virus. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20558062 |
| Takada K et al. | Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-α-induced E-selectin expression by cultured umbilical vein endothelial cells. | 2010 | Phytomedicine | pmid:20579861 |
| Akak CM et al. | New coumarin glycosides from the leaves of Diospyros crassiflora (Hiern). | 2010 | Fitoterapia | pmid:20580922 |
| Jung TY et al. | Ursolic acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFN-gamma by CD4+ naïve T cells. | 2010 | Eur. J. Pharmacol. | pmid:20599915 |
| Ibarra A et al. | Importance of extract standardization and in vitro/ex vivo assay selection for the evaluation of antioxidant activity of botanicals: a case study on three Rosmarinus officinalis L. extracts. | 2010 | J Med Food | pmid:20626255 |
| pmid:20628965 | ||||
| Yang L et al. | Ursolic acid induces doxorubicin-resistant HepG2 cell death via the release of apoptosis-inducing factor. | 2010 | Cancer Lett. | pmid:20630652 |
| Saaby L et al. | Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.). | 2011 | Phytother Res | pmid:20632303 |
| Ganbold M et al. | Cytotoxicity and bioavailability studies on a decoction of Oldenlandia diffusa and its fractions separated by HPLC. | 2010 | J Ethnopharmacol | pmid:20633624 |
| Song FL et al. | Total phenolic contents and antioxidant capacities of selected chinese medicinal plants. | 2010 | Int J Mol Sci | pmid:20640157 |
| Cunha WR et al. | Evaluation of the antibacterial activity of the methylene chloride extract of Miconia ligustroides, isolated triterpene acids, and ursolic acid derivatives. | 2010 | Pharm Biol | pmid:20645834 |
| Meng Y et al. | Synthesis and in vitro cytotoxicity of novel ursolic acid derivatives. | 2010 | Molecules | pmid:20657424 |
| pmid:20658673 | ||||
| Ramos AA et al. | Protective effects of ursolic acid and luteolin against oxidative DNA damage include enhancement of DNA repair in Caco-2 cells. | 2010 | Mutat. Res. | pmid:20659486 |
| Musabayane CT et al. | Synergistic antihyperglycemic effects between plant-derived oleanolic acid and insulin in streptozotocin-induced diabetic rats. | 2010 | Ren Fail | pmid:20662697 |
| Tian S et al. | Determination of oleanolic acid and ursolic acid contents in Ziziphora clinopodioides Lam. by HPLC method. | 2010 | Pharmacogn Mag | pmid:20668577 |
| pmid:20712364 | ||||
| Kim E et al. | Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes. | 2011 | Planta Med. | pmid:20717876 |
| Mandukhail SU et al. | Studies on antidyslipidemic effects of Morinda citrifolia (Noni) fruit, leaves and root extracts. | 2010 | Lipids Health Dis | pmid:20727145 |
| pmid:20738162 | ||||
| Dai Z et al. | Pomegranate extract inhibits the proliferation and viability of MMTV-Wnt-1 mouse mammary cancer stem cells in vitro. | 2010 | Oncol. Rep. | pmid:20811693 |
| Zhou Y et al. | Ursolic acid inhibits early lesions of diabetic nephropathy. | 2010 | Int. J. Mol. Med. | pmid:20818497 |
| Yu YX et al. | Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway. | 2010 | Chin. Med. J. | pmid:20819578 |
| Shammas G et al. | [Chemical constituents of the flowers of Fraxinus ornus L]. | 1990 | Ann Pharm Fr | pmid:2082796 |
| Lee J et al. | Ursolic acid ameliorates thymic atrophy and hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice. | 2010 | Chem. Biol. Interact. | pmid:20869956 |
| Zhou C et al. | Variation of oleanolic and ursolic acid in the flesh of persimmon fruit among different cultivars. | 2010 | Molecules | pmid:20877245 |
| Passero LF et al. | Anti-leishmanial effects of purified compounds from aerial parts of Baccharis uncinella C. DC. (Asteraceae). | 2011 | Parasitol. Res. | pmid:20886232 |
| Tang XH et al. | Preservation on calcium homeostasis is involved in mitochondrial protection of Limonium sinense against liver damage in mice. | 2010 | Pharmacogn Mag | pmid:20931078 |
| Kwon SH et al. | Apoptotic action of ursolic acid isolated from Corni fructus in RC-58T/h/SA#4 primary human prostate cancer cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20943386 |
| Zhang T et al. | Ursolic acid induces HL60 monocytic differentiation and upregulates C/EBPβ expression by ERK pathway activation. | 2011 | Anticancer Drugs | pmid:20948428 |
| Abdureyim S et al. | Anti-inflammatory, immunomodulatory, and heme oxygenase-1 inhibitory activities of ravan napas, a formulation of uighur traditional medicine, in a rat model of allergic asthma. | 2011 | Evid Based Complement Alternat Med | pmid:20953388 |
| Mohan L et al. | Evaluation of the Anxiolytic Activity of NR-ANX-C (a Polyherbal Formulation) in Ethanol Withdrawal-Induced Anxiety Behavior in Rats. | 2011 | Evid Based Complement Alternat Med | pmid:20953426 |
| Nozaki H et al. | Antitumor agents, 116. Cytotoxic triterpenes from Maytenus diversifolia. | 1990 Jul-Aug | J. Nat. Prod. | pmid:2095372 |
| Arora R et al. | Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud. | 2011 | Evid Based Complement Alternat Med | pmid:20976081 |
| Wen KC et al. | Inhibitory Effects of Terminalia catappa on UVB-Induced Photodamage in Fibroblast Cell Line. | 2011 | Evid Based Complement Alternat Med | pmid:20981325 |
| Schwaiger S et al. | Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.). | 2011 | J Ethnopharmacol | pmid:21040770 |
| Zhang HP and Tao L | [Studies on the chemical constituents of Buddleja albiflora (II)]. | 2010 | Zhong Yao Cai | pmid:21049618 |
| De Angel RE et al. | Antitumor effects of ursolic acid in a mouse model of postmenopausal breast cancer. | 2010 | Nutr Cancer | pmid:21058195 |
| Feng L et al. | Combination of active components enhances the efficacy of Prunella in prevention and treatment of lung cancer. | 2010 | Molecules | pmid:21060297 |
| Lee AW et al. | Ursolic acid induces allograft inflammatory factor-1 expression via a nitric oxide-related mechanism and increases neovascularization. | 2010 | J. Agric. Food Chem. | pmid:21070071 |
| pmid:21112365 | ||||
| Ko CH et al. | Osteoprotective effects of Fructus Ligustri Lucidi aqueous extract in aged ovariectomized rats. | 2010 | Chin Med | pmid:21114821 |