| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Genet C et al. | Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. | 2010 | J. Med. Chem. | pmid:19911773 |
| Akak CM et al. | New coumarin glycosides from the leaves of Diospyros crassiflora (Hiern). | 2010 | Fitoterapia | pmid:20580922 |
| Purnima A et al. | Antiinflammatory, Analgesic and Antipyretic Activities of Mimusops elengi Linn. | 2010 | Indian J Pharm Sci | pmid:21218059 |
| Ashok P et al. | Antiurolithiatic and antioxidant activity of Mimusops elengi on ethylene glycol-induced urolithiasis in rats. | 2010 | Indian J Pharmacol | pmid:21189910 |
| Wu CR et al. | Triterpenoid contents and anti-inflammatory properties of the methanol extracts of ligustrum species leaves. | 2010 | Molecules | pmid:21187813 |
| Nsonde Ntandou GF et al. | Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts. | 2010 | J Ethnopharmacol | pmid:19799981 |
| Prajapati MS et al. | Leucas aspera: A review. | 2010 | Pharmacogn Rev | pmid:22228946 |
| Lee J et al. | Ursolic acid ameliorates thymic atrophy and hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice. | 2010 | Chem. Biol. Interact. | pmid:20869956 |
| Lu J et al. | Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-κB pathway activation. | 2010 | Cereb. Cortex | pmid:20133359 |
| Yu LB et al. | [Inhibitive effect of ursolic acid on the invasion and metastasis of ovarian carcinoma cells HO-8910PM]. | 2010 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:21265099 |
| Singh SK et al. | Molluscicides from some common medicinal plants of eastern Uttar Pradesh, India. | 2010 | J Appl Toxicol | pmid:19943357 |
| Uprety Y et al. | Indigenous use and bio-efficacy of medicinal plants in the Rasuwa District, Central Nepal. | 2010 | J Ethnobiol Ethnomed | pmid:20102631 |
| Kazakova OB et al. | Betulin and ursolic acid synthetic derivatives as inhibitors of Papilloma virus. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20558062 |
| Kunwar RM et al. | Traditional herbal medicine in far-west Nepal: a pharmacological appraisal. | 2010 | J Ethnobiol Ethnomed | pmid:21144003 |
| Yeh CT et al. | Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling. | 2010 | Mol Nutr Food Res | pmid:20352621 |
| Li Y et al. | Enhancement of chemotherapeutic agent-induced apoptosis by inhibition of NF-kappaB using ursolic acid. | 2010 | Int. J. Cancer | pmid:19908232 |
| Jang SM et al. | Inhibitory effects of ursolic acid on hepatic polyol pathway and glucose production in streptozotocin-induced diabetic mice. | 2010 | Metab. Clin. Exp. | pmid:19846180 |
| Li J et al. | A new dilactone from the seeds of Gaultheria yunnanensis. | 2010 | Fitoterapia | pmid:19628028 |
| Bibi N et al. | In vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicum. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20542692 |
| Yadav VR et al. | Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. | 2010 | Toxins (Basel) | pmid:22069560 |
| Bankeu JJ et al. | Ceramide and Cerebroside from the stem bark of Ficus mucuso (Moraceae). | 2010 | Chem. Pharm. Bull. | pmid:21139276 |
| Liu Y et al. | Evaluation of inhibition of fatty acid synthase by ursolic acid: positive cooperation mechanism. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20074555 |
| Suanarunsawat T et al. | Antioxidant Activity and Lipid-Lowering Effect of Essential Oils Extracted from Ocimum sanctum L. Leaves in Rats Fed with a High Cholesterol Diet. | 2010 | J Clin Biochem Nutr | pmid:20104265 |
| Mullié C et al. | Inhibitory effect of ursolic acid derivatives on hydrogen peroxide- and glutathione-mediated degradation of hemin: a possible additional mechanism of action for antimalarial activity. | 2010 | Exp. Parasitol. | pmid:20109452 |
| Ramos AA et al. | Protective effects of ursolic acid and luteolin against oxidative DNA damage include enhancement of DNA repair in Caco-2 cells. | 2010 | Mutat. Res. | pmid:20659486 |
| Ghosh P et al. | Triterpenoids from Psidium guajava with Biocidal Activity. | 2010 | Indian J Pharm Sci | pmid:21218065 |
| Annegowda HV et al. | Influence of sonication on the phenolic content and antioxidant activity of Terminalia catappa L. leaves. | 2010 | Pharmacognosy Res | pmid:21713141 |
| Wang ZH et al. | Anti-glycative effects of oleanolic acid and ursolic acid in kidney of diabetic mice. | 2010 | Eur. J. Pharmacol. | pmid:19917277 |
| Kurek A et al. | Oleanolic acid and ursolic acid affect peptidoglycan metabolism in Listeria monocytogenes. | 2010 | Antonie Van Leeuwenhoek | pmid:19894138 |
| Yan SL et al. | Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines. | 2010 | Toxicol In Vitro | pmid:20005942 |
| Dai Z et al. | Pomegranate extract inhibits the proliferation and viability of MMTV-Wnt-1 mouse mammary cancer stem cells in vitro. | 2010 | Oncol. Rep. | pmid:20811693 |
| Nabekura T et al. | Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals. | 2010 | Pharmacol. Res. | pmid:19944162 |
| Takada K et al. | Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-α-induced E-selectin expression by cultured umbilical vein endothelial cells. | 2010 | Phytomedicine | pmid:20579861 |
| Cunha WR et al. | Evaluation of the antibacterial activity of the methylene chloride extract of Miconia ligustroides, isolated triterpene acids, and ursolic acid derivatives. | 2010 | Pharm Biol | pmid:20645834 |
| Musabayane CT et al. | Synergistic antihyperglycemic effects between plant-derived oleanolic acid and insulin in streptozotocin-induced diabetic rats. | 2010 | Ren Fail | pmid:20662697 |
| Kuigoua GM et al. | Minor secondary metabolic products from the stem bark of Plumeria rubra Linn. displaying antimicrobial activities. | 2010 | Planta Med. | pmid:19937550 |
| Ganbold M et al. | Cytotoxicity and bioavailability studies on a decoction of Oldenlandia diffusa and its fractions separated by HPLC. | 2010 | J Ethnopharmacol | pmid:20633624 |
| Singh M et al. | Anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. leaves. | 2010 | Pharmacognosy Res | pmid:21713140 |
| Ko CH et al. | Osteoprotective effects of Fructus Ligustri Lucidi aqueous extract in aged ovariectomized rats. | 2010 | Chin Med | pmid:21114821 |
| Feng L et al. | Combination of active components enhances the efficacy of Prunella in prevention and treatment of lung cancer. | 2010 | Molecules | pmid:21060297 |
| Yasukawa K et al. | Anti-tumor promoters phenolics and triterpenoid from Hippophae rhamnoides. | 2009 | Fitoterapia | pmid:19535023 |
| Liu M et al. | Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma. | 2009 | Fitoterapia | pmid:19446614 |
| Tang C et al. | Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis. | 2009 | Anticancer Drugs | pmid:19174695 |
| da Silva Filho AA et al. | In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae). | 2009 | Fitoterapia | pmid:19540316 |
| Chen IH et al. | Cytotoxic triterpenoids from the stems of Microtropis japonica. | 2009 | J. Nat. Prod. | pmid:19534471 |
| Wu PK et al. | Oleanolic acid isolated from Oldenlandia diffusa exhibits a unique growth inhibitory effect against ras-transformed fibroblasts. | 2009 | Life Sci. | pmid:19433096 |
| Gautam R and Jachak SM | Recent developments in anti-inflammatory natural products. | 2009 | Med Res Rev | pmid:19378317 |
| Li J et al. | Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. | 2009 | J. Nat. Prod. | pmid:19555121 |
| Ali S et al. | Mutiniside, new antioxidant phenolic glucoside from Abutilon muticum. | 2009 | J Asian Nat Prod Res | pmid:19504389 |
| Dinda B et al. | Iridoid glucosides from leaves and stem barks of Parkia javanica. | 2009 | J Asian Nat Prod Res | pmid:19408146 |