| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hsu YL et al. | Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells. | 2004 | Life Sci. | pmid:15350828 |
| Nakamura N | [Inhibitory effects of some traditional medicines on proliferation of HIV-1 and its protease]. | 2004 | Yakugaku Zasshi | pmid:15297721 |
| pmid:15287070 | ||||
| Qi SH et al. | Constituents of Carapa guianensis Aubl. (Meliaceae). | 2004 | Pharmazie | pmid:15248467 |
| pmid:15241893 | ||||
| Li Y and Ohizumi Y | Search for constituents with neurotrophic factor-potentiating activity from the medicinal plants of paraguay and Thailand. | 2004 | Yakugaku Zasshi | pmid:15235225 |
| Gu JQ et al. | Antitubercular constituents of Valeriana laxiflora. | 2004 | Planta Med. | pmid:15229801 |
| Varanda EM et al. | Effect of ursolic acid from epicuticular waxes of Jacaranda decurrens on Schizaphis graminum. | 1992 | J. Nat. Prod. | pmid:1522421 |
| Cárdenas C et al. | Effects of ursolic acid on different steps of the angiogenic process. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15219842 |
| Nguyen QC et al. | New 3-O-acyl betulinic acids from Strychnos vanprukii Craib. | 2004 | J. Nat. Prod. | pmid:15217281 |
| Cao S et al. | Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest. | 2004 | J. Nat. Prod. | pmid:15217279 |
| pmid:15214489 | ||||
| Ragasa CY et al. | New cycloartenol esters from Ixora coccinea. | 2004 | Nat. Prod. Res. | pmid:15214483 |
| Basappa M et al. | Novel delta2-isoxazolines as group II phospholipase A2 inhibitors. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15203142 |
| Shih YH et al. | Ursolic acid protects hippocampal neurons against kainate-induced excitotoxicity in rats. | 2004 | Neurosci. Lett. | pmid:15193771 |
| pmid:15180300 | ||||
| Dallavalle S et al. | A new 3,4-seco-lupane derivative from Lasianthus gardneri. | 2004 | J. Nat. Prod. | pmid:15165165 |
| Chaturvedula VS et al. | A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase beta lyase. | 2004 | J. Nat. Prod. | pmid:15165161 |
| pmid:15158981 | ||||
| Murakami S et al. | Ursolic acid, an antagonist for transforming growth factor (TGF)-beta1. | 2004 | FEBS Lett. | pmid:15147868 |
| pmid:15125580 | ||||
| Somova LI et al. | Cardiotonic and antidysrhythmic effects of oleanolic and ursolic acids, methyl maslinate and uvaol. | 2004 | Phytomedicine | pmid:15070161 |
| Kim KA et al. | Inhibition of cytochrome P450 activities by oleanolic acid and ursolic acid in human liver microsomes. | 2004 | Life Sci. | pmid:15043991 |
| pmid:15022717 | ||||
| Guo J et al. | [Studies on chemical constituents from the stems of Schisandra sphaerandra]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015287 |
| pmid:14984086 | ||||
| Xue PF et al. | [Studies on the chemical constituents from Potentilla multifida L]. | 2004 | Beijing Da Xue Xue Bao | pmid:14970881 |
| LE MEN J and POURRAT H | [The presence of ursolic acid in the leaves of Vinca minor L., Nerium oleander L. and Salvia officinalis L]. | 1952 | Ann Pharm Fr | pmid:14953076 |
| KING NM et al. | A note on the isolation of ursolic acid from Verbena stricta, Vent. | 1950 | J Am Pharm Assoc Am Pharm Assoc | pmid:14778784 |
| Banno N et al. | Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. | 2004 | Biosci. Biotechnol. Biochem. | pmid:14745168 |
| Chang CI et al. | Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines. | 2004 | J. Nat. Prod. | pmid:14738395 |
| Jung HA et al. | A new pentacyclic triterpenoid glucoside from Prunus serrulata var. spontanea. | 2004 | Chem. Pharm. Bull. | pmid:14709888 |
| Xiong X et al. | [Effects of ursolic acid on liver-protection and bile secretion]. | 2003 | Zhong Yao Cai | pmid:14649204 |
| Oliveira AF et al. | Epicuticular waxes from caatinga and cerrado species and their efficiency against water loss. | 2003 | An. Acad. Bras. Cienc. | pmid:14605678 |
| Liu H et al. | MECC determination of oleanolic acid and ursolic acid isomers in Ligustrum lucidum Ait. | 2003 | J Pharm Biomed Anal | pmid:14565552 |
| Tapondjou LA et al. | Saponins from Cussonia bancoensis and their inhibitory effects on nitric oxide production. | 2003 | J. Nat. Prod. | pmid:14510614 |
| LE MEN J and POURRAT H | [Distribution of ursolic acid in the leaves of various Rosaceae; ursolic acid. V..]. | 1955 | Ann Pharm Fr | pmid:14388439 |
| Raphael TJ and Kuttan G | Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system. | 2003 | Phytomedicine | pmid:13678231 |
| SCHINDLER H and HERB M | [Chemistry of Ilex aquifolium L. I. Isolation of ursolic acid and rutin from leaves]. | 1955 | Arch Pharm Ber Dtsch Pharm Ges | pmid:13303362 |
| BRIESKORN CH and KESKIN M | [Triterpenes in the bark, peel and leaf of Punica granatum L. 5. Knowledge of biochemistry of triterpenes]. | 1954 | Pharm Acta Helv | pmid:13236480 |
| POURRAT H et al. | [Ursolic acid; distribution of ursolic acid in Oleaceae]. | 1954 | Ann Pharm Fr | pmid:13171723 |
| WU BY and PARKS LM | Chemical studies on ursolic acid. | 1953 | J Am Pharm Assoc Am Pharm Assoc (Baltim) | pmid:13096400 |
| WU BY and PARKS LM | Oleanolic acid from cranberries. | 1953 | J Am Pharm Assoc Am Pharm Assoc (Baltim) | pmid:13096399 |
| LE MEN J and POURRAT H | [Distribution of ursolic acid in the Apocynaceae]. | 1953 | Ann Pharm Fr | pmid:13092702 |
| BRIESKORN CH and EBERHARDT KH | [Oxytriterpenic acids of sage oil. 9. Constituents of Salvia officinalis L..]. | 1953 | Arch Pharm Ber Dtsch Pharm Ges | pmid:13081104 |
| POURRAT H and LE MEN J | [Ursolic acid: distribution of ursolic acid in labiate plants]. | 1953 | Ann Pharm Fr | pmid:13058228 |
| JANOT MM et al. | [Study of a deposit of crystals from a fluid extract of Salvia officinalis]. | 1952 | Ann Pharm Fr | pmid:12986502 |
| Soo Lee Y et al. | Inhibition of ultraviolet-A-modulated signaling pathways by asiatic acid and ursolic acid in HaCaT human keratinocytes. | 2003 | Eur. J. Pharmacol. | pmid:12969763 |
| pmid:12963155 | ||||
| Ryu JH et al. | The role of hydrogen peroxide produced by polychlorinated biphenyls in PMR1-deficient yeast cells. | 2003 | J. Biochem. | pmid:12944380 |
| Baglin I et al. | New ursolic and betulinic derivatives as potential cytotoxic agents. | 2003 | J Enzyme Inhib Med Chem | pmid:12943194 |
| Elliott S et al. | The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes. | 2003 | Arthritis Res. Ther. | pmid:12932292 |
| Andersson D et al. | Ursolic acid inhibits proliferation and stimulates apoptosis in HT29 cells following activation of alkaline sphingomyelinase. | 2003 Jul-Aug | Anticancer Res. | pmid:12926069 |
| Gu BP et al. | [Comparative study of the spectral characteristics of ursolic acid between laser Raman spectra and IR spectrum]. | 2002 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:12914177 |
| Shishodia S et al. | Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. | 2003 | Cancer Res. | pmid:12907607 |
| pmid:12907261 | ||||
| Yoshimura H et al. | In vitro TGF-beta1 antagonistic activity of ursolic and oleanolic acids isolated from Clerodendranthus spicatus. | 2003 | Planta Med. | pmid:12898427 |
| Chiang LC et al. | Immunomodulatory activities of flavonoids, monoterpenoids, triterpenoids, iridoid glycosides and phenolic compounds of Plantago species. | 2003 | Planta Med. | pmid:12898413 |
| Bolta Z et al. | Biomass segregation in sage cell suspension culture. | 2003 | Biotechnol. Lett. | pmid:12882308 |
| Baglin I et al. | A review of natural and modified betulinic, ursolic and echinocystic acid derivatives as potential antitumor and anti-HIV agents. | 2003 | Mini Rev Med Chem | pmid:12871156 |
| Harmand PO et al. | Ursolic acid induces apoptosis through caspase-3 activation and cell cycle arrest in HaCat cells. | 2003 | Int. J. Oncol. | pmid:12792782 |
| Liu CH and Liu Y | [Determination of ursolic acid in herba of Verbena officinalis by HPLC]. | 2002 | Zhongguo Zhong Yao Za Zhi | pmid:12776531 |
| Li Y et al. | Sterol and triterpenoid constituents of Verbena littoralis with NGF-potentiating activity. | 2003 | J. Nat. Prod. | pmid:12762811 |
| pmid:12748987 | ||||
| Somova LO et al. | Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension. | 2003 | Phytomedicine | pmid:12725563 |
| Chiang LC et al. | Antileukemic activity of selected natural products in Taiwan. | 2003 | Am. J. Chin. Med. | pmid:12723753 |
| pmid:12709904 | ||||
| pmid:12709899 | ||||
| Novotny L et al. | Development of LC-MS method for determination of ursolic acid: application to the analysis of ursolic acid in Staphylea holocarpa Hemsl. | 2003 | J Pharm Biomed Anal | pmid:12684108 |
| Prakash Chaturvedula VS et al. | New cytotoxic lupane triterpenoids from the twigs of Coussarea paniculata. | 2003 | J. Nat. Prod. | pmid:12662105 |
| Hossain CF et al. | Genipatriol, a new cycloartane triterpene from Genipa spruceana. | 2003 | J. Nat. Prod. | pmid:12662099 |
| Somova LI et al. | Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves. | 2003 | J Ethnopharmacol | pmid:12648829 |
| Mallavadhani UV et al. | Antifeedant activity of some pentacyclic triterpene acids and their fatty acid ester analogues. | 2003 | J. Agric. Food Chem. | pmid:12643657 |
| Tapondjou LA et al. | In vivo anti-nociceptive and anti-inflammatory effect of the two triterpenes, ursolic acid and 23-hydroxyursolic acid, from Cussonia bancoensis. | 2003 | Arch. Pharm. Res. | pmid:12643591 |
| Zhang HJ et al. | Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea. | 2003 | J. Nat. Prod. | pmid:12608862 |
| Chandramu C et al. | Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L. | 2003 | Phytother Res | pmid:12601674 |
| pmid:12576208 | ||||
| Wen ZM and Xu LX | [Isolation and elucidation of chemical constituents of Shandanshaoyao Decoction(I)]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12528509 |
| Wu ZJ | [Lipid chemical constituents of Salvia sochifolia C. Y. Wu]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12525052 |
| Yang J et al. | [Studies on constituents in Uncaria macrophylla Wall]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12515211 |
| Flores-Sánchez IJ et al. | Biosynthesis of sterols and triterpenes in cell suspension cultures of Uncaria tomentosa. | 2002 | Plant Cell Physiol. | pmid:12514247 |
| Xu XZ and Tian X | [Studies on chemical components of Gentiana tizuensis Franch. (I)]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12512438 |
| Andrikopoulos NK et al. | Inhibitory activity of minor polyphenolic and nonpolyphenolic constituents of olive oil against in vitro low-density lipoprotein oxidation. | 2002 | J Med Food | pmid:12511107 |
| Goun E et al. | Antithrombin activity of some constituents from Origanum vulgare. | 2002 | Fitoterapia | pmid:12490231 |
| pmid:12482456 | ||||
| Pires VS et al. | Triterpenes and saponins from Ilex psammophila. | 2002 | Nat Prod Lett | pmid:12462345 |
| pmid:12453510 | ||||
| Huss U et al. | Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. | 2002 | J. Nat. Prod. | pmid:12444669 |
| pmid:12433200 | ||||
| Wang Q et al. | Extract and identify ingredient from Ligustrum Lucidum Ait and study its effect to periodontal pathogen. | 2002 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:12425858 |
| Abe F et al. | Ursolic acid as a trypanocidal constituent in rosemary. | 2002 | Biol. Pharm. Bull. | pmid:12419966 |
| Lee S et al. | Sessiline, a new nitrogenous compound from the fruits of Acanthopanax sessiliflorus. | 2002 | Planta Med. | pmid:12391563 |
| pmid:12391559 | ||||
| Jiang B et al. | Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata. | 2002 | Planta Med. | pmid:12391557 |
| pmid:12242000 | ||||
| Wen D et al. | [Studies on chemical constituents of Ilex Merr]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12205946 |
| WolbiÅ› M et al. | Triterpenes and sterols in the flowers and leaves of Prunus spinosa L. (Rosaceae). | 2001 Nov-Dec | Acta Pol Pharm | pmid:12197619 |
| Ismaili H et al. | Topical anti-inflammatory activity of extracts and compounds from Thymus broussonettii. | 2002 | J. Pharm. Pharmacol. | pmid:12195830 |
| Lee S et al. | Phytochemical constituents from the fruits of Acanthopanax sessiliflorus. | 2002 | Arch. Pharm. Res. | pmid:12135097 |
| pmid:12135095 |