| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xue YM et al. | [Determination of ursolic acid of Sambucus adnata]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:24010309 |
| do Nascimento PG et al. | Antibacterial and antioxidant activities of ursolic acid and derivatives. | 2013 | Molecules | pmid:24451251 |
| Wan LS et al. | Two new chiratane-type triterpenoids from Swertia kouitchensis. | 2013 | Molecules | pmid:23873389 |
| Nguyen PH et al. | Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity. | 2013 | J. Nat. Prod. | pmid:24224843 |
| Chen Y et al. | Optimisation of potassium chloride nutrition for proper growth, physiological development and bioactive component production in Prunella vulgaris L. | 2013 | PLoS ONE | pmid:23874390 |
| Wang YL et al. | Effects of artesunate and ursolic acid on hyperlipidemia and its complications in rabbit. | 2013 | Eur J Pharm Sci | pmid:23954455 |
| Wang ZW et al. | α-Glucosidase inhibitory triterpenoids from the stem barks of Uncaria laevigata. | 2013 | Fitoterapia | pmid:23856092 |
| da Silva Ferreira D et al. | In vivo activity of ursolic and oleanolic acids during the acute phase of Trypanosoma cruzi infection. | 2013 | Exp. Parasitol. | pmid:23648663 |
| Banihani S et al. | Pomegranate and type 2 diabetes. | 2013 | Nutr Res | pmid:23684435 |
| Wu L et al. | Processing technology investigation of loquat (Eriobotrya japonica) leaf by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry combined with chemometrics. | 2013 | PLoS ONE | pmid:23667702 |
| Çulhaoğlu B et al. | Bioactive constituents of Salvia chrysophylla Stapf. | 2013 | Nat. Prod. Res. | pmid:23126495 |
| Kim SH et al. | Ursolic acid, a potential PPARγ agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of allergic asthma. | 2013 | Eur. J. Pharmacol. | pmid:23201068 |
| Zheng QY et al. | Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells. | 2013 | Cell. Signal. | pmid:23000344 |
| Junco JJ et al. | Resveratrol and P-glycoprotein inhibitors enhance the anti-skin cancer effects of ursolic acid. | 2013 | Mol. Cancer Res. | pmid:24072817 |
| Jiménez-Arellanes A et al. | Ursolic and oleanolic acids as antimicrobial and immunomodulatory compounds for tuberculosis treatment. | 2013 | BMC Complement Altern Med | pmid:24098949 |
| Rao AR et al. | In vitro and in vivo inhibitory activities of four Indian medicinal plant extracts and their major components on rat aldose reductase and generation of advanced glycation endproducts. | 2013 | Phytother Res | pmid:22826152 |
| Fu SB et al. | Biotransformation of ursolic acid by Syncephalastrum racemosum CGMCC 3.2500 and anti-HCV activity. | 2013 | Fitoterapia | pmid:23425601 |
| Verma SC et al. | Microwave-assisted extraction and rapid isolation of ursolic acid from the leaves of Eucalyptus × hybrida Maiden and its quantification using HPLC-diode array technique. | 2013 | J Sep Sci | pmid:23471897 |
| Shanmugam MK et al. | Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies. | 2013 | Biochem. Pharmacol. | pmid:23499879 |
| Rashid S et al. | Synthesis and biological evaluation of ursolic acid-triazolyl derivatives as potential anti-cancer agents. | 2013 | Eur J Med Chem | pmid:23811086 |
| da Silva GN et al. | Two series of new semisynthetic triterpene derivatives: differences in anti-malarial activity, cytotoxicity and mechanism of action. | 2013 | Malar. J. | pmid:23497003 |
| Wang J et al. | Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells. | 2013 | PLoS ONE | pmid:23737956 |
| Zhao C et al. | Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells. | 2013 | Autophagy | pmid:23182854 |
| He Y et al. | Ursolic acid inhibits adipogenesis in 3T3-L1 adipocytes through LKB1/AMPK pathway. | 2013 | PLoS ONE | pmid:23922935 |
| Caldeira de Araújo Lopes S et al. | Preparation, physicochemical characterization, and cell viability evaluation of long-circulating and pH-sensitive liposomes containing ursolic acid. | 2013 | Biomed Res Int | pmid:23984367 |
| Brandão GC et al. | Chemistry and Antiviral Activity of Arrabidaea pulchra (Bignoniaceae). | 2013 | Molecules | pmid:23959197 |
| Zhang ZF et al. | Two new ursolic acid saponins from Morina nepalensis var. alba Hand-Mazz. | 2013 | Nat. Prod. Res. | pmid:23962075 |
| Yu ZL and Zeng WC | Antioxidant, antibrowning, and cytoprotective activities of Ligustrum robustum (Rxob.) Blume extract. | 2013 | J. Food Sci. | pmid:23924383 |
| Verano J et al. | Ursolic acid from Agastache mexicana aerial parts produces antinociceptive activity involving TRPV1 receptors, cGMP and a serotonergic synergism. | 2013 | Pharmacol. Biochem. Behav. | pmid:23932918 |
| Nowak R et al. | HPTLC-densitometry determination of triterpenic acids in Origanum vulgare, Rosmarinus officinalis and Syzygium aromaticum. | 2013 May-Jun | Acta Pol Pharm | pmid:23757931 |
| Kim HI et al. | Inhibition of estrogen signaling through depletion of estrogen receptor alpha by ursolic acid and betulinic acid from Prunella vulgaris var. lilacina. | 2014 | Biochem. Biophys. Res. Commun. | pmid:25088993 |
| Li R et al. | Ursolic acid promotes apoptosis of SGC-7901 gastric cancer cells through ROCK/PTEN mediated mitochondrial translocation of cofilin-1. | 2014 | Asian Pac. J. Cancer Prev. | pmid:25520072 |
| Tang Q et al. | Mitochondrial translocation of cofilin-1 promotes apoptosis of gastric cancer BGC-823 cells induced by ursolic acid. | 2014 | Tumour Biol. | pmid:24197982 |
| Kalani K et al. | In vitro, in silico and in vivo studies of ursolic acid as an anti-filarial agent. | 2014 | PLoS ONE | pmid:25375886 |
| Hwang TL et al. | Ursolic acid inhibits superoxide production in activated neutrophils and attenuates trauma-hemorrhage shock-induced organ injury in rats. | 2014 | PLoS ONE | pmid:25360589 |
| He Y et al. | Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes. | 2014 | PLoS ONE | pmid:25329874 |
| Chen J et al. | A new synthetic ursolic acid derivative IUA with anti-tumor efficacy against osteosarcoma cells via inhibition of JNK signaling pathway. | 2014 | Cell. Physiol. Biochem. | pmid:25171517 |
| Song J et al. | Development and characterisation of ursolic acid nanocrystals without stabiliser having improved dissolution rate and in vitro anticancer activity. | 2014 | AAPS PharmSciTech | pmid:24022345 |
| Wu P et al. | Effects of ursolic acid derivatives on Caco-2 cells and their alleviating role in streptozocin-induced type 2 diabetic rats. | 2014 | Molecules | pmid:25153871 |
| Baek SY et al. | Ursolic acid ameliorates autoimmune arthritis via suppression of Th17 and B cell differentiation. | 2014 | Acta Pharmacol. Sin. | pmid:25087995 |
| Qin N et al. | RNA-Seq-based transcriptome analysis of methicillin-resistant Staphylococcus aureus biofilm inhibition by ursolic acid and resveratrol. | 2014 | Sci Rep | pmid:24970710 |
| Micota B et al. | Leonurus cardiaca L. herb--a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis. | 2014 | Acta Biochim. Pol. | pmid:24918490 |
| Colla AR et al. | Serotonergic and noradrenergic systems are implicated in the antidepressant-like effect of ursolic acid in mice. | 2014 | Pharmacol. Biochem. Behav. | pmid:24887451 |
| Fu HJ et al. | Tryptophan hydroxylase 1 (Tph-1)-targeted bone anabolic agents for osteoporosis. | 2014 | J. Med. Chem. | pmid:24844139 |
| Li Y et al. | Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and suppression of ERK1/2 MAPK in HeLa cells. | 2014 | J. Pharmacol. Sci. | pmid:24881958 |
| Shen S et al. | Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress. | 2014 | Chem. Biol. Interact. | pmid:24802810 |
| Ou X et al. | Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome. | 2014 | PLoS ONE | pmid:24740400 |
| Lee J et al. | Effects of ursolic acid on glucose metabolism, the polyol pathway and dyslipidemia in non-obese type 2 diabetic mice. | 2014 | Indian J. Exp. Biol. | pmid:25059036 |
| Hua WJ et al. | The influence of herbal medicine ursolic acid on the uptake of rosuvastatin mediated by OATP1B1*1a and *5. | 2014 | Eur J Drug Metab Pharmacokinet | pmid:24736980 |
| Chun J et al. | Ursolic acid inhibits nuclear factor-κB signaling in intestinal epithelial cells and macrophages, and attenuates experimental colitis in mice. | 2014 | Life Sci. | pmid:24992474 |
| Ullevig SL et al. | Ursolic acid protects monocytes against metabolic stress-induced priming and dysfunction by preventing the induction of Nox4. | 2014 | Redox Biol | pmid:24494201 |
| Innocente A et al. | Synthesis of isosteric triterpenoid derivatives and antifungal activity. | 2014 | Chem Biol Drug Des | pmid:24138556 |
| Peng W et al. | Bioavailability and activity of natural food additive triterpenoids as influenced by protein. | 2014 | J. Agric. Food Chem. | pmid:24548018 |
| Ma D et al. | Crucial role of heme oxygenase-1 in the sensitivity of acute myeloid leukemia cell line Kasumi-1 to ursolic acid. | 2014 | Anticancer Drugs | pmid:24413389 |
| Wang J et al. | Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis. | 2014 | Sci Rep | pmid:25833312 |
| Innocente AM et al. | Anti-Trichomonas vaginalis activity from triterpenoid derivatives. | 2014 | Parasitol. Res. | pmid:24880238 |
| Yang Y et al. | Ursolic acid prevents endoplasmic reticulum stress-mediated apoptosis induced by heat stress in mouse cardiac myocytes. | 2014 | J. Mol. Cell. Cardiol. | pmid:24389342 |
| Zang LL et al. | Research progress of ursolic acid's anti-tumor actions. | 2014 | Chin J Integr Med | pmid:24374755 |
| Xue C et al. | Powerful protection against renal ischemia reperfusion injury by T cell-specific NF-κB inhibition. | 2014 | Transplantation | pmid:24398854 |
| Han YY et al. | Oleanolic acid and ursolic acid inhibit proliferation in transformed rat hepatic oval cells. | 2014 | World J. Gastroenterol. | pmid:24574810 |
| Wang CM et al. | The role of pentacyclic triterpenoids in the allelopathic effects of Alstonia scholaris. | 2014 | J. Chem. Ecol. | pmid:24390624 |
| Yang G et al. | In vitro and in vivo antitumor effects of folate-targeted ursolic acid stealth liposome. | 2014 | J. Agric. Food Chem. | pmid:24528163 |
| Deng L et al. | Ursolic acid induces U937 cells differentiation by PI3K/Akt pathway activation. | 2014 | Chin J Nat Med | pmid:24484591 |
| Li S et al. | Therapeutic role of ursolic acid on ameliorating hepatic steatosis and improving metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease rats. | 2014 | PLoS ONE | pmid:24489777 |
| Chen J et al. | Ursolic Acid-enriched herba cynomorii extract induces mitochondrial uncoupling and glutathione redox cycling through mitochondrial reactive oxygen species generation: protection against menadione cytotoxicity in h9c2 cells. | 2014 | Molecules | pmid:24473214 |
| Way TD et al. | Chemical constituents of Rhododendron formosanum show pronounced growth inhibitory effect on non-small-cell lung carcinoma cells. | 2014 | J. Agric. Food Chem. | pmid:24447325 |
| Kim HY et al. | Accentuation of ursolic acid on muscarinic receptor-induced ANP secretion in beating rabbit atria. | 2014 | Life Sci. | pmid:24334003 |
| Kim JH et al. | Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of β-catenin degradation. | 2014 | Food Chem. Toxicol. | pmid:24566423 |
| Jia WW et al. | [Inducing effects of ursolic acid on Jurkat cell apoptosis and its mechanisms]. | 2014 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:24762997 |
| Déciga-Campos M et al. | Isobolographic analysis of the antinociceptive interaction between ursolic acid and diclofenac or tramadol in mice. | 2014 | Planta Med. | pmid:24431012 |
| Lee YH et al. | Ursolic acid differentially modulates apoptosis in skin melanoma and retinal pigment epithelial cells exposed to UV-VIS broadband radiation. | 2014 | Apoptosis | pmid:24375173 |
| Yoon JH et al. | p-Coumaric acid and ursolic acid from Corni fructus attenuated β-amyloid(25-35)-induced toxicity through regulation of the NF-κB signaling pathway in PC12 cells. | 2014 | J. Agric. Food Chem. | pmid:24815946 |
| Fabri RL et al. | Chromatographic fingerprint analysis and effects of the medicinal plant species Mitracarpus frigidus on adult Schistosoma mansoni worms. | 2014 | Biomed Res Int | pmid:24901000 |
| Liu L et al. | Inhibition of HepG2 cell proliferation by ursolic acid and polysaccharides via the downregulation of cyclooxygenase-2. | 2014 | Mol Med Rep | pmid:24638056 |
| Fabri RL et al. | Anti-inflammatory and antioxidative effects of the methanolic extract of the aerial parts of Mitracarpus frigidus in established animal models. | 2014 | J. Pharm. Pharmacol. | pmid:24350832 |
| Zhang W et al. | Review on anti-tumor effect of triterpene acid compounds. | 2014 | J Cancer Res Ther | pmid:25207885 |
| Zhao CH et al. | Inhibition of human enterovirus 71 replication by pentacyclic triterpenes and their novel synthetic derivatives. | 2014 | Chem. Pharm. Bull. | pmid:25087628 |
| Lopes SC et al. | Ursolic acid incorporation does not prevent the formation of a non-lamellar phase in pH-sensitive and long-circulating liposomes. | 2014 | Langmuir | pmid:25490253 |
| Yamamoto ES et al. | Treatment with triterpenic fraction purified from Baccharis uncinella leaves inhibits Leishmania (Leishmania) amazonensis spreading and improves Th1 immune response in infected mice. | 2014 | Parasitol. Res. | pmid:24173812 |
| Soica C et al. | The synergistic biologic activity of oleanolic and ursolic acids in complex with hydroxypropyl-γ-cyclodextrin. | 2014 | Molecules | pmid:24747649 |
| Kurek A et al. | The effect of oleanolic and ursolic acids on the hemolytic properties and biofilm formation of Listeria monocytogenes. | 2014 | Pol. J. Microbiol. | pmid:25033658 |
| Lu CC et al. | Ursolic acid triggers nonprogrammed death (necrosis) in human glioblastoma multiforme DBTRG-05MG cells through MPT pore opening and ATP decline. | 2014 | Mol Nutr Food Res | pmid:25131308 |
| Flasiński M et al. | Incorporation of pentacyclic triterpenes into mitochondrial membrane--studies on the interactions in model 2D lipid systems. | 2014 | J Phys Chem B | pmid:25358079 |
| Siewert B et al. | The chemical and biological potential of C ring modified triterpenoids. | 2014 | Eur J Med Chem | pmid:24361521 |
| Castro AJ et al. | The mechanism of action of ursolic acid as insulin secretagogue and insulinomimetic is mediated by cross-talk between calcium and kinases to regulate glucose balance. | 2015 | Biochim. Biophys. Acta | pmid:25312987 |
| Junco JJ et al. | Ursolic acid and resveratrol synergize with chloroquine to reduce melanoma cell viability. | 2015 | Melanoma Res. | pmid:25647735 |
| Gao R et al. | Simultaneous determination of oleanolic acid, ursolic acid, quercetin and apigenin in Swertia mussotii Franch by capillary zone electrophoresis with running buffer modifier. | 2015 | Biomed. Chromatogr. | pmid:25042239 |
| López-GarcÃa S et al. | Macrophage Activation by Ursolic and Oleanolic Acids during Mycobacterial Infection. | 2015 | Molecules | pmid:26287131 |
| Park SN et al. | Oleanolic acid and ursolic acid inhibit peptidoglycan biosynthesis in Streptococcus mutans UA159. | 2015 | Braz. J. Microbiol. | pmid:26273281 |
| Nelson AT et al. | Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties. | 2015 | Bioorg. Med. Chem. Lett. | pmid:26259803 |
| Cho J et al. | Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate. | 2015 | Cancer Prev Res (Phila) | pmid:26100520 |
| Flores-Bocanegra L et al. | α-Glucosidase Inhibitors from Vauquelinia corymbosa. | 2015 | Molecules | pmid:26307962 |
| Cho J et al. | Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. | 2015 | Oncotarget | pmid:26513295 |
| Kim SH et al. | Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells. | 2015 | Sci Rep | pmid:26412148 |
| Wu P et al. | Synthesis and Evaluation of Novel Triterpene Analogues of Ursolic Acid as Potential Antidiabetic Agent. | 2015 | PLoS ONE | pmid:26406581 |
| Wu J et al. | Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells. | 2015 | J. Exp. Clin. Cancer Res. | pmid:26362062 |
| He W et al. | A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver. | 2015 | Drug Des Devel Ther | pmid:26347199 |
| Ebert SM et al. | Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. | 2015 | J. Biol. Chem. | pmid:26338703 |
| Yang Y et al. | Enhancement of Radiation Effects by Ursolic Acid in BGC-823 Human Adenocarcinoma Gastric Cancer Cell Line. | 2015 | PLoS ONE | pmid:26177078 |
| Aguiriano-Moser V et al. | Ursolic acid from Trailliaedoxa gracilis induces apoptosis in medullary thyroid carcinoma cells. | 2015 | Mol Med Rep | pmid:26151624 |