ursolic acid

Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with ursolic acid?

ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with ursolic acid

MeSH term MeSH ID Detail
Dermatitis, Contact D003877 59 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Carcinogenesis D063646 3 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with ursolic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with ursolic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with ursolic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with ursolic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with ursolic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with ursolic acid?

Mouse Model

Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).

Knock-out

Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Cancer Model

Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with ursolic acid

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Authors Title Published Journal PubMed Link
Yu SG et al. Ursolic acid derivative ameliorates streptozotocin-induced diabestic bone deleterious effects in mice. 2015 Int J Clin Exp Pathol pmid:26097549
Park SN et al. Oleanolic acid and ursolic acid inhibit peptidoglycan biosynthesis in Streptococcus mutans UA159. 2015 Braz. J. Microbiol. pmid:26273281
Nelson AT et al. Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties. 2015 Bioorg. Med. Chem. Lett. pmid:26259803
Cho J et al. Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate. 2015 Cancer Prev Res (Phila) pmid:26100520
Cho J et al. Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. 2015 Oncotarget pmid:26513295
Yang Y et al. Enhancement of Radiation Effects by Ursolic Acid in BGC-823 Human Adenocarcinoma Gastric Cancer Cell Line. 2015 PLoS ONE pmid:26177078
Aguiriano-Moser V et al. Ursolic acid from Trailliaedoxa gracilis induces apoptosis in medullary thyroid carcinoma cells. 2015 Mol Med Rep pmid:26151624
Tan X et al. Transcriptome analysis of the biofilm formed by methicillin-susceptible Staphylococcus aureus. 2015 Sci Rep pmid:26149474
Zerin T et al. Ursolic Acid Reduces Mycobacterium tuberculosis-Induced Nitric Oxide Release in Human Alveolar A549 cells. 2015 Mol. Cells pmid:26084752
Carranza-Torres IE et al. Organotypic culture of breast tumor explants as a multicellular system for the screening of natural compounds with antineoplastic potential. 2015 Biomed Res Int pmid:26075250