MeSH term | MeSH ID | Detail |
---|---|---|
Dermatitis, Contact | D003877 | 59 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with ursolic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Dermatitis, Contact | D003877 | 59 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bonaccorsi I et al. | Endogenous reverse transcriptase as a mediator of ursolic acid's anti-proliferative and differentiating effects in human cancer cell lines. | 2008 | Cancer Lett. | pmid:18282657 |
Shen YM et al. | [Effect of ursolic acid on proliferation and apoptosis of hepatic stellate cells in vitro]. | 2008 | Zhonghua Gan Zang Bing Za Zhi | pmid:18423155 |
da Silva VC et al. | Chemical constituents from leaves of Palicourea coriacea (Rubiaceae). | 2008 | J Nat Med | pmid:18404310 |
Tsai SJ and Yin MC | Antioxidative and anti-inflammatory protection of oleanolic acid and ursolic acid in PC12 cells. | 2008 | J. Food Sci. | pmid:18803714 |
Chadalapaka G et al. | Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18359628 |
Liu H et al. | Solid-phase extraction of ursolic acid from herb using beta-cyclodextrin-based molecularly imprinted microspheres. | 2008 | J Sep Sci | pmid:18844208 |
Tran TA et al. | The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection. | 2008 | J Neuroinflammation | pmid:18474101 |
Furtado RA et al. | Ursolic acid and oleanolic acid suppress preneoplastic lesions induced by 1,2-dimethylhydrazine in rat colon. | 2008 | Toxicol Pathol | pmid:18467683 |
Gnoatto SC et al. | Synthesis and preliminary evaluation of new ursolic and oleanolic acids derivatives as antileishmanial agents. | 2008 | J Enzyme Inhib Med Chem | pmid:18608757 |
Anand P et al. | Cancer is a preventable disease that requires major lifestyle changes. | 2008 | Pharm. Res. | pmid:18626751 |
Cunha WR et al. | Hypoglicemic effect of Leandra lacunosa in normal and alloxan-induced diabetic rats. | 2008 | Fitoterapia | pmid:18538949 |
Yu XH et al. | [Study on ursolic acid extraction rate by ultramicro smashing and conventional smashing from leaves of Paulownia fortunei]. | 2008 | Zhong Yao Cai | pmid:19230417 |
Cheung HY and Zhang QF | Enhanced analysis of triterpenes, flavonoids and phenolic compounds in Prunella vulgaris L. by capillary zone electrophoresis with the addition of running buffer modifiers. | 2008 | J Chromatogr A | pmid:18980769 |
Tanachatchairatana T et al. | Antimycobacterial activity of cinnamate-based esters of the triterpenes betulinic, oleanolic and ursolic acids. | 2008 | Chem. Pharm. Bull. | pmid:18239308 |
Ramachandran S and Prasad NR | Effect of ursolic acid, a triterpenoid antioxidant, on ultraviolet-B radiation-induced cytotoxicity, lipid peroxidation and DNA damage in human lymphocytes. | 2008 | Chem. Biol. Interact. | pmid:18793624 |
Ibrahim A et al. | Microbial metabolism of biologically active secondary metabolites from Nerium oleander L. | 2008 | Chem. Pharm. Bull. | pmid:18758096 |
Gnoatto SC et al. | Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition. | 2008 | Eur J Med Chem | pmid:18192087 |
Ikeda Y et al. | Strain differences regarding susceptibility to ursolic acid-induced interleukin-1beta release in murine macrophages. | 2008 | Life Sci. | pmid:18538348 |
Kiran MS et al. | Modulation of angiogenic factors by ursolic acid. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18448068 |
Hassan EM et al. | A new monoterpene alkaloid and other constituents of Plumeria acutifolia. | 2008 | Planta Med. | pmid:18975263 |
Duval RE et al. | Differential involvement of mitochondria during ursolic acid-induced apoptotic process in HaCaT and M4Beu cells. | 2008 | Oncol. Rep. | pmid:18097588 |
Kang SY et al. | The anti-arthritic effect of ursolic acid on zymosan-induced acute inflammation and adjuvant-induced chronic arthritis models. | 2008 | J. Pharm. Pharmacol. | pmid:18812028 |
Zhao WJ et al. | Determination of glycyrrhetic acid in human plasma by HPLC-MS method and investigation of its pharmacokinetics. | 2008 | J Clin Pharm Ther | pmid:18452416 |
Ahmad M et al. | Urease inhibitor from Datisca cannabina linn. | 2008 | J Enzyme Inhib Med Chem | pmid:18569344 |
Chen CC et al. | Fructus Corni suppresses hepatic gluconeogenesis related gene transcription, enhances glucose responsiveness of pancreatic beta-cells, and prevents toxin induced beta-cell death. | 2008 | J Ethnopharmacol | pmid:18400427 |
Kantamreddi VS and Wright CW | Investigation of Indian diospyros species for antiplasmodial properties. | 2008 | Evid Based Complement Alternat Med | pmid:18604258 |
Srinivasan GV et al. | Identification of chemical compounds from the leaves of Leea indica. | 2008 | Acta Pharm | pmid:18515230 |
Hao J et al. | Efficient access to 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid. | 2008 | J. Org. Chem. | pmid:18710287 |
Sekiguchi H et al. | Suppressive Effects of Selected Food Phytochemicals on CD74 Expression in NCI-N87 Gastric Carcinoma Cells. | 2008 | J Clin Biochem Nutr | pmid:18818744 |
Kim JM et al. | Aldose-reductase- and protein-glycation-inhibitory principles from the whole plant of Duchesnea chrysantha. | 2008 | Chem. Biodivers. | pmid:18293434 |
Yang W et al. | Ethoxy-carbonyl-methyl ursolate. | 2008 | Acta Crystallogr Sect E Struct Rep Online | pmid:21581459 |
Silva MG et al. | Variation of ursolic acid content in eight Ocimum species from northeastern Brazil. | 2008 | Molecules | pmid:18923339 |
Fontanay S et al. | Ursolic, oleanolic and betulinic acids: antibacterial spectra and selectivity indexes. | 2008 | J Ethnopharmacol | pmid:18835348 |
Ramos AA et al. | Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells: evaluation by the comet assay. | 2008 | Toxicol. Lett. | pmid:18276086 |
Gnoatto SC et al. | Pharmacomodulation on the 3-acetylursolic acid skeleton: Design, synthesis, and biological evaluation of novel N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-O-acetylursolamide derivatives as antimalarial agents. | 2008 | Bioorg. Med. Chem. | pmid:17967541 |
Jaki BU et al. | Purity-activity relationships of natural products: the case of anti-TB active ursolic acid. | 2008 | J. Nat. Prod. | pmid:18798682 |
Andersson D et al. | Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats. | 2008 | J. Cancer Res. Clin. Oncol. | pmid:17605045 |
Raphael TJ and Kuttan G | Effect of naturally occurring triterpenoids ursolic acid and glycyrrhizic acid on the cell-mediated immune responses of metastatic tumor-bearing animals. | 2008 | Immunopharmacol Immunotoxicol | pmid:18569082 |
Zheng MS et al. | Chemical constituents of Melandrium firmum Rohrbach and their anti-inflammatory activity. | 2008 | Arch. Pharm. Res. | pmid:18409044 |
Ikeda Y et al. | Ursolic acid: an anti- and pro-inflammatory triterpenoid. | 2008 | Mol Nutr Food Res | pmid:18203131 |
Modnicki D et al. | Flavonoids and phenolic acids of Nepeta cataria L. var. citriodora (Becker) Balb. (Lamiaceae). | 2007 May-Jun | Acta Pol Pharm | pmid:17695148 |
Lai MY et al. | Up-regulation of matrix metalloproteinase family gene involvement in ursolic acid-induced human lung non-small carcinoma cell apoptosis. | 2007 Jan-Feb | Anticancer Res. | pmid:17352226 |
Jovel EM et al. | Bioactivity-guided isolation of the active compounds from Rosa nutkana and quantitative analysis of ascorbic acid by HPLC. | 2007 | Can. J. Physiol. Pharmacol. | pmid:18066132 |
Pathak AK et al. | Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. | 2007 | Mol. Cancer Res. | pmid:17855663 |
Santos Rosa C et al. | Antihistaminic and antieicosanoid effects of oleanolic and ursolic acid fraction from Helichrysum picardii. | 2007 | Pharmazie | pmid:17663195 |
Senthil S et al. | Isomers (oleanolic and ursolic acids) differ in their protective effect against isoproterenol-induced myocardial ischemia in rats. | 2007 | Int. J. Cardiol. | pmid:17052790 |
Lim SW et al. | Simultaneous effect of ursolic acid and oleanolic acid on epidermal permeability barrier function and epidermal keratinocyte differentiation via peroxisome proliferator-activated receptor-alpha. | 2007 | J. Dermatol. | pmid:17727365 |
Steinkamp-Fenske K et al. | Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells. | 2007 | Atherosclerosis | pmid:17481637 |
Huang L et al. | [Studies on chemical constituents of Patrinia villosa]. | 2007 | Zhong Yao Cai | pmid:17674792 |
Liu XS and Jiang J | Induction of apoptosis and regulation of the MAPK pathway by ursolic acid in human leukemia K562 cells. | 2007 | Planta Med. | pmid:17764066 |