| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chang CW et al. | Analgesic and Anti-Inflammatory Activities of Methanol Extract of Cissus repens in Mice. | 2012 | Evid Based Complement Alternat Med | pmid:22991570 |
| Orhan IE | Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential. | 2012 | Evid Based Complement Alternat Med | pmid:22666298 |
| Wen KC et al. | Inhibitory Effects of Terminalia catappa on UVB-Induced Photodamage in Fibroblast Cell Line. | 2011 | Evid Based Complement Alternat Med | pmid:20981325 |
| Arora R et al. | Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud. | 2011 | Evid Based Complement Alternat Med | pmid:20976081 |
| Abdureyim S et al. | Anti-inflammatory, immunomodulatory, and heme oxygenase-1 inhibitory activities of ravan napas, a formulation of uighur traditional medicine, in a rat model of allergic asthma. | 2011 | Evid Based Complement Alternat Med | pmid:20953388 |
| Ismail M et al. | Antibacterial, Antifungal, Cytotoxic, Phytotoxic, Insecticidal, and Enzyme Inhibitory Activities of Geranium wallichianum. | 2012 | Evid Based Complement Alternat Med | pmid:23049606 |
| Kantamreddi VS and Wright CW | Investigation of Indian diospyros species for antiplasmodial properties. | 2008 | Evid Based Complement Alternat Med | pmid:18604258 |
| Alshawsh MA et al. | Hepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in Rats. | 2011 | Evid Based Complement Alternat Med | pmid:21647311 |
| Saxena RC et al. | Efficacy of an Extract of Ocimum tenuiflorum (OciBest) in the Management of General Stress: A Double-Blind, Placebo-Controlled Study. | 2012 | Evid Based Complement Alternat Med | pmid:21977056 |
| Mohan L et al. | Evaluation of the Anxiolytic Activity of NR-ANX-C (a Polyherbal Formulation) in Ethanol Withdrawal-Induced Anxiety Behavior in Rats. | 2011 | Evid Based Complement Alternat Med | pmid:20953426 |
| Cunha NL et al. | In vitro schistosomicidal activity of some brazilian cerrado species and their isolated compounds. | 2012 | Evid Based Complement Alternat Med | pmid:22924053 |
| Wang J et al. | 55-week treatment of mice with the unani and ayurvedic medicine pomegranate flower ameliorates ageing-associated insulin resistance and skin abnormalities. | 2012 | Evid Based Complement Alternat Med | pmid:22253646 |
| Huang SS et al. | Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice. | 2011 | Evid Based Complement Alternat Med | pmid:21584194 |
| Zhang X et al. | p21 induction plays a dual role in anti-cancer activity of ursolic acid. | 2016 | Exp. Biol. Med. (Maywood) | pmid:26582056 |
| Pinon A et al. | A novel form of melanoma apoptosis resistance: melanogenesis up-regulation in apoptotic B16-F0 cells delays ursolic acid-triggered cell death. | 2011 | Exp. Cell Res. | pmid:21565187 |
| Hassan L et al. | Resistance to ursolic acid-induced apoptosis through involvement of melanogenesis and COX-2/PGE2 pathways in human M4Beu melanoma cancer cells. | 2016 | Exp. Cell Res. | pmid:27262506 |
| Lee HK et al. | Phytocomponents of triterpenoids, oleanolic acid and ursolic acid, regulated differently the processing of epidermal keratinocytes via PPAR-alpha pathway. | 2006 | Exp. Dermatol. | pmid:16364033 |
| Bayer M et al. | Photoprotection against UVAR: effective triterpenoids require a lipid raft stabilizing chemical structure. | 2011 | Exp. Dermatol. | pmid:21824200 |
| Sonnet P and Mullié C | In vitro antimalarial activity of ICL670: a further proof of the correlation between inhibition of β-hematin formation and of peroxidative degradation of hemin. | 2011 | Exp. Parasitol. | pmid:21295029 |
| da Silva Ferreira D et al. | In vivo activity of ursolic and oleanolic acids during the acute phase of Trypanosoma cruzi infection. | 2013 | Exp. Parasitol. | pmid:23648663 |
| Mullié C et al. | Inhibitory effect of ursolic acid derivatives on hydrogen peroxide- and glutathione-mediated degradation of hemin: a possible additional mechanism of action for antimalarial activity. | 2010 | Exp. Parasitol. | pmid:20109452 |
| Martin-Aragón S et al. | Pharmacological modification of endogenous antioxidant enzymes by ursolic acid on tetrachloride-induced liver damage in rats and primary cultures of rat hepatocytes. | 2001 | Exp. Toxicol. Pathol. | pmid:11484840 |
| Wang XH et al. | Evaluation of toxicity and single-dose pharmacokinetics of intravenous ursolic acid liposomes in healthy adult volunteers and patients with advanced solid tumors. | 2013 | Expert Opin Drug Metab Toxicol | pmid:23134084 |
| Aggarwal BB et al. | From chemoprevention to chemotherapy: common targets and common goals. | 2004 | Expert Opin Investig Drugs | pmid:15461561 |
| Farina C et al. | Synthesis and anti-ulcer activity of new derivatives of glycyrrhetic, oleanolic and ursolic acids. | 1998 | Farmaco | pmid:9543723 |
| Brendolise C et al. | An unusual plant triterpene synthase with predominant α-amyrin-producing activity identified by characterizing oxidosqualene cyclases from Malus × domestica. | 2011 | FEBS J. | pmid:21575133 |
| Murakami S et al. | Ursolic acid, an antagonist for transforming growth factor (TGF)-beta1. | 2004 | FEBS Lett. | pmid:15147868 |
| Najid A et al. | Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL60 leukemic cells. | 1992 | FEBS Lett. | pmid:1544497 |
| You HJ et al. | Ursolic acid enhances nitric oxide and tumor necrosis factor-alpha production via nuclear factor-kappaB activation in the resting macrophages. | 2001 | FEBS Lett. | pmid:11741581 |
| Akak CM et al. | New coumarin glycosides from the leaves of Diospyros crassiflora (Hiern). | 2010 | Fitoterapia | pmid:20580922 |
| Yasukawa K et al. | Anti-tumor promoters phenolics and triterpenoid from Hippophae rhamnoides. | 2009 | Fitoterapia | pmid:19535023 |
| Wang ZW et al. | α-Glucosidase inhibitory triterpenoids from the stem barks of Uncaria laevigata. | 2013 | Fitoterapia | pmid:23856092 |
| Liu M et al. | Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma. | 2009 | Fitoterapia | pmid:19446614 |
| Tuntiwachwuttikul P et al. | Constituents of the leaves of Holarrhena pubescens. | 2007 | Fitoterapia | pmid:17329039 |
| Cunha WR et al. | Hypoglicemic effect of Leandra lacunosa in normal and alloxan-induced diabetic rats. | 2008 | Fitoterapia | pmid:18538949 |
| da Silva Filho AA et al. | In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae). | 2009 | Fitoterapia | pmid:19540316 |
| Wu Q et al. | Antiviral flavonoids from Mosla scabra. | 2010 | Fitoterapia | pmid:20006976 |
| Li J et al. | A new dilactone from the seeds of Gaultheria yunnanensis. | 2010 | Fitoterapia | pmid:19628028 |
| Li LQ et al. | Lignans from the heartwood of Streblus asper and their inhibiting activities to hepatitis B virus. | 2012 | Fitoterapia | pmid:22119765 |
| Kazmi I et al. | Anti-diabetic potential of ursolic acid stearoyl glucoside: a new triterpenic gycosidic ester from Lantana camara. | 2012 | Fitoterapia | pmid:22051701 |
| Fu SB et al. | Multihydroxylation of ursolic acid by Pestalotiopsis microspora isolated from the medicinal plant Huperzia serrata. | 2011 | Fitoterapia | pmid:21767617 |
| Fu SB et al. | Biotransformation of ursolic acid by Syncephalastrum racemosum CGMCC 3.2500 and anti-HCV activity. | 2013 | Fitoterapia | pmid:23425601 |
| Goun E et al. | Antithrombin activity of some constituents from Origanum vulgare. | 2002 | Fitoterapia | pmid:12490231 |
| Xiang W et al. | Constituents of Gnetum montanum. | 2002 | Fitoterapia | pmid:11864762 |
| Wójciak-Kosior M et al. | The effect of ursolic and oleanolic acids on human skin fibroblast cells. | 2011 | Folia Histochem. Cytobiol. | pmid:22252762 |
| Dorota W et al. | Effect of asiatic and ursolic acids on morphology, hydrophobicity, and adhesion of UPECs to uroepithelial cells. | 2013 | Folia Microbiol. (Praha) | pmid:23132656 |
| Caligiani A et al. | A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients. | 2013 | Food Chem | pmid:23122121 |
| Nam H and Kim MM | Ursolic acid induces apoptosis of SW480 cells via p53 activation. | 2013 | Food Chem. Toxicol. | pmid:24071474 |
| Kim JH et al. | Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of β-catenin degradation. | 2014 | Food Chem. Toxicol. | pmid:24566423 |
| Lee JH et al. | Gardenia jasminoides Ellis ethanol extract and its constituents reduce the risks of gastritis and reverse gastric lesions in rats. | 2009 | Food Chem. Toxicol. | pmid:19425231 |