| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bonaccorsi I et al. | Endogenous reverse transcriptase as a mediator of ursolic acid's anti-proliferative and differentiating effects in human cancer cell lines. | 2008 | Cancer Lett. | pmid:18282657 |
| Shen YM et al. | [Effect of ursolic acid on proliferation and apoptosis of hepatic stellate cells in vitro]. | 2008 | Zhonghua Gan Zang Bing Za Zhi | pmid:18423155 |
| da Silva VC et al. | Chemical constituents from leaves of Palicourea coriacea (Rubiaceae). | 2008 | J Nat Med | pmid:18404310 |
| Shyu MH et al. | Hsian-tsao (Mesona procumbens Heml.) prevents against rat liver fibrosis induced by CCl(4) via inhibition of hepatic stellate cells activation. | 2008 | Food Chem. Toxicol. | pmid:18929613 |
| Tsai SJ and Yin MC | Antioxidative and anti-inflammatory protection of oleanolic acid and ursolic acid in PC12 cells. | 2008 | J. Food Sci. | pmid:18803714 |
| Chadalapaka G et al. | Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18359628 |
| Liu H et al. | Solid-phase extraction of ursolic acid from herb using beta-cyclodextrin-based molecularly imprinted microspheres. | 2008 | J Sep Sci | pmid:18844208 |
| Tran TA et al. | The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection. | 2008 | J Neuroinflammation | pmid:18474101 |
| Gnoatto SC et al. | Synthesis and preliminary evaluation of new ursolic and oleanolic acids derivatives as antileishmanial agents. | 2008 | J Enzyme Inhib Med Chem | pmid:18608757 |
| Anand P et al. | Cancer is a preventable disease that requires major lifestyle changes. | 2008 | Pharm. Res. | pmid:18626751 |
| Cunha WR et al. | Hypoglicemic effect of Leandra lacunosa in normal and alloxan-induced diabetic rats. | 2008 | Fitoterapia | pmid:18538949 |
| Yu XH et al. | [Study on ursolic acid extraction rate by ultramicro smashing and conventional smashing from leaves of Paulownia fortunei]. | 2008 | Zhong Yao Cai | pmid:19230417 |
| Cheung HY and Zhang QF | Enhanced analysis of triterpenes, flavonoids and phenolic compounds in Prunella vulgaris L. by capillary zone electrophoresis with the addition of running buffer modifiers. | 2008 | J Chromatogr A | pmid:18980769 |
| Tanachatchairatana T et al. | Antimycobacterial activity of cinnamate-based esters of the triterpenes betulinic, oleanolic and ursolic acids. | 2008 | Chem. Pharm. Bull. | pmid:18239308 |
| Ramachandran S and Prasad NR | Effect of ursolic acid, a triterpenoid antioxidant, on ultraviolet-B radiation-induced cytotoxicity, lipid peroxidation and DNA damage in human lymphocytes. | 2008 | Chem. Biol. Interact. | pmid:18793624 |
| Ibrahim A et al. | Microbial metabolism of biologically active secondary metabolites from Nerium oleander L. | 2008 | Chem. Pharm. Bull. | pmid:18758096 |
| Gnoatto SC et al. | Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition. | 2008 | Eur J Med Chem | pmid:18192087 |
| Hassan EM et al. | A new monoterpene alkaloid and other constituents of Plumeria acutifolia. | 2008 | Planta Med. | pmid:18975263 |
| Manu KA and Kuttan G | Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cells. | 2008 | Int. Immunopharmacol. | pmid:18486908 |
| Zhang YP et al. | [Studies on the chemical constituents of Salvia miltiorrhiz of Lijiang]. | 2008 | Zhong Yao Cai | pmid:18619267 |
| Duval RE et al. | Differential involvement of mitochondria during ursolic acid-induced apoptotic process in HaCaT and M4Beu cells. | 2008 | Oncol. Rep. | pmid:18097588 |
| Kang SY et al. | The anti-arthritic effect of ursolic acid on zymosan-induced acute inflammation and adjuvant-induced chronic arthritis models. | 2008 | J. Pharm. Pharmacol. | pmid:18812028 |
| Ahmad M et al. | Urease inhibitor from Datisca cannabina linn. | 2008 | J Enzyme Inhib Med Chem | pmid:18569344 |
| Chen CC et al. | Fructus Corni suppresses hepatic gluconeogenesis related gene transcription, enhances glucose responsiveness of pancreatic beta-cells, and prevents toxin induced beta-cell death. | 2008 | J Ethnopharmacol | pmid:18400427 |
| Kantamreddi VS and Wright CW | Investigation of Indian diospyros species for antiplasmodial properties. | 2008 | Evid Based Complement Alternat Med | pmid:18604258 |
| Hao J et al. | Efficient access to 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid. | 2008 | J. Org. Chem. | pmid:18710287 |
| Sekiguchi H et al. | Suppressive Effects of Selected Food Phytochemicals on CD74 Expression in NCI-N87 Gastric Carcinoma Cells. | 2008 | J Clin Biochem Nutr | pmid:18818744 |
| Kim JM et al. | Aldose-reductase- and protein-glycation-inhibitory principles from the whole plant of Duchesnea chrysantha. | 2008 | Chem. Biodivers. | pmid:18293434 |
| Prediger RD et al. | Effects of acute administration of the hydroalcoholic extract of mate tea leaves (Ilex paraguariensis) in animal models of learning and memory. | 2008 | J Ethnopharmacol | pmid:18948179 |
| Cáceres-Castillo D et al. | 21beta-Hydroxy-oleanane-type triterpenes from Hippocratea excelsa. | 2008 | Phytochemistry | pmid:18061220 |
| Yang W et al. | Ethoxy-carbonyl-methyl ursolate. | 2008 | Acta Crystallogr Sect E Struct Rep Online | pmid:21581459 |
| Silva MG et al. | Variation of ursolic acid content in eight Ocimum species from northeastern Brazil. | 2008 | Molecules | pmid:18923339 |
| Fontanay S et al. | Ursolic, oleanolic and betulinic acids: antibacterial spectra and selectivity indexes. | 2008 | J Ethnopharmacol | pmid:18835348 |
| Ramos AA et al. | Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells: evaluation by the comet assay. | 2008 | Toxicol. Lett. | pmid:18276086 |
| Gnoatto SC et al. | Pharmacomodulation on the 3-acetylursolic acid skeleton: Design, synthesis, and biological evaluation of novel N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-O-acetylursolamide derivatives as antimalarial agents. | 2008 | Bioorg. Med. Chem. | pmid:17967541 |
| Jaki BU et al. | Purity-activity relationships of natural products: the case of anti-TB active ursolic acid. | 2008 | J. Nat. Prod. | pmid:18798682 |
| Andersson D et al. | Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats. | 2008 | J. Cancer Res. Clin. Oncol. | pmid:17605045 |
| Raphael TJ and Kuttan G | Effect of naturally occurring triterpenoids ursolic acid and glycyrrhizic acid on the cell-mediated immune responses of metastatic tumor-bearing animals. | 2008 | Immunopharmacol Immunotoxicol | pmid:18569082 |
| Zheng MS et al. | Chemical constituents of Melandrium firmum Rohrbach and their anti-inflammatory activity. | 2008 | Arch. Pharm. Res. | pmid:18409044 |
| Ikeda Y et al. | Ursolic acid: an anti- and pro-inflammatory triterpenoid. | 2008 | Mol Nutr Food Res | pmid:18203131 |
| Modnicki D et al. | Flavonoids and phenolic acids of Nepeta cataria L. var. citriodora (Becker) Balb. (Lamiaceae). | 2007 May-Jun | Acta Pol Pharm | pmid:17695148 |
| Lai MY et al. | Up-regulation of matrix metalloproteinase family gene involvement in ursolic acid-induced human lung non-small carcinoma cell apoptosis. | 2007 Jan-Feb | Anticancer Res. | pmid:17352226 |
| Khaliq S et al. | Phytochemical investigation of Perovskia abrotanoides. | 2007 | Planta Med. | pmid:17315312 |
| Ko KM and Leung HY | Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. | 2007 | Chin Med | pmid:17386115 |
| Tuntiwachwuttikul P et al. | Constituents of the leaves of Holarrhena pubescens. | 2007 | Fitoterapia | pmid:17329039 |
| Rosas LV et al. | In vitro evaluation of the cytotoxic and trypanocidal activities of Ampelozizyphus amazonicus (Rhamnaceae). | 2007 | Braz. J. Med. Biol. Res. | pmid:17464428 |
| Li YL et al. | [Studies on chemical constituents from Serissa serissoides]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17583202 |
| Sun M et al. | [Experimental study on treating hyperlipidemic fatty liver with Taizhi'an capsule]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17583205 |
| Nangia-Makker P et al. | Inhibition of breast tumor growth and angiogenesis by a medicinal herb: Ocimum gratissimum. | 2007 | Int. J. Cancer | pmid:17437270 |
| Vidya SM et al. | Evaluation of hepatoprotective activity of Clerodendrum serratum L. | 2007 | Indian J. Exp. Biol. | pmid:17585689 |