| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:17288440 | ||||
| pmid:17291738 | ||||
| Jedinák A et al. | Antiprotease and antimetastatic activity of ursolic acid isolated from Salvia officinalis. | 2006 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:17294686 |
| Ali MS et al. | Ursolic acid: a potent inhibitor of superoxides produced in the cellular system. | 2007 | Phytother Res | pmid:17295383 |
| pmid:17311714 | ||||
| Khaliq S et al. | Phytochemical investigation of Perovskia abrotanoides. | 2007 | Planta Med. | pmid:17315312 |
| Tuntiwachwuttikul P et al. | Constituents of the leaves of Holarrhena pubescens. | 2007 | Fitoterapia | pmid:17329039 |
| Moghaddam FM et al. | Chemical Constituents of Dichloromethane Extract of Cultivated Satureja khuzistanica. | 2007 | Evid Based Complement Alternat Med | pmid:17342246 |
| Lai MY et al. | Up-regulation of matrix metalloproteinase family gene involvement in ursolic acid-induced human lung non-small carcinoma cell apoptosis. | 2007 Jan-Feb | Anticancer Res. | pmid:17352226 |
| Wu JY et al. | [Chemical constituents of the non-alkaloid fraction of Uncaria macrophylla]. | 2007 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:17355944 |
| Gao X et al. | Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling. | 2007 | J. Neurooncol. | pmid:17361329 |
| Zhou C et al. | Determination of oleanolic acid, ursolic acid and amygdalin in the flower of Eriobotrya japonica Lindl. by HPLC. | 2007 | Biomed. Chromatogr. | pmid:17385800 |
| Ko KM and Leung HY | Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. | 2007 | Chin Med | pmid:17386115 |
| Ikeda Y et al. | Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36. | 2007 | J. Immunol. | pmid:17404266 |
| Huang Y et al. | Effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf on inflammatory cytokine and mediator induction from alveolar macrophages of chronic bronchitic rats. | 2007 | Inflamm. Res. | pmid:17431744 |
| Nangia-Makker P et al. | Inhibition of breast tumor growth and angiogenesis by a medicinal herb: Ocimum gratissimum. | 2007 | Int. J. Cancer | pmid:17437270 |
| Nataraju A et al. | Group IIA secretory PLA2 inhibition by ursolic acid: a potent anti-inflammatory molecule. | 2007 | Curr Top Med Chem | pmid:17456043 |
| Rosas LV et al. | In vitro evaluation of the cytotoxic and trypanocidal activities of Ampelozizyphus amazonicus (Rhamnaceae). | 2007 | Braz. J. Med. Biol. Res. | pmid:17464428 |
| Saimaru H et al. | Production of triterpene acids by cell suspension cultures of Olea europaea. | 2007 | Chem. Pharm. Bull. | pmid:17473469 |
| Steinkamp-Fenske K et al. | Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells. | 2007 | Atherosclerosis | pmid:17481637 |