| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kazmi I et al. | Pharmacological evaluation of anxiolytic activity of ursolic acid stearoyl glucoside isolated from Lantana camara. | 2012 | CNS Neurosci Ther | pmid:22715920 |
| Liao CR et al. | Analgesic and anti-inflammatory activities of the methanol extract of Elaeagnus oldhamii Maxim. in mice. | 2012 | Am. J. Chin. Med. | pmid:22745072 |
| Kunkel SD et al. | Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease. | 2012 | PLoS ONE | pmid:22745735 |
| Song YH et al. | Ursolic acid from Oldenlandia diffusa induces apoptosis via activation of caspases and phosphorylation of glycogen synthase kinase 3 beta in SK-OV-3 ovarian cancer cells. | 2012 | Biol. Pharm. Bull. | pmid:22791147 |
| Kadu CA et al. | Bioactive constituents in Prunus africana: geographical variation throughout Africa and associations with environmental and genetic parameters. | 2012 | Phytochemistry | pmid:22795601 |
| Mooi LY et al. | Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22799301 |
| Huang FX et al. | Microbial transformation of ursolic acid by Syncephalastrum racemosum (Cohn) Schroter AS 3.264. | 2012 | Phytochemistry | pmid:22800913 |
| Wang L et al. | [Effects of ursolic acid in ameliorating insulin resistance in liver of KKAy mice via peroxisome proliferator-activated receptors α and γ]. | 2012 | Zhong Xi Yi Jie He Xue Bao | pmid:22805086 |
| Leal AS et al. | Semisynthetic ursolic acid fluorolactone derivatives inhibit growth with induction of p21(waf1) and induce apoptosis with upregulation of NOXA and downregulation of c-FLIP in cancer cells. | 2012 | ChemMedChem | pmid:22807348 |
| Pai PG et al. | Nephroprotective effect of ursolic Acid in a murine model of gentamicin-induced renal damage. | 2012 | ISRN Pharmacol | pmid:22811930 |
| pmid:22816768 | ||||
| Rao AR et al. | In vitro and in vivo inhibitory activities of four Indian medicinal plant extracts and their major components on rat aldose reductase and generation of advanced glycation endproducts. | 2013 | Phytother Res | pmid:22826152 |
| Prasad S et al. | Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine. | 2012 | Clin. Cancer Res. | pmid:22832932 |
| Huang L et al. | Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus. | 2012 | Planta | pmid:22837051 |
| Khan AW et al. | Phytochemical analysis and Enzyme Inhibition Assay of Aerva javanica for Ulcer. | 2012 | Chem Cent J | pmid:22849857 |
| Liu W et al. | Ursolic acid inhibits cigarette smoke extract-induced human bronchial epithelial cell injury and prevents development of lung cancer. | 2012 | Molecules | pmid:22858837 |
| Crown PL et al. | Ritual Black Drink consumption at Cahokia. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22869743 |
| Li D et al. | [Effects of ursolic acid on c-Cbl-associated protein expression in 3T3-L1 adipocytes with insulin resistance]. | 2012 | Zhong Xi Yi Jie He Xue Bao | pmid:22883405 |
| Radhiga T et al. | Effect of ursolic acid on cardiac marker enzymes, lipid profile and macroscopic enzyme mapping assay in isoproterenol-induced myocardial ischemic rats. | 2012 | Food Chem. Toxicol. | pmid:22898613 |
| Adotey JP et al. | A Review of the Ethnobotany and Pharmacological Importance of Alstonia boonei De Wild (Apocynaceae). | 2012 | ISRN Pharmacol | pmid:22900200 |
| Sarkar D et al. | Rapid identification of molecular changes in tulsi (Ocimum sanctum Linn) upon ageing using leaf spray ionization mass spectrometry. | 2012 | Analyst | pmid:22900261 |
| Cunha NL et al. | In vitro schistosomicidal activity of some brazilian cerrado species and their isolated compounds. | 2012 | Evid Based Complement Alternat Med | pmid:22924053 |
| He X et al. | In vitro and in vivo antimammary tumor activities and mechanisms of the apple total triterpenoids. | 2012 | J. Agric. Food Chem. | pmid:22924395 |
| Choi YH et al. | Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22940448 |
| Machado DG et al. | Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: evidence for the involvement of the dopaminergic system. | 2012 | Pharmacol. Biochem. Behav. | pmid:22940588 |
| Kazmi I et al. | Antiepileptic potential of ursolic acid stearoyl glucoside by GABA receptor stimulation. | 2012 | CNS Neurosci Ther | pmid:22943148 |
| Leal AS et al. | Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells. | 2012 | Bioorg. Med. Chem. | pmid:22959527 |
| Hong SY et al. | Protective effects of the key compounds isolated from Corni fructus against β-amyloid-induced neurotoxicity in PC12 cells. | 2012 | Molecules | pmid:22964500 |
| Zhong Y et al. | Preparation and evaluation of liposome-encapsulated codrug LMX. | 2012 | Int J Pharm | pmid:22981689 |
| Chang CW et al. | Analgesic and Anti-Inflammatory Activities of Methanol Extract of Cissus repens in Mice. | 2012 | Evid Based Complement Alternat Med | pmid:22991570 |
| Zheng QY et al. | Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells. | 2013 | Cell. Signal. | pmid:23000344 |
| Agiomyrgianaki A and Dais P | Simultaneous determination of phenolic compounds and triterpenic acids in oregano growing wild in Greece by 31P NMR spectroscopy. | 2012 | Magn Reson Chem | pmid:23001915 |
| Zhou BJ et al. | [The quality standard study on Hugan qingzhi tablets]. | 2012 | Zhong Yao Cai | pmid:23019914 |
| Sundaresan A et al. | Ursolic acid and rosiglitazone combination alleviates metabolic syndrome in high fat diet fed C57BL/6J mice. | 2012 | Gen. Physiol. Biophys. | pmid:23047945 |
| Ismail M et al. | Antibacterial, Antifungal, Cytotoxic, Phytotoxic, Insecticidal, and Enzyme Inhibitory Activities of Geranium wallichianum. | 2012 | Evid Based Complement Alternat Med | pmid:23049606 |
| de Oliveira Eloy J et al. | Solid dispersion of ursolic acid in Gelucire 50/13: a strategy to enhance drug release and trypanocidal activity. | 2012 | AAPS PharmSciTech | pmid:23070562 |
| e Silva Mde L et al. | Bioactive oleanane, lupane and ursane triterpene acid derivatives. | 2012 | Molecules | pmid:23075816 |
| Innocente AM et al. | Synthesis and antiplasmodial activity of betulinic acid and ursolic acid analogues. | 2012 | Molecules | pmid:23085651 |
| Chen Y et al. | Variation in concentrations of major bioactive compounds in Prunella vulgaris L. related to plant parts and phenological stages. | 2012 | Biol. Res. | pmid:23096361 |
| Manguro LO et al. | Triterpene saponins of Maesa lanceolata stem wood. | 2012 | J Asian Nat Prod Res | pmid:23098176 |
| pmid:23114261 | ||||
| Caligiani A et al. | A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients. | 2013 | Food Chem | pmid:23122121 |
| Liu MC et al. | Synthesis and cytotoxicity of novel ursolic acid derivatives containing an acyl piperazine moiety. | 2012 | Eur J Med Chem | pmid:23124210 |
| Çulhaoğlu B et al. | Bioactive constituents of Salvia chrysophylla Stapf. | 2013 | Nat. Prod. Res. | pmid:23126495 |
| Dorota W et al. | Effect of asiatic and ursolic acids on morphology, hydrophobicity, and adhesion of UPECs to uroepithelial cells. | 2013 | Folia Microbiol. (Praha) | pmid:23132656 |
| Wang XH et al. | Evaluation of toxicity and single-dose pharmacokinetics of intravenous ursolic acid liposomes in healthy adult volunteers and patients with advanced solid tumors. | 2013 | Expert Opin Drug Metab Toxicol | pmid:23134084 |
| Cui Y et al. | New diterpene furanoids from the Antarctic lichen Huea sp. | 2012 | Bioorg. Med. Chem. Lett. | pmid:23141910 |
| Zhao C et al. | Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells. | 2013 | Autophagy | pmid:23182854 |
| Yan H et al. | [Optimization of biotransformation of ursolic acid by alternaria longipes]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23189734 |
| Zhang H et al. | Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2). | 2013 | Int J Pharm | pmid:23194884 |