| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li J et al. | Effects of ursolic acid and oleanolic acid on human colon carcinoma cell line HCT15. | 2002 | World J. Gastroenterol. | pmid:12046077 |
| Heo HJ et al. | Ursolic acid of Origanum majorana L. reduces Abeta-induced oxidative injury. | 2002 | Mol. Cells | pmid:11911474 |
| Both DM et al. | Liposome-encapsulated ursolic acid increases ceramides and collagen in human skin cells. | 2002 | Arch. Dermatol. Res. | pmid:11876525 |
| Sang S et al. | New prenylated benzoic acid and other constituents from almond hulls (Prunus amygdalus Batsch). | 2002 | J. Agric. Food Chem. | pmid:11804537 |
| Dzhambazov B et al. | In vitro screening for antitumour activity of Clinopodium vulgare L. (Lamiaceae) extracts. | 2002 | Biol. Pharm. Bull. | pmid:11995932 |
| Pires VS et al. | Triterpenes and saponins from Ilex psammophila. | 2002 | Nat Prod Lett | pmid:12462345 |
| Gu BP et al. | [Comparative study of the spectral characteristics of ursolic acid between laser Raman spectra and IR spectrum]. | 2002 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:12914177 |
| Hollósy F et al. | Activation of caspase-3 protease during the process of ursolic acid and its derivative-induced apoptosis. | 2001 Sep-Oct | Anticancer Res. | pmid:11848513 |
| Ahumada C et al. | Influence of the parasite Viscum cruciatum Sieber on the chemical constituents of Crataegus monogyna Jacq. | 2001 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:11837662 |
| WolbiÅ› M et al. | Triterpenes and sterols in the flowers and leaves of Prunus spinosa L. (Rosaceae). | 2001 Nov-Dec | Acta Pol Pharm | pmid:12197619 |
| Lee I et al. | Ursolic acid-induced changes in tumor growth, O2 consumption, and tumor interstitial fluid pressure. | 2001 Jul-Aug | Anticancer Res. | pmid:11724362 |
| Martinet A et al. | NMR and LC-MSn characterisation of two minor saponins from Ilex paraguariensis. | 2001 Jan-Feb | Phytochem Anal | pmid:11704961 |
| Upadhyay RK et al. | Eclalbatin, a triterpene saponin from Eclipta alba. | 2001 | J Asian Nat Prod Res | pmid:11491397 |
| Ismaili H et al. | Topical anti-inflammatory activity of Thymus willdenowii. | 2001 | J. Pharm. Pharmacol. | pmid:11804395 |
| Cantrell CL et al. | Antimycobacterial plant terpenoids. | 2001 | Planta Med. | pmid:11731906 |
| Novotný L et al. | Ursolic acid: an anti-tumorigenic and chemopreventive activity. Minireview. | 2001 | Neoplasma | pmid:11712672 |
| Rios MY et al. | Sterols, triterpenes and biflavonoids of Viburnum jucundum and cytotoxic activity of ursolic acid. | 2001 | Planta Med. | pmid:11582553 |
| Martin-Aragón S et al. | Pharmacological modification of endogenous antioxidant enzymes by ursolic acid on tetrachloride-induced liver damage in rats and primary cultures of rat hepatocytes. | 2001 | Exp. Toxicol. Pathol. | pmid:11484840 |
| You HJ et al. | Ursolic acid enhances nitric oxide and tumor necrosis factor-alpha production via nuclear factor-kappaB activation in the resting macrophages. | 2001 | FEBS Lett. | pmid:11741581 |
| Baricevic D et al. | Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid. | 2001 | J Ethnopharmacol | pmid:11297842 |
| Chung YK et al. | Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase. | 2001 | Mol. Cells | pmid:11355692 |
| Wen ZM and Xu LX | [Isolation and elucidation of chemical constituents of Shandanshaoyao Decoction(I)]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12528509 |
| Wu ZJ | [Lipid chemical constituents of Salvia sochifolia C. Y. Wu]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12525052 |
| Hollósy F et al. | Cytostatic, cytotoxic and protein tyrosine kinase inhibitory activity of ursolic acid in A431 human tumor cells. | 2000 Nov-Dec | Anticancer Res. | pmid:11205305 |
| Neto CC et al. | Cytotoxic triterpene acids from the Peruvian medicinal plant Polylepis racemosa. | 2000 | Planta Med. | pmid:10909276 |
| Kashiwada Y et al. | Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives. | 2000 | J. Nat. Prod. | pmid:11141100 |
| Kim YK et al. | Cytotoxic triterpenes from stem bark of Physocarpus intermedius. | 2000 | Planta Med. | pmid:10909277 |
| Syrovets T et al. | Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIalpha. | 2000 | Mol. Pharmacol. | pmid:10860928 |
| Lauthier F et al. | Ursolic acid triggers calcium-dependent apoptosis in human Daudi cells. | 2000 | Anticancer Drugs | pmid:11129737 |
| Yarosh DB et al. | Liposomal ursolic acid (merotaine) increases ceramides and collagen in human skin. | 2000 | Horm. Res. | pmid:11595826 |
| Subbaramaiah K et al. | Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. | 2000 | Cancer Res. | pmid:10811116 |
| Xu XZ and Tian X | [Studies on chemical components of Gentiana tizuensis Franch. (I)]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12512438 |
| Yang J et al. | [Studies on constituents in Uncaria macrophylla Wall]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12515211 |
| Saraswat B et al. | Ursolic acid isolated from Eucalyptus tereticornis protects against ethanol toxicity in isolated rat hepatocytes. | 2000 | Phytother Res | pmid:10815008 |
| Min BS et al. | Cytotoxic triterpenes from Crataegus pinnatifida. | 2000 | Arch. Pharm. Res. | pmid:10836742 |
| Akbarsha MA et al. | Retention of cytoplasmic droplet by rat cauda epididymal spermatozoa after treatment with cytotoxic and xenobiotic agents. | 2000 | J. Reprod. Fertil. | pmid:11058454 |
| Choi YH et al. | Induction of apoptosis by ursolic acid through activation of caspases and down-regulation of c-IAPs in human prostate epithelial cells. | 2000 | Int. J. Oncol. | pmid:10938399 |
| Kim DK et al. | Apoptotic activity of ursolic acid may correlate with the inhibition of initiation of DNA replication. | 2000 | Int. J. Cancer | pmid:10925354 |
| Choi BM et al. | Cyclic adenosine monophosphate inhibits ursolic acid-induced apoptosis via activation of protein kinase A in human leukaemic HL-60 cells. | 2000 | Pharmacol. Toxicol. | pmid:10728914 |
| Steele JC et al. | In vitro and in vivo evaluation of betulinic acid as an antimalarial. | 1999 | Phytother Res | pmid:10190183 |
| Haraguchi H et al. | Antimicrobial triterpenes from Ilex integra and the mechanism of antifungal action. | 1999 | Phytother Res | pmid:10190191 |
| Min BS et al. | Inhibitory effect of triterpenes from Crataegus pinatifida on HIV-I protease. | 1999 | Planta Med. | pmid:10364847 |
| Jeong TS et al. | Chitin synthase II inhibitory activity of ursolic acid, isolated from Crataegus pinnatifida. | 1999 | Planta Med. | pmid:10232075 |
| Huang J et al. | [Experimental study on apoptosis induced by ursolic acid isolated from asparagus in HL-60 cells]. | 1999 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11783246 |
| Wen D et al. | [Studies on chemical constituents of Ilex Merr]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12205946 |
| Pérez-Camino MC and Cert A | Quantitative determination of hydroxy pentacyclic triterpene acids in vegetable oils. | 1999 | J. Agric. Food Chem. | pmid:10564016 |
| Kitani K et al. | Pharmacological modifications of endogenous antioxidant enzymes with special reference to the effects of deprenyl: a possible antioxidant strategy. | 1999 | Mech. Ageing Dev. | pmid:10656538 |
| PokrovskiÄ AG et al. | [Immunomodulating activity of ursolic acid derivatives]. | 1999 | Dokl. Akad. Nauk. | pmid:10613250 |
| Ringbom T et al. | Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis. | 1998 | J. Nat. Prod. | pmid:9784154 |
| Paik KJ et al. | Induction of differentiation of the cultured rat mammary epithelial cells by triterpene acids. | 1998 | Arch. Pharm. Res. | pmid:9875466 |