| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chang CW et al. | Analgesic and Anti-Inflammatory Activities of Methanol Extract of Cissus repens in Mice. | 2012 | Evid Based Complement Alternat Med | pmid:22991570 |
| RodrÃguez-Berriguete G et al. | MAP Kinases and Prostate Cancer. | 2012 | J Signal Transduct | pmid:22046506 |
| Silva LL et al. | Effects of Lecythis pisonis Camb. (Lecythidaceae) in a mouse model of pruritus. | 2012 | J Ethnopharmacol | pmid:22063727 |
| Adotey JP et al. | A Review of the Ethnobotany and Pharmacological Importance of Alstonia boonei De Wild (Apocynaceae). | 2012 | ISRN Pharmacol | pmid:22900200 |
| Rivero-Chan BE et al. | Rapid access to ketones related to oleanolic and ursolic acids. | 2012 | Nat. Prod. Res. | pmid:21859373 |
| Kim SH et al. | Effects of Corni fructus on ovalbumin-induced airway inflammation and airway hyper-responsiveness in a mouse model of allergic asthma. | 2012 | J Inflamm (Lond) | pmid:22439901 |
| Kadu CA et al. | Bioactive constituents in Prunus africana: geographical variation throughout Africa and associations with environmental and genetic parameters. | 2012 | Phytochemistry | pmid:22795601 |
| Masuda M et al. | Matrix metalloproteinase-1 inhibitory activities of Morinda citrifolia seed extract and its constituents in UVA-irradiated human dermal fibroblasts. | 2012 | Biol. Pharm. Bull. | pmid:22293351 |
| Limami Y et al. | The P2Y2/Src/p38/COX-2 pathway is involved in the resistance to ursolic acid-induced apoptosis in colorectal and prostate cancer cells. | 2012 | Biochimie | pmid:22521508 |
| Bag P et al. | Anti-herpes virus activities of bioactive fraction and isolated pure constituent of Mallotus peltatus: an ethnomedicine from Andaman Islands. | 2012 | Virol. J. | pmid:22624581 |
| Kato E and Takahashi N | Improvement by sodium dl-α-tocopheryl-6-O-phosphate treatment of moisture-retaining ability in stratum corneum through increased ceramide levels. | 2012 | Bioorg. Med. Chem. | pmid:22579618 |
| Zeller I et al. | Inhibition of cell surface expression of endothelial adhesion molecules by ursolic acid prevents intimal hyperplasia of venous bypass grafts in rats. | 2012 | Eur J Cardiothorac Surg | pmid:22551965 |
| Fu S et al. | Anti-inflammatory effects of active constituents extracted from Chinese medicinal herbs against Propionibacterium acnes. | 2012 | Nat. Prod. Res. | pmid:21999396 |
| Gao N et al. | Ursolic acid induces apoptosis in human leukaemia cells and exhibits anti-leukaemic activity in nude mice through the PKB pathway. | 2012 | Br. J. Pharmacol. | pmid:21950524 |
| Zeng G et al. | Ursolic acid inhibits T-cell activation through modulating nuclear factor-κ B signaling. | 2012 | Chin J Integr Med | pmid:21994027 |
| Shin IS et al. | Ursolic acid reduces prostate size and dihydrotestosterone level in a rat model of benign prostatic hyperplasia. | 2012 | Food Chem. Toxicol. | pmid:22266360 |
| Ni Q et al. | Seasonal variations of the antioxidant composition in ground bamboo Sasa argenteastriatus leaves. | 2012 | Int J Mol Sci | pmid:22408451 |
| Ismail M et al. | Antibacterial, Antifungal, Cytotoxic, Phytotoxic, Insecticidal, and Enzyme Inhibitory Activities of Geranium wallichianum. | 2012 | Evid Based Complement Alternat Med | pmid:23049606 |
| Khan AW et al. | Phytochemical analysis and Enzyme Inhibition Assay of Aerva javanica for Ulcer. | 2012 | Chem Cent J | pmid:22849857 |
| Pai PG et al. | Nephroprotective effect of ursolic Acid in a murine model of gentamicin-induced renal damage. | 2012 | ISRN Pharmacol | pmid:22811930 |
| Wang L et al. | [Effects of ursolic acid in ameliorating insulin resistance in liver of KKAy mice via peroxisome proliferator-activated receptors α and γ]. | 2012 | Zhong Xi Yi Jie He Xue Bao | pmid:22805086 |
| Massaoka MH et al. | Jacaranone induces apoptosis in melanoma cells via ROS-mediated downregulation of Akt and p38 MAPK activation and displays antitumor activity in vivo. | 2012 | PLoS ONE | pmid:22701695 |
| Mooi LY et al. | Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22799301 |
| Mullié C et al. | Differences in anti-malarial activity of 4-aminoalcohol quinoline enantiomers and investigation of the presumed underlying mechanism of action. | 2012 | Malar. J. | pmid:22401346 |
| Liao CR et al. | Analgesic and anti-inflammatory activities of the methanol extract of Elaeagnus oldhamii Maxim. in mice. | 2012 | Am. J. Chin. Med. | pmid:22745072 |
| Xiang M et al. | Attenuation of aortic injury by ursolic acid through RAGE-Nox-NFκB pathway in streptozocin-induced diabetic rats. | 2012 | Arch. Pharm. Res. | pmid:22644855 |
| Saxena RC et al. | Efficacy of an Extract of Ocimum tenuiflorum (OciBest) in the Management of General Stress: A Double-Blind, Placebo-Controlled Study. | 2012 | Evid Based Complement Alternat Med | pmid:21977056 |
| Bai KK et al. | Synthesis and evaluation of ursolic acid derivatives as potent cytotoxic agents. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22370266 |
| Wang J et al. | Ursolic acid inhibits proliferation and induces apoptosis in human glioblastoma cell lines U251 by suppressing TGF-β1/miR-21/PDCD4 pathway. | 2012 | Basic Clin. Pharmacol. Toxicol. | pmid:22353043 |
| Checker R et al. | Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-κB, AP-1 and NF-AT. | 2012 | PLoS ONE | pmid:22363615 |
| Zheng QY et al. | Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22387548 |
| Youn K and Jun M | Inhibitory effects of key compounds isolated from Corni fructus on BACE1 Activity. | 2012 | Phytother Res | pmid:22407769 |
| Figueiredo VC and Nader GA | Ursolic acid directly promotes protein accretion in myotubes but does not affect myoblast proliferation. | 2012 | Cell Biochem. Funct. | pmid:22411156 |
| Katsargyris A et al. | Cranberry as promising natural source of potential anticancer agents: current evidence and future perspectives. | 2012 | Anticancer Agents Med Chem | pmid:22043998 |
| Liu W et al. | Ursolic acid inhibits cigarette smoke extract-induced human bronchial epithelial cell injury and prevents development of lung cancer. | 2012 | Molecules | pmid:22858837 |
| Chen Y et al. | Changes in bioactive components related to the harvest time from the spicas of Prunella vulgaris. | 2012 | Pharm Biol | pmid:22686260 |
| Cunha NL et al. | In vitro schistosomicidal activity of some brazilian cerrado species and their isolated compounds. | 2012 | Evid Based Complement Alternat Med | pmid:22924053 |
| Ahmed MK | 2012 - Another successful new year for Pharmacogn Mag. | 2012 | Pharmacogn Mag | pmid:22438655 |
| Yoo KY and Park SY | Terpenoids as potential anti-Alzheimer's disease therapeutics. | 2012 | Molecules | pmid:22430119 |
| Liu MC et al. | Synthesis and cytotoxicity of novel ursolic acid derivatives containing an acyl piperazine moiety. | 2012 | Eur J Med Chem | pmid:23124210 |
| Wang J et al. | 55-week treatment of mice with the unani and ayurvedic medicine pomegranate flower ameliorates ageing-associated insulin resistance and skin abnormalities. | 2012 | Evid Based Complement Alternat Med | pmid:22253646 |
| Sundaresan A et al. | Ursolic acid and rosiglitazone combination alleviates metabolic syndrome in high fat diet fed C57BL/6J mice. | 2012 | Gen. Physiol. Biophys. | pmid:23047945 |
| Innocente AM et al. | Synthesis and antiplasmodial activity of betulinic acid and ursolic acid analogues. | 2012 | Molecules | pmid:23085651 |
| Manguro LO et al. | Triterpene saponins of Maesa lanceolata stem wood. | 2012 | J Asian Nat Prod Res | pmid:23098176 |
| Wong KC et al. | Chemical constituents and antibacterial activity of Melastoma malabathricum L. | 2012 | Nat. Prod. Res. | pmid:21834640 |
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| Zhou C et al. | Molecular cloning and expression of squalene synthase and 2,3-oxidosqualene cyclase genes in persimmon (Diospyros kaki L.) fruits. | 2012 | Mol. Biol. Rep. | pmid:21573791 |
| Huang L et al. | Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus. | 2012 | Planta | pmid:22837051 |
| de Oliveira Eloy J et al. | Solid dispersion of ursolic acid in Gelucire 50/13: a strategy to enhance drug release and trypanocidal activity. | 2012 | AAPS PharmSciTech | pmid:23070562 |
| Sarkar D et al. | Rapid identification of molecular changes in tulsi (Ocimum sanctum Linn) upon ageing using leaf spray ionization mass spectrometry. | 2012 | Analyst | pmid:22900261 |