| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Arapitsas P et al. | A metabolomic approach to the study of wine micro-oxygenation. | 2012 | PLoS ONE | pmid:22662221 |
| Orhan IE | Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential. | 2012 | Evid Based Complement Alternat Med | pmid:22666298 |
| Joffry SM et al. | Melastoma malabathricum (L.) Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A Review. | 2012 | Evid Based Complement Alternat Med | pmid:22242040 |
| Liu YQ et al. | Retigeric acid B exhibits antitumor activity through suppression of nuclear factor-κB signaling in prostate cancer cells in vitro and in vivo. | 2012 | PLoS ONE | pmid:22666431 |
| Quave CL et al. | Ellagic acid derivatives from Rubus ulmifolius inhibit Staphylococcus aureus biofilm formation and improve response to antibiotics. | 2012 | PLoS ONE | pmid:22242149 |
| Murakami A and Ohnishi K | Target molecules of food phytochemicals: food science bound for the next dimension. | 2012 | Food Funct | pmid:22377900 |
| Tang LI et al. | Screening of anti-dengue activity in methanolic extracts of medicinal plants. | 2012 | BMC Complement Altern Med | pmid:22244370 |
| González-Trujano ME et al. | Spasmolytic and antinociceptive activities of ursolic acid and acacetin identified in Agastache mexicana. | 2012 | Planta Med. | pmid:22473340 |
| Liu YW et al. | Bioactive diterpenes from Callicarpa longissima. | 2012 | J. Nat. Prod. | pmid:22429052 |
| Kalani K et al. | Pharmacophore, QSAR, and ADME based semisynthesis and in vitro evaluation of ursolic acid analogs for anticancer activity. | 2012 | J Mol Model | pmid:22271093 |
| Choi YH et al. | Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22940448 |
| Machado DG et al. | Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: evidence for the involvement of the dopaminergic system. | 2012 | Pharmacol. Biochem. Behav. | pmid:22940588 |
| Kazmi I et al. | Antiepileptic potential of ursolic acid stearoyl glucoside by GABA receptor stimulation. | 2012 | CNS Neurosci Ther | pmid:22943148 |
| Wilkinson K and El Khoury J | Microglial scavenger receptors and their roles in the pathogenesis of Alzheimer's disease. | 2012 | Int J Alzheimers Dis | pmid:22666621 |
| Ma T et al. | Human papillomavirus type 18 E6 and E7 genes integrate into human hepatoma derived cell line Hep G2. | 2012 | PLoS ONE | pmid:22655088 |
| Feldman M et al. | Cranberry proanthocyanidins inhibit the adherence properties of Candida albicans and cytokine secretion by oral epithelial cells. | 2012 | BMC Complement Altern Med | pmid:22248145 |
| Katsuyama M et al. | Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme. | 2012 | J Clin Biochem Nutr | pmid:22247596 |
| Gao J et al. | Facile synthesis of triterpenoid saponins bearing β-Glu/Gal-(1→3)-β-GluA methyl ester and their cytotoxic activities. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22406153 |
| Crown PL et al. | Ritual Black Drink consumption at Cahokia. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22869743 |
| Radhiga T et al. | Effect of ursolic acid on cardiac marker enzymes, lipid profile and macroscopic enzyme mapping assay in isoproterenol-induced myocardial ischemic rats. | 2012 | Food Chem. Toxicol. | pmid:22898613 |
| Li D et al. | [Effects of ursolic acid on c-Cbl-associated protein expression in 3T3-L1 adipocytes with insulin resistance]. | 2012 | Zhong Xi Yi Jie He Xue Bao | pmid:22883405 |
| Prasad S et al. | Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine. | 2012 | Clin. Cancer Res. | pmid:22832932 |
| Liu Y et al. | Study on the noncovalent interactions of saikosaponins and cytochrome c by electrospray ionization mass spectrometry. | 2012 | Rapid Commun. Mass Spectrom. | pmid:22368050 |
| Radhiga T et al. | Effect of ursolic acid treatment on apoptosis and DNA damage in isoproterenol-induced myocardial infarction. | 2012 | Biochimie | pmid:22289617 |
| Multhoff G and Radons J | Radiation, inflammation, and immune responses in cancer. | 2012 | Front Oncol | pmid:22675673 |
| Cui Y et al. | New diterpene furanoids from the Antarctic lichen Huea sp. | 2012 | Bioorg. Med. Chem. Lett. | pmid:23141910 |
| Lee EH et al. | Inhibitory effect of ursolic acid derivatives on recombinant human aldose reductase. | 2011 Sep-Oct | Bioorg. Khim. | pmid:22332359 |
| Sultana N | Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product. | 2011 | J Enzyme Inhib Med Chem | pmid:21417964 |
| Shanmugam MK et al. | Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model. | 2011 | Int. J. Cancer | pmid:21480220 |
| Wang YJ et al. | Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways. | 2011 | Neurobiol Learn Mem | pmid:21496491 |
| Huang CY et al. | Inhibition of cell proliferation, invasion and migration by ursolic acid in human lung cancer cell lines. | 2011 | Toxicol In Vitro | pmid:21539908 |
| Shao JW et al. | In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives. | 2011 | Eur J Med Chem | pmid:21514015 |
| Shanmugam MK et al. | Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice. | 2011 | J. Mol. Med. | pmid:21465181 |
| Sporn MB et al. | New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. | 2011 | J. Nat. Prod. | pmid:21309592 |
| Roth M et al. | Isolation of modulators of the liver-specific organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae). | 2011 | J. Pharmacol. Exp. Ther. | pmid:21846839 |
| Chiou JF et al. | A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging. | 2011 | Evid Based Complement Alternat Med | pmid:21785640 |
| Kikuchi T et al. | 3-O-(E)-p-coumaroyl tormentic acid from Eriobotrya japonica leaves induces caspase-dependent apoptotic cell death in human leukemia cell line. | 2011 | Chem. Pharm. Bull. | pmid:21372421 |
| Walch SG et al. | Antioxidant Capacity and Polyphenolic Composition as Quality Indicators for Aqueous Infusions of Salvia officinalis L. (sage tea). | 2011 | Front Pharmacol | pmid:22194722 |
| Rasoanaivo P et al. | Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. | 2011 | Malar. J. | pmid:21411015 |
| Lúcio KA et al. | Oleanolic acid initiates apoptosis in non-small cell lung cancer cell lines and reduces metastasis of a B16F10 melanoma model in vivo. | 2011 | PLoS ONE | pmid:22174843 |
| Yao L et al. | Protective effects of polysaccharides from soybean meal against X-ray radiation induced damage in mouse spleen lymphocytes. | 2011 | Int J Mol Sci | pmid:22174652 |
| Kavitha CV et al. | Asiatic acid inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture models. | 2011 | PLoS ONE | pmid:21826202 |
| Ansarullah S et al. | Influence of Oreocnide integrifolia (Gaud.) Miq on IRS-1, Akt and Glut-4 in Fat-Fed C57BL/6J Type 2 Diabetes Mouse Model. | 2011 | Evid Based Complement Alternat Med | pmid:21785636 |
| Kiran MS et al. | Changes in expression of VE-cadherin and MMPs in endothelial cells: Implications for angiogenesis. | 2011 | pmid:21349163 | |
| Peixoto JA et al. | Antileishmanial activity of the hydroalcoholic extract of Miconia langsdorffii, isolated compounds, and semi-synthetic derivatives. | 2011 | Molecules | pmid:21343887 |
| Szuster-Ciesielska A et al. | Betulin and betulinic acid attenuate ethanol-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS), cytokine (TNF-α, TGF-β) production and by influencing intracellular signaling. | 2011 | Toxicology | pmid:21172400 |
| Cárdenas C et al. | Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene. | 2011 | PLoS ONE | pmid:21858104 |
| Lin CC et al. | Antiangiogenic potential of three triterpenic acids in human liver cancer cells. | 2011 | J. Agric. Food Chem. | pmid:21175131 |
| Lee HZ et al. | Clarification of the phenotypic characteristics and anti-tumor activity of Hedyotis diffusa. | 2011 | Am. J. Chin. Med. | pmid:21213409 |
| Zhou C et al. | Herbaceous peony (Paeonia lactiflora Pall.) as an alternative source of oleanolic and ursolic acids. | 2011 | Int J Mol Sci | pmid:21340006 |