ursolic acid

Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.

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Introduction

To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with ursolic acid?

ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with ursolic acid

MeSH term MeSH ID Detail
Dermatitis, Contact D003877 59 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Carcinogenesis D063646 3 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with ursolic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with ursolic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with ursolic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with ursolic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with ursolic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with ursolic acid?

Mouse Model

Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).

Knock-out

Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Cancer Model

Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with ursolic acid

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Authors Title Published Journal PubMed Link
Gao J et al. Hepatoprotective activity of Terminalia catappa L. leaves and its two triterpenoids. 2004 J. Pharm. Pharmacol. pmid:15525453
Chávez IO et al. Cytotoxic activity and effect on nitric oxide production of tirucallane-type triterpenes. 2005 J. Pharm. Pharmacol. pmid:16105229
Ismaili H et al. Topical anti-inflammatory activity of Thymus willdenowii. 2001 J. Pharm. Pharmacol. pmid:11804395
Urech K et al. Apoptosis inducing activity of viscin, a lipophilic extract from Viscum album L. 2005 J. Pharm. Pharmacol. pmid:15638998
Fabri RL et al. Anti-inflammatory and antioxidative effects of the methanolic extract of the aerial parts of Mitracarpus frigidus in established animal models. 2014 J. Pharm. Pharmacol. pmid:24350832
Kang SY et al. The anti-arthritic effect of ursolic acid on zymosan-induced acute inflammation and adjuvant-induced chronic arthritis models. 2008 J. Pharm. Pharmacol. pmid:18812028
Muñoz O et al. Chemical study and anti-inflammatory, analgesic and antioxidant activities of the leaves of Aristotelia chilensis (Mol.) Stuntz, Elaeocarpaceae. 2011 J. Pharm. Pharmacol. pmid:21585384
Hao J et al. Efficient access to 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid. 2008 J. Org. Chem. pmid:18710287
Gao X et al. Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling. 2007 J. Neurooncol. pmid:17361329
León F et al. Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells. 2004 J. Nat. Prod. pmid:15620242
Liobikas J et al. Uncoupling and antioxidant effects of ursolic acid in isolated rat heart mitochondria. 2011 J. Nat. Prod. pmid:21648406
Taketa AT et al. Triterpenoids from Brazilian Ilex species and their in vitro antitrypanosomal activity. 2004 J. Nat. Prod. pmid:15497942
Ringbom T et al. Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis. 1998 J. Nat. Prod. pmid:9784154
Nguyen PH et al. Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity. 2013 J. Nat. Prod. pmid:24224843
Prakash Chaturvedula VS et al. New cytotoxic lupane triterpenoids from the twigs of Coussarea paniculata. 2003 J. Nat. Prod. pmid:12662105
Sporn MB et al. New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. 2011 J. Nat. Prod. pmid:21309592
Hu JF et al. Bacterial biofilm inhibitors from Diospyros dendo. 2006 J. Nat. Prod. pmid:16441080
Cao S et al. Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest. 2004 J. Nat. Prod. pmid:15217279
Dallavalle S et al. A new 3,4-seco-lupane derivative from Lasianthus gardneri. 2004 J. Nat. Prod. pmid:15165165
Kashiwada Y et al. Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives. 2000 J. Nat. Prod. pmid:11141100
Nozaki H et al. Antitumor agents, 116. Cytotoxic triterpenes from Maytenus diversifolia. 1990 Jul-Aug J. Nat. Prod. pmid:2095372
Lin CN et al. The cytotoxic principles of Solanum incanum. 1990 Mar-Apr J. Nat. Prod. pmid:2380724
Schun Y and Cordell GA Cytotoxic steroids of Gelsemium sempervirens. 1987 Mar-Apr J. Nat. Prod. pmid:3655795
Chang CI et al. Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines. 2004 J. Nat. Prod. pmid:14738395
Varanda EM et al. Effect of ursolic acid from epicuticular waxes of Jacaranda decurrens on Schizaphis graminum. 1992 J. Nat. Prod. pmid:1522421
Zhang HJ et al. Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea. 2003 J. Nat. Prod. pmid:12608862
Fu L et al. Three new triterpenes from Nerium oleander and biological activity of the isolated compounds. 2005 J. Nat. Prod. pmid:15730243
Cristians S et al. Hypoglycemic activity of extracts and compounds from the leaves of Hintonia standleyana and H. latiflora: potential alternatives to the use of the stem bark of these species. 2009 J. Nat. Prod. pmid:19140696
Li Y et al. Sterol and triterpenoid constituents of Verbena littoralis with NGF-potentiating activity. 2003 J. Nat. Prod. pmid:12762811
Xu HX et al. Anti-HIV triterpene acids from Geum japonicum. 1996 J. Nat. Prod. pmid:8759159
Liu YW et al. Bioactive diterpenes from Callicarpa longissima. 2012 J. Nat. Prod. pmid:22429052
Zhang P et al. Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. 2009 J. Nat. Prod. pmid:19642687
Chen IH et al. Cytotoxic triterpenoids from the stems of Microtropis japonica. 2009 J. Nat. Prod. pmid:19534471
Ma CH et al. Two pyranocoumarins from the seeds of Calophyllum polyanthum. 2004 J. Nat. Prod. pmid:15387670
Huss U et al. Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. 2002 J. Nat. Prod. pmid:12444669
Kashiwada Y et al. Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids. 1998 J. Nat. Prod. pmid:9748372
Nguyen QC et al. New 3-O-acyl betulinic acids from Strychnos vanprukii Craib. 2004 J. Nat. Prod. pmid:15217281
Truong NB et al. Antituberculosis cycloartane triterpenoids from Radermachera boniana. 2011 J. Nat. Prod. pmid:21469696
Li J et al. Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. 2009 J. Nat. Prod. pmid:19555121
Hossain CF et al. Genipatriol, a new cycloartane triterpene from Genipa spruceana. 2003 J. Nat. Prod. pmid:12662099
Jilani K et al. Triggering of erythrocyte cell membrane scrambling by ursolic acid. 2011 J. Nat. Prod. pmid:21923134
Jaki BU et al. Purity-activity relationships of natural products: the case of anti-TB active ursolic acid. 2008 J. Nat. Prod. pmid:18798682
Saifudin A et al. Sesquiterpenes from the rhizomes of Curcuma heyneana. 2013 J. Nat. Prod. pmid:23387824
Chaturvedula VS et al. A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase beta lyase. 2004 J. Nat. Prod. pmid:15165161
Tapondjou LA et al. Saponins from Cussonia bancoensis and their inhibitory effects on nitric oxide production. 2003 J. Nat. Prod. pmid:14510614
Kang KS et al. Effect of intraperitoneal injection of curcumin on food intake in a goldfish model. 2011 J. Mol. Neurosci. pmid:20514526
Shanmugam MK et al. Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice. 2011 J. Mol. Med. pmid:21465181
Yang Y et al. Ursolic acid prevents endoplasmic reticulum stress-mediated apoptosis induced by heat stress in mouse cardiac myocytes. 2014 J. Mol. Cell. Cardiol. pmid:24389342
Podder B et al. Ursolic Acid Activates Intracellular Killing Effect of Macrophages During Mycobacterium tuberculosis Infection. 2015 J. Microbiol. Biotechnol. pmid:25406534
Genet C et al. Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. 2010 J. Med. Chem. pmid:19911773