| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hsu CL et al. | Antioxidant and anti-inflammatory effects of Orthosiphon aristatus and its bioactive compounds. | 2010 | J. Agric. Food Chem. | pmid:20095565 |
| Miyazawa M et al. | Suppression of the SOS-inducing activity of mutagenic heterocyclic amine, Trp-P-1, by triterpenoid from Uncaria sinensis in the Salmonella typhimurium TA1535/pSK1002 Umu test. | 2005 | J. Agric. Food Chem. | pmid:15769173 |
| Lee AW et al. | Ursolic acid induces allograft inflammatory factor-1 expression via a nitric oxide-related mechanism and increases neovascularization. | 2010 | J. Agric. Food Chem. | pmid:21070071 |
| Peng W et al. | Bioavailability and activity of natural food additive triterpenoids as influenced by protein. | 2014 | J. Agric. Food Chem. | pmid:24548018 |
| Jayaprakasam B et al. | Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). | 2006 | J. Agric. Food Chem. | pmid:16390206 |
| Yang G et al. | In vitro and in vivo antitumor effects of folate-targeted ursolic acid stealth liposome. | 2014 | J. Agric. Food Chem. | pmid:24528163 |
| Way TD et al. | Chemical constituents of Rhododendron formosanum show pronounced growth inhibitory effect on non-small-cell lung carcinoma cells. | 2014 | J. Agric. Food Chem. | pmid:24447325 |
| Allouche Y et al. | Triterpenic content and chemometric analysis of virgin olive oils from forty olive cultivars. | 2009 | J. Agric. Food Chem. | pmid:19326867 |
| Yoon JH et al. | p-Coumaric acid and ursolic acid from Corni fructus attenuated β-amyloid(25-35)-induced toxicity through regulation of the NF-κB signaling pathway in PC12 cells. | 2014 | J. Agric. Food Chem. | pmid:24815946 |
| Cui T et al. | Quantification of the polyphenols and triterpene acids in chinese hawthorn fruit by high-performance liquid chromatography. | 2006 | J. Agric. Food Chem. | pmid:16787000 |
| Mallavadhani UV et al. | Antifeedant activity of some pentacyclic triterpene acids and their fatty acid ester analogues. | 2003 | J. Agric. Food Chem. | pmid:12643657 |
| He X et al. | In vitro and in vivo antimammary tumor activities and mechanisms of the apple total triterpenoids. | 2012 | J. Agric. Food Chem. | pmid:22924395 |
| Puangpraphant S and de Mejia EG | Saponins in yerba mate tea ( Ilex paraguariensis A. St.-Hil) and quercetin synergistically inhibit iNOS and COX-2 in lipopolysaccharide-induced macrophages through NFkappaB pathways. | 2009 | J. Agric. Food Chem. | pmid:19807157 |
| Sang S et al. | New prenylated benzoic acid and other constituents from almond hulls (Prunus amygdalus Batsch). | 2002 | J. Agric. Food Chem. | pmid:11804537 |
| He X and Liu RH | Cranberry phytochemicals: Isolation, structure elucidation, and their antiproliferative and antioxidant activities. | 2006 | J. Agric. Food Chem. | pmid:16968064 |
| Yin MC and Chan KC | Nonenzymatic antioxidative and antiglycative effects of oleanolic acid and ursolic acid. | 2007 | J. Agric. Food Chem. | pmid:17658830 |
| Kowalski R | Studies of selected plant raw materials as alternative sources of triterpenes of oleanolic and ursolic acid types. | 2007 | J. Agric. Food Chem. | pmid:17263457 |
| Xiang W et al. | Four new prenylated isoflavonoids in Tadehagi triquetrum. | 2005 | J. Agric. Food Chem. | pmid:15656660 |
| Li GL et al. | Development of a new HPLC method with precolumn fluorescent derivatization for rapid, selective and sensitive detection of triterpenic acids in fruits. | 2011 | J. Agric. Food Chem. | pmid:21388126 |
| Wu HY et al. | Suppression of hepatitis B virus x protein-mediated tumorigenic effects by ursolic Acid. | 2011 | J. Agric. Food Chem. | pmid:21314126 |
| Shyu MH et al. | Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP. | 2010 | J. Agric. Food Chem. | pmid:20415421 |
| Pérez-Camino MC and Cert A | Quantitative determination of hydroxy pentacyclic triterpene acids in vegetable oils. | 1999 | J. Agric. Food Chem. | pmid:10564016 |
| Lin CC et al. | Antiangiogenic potential of three triterpenic acids in human liver cancer cells. | 2011 | J. Agric. Food Chem. | pmid:21175131 |
| Shen D et al. | LC-MS method for the simultaneous quantitation of the anti-inflammatory constituents in oregano (Origanum species). | 2010 | J. Agric. Food Chem. | pmid:20496910 |
| Jeon BW et al. | Phosphoinositide 3-OH kinase/protein kinase B inhibits apoptotic cell death induced by reactive oxygen species in Saccharomyces cerevisiae. | 2002 | J. Biochem. | pmid:11983076 |
| Ryu JH et al. | The role of hydrogen peroxide produced by polychlorinated biphenyls in PMR1-deficient yeast cells. | 2003 | J. Biochem. | pmid:12944380 |
| Prasad S et al. | Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK. | 2011 | J. Biol. Chem. | pmid:21156789 |
| Xu T et al. | Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein. | 2011 | J. Biol. Chem. | pmid:21566134 |
| Wilkinson K et al. | A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36. | 2011 | J. Biol. Chem. | pmid:21835916 |
| Yamaguchi H et al. | Ligand-receptor interaction between triterpenoids and the 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) enzyme predicts their toxic effects against tumorigenic r/m HM-SFME-1 cells. | 2011 | J. Biol. Chem. | pmid:21880714 |
| Ebert SM et al. | Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. | 2015 | J. Biol. Chem. | pmid:26338703 |
| Yang EJ et al. | Acanthopanax koreanum fruit waste inhibits lipopolysaccharide-induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages. | 2010 | J. Biomed. Biotechnol. | pmid:20368786 |
| Wang X et al. | Ursolic acid inhibits proliferation and induces apoptosis of cancer cells in vitro and in vivo. | 2011 | J. Biomed. Biotechnol. | pmid:21716649 |
| Kassi E et al. | Ursolic acid, a naturally occurring triterpenoid, demonstrates anticancer activity on human prostate cancer cells. | 2007 | J. Cancer Res. Clin. Oncol. | pmid:17516089 |
| Andersson D et al. | Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats. | 2008 | J. Cancer Res. Clin. Oncol. | pmid:17605045 |
| Zhang YX et al. | Ursolic acid overcomes Bcl-2-mediated resistance to apoptosis in prostate cancer cells involving activation of JNK-induced Bcl-2 phosphorylation and degradation. | 2010 | J. Cell. Biochem. | pmid:20052671 |
| Gu G et al. | Oldenlandia diffusa extracts exert antiproliferative and apoptotic effects on human breast cancer cells through ERα/Sp1-mediated p53 activation. | 2012 | J. Cell. Physiol. | pmid:22213398 |
| Wang CM et al. | The role of pentacyclic triterpenoids in the allelopathic effects of Alstonia scholaris. | 2014 | J. Chem. Ecol. | pmid:24390624 |
| Xia Y et al. | Quantitation of ursolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry and its pharmacokinetic study. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21169069 |
| Cheung HY et al. | Simultaneous determination of key bioactive components in Hedyotis diffusa by capillary electrophoresis. | 2006 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16516568 |
| Lim SW et al. | Simultaneous effect of ursolic acid and oleanolic acid on epidermal permeability barrier function and epidermal keratinocyte differentiation via peroxisome proliferator-activated receptor-alpha. | 2007 | J. Dermatol. | pmid:17727365 |
| Xu X et al. | Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway. | 2011 | J. Exp. Clin. Cancer Res. | pmid:21447176 |
| Yang LJ et al. | Inter-regulation of IGFBP1 and FOXO3a unveils novel mechanism in ursolic acid-inhibited growth of hepatocellular carcinoma cells. | 2016 | J. Exp. Clin. Cancer Res. | pmid:27036874 |
| Wu J et al. | Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells. | 2015 | J. Exp. Clin. Cancer Res. | pmid:26362062 |
| Tsai SJ and Yin MC | Antioxidative and anti-inflammatory protection of oleanolic acid and ursolic acid in PC12 cells. | 2008 | J. Food Sci. | pmid:18803714 |
| Shen D et al. | A rapid LC/MS/MS method for the analysis of nonvolatile antiinflammatory agents from Mentha spp. | 2011 | J. Food Sci. | pmid:22417488 |
| Miao J et al. | Chemical Composition and Bioactivities of Two Common Chaenomeles Fruits in China: Chaenomeles speciosa and Chaenomeles sinensis. | 2016 | J. Food Sci. | pmid:27384225 |
| Yu ZL and Zeng WC | Antioxidant, antibrowning, and cytoprotective activities of Ligustrum robustum (Rxob.) Blume extract. | 2013 | J. Food Sci. | pmid:23924383 |
| Wang X et al. | Ursolic acid ameliorates hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells. | 2011 | J. Hepatol. | pmid:21168456 |
| Wang X et al. | Effects of ursolic acid on the proliferation and apoptosis of human ovarian cancer cells. | 2009 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:20037823 |
| Zhao J et al. | Anti-viral effects of urosolic acid on guinea pig cytomegalovirus in vitro. | 2012 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:23271291 |
| Ikeda Y et al. | Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36. | 2007 | J. Immunol. | pmid:17404266 |
| Acda MN | Toxicity, tunneling and feeding behavior of the termite, Coptotermes vastator, in sand treated with oil of the physic nut, Jatropha curcas. | 2009 | J. Insect Sci. | pmid:20053119 |
| Leng S et al. | Ursolic acid enhances macrophage autophagy and attenuates atherogenesis. | 2016 | J. Lipid Res. | pmid:27063951 |
| Genet C et al. | Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. | 2010 | J. Med. Chem. | pmid:19911773 |
| Fu HJ et al. | Tryptophan hydroxylase 1 (Tph-1)-targeted bone anabolic agents for osteoporosis. | 2014 | J. Med. Chem. | pmid:24844139 |
| Podder B et al. | Ursolic Acid Activates Intracellular Killing Effect of Macrophages During Mycobacterium tuberculosis Infection. | 2015 | J. Microbiol. Biotechnol. | pmid:25406534 |
| Yang Y et al. | Ursolic acid prevents endoplasmic reticulum stress-mediated apoptosis induced by heat stress in mouse cardiac myocytes. | 2014 | J. Mol. Cell. Cardiol. | pmid:24389342 |
| Shanmugam MK et al. | Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice. | 2011 | J. Mol. Med. | pmid:21465181 |
| Kang KS et al. | Effect of intraperitoneal injection of curcumin on food intake in a goldfish model. | 2011 | J. Mol. Neurosci. | pmid:20514526 |
| León F et al. | Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells. | 2004 | J. Nat. Prod. | pmid:15620242 |
| Liobikas J et al. | Uncoupling and antioxidant effects of ursolic acid in isolated rat heart mitochondria. | 2011 | J. Nat. Prod. | pmid:21648406 |
| Taketa AT et al. | Triterpenoids from Brazilian Ilex species and their in vitro antitrypanosomal activity. | 2004 | J. Nat. Prod. | pmid:15497942 |
| Ringbom T et al. | Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis. | 1998 | J. Nat. Prod. | pmid:9784154 |
| Nguyen PH et al. | Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity. | 2013 | J. Nat. Prod. | pmid:24224843 |
| Prakash Chaturvedula VS et al. | New cytotoxic lupane triterpenoids from the twigs of Coussarea paniculata. | 2003 | J. Nat. Prod. | pmid:12662105 |
| Sporn MB et al. | New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. | 2011 | J. Nat. Prod. | pmid:21309592 |
| Hu JF et al. | Bacterial biofilm inhibitors from Diospyros dendo. | 2006 | J. Nat. Prod. | pmid:16441080 |
| Cao S et al. | Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest. | 2004 | J. Nat. Prod. | pmid:15217279 |
| Dallavalle S et al. | A new 3,4-seco-lupane derivative from Lasianthus gardneri. | 2004 | J. Nat. Prod. | pmid:15165165 |
| Kashiwada Y et al. | Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives. | 2000 | J. Nat. Prod. | pmid:11141100 |
| Nozaki H et al. | Antitumor agents, 116. Cytotoxic triterpenes from Maytenus diversifolia. | 1990 Jul-Aug | J. Nat. Prod. | pmid:2095372 |
| Lin CN et al. | The cytotoxic principles of Solanum incanum. | 1990 Mar-Apr | J. Nat. Prod. | pmid:2380724 |
| Schun Y and Cordell GA | Cytotoxic steroids of Gelsemium sempervirens. | 1987 Mar-Apr | J. Nat. Prod. | pmid:3655795 |
| Chang CI et al. | Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines. | 2004 | J. Nat. Prod. | pmid:14738395 |
| Varanda EM et al. | Effect of ursolic acid from epicuticular waxes of Jacaranda decurrens on Schizaphis graminum. | 1992 | J. Nat. Prod. | pmid:1522421 |
| Zhang HJ et al. | Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea. | 2003 | J. Nat. Prod. | pmid:12608862 |
| Fu L et al. | Three new triterpenes from Nerium oleander and biological activity of the isolated compounds. | 2005 | J. Nat. Prod. | pmid:15730243 |
| Cristians S et al. | Hypoglycemic activity of extracts and compounds from the leaves of Hintonia standleyana and H. latiflora: potential alternatives to the use of the stem bark of these species. | 2009 | J. Nat. Prod. | pmid:19140696 |
| Li Y et al. | Sterol and triterpenoid constituents of Verbena littoralis with NGF-potentiating activity. | 2003 | J. Nat. Prod. | pmid:12762811 |
| Xu HX et al. | Anti-HIV triterpene acids from Geum japonicum. | 1996 | J. Nat. Prod. | pmid:8759159 |
| Liu YW et al. | Bioactive diterpenes from Callicarpa longissima. | 2012 | J. Nat. Prod. | pmid:22429052 |
| Zhang P et al. | Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. | 2009 | J. Nat. Prod. | pmid:19642687 |
| Chen IH et al. | Cytotoxic triterpenoids from the stems of Microtropis japonica. | 2009 | J. Nat. Prod. | pmid:19534471 |
| Ma CH et al. | Two pyranocoumarins from the seeds of Calophyllum polyanthum. | 2004 | J. Nat. Prod. | pmid:15387670 |
| Huss U et al. | Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. | 2002 | J. Nat. Prod. | pmid:12444669 |
| Kashiwada Y et al. | Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids. | 1998 | J. Nat. Prod. | pmid:9748372 |
| Nguyen QC et al. | New 3-O-acyl betulinic acids from Strychnos vanprukii Craib. | 2004 | J. Nat. Prod. | pmid:15217281 |
| Truong NB et al. | Antituberculosis cycloartane triterpenoids from Radermachera boniana. | 2011 | J. Nat. Prod. | pmid:21469696 |
| Li J et al. | Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. | 2009 | J. Nat. Prod. | pmid:19555121 |
| Hossain CF et al. | Genipatriol, a new cycloartane triterpene from Genipa spruceana. | 2003 | J. Nat. Prod. | pmid:12662099 |
| Jilani K et al. | Triggering of erythrocyte cell membrane scrambling by ursolic acid. | 2011 | J. Nat. Prod. | pmid:21923134 |
| Jaki BU et al. | Purity-activity relationships of natural products: the case of anti-TB active ursolic acid. | 2008 | J. Nat. Prod. | pmid:18798682 |
| Saifudin A et al. | Sesquiterpenes from the rhizomes of Curcuma heyneana. | 2013 | J. Nat. Prod. | pmid:23387824 |
| Chaturvedula VS et al. | A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase beta lyase. | 2004 | J. Nat. Prod. | pmid:15165161 |
| Tapondjou LA et al. | Saponins from Cussonia bancoensis and their inhibitory effects on nitric oxide production. | 2003 | J. Nat. Prod. | pmid:14510614 |
| Gao X et al. | Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling. | 2007 | J. Neurooncol. | pmid:17361329 |
| Hao J et al. | Efficient access to 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid. | 2008 | J. Org. Chem. | pmid:18710287 |
| Ismaili H et al. | Topical anti-inflammatory activity of Thymus willdenowii. | 2001 | J. Pharm. Pharmacol. | pmid:11804395 |
| Fabri RL et al. | Anti-inflammatory and antioxidative effects of the methanolic extract of the aerial parts of Mitracarpus frigidus in established animal models. | 2014 | J. Pharm. Pharmacol. | pmid:24350832 |