| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kazmi I et al. | Pharmacological evaluation of anxiolytic activity of ursolic acid stearoyl glucoside isolated from Lantana camara. | 2012 | CNS Neurosci Ther | pmid:22715920 |
| Liao CR et al. | Analgesic and anti-inflammatory activities of the methanol extract of Elaeagnus oldhamii Maxim. in mice. | 2012 | Am. J. Chin. Med. | pmid:22745072 |
| Kunkel SD et al. | Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease. | 2012 | PLoS ONE | pmid:22745735 |
| Song YH et al. | Ursolic acid from Oldenlandia diffusa induces apoptosis via activation of caspases and phosphorylation of glycogen synthase kinase 3 beta in SK-OV-3 ovarian cancer cells. | 2012 | Biol. Pharm. Bull. | pmid:22791147 |
| Kadu CA et al. | Bioactive constituents in Prunus africana: geographical variation throughout Africa and associations with environmental and genetic parameters. | 2012 | Phytochemistry | pmid:22795601 |
| Mooi LY et al. | Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22799301 |
| Huang FX et al. | Microbial transformation of ursolic acid by Syncephalastrum racemosum (Cohn) Schroter AS 3.264. | 2012 | Phytochemistry | pmid:22800913 |
| Wang L et al. | [Effects of ursolic acid in ameliorating insulin resistance in liver of KKAy mice via peroxisome proliferator-activated receptors α and γ]. | 2012 | Zhong Xi Yi Jie He Xue Bao | pmid:22805086 |
| Leal AS et al. | Semisynthetic ursolic acid fluorolactone derivatives inhibit growth with induction of p21(waf1) and induce apoptosis with upregulation of NOXA and downregulation of c-FLIP in cancer cells. | 2012 | ChemMedChem | pmid:22807348 |
| Pai PG et al. | Nephroprotective effect of ursolic Acid in a murine model of gentamicin-induced renal damage. | 2012 | ISRN Pharmacol | pmid:22811930 |
| pmid:22816768 | ||||
| Rao AR et al. | In vitro and in vivo inhibitory activities of four Indian medicinal plant extracts and their major components on rat aldose reductase and generation of advanced glycation endproducts. | 2013 | Phytother Res | pmid:22826152 |
| Prasad S et al. | Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine. | 2012 | Clin. Cancer Res. | pmid:22832932 |
| Huang L et al. | Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus. | 2012 | Planta | pmid:22837051 |
| Khan AW et al. | Phytochemical analysis and Enzyme Inhibition Assay of Aerva javanica for Ulcer. | 2012 | Chem Cent J | pmid:22849857 |
| Liu W et al. | Ursolic acid inhibits cigarette smoke extract-induced human bronchial epithelial cell injury and prevents development of lung cancer. | 2012 | Molecules | pmid:22858837 |
| Crown PL et al. | Ritual Black Drink consumption at Cahokia. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22869743 |
| Li D et al. | [Effects of ursolic acid on c-Cbl-associated protein expression in 3T3-L1 adipocytes with insulin resistance]. | 2012 | Zhong Xi Yi Jie He Xue Bao | pmid:22883405 |
| Radhiga T et al. | Effect of ursolic acid on cardiac marker enzymes, lipid profile and macroscopic enzyme mapping assay in isoproterenol-induced myocardial ischemic rats. | 2012 | Food Chem. Toxicol. | pmid:22898613 |
| Adotey JP et al. | A Review of the Ethnobotany and Pharmacological Importance of Alstonia boonei De Wild (Apocynaceae). | 2012 | ISRN Pharmacol | pmid:22900200 |
| Sarkar D et al. | Rapid identification of molecular changes in tulsi (Ocimum sanctum Linn) upon ageing using leaf spray ionization mass spectrometry. | 2012 | Analyst | pmid:22900261 |
| Cunha NL et al. | In vitro schistosomicidal activity of some brazilian cerrado species and their isolated compounds. | 2012 | Evid Based Complement Alternat Med | pmid:22924053 |
| He X et al. | In vitro and in vivo antimammary tumor activities and mechanisms of the apple total triterpenoids. | 2012 | J. Agric. Food Chem. | pmid:22924395 |
| Choi YH et al. | Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22940448 |
| Machado DG et al. | Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: evidence for the involvement of the dopaminergic system. | 2012 | Pharmacol. Biochem. Behav. | pmid:22940588 |
| Kazmi I et al. | Antiepileptic potential of ursolic acid stearoyl glucoside by GABA receptor stimulation. | 2012 | CNS Neurosci Ther | pmid:22943148 |
| Leal AS et al. | Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells. | 2012 | Bioorg. Med. Chem. | pmid:22959527 |
| Hong SY et al. | Protective effects of the key compounds isolated from Corni fructus against β-amyloid-induced neurotoxicity in PC12 cells. | 2012 | Molecules | pmid:22964500 |
| Zhong Y et al. | Preparation and evaluation of liposome-encapsulated codrug LMX. | 2012 | Int J Pharm | pmid:22981689 |
| Chang CW et al. | Analgesic and Anti-Inflammatory Activities of Methanol Extract of Cissus repens in Mice. | 2012 | Evid Based Complement Alternat Med | pmid:22991570 |
| Zheng QY et al. | Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells. | 2013 | Cell. Signal. | pmid:23000344 |
| Agiomyrgianaki A and Dais P | Simultaneous determination of phenolic compounds and triterpenic acids in oregano growing wild in Greece by 31P NMR spectroscopy. | 2012 | Magn Reson Chem | pmid:23001915 |
| Zhou BJ et al. | [The quality standard study on Hugan qingzhi tablets]. | 2012 | Zhong Yao Cai | pmid:23019914 |
| Sundaresan A et al. | Ursolic acid and rosiglitazone combination alleviates metabolic syndrome in high fat diet fed C57BL/6J mice. | 2012 | Gen. Physiol. Biophys. | pmid:23047945 |
| Ismail M et al. | Antibacterial, Antifungal, Cytotoxic, Phytotoxic, Insecticidal, and Enzyme Inhibitory Activities of Geranium wallichianum. | 2012 | Evid Based Complement Alternat Med | pmid:23049606 |
| de Oliveira Eloy J et al. | Solid dispersion of ursolic acid in Gelucire 50/13: a strategy to enhance drug release and trypanocidal activity. | 2012 | AAPS PharmSciTech | pmid:23070562 |
| e Silva Mde L et al. | Bioactive oleanane, lupane and ursane triterpene acid derivatives. | 2012 | Molecules | pmid:23075816 |
| Innocente AM et al. | Synthesis and antiplasmodial activity of betulinic acid and ursolic acid analogues. | 2012 | Molecules | pmid:23085651 |
| Chen Y et al. | Variation in concentrations of major bioactive compounds in Prunella vulgaris L. related to plant parts and phenological stages. | 2012 | Biol. Res. | pmid:23096361 |
| Manguro LO et al. | Triterpene saponins of Maesa lanceolata stem wood. | 2012 | J Asian Nat Prod Res | pmid:23098176 |
| pmid:23114261 | ||||
| Caligiani A et al. | A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients. | 2013 | Food Chem | pmid:23122121 |
| Liu MC et al. | Synthesis and cytotoxicity of novel ursolic acid derivatives containing an acyl piperazine moiety. | 2012 | Eur J Med Chem | pmid:23124210 |
| Çulhaoğlu B et al. | Bioactive constituents of Salvia chrysophylla Stapf. | 2013 | Nat. Prod. Res. | pmid:23126495 |
| Dorota W et al. | Effect of asiatic and ursolic acids on morphology, hydrophobicity, and adhesion of UPECs to uroepithelial cells. | 2013 | Folia Microbiol. (Praha) | pmid:23132656 |
| Wang XH et al. | Evaluation of toxicity and single-dose pharmacokinetics of intravenous ursolic acid liposomes in healthy adult volunteers and patients with advanced solid tumors. | 2013 | Expert Opin Drug Metab Toxicol | pmid:23134084 |
| Cui Y et al. | New diterpene furanoids from the Antarctic lichen Huea sp. | 2012 | Bioorg. Med. Chem. Lett. | pmid:23141910 |
| Zhao C et al. | Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells. | 2013 | Autophagy | pmid:23182854 |
| Yan H et al. | [Optimization of biotransformation of ursolic acid by alternaria longipes]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23189734 |
| Zhang H et al. | Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2). | 2013 | Int J Pharm | pmid:23194884 |
| Kim SH et al. | Ursolic acid, a potential PPARγ agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of allergic asthma. | 2013 | Eur. J. Pharmacol. | pmid:23201068 |
| Liu CS et al. | [Chemical constituents from Gentiana striata]. | 2012 | Zhong Yao Cai | pmid:23236825 |
| Shin SW and Park JW | Ursolic acid sensitizes prostate cancer cells to TRAIL-mediated apoptosis. | 2013 | Biochim. Biophys. Acta | pmid:23247106 |
| Chen X et al. | Ursolic acid attenuates lipopolysaccharide-induced acute lung injury in a mouse model. | 2013 | Immunotherapy | pmid:23256797 |
| Li BX et al. | [Ursolic acid activates chloride channels and decreases cell volume in poorly differentiated nasopharyngeal carcinoma cells]. | 2012 | Sheng Li Xue Bao | pmid:23258331 |
| Zhao J et al. | Anti-viral effects of urosolic acid on guinea pig cytomegalovirus in vitro. | 2012 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:23271291 |
| Li L et al. | Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice. | 2013 | Brain Res. | pmid:23276496 |
| Zhu Z et al. | A phase I pharmacokinetic study of ursolic acid nanoliposomes in healthy volunteers and patients with advanced solid tumors. | 2013 | Int J Nanomedicine | pmid:23319864 |
| Son HS et al. | Activation of AMP-activated protein kinase and phosphorylation of glycogen synthase kinase3 β mediate ursolic acid induced apoptosis in HepG2 liver cancer cells. | 2013 | Phytother Res | pmid:23325562 |
| Saifudin A et al. | Sesquiterpenes from the rhizomes of Curcuma heyneana. | 2013 | J. Nat. Prod. | pmid:23387824 |
| Kong L et al. | Oleanolic acid and ursolic acid: novel hepatitis C virus antivirals that inhibit NS5B activity. | 2013 | Antiviral Res. | pmid:23422646 |
| Fu SB et al. | Biotransformation of ursolic acid by Syncephalastrum racemosum CGMCC 3.2500 and anti-HCV activity. | 2013 | Fitoterapia | pmid:23425601 |
| Verma SC et al. | Microwave-assisted extraction and rapid isolation of ursolic acid from the leaves of Eucalyptus × hybrida Maiden and its quantification using HPLC-diode array technique. | 2013 | J Sep Sci | pmid:23471897 |
| Gai L et al. | Ursolic acid induces apoptosis via Akt/NF-κB signaling suppression in T24 human bladder cancer cells. | 2013 | Mol Med Rep | pmid:23483134 |
| da Silva GN et al. | Two series of new semisynthetic triterpene derivatives: differences in anti-malarial activity, cytotoxicity and mechanism of action. | 2013 | Malar. J. | pmid:23497003 |
| Shanmugam MK et al. | Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies. | 2013 | Biochem. Pharmacol. | pmid:23499879 |
| Liu K et al. | Ursolic acid inhibits epithelial-mesenchymal transition by suppressing the expression of astrocyte-elevated gene-1 in human nonsmall cell lung cancer A549 cells. | 2013 | Anticancer Drugs | pmid:23511428 |
| BershteÄn LM | [Ursolic acid as antitumor agent and inductor of PTEN and brown fat]. | 2012 | Vopr Onkol | pmid:23600297 |
| da Silva Ferreira D et al. | In vivo activity of ursolic and oleanolic acids during the acute phase of Trypanosoma cruzi infection. | 2013 | Exp. Parasitol. | pmid:23648663 |
| Wu L et al. | Processing technology investigation of loquat (Eriobotrya japonica) leaf by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry combined with chemometrics. | 2013 | PLoS ONE | pmid:23667702 |
| Banihani S et al. | Pomegranate and type 2 diabetes. | 2013 | Nutr Res | pmid:23684435 |
| Wu DM et al. | Ursolic acid improves domoic acid-induced cognitive deficits in mice. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23707761 |
| Leng S et al. | Ursolic acid promotes cancer cell death by inducing Atg5-dependent autophagy. | 2013 | Int. J. Cancer | pmid:23737395 |
| Wang J et al. | Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells. | 2013 | PLoS ONE | pmid:23737956 |
| Nowak R et al. | HPTLC-densitometry determination of triterpenic acids in Origanum vulgare, Rosmarinus officinalis and Syzygium aromaticum. | 2013 May-Jun | Acta Pol Pharm | pmid:23757931 |
| Lin CN et al. | The cytotoxic principles of Solanum incanum. | 1990 Mar-Apr | J. Nat. Prod. | pmid:2380724 |
| Rashid S et al. | Synthesis and biological evaluation of ursolic acid-triazolyl derivatives as potential anti-cancer agents. | 2013 | Eur J Med Chem | pmid:23811086 |
| Kowalczyk MC et al. | Effects of combined phytochemicals on skin tumorigenesis in SENCAR mice. | 2013 | Int. J. Oncol. | pmid:23835587 |
| Wang ZW et al. | α-Glucosidase inhibitory triterpenoids from the stem barks of Uncaria laevigata. | 2013 | Fitoterapia | pmid:23856092 |
| Wan LS et al. | Two new chiratane-type triterpenoids from Swertia kouitchensis. | 2013 | Molecules | pmid:23873389 |
| Chen Y et al. | Optimisation of potassium chloride nutrition for proper growth, physiological development and bioactive component production in Prunella vulgaris L. | 2013 | PLoS ONE | pmid:23874390 |
| Mazumder K et al. | Cytotoxic activity of ursolic acid derivatives obtained by isolation and oxidative derivatization. | 2013 | Molecules | pmid:23896618 |
| Ogasawara R et al. | Ursolic acid stimulates mTORC1 signaling after resistance exercise in rat skeletal muscle. | 2013 | Am. J. Physiol. Endocrinol. Metab. | pmid:23900420 |
| Lin J et al. | Ursolic acid promotes colorectal cancer cell apoptosis and inhibits cell proliferation via modulation of multiple signaling pathways. | 2013 | Int. J. Oncol. | pmid:23900560 |
| He Y et al. | Ursolic acid inhibits adipogenesis in 3T3-L1 adipocytes through LKB1/AMPK pathway. | 2013 | PLoS ONE | pmid:23922935 |
| Yu ZL and Zeng WC | Antioxidant, antibrowning, and cytoprotective activities of Ligustrum robustum (Rxob.) Blume extract. | 2013 | J. Food Sci. | pmid:23924383 |
| Verano J et al. | Ursolic acid from Agastache mexicana aerial parts produces antinociceptive activity involving TRPV1 receptors, cGMP and a serotonergic synergism. | 2013 | Pharmacol. Biochem. Behav. | pmid:23932918 |
| Wang YL et al. | Effects of artesunate and ursolic acid on hyperlipidemia and its complications in rabbit. | 2013 | Eur J Pharm Sci | pmid:23954455 |
| Brandão GC et al. | Chemistry and Antiviral Activity of Arrabidaea pulchra (Bignoniaceae). | 2013 | Molecules | pmid:23959197 |
| Zhang ZF et al. | Two new ursolic acid saponins from Morina nepalensis var. alba Hand-Mazz. | 2013 | Nat. Prod. Res. | pmid:23962075 |
| Caldeira de Araújo Lopes S et al. | Preparation, physicochemical characterization, and cell viability evaluation of long-circulating and pH-sensitive liposomes containing ursolic acid. | 2013 | Biomed Res Int | pmid:23984367 |
| Xue YM et al. | [Determination of ursolic acid of Sambucus adnata]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:24010309 |
| Song J et al. | Development and characterisation of ursolic acid nanocrystals without stabiliser having improved dissolution rate and in vitro anticancer activity. | 2014 | AAPS PharmSciTech | pmid:24022345 |
| Lin J et al. | Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways. | 2013 | Int. J. Oncol. | pmid:24042330 |
| Saraswati S et al. | Ursolic acid inhibits tumor angiogenesis and induces apoptosis through mitochondrial-dependent pathway in Ehrlich ascites carcinoma tumor. | 2013 | Chem. Biol. Interact. | pmid:24051192 |
| Nam H and Kim MM | Ursolic acid induces apoptosis of SW480 cells via p53 activation. | 2013 | Food Chem. Toxicol. | pmid:24071474 |
| Junco JJ et al. | Resveratrol and P-glycoprotein inhibitors enhance the anti-skin cancer effects of ursolic acid. | 2013 | Mol. Cancer Res. | pmid:24072817 |
| Achiwa Y et al. | Effect of ursolic acid on MAPK in cyclin D1 signaling and RING-type E3 ligase (SCF E3s) in two endometrial cancer cell lines. | 2013 | Nutr Cancer | pmid:24083669 |
| Jiménez-Arellanes A et al. | Ursolic and oleanolic acids as antimicrobial and immunomodulatory compounds for tuberculosis treatment. | 2013 | BMC Complement Altern Med | pmid:24098949 |
| Wang W et al. | Ursolic acid inhibits the growth of colon cancer-initiating cells by targeting STAT3. | 2013 | Anticancer Res. | pmid:24122993 |