| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinogenesis | D063646 | 3 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ringbom T et al. | Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis. | 1998 | J. Nat. Prod. | pmid:9784154 |
| Suh N et al. | Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages. | 1998 | Cancer Res. | pmid:9485026 |
| Farina C et al. | Synthesis and anti-ulcer activity of new derivatives of glycyrrhetic, oleanolic and ursolic acids. | 1998 | Farmaco | pmid:9543723 |
| Cha HJ et al. | Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells. | 1998 | Oncogene | pmid:9488041 |
| Kim DW et al. | Growth inhibitory activities of kalopanaxsaponins A and I against human pathogenic fungi. | 1998 | Arch. Pharm. Res. | pmid:9868538 |
| Ding H et al. | [Quantitative determination of ursolic acid in Herba cynomorii by ultraviolet spectrophotometry]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11596256 |
| Paik KJ et al. | Induction of differentiation of the cultured rat mammary epithelial cells by triterpene acids. | 1998 | Arch. Pharm. Res. | pmid:9875466 |
| Zheng X et al. | [Chemical studies on Pyrrosia gralla (Gies.) Ching]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11596269 |
| Kashiwada Y et al. | Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids. | 1998 | J. Nat. Prod. | pmid:9748372 |
| Hsu HY et al. | Effects of oleanolic acid and ursolic acid on inhibiting tumor growth and enhancing the recovery of hematopoietic system postirradiation in mice. | 1997 | Cancer Lett. | pmid:9022122 |
| Baek JH et al. | Intracellular Ca2+ release mediates ursolic acid-induced apoptosis in human leukemic HL-60 cells. | 1997 | Int. J. Cancer | pmid:9398053 |
| Máñez S et al. | Effect of selected triterpenoids on chronic dermal inflammation. | 1997 | Eur. J. Pharmacol. | pmid:9346335 |
| Tu P et al. | [Fat soluble constituents of the leaves of Vaccinium bracteatum Thunb]. | 1997 | Zhongguo Zhong Yao Za Zhi | pmid:11038902 |
| Es-Saady D et al. | MCF-7 cell cycle arrested at G1 through ursolic acid, and increased reduction of tetrazolium salts. | 1996 Jan-Feb | Anticancer Res. | pmid:8615658 |
| Quéré L et al. | Triterpenes as potential dimerization inhibitors of HIV-1 protease. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8967903 |
| Singletary K et al. | Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. | 1996 | Cancer Lett. | pmid:8640744 |
| Cha HJ et al. | Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells. | 1996 | Cancer Res. | pmid:8625299 |
| Xu HX et al. | Anti-HIV triterpene acids from Geum japonicum. | 1996 | J. Nat. Prod. | pmid:8759159 |
| Es-saady D et al. | Inhibitory effect of ursolic acid on B16 proliferation through cell cycle arrest. | 1996 | Cancer Lett. | pmid:8844972 |
| Tan GT et al. | Natural-product inhibitors of human DNA ligase I. | 1996 | Biochem. J. | pmid:8615799 |
| Sohn KH et al. | Anti-angiogenic activity of triterpene acids. | 1995 | Cancer Lett. | pmid:7543366 |
| Liu J | Pharmacology of oleanolic acid and ursolic acid. | 1995 | J Ethnopharmacol | pmid:8847885 |
| Guo Y et al. | [Quantitative determination of ursolic acid in folium Ilicis cornutae (gouguye) gathered in different and periods]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8679072 |
| Richards RM et al. | Antibacterial activity of compounds from Rubus pinfaensis. | 1994 | Planta Med. | pmid:7997480 |
| Huang MT et al. | Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. | 1994 | Cancer Res. | pmid:8306331 |
| Takechi M and Tanaka Y | Structure-activity relationships of synthetic methyl ursolate glycosides. | 1993 | Phytochemistry | pmid:7764145 |
| Niikawa M et al. | Isolation of substances from glossy privet (Ligustrum lucidum Ait.) inhibiting the mutagenicity of benzo[a]pyrene in bacteria. | 1993 | Mutat. Res. | pmid:7690454 |
| Najid A et al. | Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL60 leukemic cells. | 1992 | FEBS Lett. | pmid:1544497 |
| Simon A et al. | Inhibition of lipoxygenase activity and HL60 leukemic cell proliferation by ursolic acid isolated from heather flowers (Calluna vulgaris). | 1992 | Biochim. Biophys. Acta | pmid:1567909 |
| Varanda EM et al. | Effect of ursolic acid from epicuticular waxes of Jacaranda decurrens on Schizaphis graminum. | 1992 | J. Nat. Prod. | pmid:1522421 |
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| Lee KH et al. | The cytotoxic principles of Prunella vulgaris, Psychotria serpens, and Hyptis capitata: ursolic acid and related derivatives. | 1988 | Planta Med. | pmid:3222376 |
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| Kozai K et al. | Inhibition of glucosyltransferase from Streptococcus mutans by oleanolic acid and ursolic acid. | 1987 | Caries Res. | pmid:2949844 |
| Zhao QC | [Chemical constituents of Rabdosia japonica var. glaucocalyx]. | 1987 | Zhong Yao Tong Bao | pmid:2964305 |
| Tokuda H et al. | Inhibitory effects of ursolic and oleanolic acid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. | 1986 | Cancer Lett. | pmid:3802058 |
| Ma XH et al. | [Studies on the preventive and therapeutic effects of ursolic acid (UA) on acute hepatic injury in rats]. | 1986 | Yao Xue Xue Bao | pmid:3776541 |
| Chung MI et al. | Studies on the constituents of Formosan gentianaceous plants. Part VII. Constituents of Swertia randaiensis Hayata and pharmacological activity of norswertianolin. | 1986 | Gaoxiong Yi Xue Ke Xue Za Zhi | pmid:3482877 |
| Ohigashi H et al. | Search for possible antitumor promoters by inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation; ursolic acid and oleanolic acid from an anti-inflammatory Chinese medicinal plant, Glechoma hederaceae L. | 1986 | Cancer Lett. | pmid:3006912 |
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| SCHINDLER H and HERB M | [Chemistry of Ilex aquifolium L. I. Isolation of ursolic acid and rutin from leaves]. | 1955 | Arch Pharm Ber Dtsch Pharm Ges | pmid:13303362 |
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| WU BY and PARKS LM | Oleanolic acid from cranberries. | 1953 | J Am Pharm Assoc Am Pharm Assoc (Baltim) | pmid:13096399 |
| WU BY and PARKS LM | Chemical studies on ursolic acid. | 1953 | J Am Pharm Assoc Am Pharm Assoc (Baltim) | pmid:13096400 |
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| LE MEN J and POURRAT H | [The presence of ursolic acid in the leaves of Vinca minor L., Nerium oleander L. and Salvia officinalis L]. | 1952 | Ann Pharm Fr | pmid:14953076 |
| JANOT MM et al. | [Study of a deposit of crystals from a fluid extract of Salvia officinalis]. | 1952 | Ann Pharm Fr | pmid:12986502 |
| KING NM et al. | A note on the isolation of ursolic acid from Verbena stricta, Vent. | 1950 | J Am Pharm Assoc Am Pharm Assoc | pmid:14778784 |
| ROWE EJ and ORR JE | Isolation of oleanolic acid and ursolic acid from Thymus vulgaris, L. | 1949 | J Am Pharm Assoc Am Pharm Assoc | pmid:18116681 |
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