| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinogenesis | D063646 | 3 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:25613495 | ||||
| Chen H et al. | Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agents. | 2015 | Eur J Med Chem | pmid:25617694 |
| LÅ‘rincz A et al. | Effects of ursolic acid on the structural and morphological behaviours of dipalmitoyl lecithin vesicles. | 2015 | Biochim. Biophys. Acta | pmid:25620772 |
| pmid:25636875 | ||||
| pmid:25638028 | ||||
| pmid:25638419 | ||||
| Junco JJ et al. | Ursolic acid and resveratrol synergize with chloroquine to reduce melanoma cell viability. | 2015 | Melanoma Res. | pmid:25647735 |
| pmid:25659643 | ||||
| pmid:25662965 | ||||
| pmid:25681755 | ||||
| Lu X et al. | Ursolic acid attenuates diabetic mesangial cell injury through the up-regulation of autophagy via miRNA-21/PTEN/Akt/mTOR suppression. | 2015 | PLoS ONE | pmid:25689721 |
| pmid:25713926 | ||||
| pmid:25728024 | ||||
| pmid:25738749 | ||||
| pmid:25753845 | ||||
| pmid:25778894 | ||||
| Zhang H et al. | Efficient delivery of ursolic acid by poly(N-vinylpyrrolidone)-block-poly (ε-caprolactone) nanoparticles for inhibiting the growth of hepatocellular carcinoma in vitro and in vivo. | 2015 | Int J Nanomedicine | pmid:25792825 |
| Broniatowski M et al. | Grazing incidence diffraction studies of the interactions between ursane-type antimicrobial triterpenes and bacterial anionic phospholipids. | 2015 | Colloids Surf B Biointerfaces | pmid:25805152 |
| Adams CM et al. | Use of mRNA expression signatures to discover small molecule inhibitors of skeletal muscle atrophy. | 2015 | Curr Opin Clin Nutr Metab Care | pmid:25807353 |
| Xiang L et al. | A pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis. | 2015 | Oncotarget | pmid:25823660 |
| Wang J et al. | Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis. | 2014 | Sci Rep | pmid:25833312 |
| pmid:25835099 | ||||
| pmid:25841199 | ||||
| Colla AR et al. | Anxiolytic-like effects of ursolic acid in mice. | 2015 | Eur. J. Pharmacol. | pmid:25861934 |
| Qian Z et al. | A phase I trial to evaluate the multiple-dose safety and antitumor activity of ursolic acid liposomes in subjects with advanced solid tumors. | 2015 | Biomed Res Int | pmid:25866811 |
| pmid:25867469 | ||||
| pmid:25892149 | ||||
| pmid:25893368 | ||||
| pmid:25896270 | ||||
| pmid:25899842 | ||||
| pmid:25903305 | ||||
| pmid:25925972 | ||||
| pmid:25930119 | ||||
| pmid:25942003 | ||||
| pmid:25944715 | ||||
| Wojnicz D et al. | Pentacyclic triterpenes combined with ciprofloxacin help to eradicate the biofilm formed in vitro by Escherichia coli. | 2015 | Indian J. Med. Res. | pmid:25963496 |
| Lin RX et al. | Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells. | 2015 | Int J Clin Exp Pathol | pmid:25973027 |
| pmid:25976755 | ||||
| pmid:25978136 | ||||
| Broniatowski M et al. | Antagonistic effects of α-tocopherol and ursolic acid on model bacterial membranes. | 2015 | Biochim. Biophys. Acta | pmid:26003534 |
| pmid:26021818 | ||||
| pmid:26042707 | ||||
| Carranza-Torres IE et al. | Organotypic culture of breast tumor explants as a multicellular system for the screening of natural compounds with antineoplastic potential. | 2015 | Biomed Res Int | pmid:26075250 |
| pmid:26077799 | ||||
| Zerin T et al. | Ursolic Acid Reduces Mycobacterium tuberculosis-Induced Nitric Oxide Release in Human Alveolar A549 cells. | 2015 | Mol. Cells | pmid:26084752 |
| Yu SG et al. | Ursolic acid derivative ameliorates streptozotocin-induced diabestic bone deleterious effects in mice. | 2015 | Int J Clin Exp Pathol | pmid:26097549 |
| Cho J et al. | Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate. | 2015 | Cancer Prev Res (Phila) | pmid:26100520 |
| pmid:26102564 | ||||
| pmid:26134000 | ||||
| pmid:26147234 | ||||
| Tan X et al. | Transcriptome analysis of the biofilm formed by methicillin-susceptible Staphylococcus aureus. | 2015 | Sci Rep | pmid:26149474 |
| Aguiriano-Moser V et al. | Ursolic acid from Trailliaedoxa gracilis induces apoptosis in medullary thyroid carcinoma cells. | 2015 | Mol Med Rep | pmid:26151624 |
| Yang Y et al. | Enhancement of Radiation Effects by Ursolic Acid in BGC-823 Human Adenocarcinoma Gastric Cancer Cell Line. | 2015 | PLoS ONE | pmid:26177078 |
| pmid:26186826 | ||||
| pmid:26235805 | ||||
| Nelson AT et al. | Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties. | 2015 | Bioorg. Med. Chem. Lett. | pmid:26259803 |
| Park SN et al. | Oleanolic acid and ursolic acid inhibit peptidoglycan biosynthesis in Streptococcus mutans UA159. | 2015 | Braz. J. Microbiol. | pmid:26273281 |
| López-GarcÃa S et al. | Macrophage Activation by Ursolic and Oleanolic Acids during Mycobacterial Infection. | 2015 | Molecules | pmid:26287131 |
| pmid:26302857 | ||||
| pmid:26307724 | ||||
| Flores-Bocanegra L et al. | α-Glucosidase Inhibitors from Vauquelinia corymbosa. | 2015 | Molecules | pmid:26307962 |
| pmid:26323892 | ||||
| pmid:26331671 | ||||
| Ebert SM et al. | Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. | 2015 | J. Biol. Chem. | pmid:26338703 |
| He W et al. | A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver. | 2015 | Drug Des Devel Ther | pmid:26347199 |
| Wu J et al. | Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells. | 2015 | J. Exp. Clin. Cancer Res. | pmid:26362062 |
| Wu P et al. | Synthesis and Evaluation of Novel Triterpene Analogues of Ursolic Acid as Potential Antidiabetic Agent. | 2015 | PLoS ONE | pmid:26406581 |
| Kim SH et al. | Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells. | 2015 | Sci Rep | pmid:26412148 |
| pmid:26434296 | ||||
| pmid:26452641 | ||||
| pmid:26503559 | ||||
| Cho J et al. | Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. | 2015 | Oncotarget | pmid:26513295 |
| pmid:26524942 | ||||
| pmid:26545446 | ||||
| pmid:26567247 | ||||
| Zhang X et al. | p21 induction plays a dual role in anti-cancer activity of ursolic acid. | 2016 | Exp. Biol. Med. (Maywood) | pmid:26582056 |
| Woźniak Šet al. | Ursolic Acid--A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities. | 2015 | Molecules | pmid:26610440 |
| pmid:26619955 | ||||
| pmid:26634867 | ||||
| pmid:26657265 | ||||
| Yamamoto ES et al. | The Effect of Ursolic Acid on Leishmania (Leishmania) amazonensis Is Related to Programed Cell Death and Presents Therapeutic Potential in Experimental Cutaneous Leishmaniasis. | 2015 | PLoS ONE | pmid:26674781 |
| pmid:26686287 | ||||
| pmid:26711605 | ||||
| pmid:26719288 | ||||
| pmid:26750249 | ||||
| Luna-Vázquez FJ et al. | Role of Nitric Oxide and Hydrogen Sulfide in the Vasodilator Effect of Ursolic Acid and Uvaol from Black Cherry Prunus serotina Fruits. | 2016 | Molecules | pmid:26771591 |
| pmid:26775565 | ||||
| pmid:26777089 | ||||
| Blanchaert B et al. | Bioanalytical LC/MS study of potential bacterial transglycosylation inhibitors. | 2016 | J Pharm Biomed Anal | pmid:26782294 |
| Lin H et al. | Targeting Th17 Cells with Small Molecules and Small Interference RNA. | 2015 | Mediators Inflamm. | pmid:26792955 |
| pmid:26794949 | ||||
| pmid:26797293 | ||||
| pmid:26847129 | ||||
| pmid:26854375 | ||||
| pmid:26867795 | ||||
| pmid:26883344 | ||||
| pmid:26898441 | ||||
| Abdullah NH et al. | Hyaluronidase Inhibitory Activity of Pentacylic Triterpenoids from Prismatomeris tetrandra (Roxb.) K. Schum: Isolation, Synthesis and QSAR Study. | 2016 | Int J Mol Sci | pmid:26907251 |
| pmid:26909608 | ||||
| pmid:26941036 |