MeSH term | MeSH ID | Detail |
---|---|---|
Carcinogenesis | D063646 | 3 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Dermatitis, Contact | D003877 | 59 associated lipids |
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with ursolic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinogenesis | D063646 | 3 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Dermatitis, Contact | D003877 | 59 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid:16276968 | ||||
pmid:16306813 | ||||
pmid:16308205 | ||||
Satomi Y et al. | Glycyrrhetinic acid and related compounds induce G1 arrest and apoptosis in human hepatocellular carcinoma HepG2. | 2005 Nov-Dec | Anticancer Res. | pmid:16309197 |
Ding L et al. | Determination of glycyrrhetic acid in human plasma by LC-ESI-MS. | 2006 | J Pharm Biomed Anal | pmid:16337769 |
Garg AK et al. | Chemosensitization and radiosensitization of tumors by plant polyphenols. | Antioxid. Redox Signal. | pmid:16356126 | |
Lee HK et al. | Phytocomponents of triterpenoids, oleanolic acid and ursolic acid, regulated differently the processing of epidermal keratinocytes via PPAR-alpha pathway. | 2006 | Exp. Dermatol. | pmid:16364033 |
Jayaprakasam B et al. | Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). | 2006 | J. Agric. Food Chem. | pmid:16390206 |
Ahmad SF et al. | Amelioration of adjuvant-induced arthritis by ursolic acid through altered Th1/Th2 cytokine production. | 2006 | Pharmacol. Res. | pmid:16406805 |
Jang DS et al. | Beccaridiol, an unusual 28-nortriterpenoid from the leaves of Diplectria beccariana. | 2006 | Phytochemistry | pmid:16426647 |
Hu JF et al. | Bacterial biofilm inhibitors from Diospyros dendo. | 2006 | J. Nat. Prod. | pmid:16441080 |
Qi X et al. | [Study on chemical constituents from stem of Mallotus apelta]. | 2005 | Zhong Yao Cai | pmid:16447866 |
pmid:16450302 | ||||
Lee WS et al. | Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus TURCZ. | 2006 | Biol. Pharm. Bull. | pmid:16462051 |
Cipak L et al. | Dual activity of triterpenoids: apoptotic versus antidifferentiation effects. | 2006 | Arch. Toxicol. | pmid:16496127 |
Holy J et al. | Disruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarine. | 2006 | BMC Cell Biol. | pmid:16512916 |
Cheung HY et al. | Simultaneous determination of key bioactive components in Hedyotis diffusa by capillary electrophoresis. | 2006 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16516568 |
Tian Z et al. | Anti-hepatoma activity and mechanism of ursolic acid and its derivatives isolated from Aralia decaisneana. | 2006 | World J. Gastroenterol. | pmid:16521214 |
Saravanan R and Pugalendi V | Impact of ursolic acid on chronic ethanol-induced oxidative stress in the rat heart. | 2006 Jan-Feb | Pharmacol Rep | pmid:16531629 |
pmid:16534732 |