MeSH term | MeSH ID | Detail |
---|---|---|
Carcinogenesis | D063646 | 3 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Dermatitis, Contact | D003877 | 59 associated lipids |
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with ursolic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinogenesis | D063646 | 3 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Dermatitis, Contact | D003877 | 59 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Chiou JF et al. | A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging. | 2011 | Evid Based Complement Alternat Med | pmid:21785640 |
Yau Hsiung W and Abdul Kadir H | Leea indica Ethyl Acetate Fraction Induces Growth-Inhibitory Effect in Various Cancer Cell Lines and Apoptosis in Ca Ski Human Cervical Epidermoid Carcinoma Cells. | 2011 | Evid Based Complement Alternat Med | pmid:21423690 |
Berrington D and Lall N | Anticancer Activity of Certain Herbs and Spices on the Cervical Epithelial Carcinoma (HeLa) Cell Line. | 2012 | Evid Based Complement Alternat Med | pmid:22649474 |
Bei WJ et al. | Lipid-regulating effect of traditional chinese medicine: mechanisms of actions. | 2012 | Evid Based Complement Alternat Med | pmid:22611438 |
Debprasad C et al. | Inhibition of NO(2), PGE(2), TNF-α, and iNOS EXpression by Shorea robusta L.: An Ethnomedicine Used for Anti-Inflammatory and Analgesic Activity. | 2012 | Evid Based Complement Alternat Med | pmid:22649472 |
Chang CL et al. | Phytochemical characteristics, free radical scavenging activities, and neuroprotection of five medicinal plant extracts. | 2012 | Evid Based Complement Alternat Med | pmid:21845204 |
Ansarullah S et al. | Influence of Oreocnide integrifolia (Gaud.) Miq on IRS-1, Akt and Glut-4 in Fat-Fed C57BL/6J Type 2 Diabetes Mouse Model. | 2011 | Evid Based Complement Alternat Med | pmid:21785636 |
Chang CL and Lin CS | Phytochemical Composition, Antioxidant Activity, and Neuroprotective Effect of Terminalia chebula Retzius Extracts. | 2012 | Evid Based Complement Alternat Med | pmid:21754945 |
Kaur M and Goel RK | Anti-Convulsant Activity of Boerhaavia diffusa: Plausible Role of Calcium Channel Antagonism. | 2011 | Evid Based Complement Alternat Med | pmid:19948752 |
Zhang X et al. | p21 induction plays a dual role in anti-cancer activity of ursolic acid. | 2016 | Exp. Biol. Med. (Maywood) | pmid:26582056 |
Pinon A et al. | A novel form of melanoma apoptosis resistance: melanogenesis up-regulation in apoptotic B16-F0 cells delays ursolic acid-triggered cell death. | 2011 | Exp. Cell Res. | pmid:21565187 |
Hassan L et al. | Resistance to ursolic acid-induced apoptosis through involvement of melanogenesis and COX-2/PGE2 pathways in human M4Beu melanoma cancer cells. | 2016 | Exp. Cell Res. | pmid:27262506 |
Lee HK et al. | Phytocomponents of triterpenoids, oleanolic acid and ursolic acid, regulated differently the processing of epidermal keratinocytes via PPAR-alpha pathway. | 2006 | Exp. Dermatol. | pmid:16364033 |
Bayer M et al. | Photoprotection against UVAR: effective triterpenoids require a lipid raft stabilizing chemical structure. | 2011 | Exp. Dermatol. | pmid:21824200 |
Sonnet P and Mullié C | In vitro antimalarial activity of ICL670: a further proof of the correlation between inhibition of β-hematin formation and of peroxidative degradation of hemin. | 2011 | Exp. Parasitol. | pmid:21295029 |
da Silva Ferreira D et al. | In vivo activity of ursolic and oleanolic acids during the acute phase of Trypanosoma cruzi infection. | 2013 | Exp. Parasitol. | pmid:23648663 |
Mullié C et al. | Inhibitory effect of ursolic acid derivatives on hydrogen peroxide- and glutathione-mediated degradation of hemin: a possible additional mechanism of action for antimalarial activity. | 2010 | Exp. Parasitol. | pmid:20109452 |
Martin-Aragón S et al. | Pharmacological modification of endogenous antioxidant enzymes by ursolic acid on tetrachloride-induced liver damage in rats and primary cultures of rat hepatocytes. | 2001 | Exp. Toxicol. Pathol. | pmid:11484840 |
Wang XH et al. | Evaluation of toxicity and single-dose pharmacokinetics of intravenous ursolic acid liposomes in healthy adult volunteers and patients with advanced solid tumors. | 2013 | Expert Opin Drug Metab Toxicol | pmid:23134084 |
Aggarwal BB et al. | From chemoprevention to chemotherapy: common targets and common goals. | 2004 | Expert Opin Investig Drugs | pmid:15461561 |
Farina C et al. | Synthesis and anti-ulcer activity of new derivatives of glycyrrhetic, oleanolic and ursolic acids. | 1998 | Farmaco | pmid:9543723 |
Brendolise C et al. | An unusual plant triterpene synthase with predominant α-amyrin-producing activity identified by characterizing oxidosqualene cyclases from Malus × domestica. | 2011 | FEBS J. | pmid:21575133 |
Murakami S et al. | Ursolic acid, an antagonist for transforming growth factor (TGF)-beta1. | 2004 | FEBS Lett. | pmid:15147868 |
Najid A et al. | Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL60 leukemic cells. | 1992 | FEBS Lett. | pmid:1544497 |
You HJ et al. | Ursolic acid enhances nitric oxide and tumor necrosis factor-alpha production via nuclear factor-kappaB activation in the resting macrophages. | 2001 | FEBS Lett. | pmid:11741581 |
Akak CM et al. | New coumarin glycosides from the leaves of Diospyros crassiflora (Hiern). | 2010 | Fitoterapia | pmid:20580922 |
Yasukawa K et al. | Anti-tumor promoters phenolics and triterpenoid from Hippophae rhamnoides. | 2009 | Fitoterapia | pmid:19535023 |
Wang ZW et al. | α-Glucosidase inhibitory triterpenoids from the stem barks of Uncaria laevigata. | 2013 | Fitoterapia | pmid:23856092 |
Liu M et al. | Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma. | 2009 | Fitoterapia | pmid:19446614 |
Tuntiwachwuttikul P et al. | Constituents of the leaves of Holarrhena pubescens. | 2007 | Fitoterapia | pmid:17329039 |
Cunha WR et al. | Hypoglicemic effect of Leandra lacunosa in normal and alloxan-induced diabetic rats. | 2008 | Fitoterapia | pmid:18538949 |
da Silva Filho AA et al. | In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae). | 2009 | Fitoterapia | pmid:19540316 |
Wu Q et al. | Antiviral flavonoids from Mosla scabra. | 2010 | Fitoterapia | pmid:20006976 |
Li J et al. | A new dilactone from the seeds of Gaultheria yunnanensis. | 2010 | Fitoterapia | pmid:19628028 |
Li LQ et al. | Lignans from the heartwood of Streblus asper and their inhibiting activities to hepatitis B virus. | 2012 | Fitoterapia | pmid:22119765 |
Kazmi I et al. | Anti-diabetic potential of ursolic acid stearoyl glucoside: a new triterpenic gycosidic ester from Lantana camara. | 2012 | Fitoterapia | pmid:22051701 |
Fu SB et al. | Multihydroxylation of ursolic acid by Pestalotiopsis microspora isolated from the medicinal plant Huperzia serrata. | 2011 | Fitoterapia | pmid:21767617 |
Fu SB et al. | Biotransformation of ursolic acid by Syncephalastrum racemosum CGMCC 3.2500 and anti-HCV activity. | 2013 | Fitoterapia | pmid:23425601 |
Goun E et al. | Antithrombin activity of some constituents from Origanum vulgare. | 2002 | Fitoterapia | pmid:12490231 |
Xiang W et al. | Constituents of Gnetum montanum. | 2002 | Fitoterapia | pmid:11864762 |
Wójciak-Kosior M et al. | The effect of ursolic and oleanolic acids on human skin fibroblast cells. | 2011 | Folia Histochem. Cytobiol. | pmid:22252762 |
Dorota W et al. | Effect of asiatic and ursolic acids on morphology, hydrophobicity, and adhesion of UPECs to uroepithelial cells. | 2013 | Folia Microbiol. (Praha) | pmid:23132656 |
Caligiani A et al. | A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients. | 2013 | Food Chem | pmid:23122121 |
Shyu MH et al. | Hsian-tsao (Mesona procumbens Heml.) prevents against rat liver fibrosis induced by CCl(4) via inhibition of hepatic stellate cells activation. | 2008 | Food Chem. Toxicol. | pmid:18929613 |
Lee JH et al. | Gardenia jasminoides Ellis ethanol extract and its constituents reduce the risks of gastritis and reverse gastric lesions in rats. | 2009 | Food Chem. Toxicol. | pmid:19425231 |
Shin IS et al. | Ursolic acid reduces prostate size and dihydrotestosterone level in a rat model of benign prostatic hyperplasia. | 2012 | Food Chem. Toxicol. | pmid:22266360 |