| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinogenesis | D063646 | 3 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shishodia S et al. | Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. | 2003 | Cancer Res. | pmid:12907607 |
| Gu BP et al. | [Comparative study of the spectral characteristics of ursolic acid between laser Raman spectra and IR spectrum]. | 2002 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:12914177 |
| Andersson D et al. | Ursolic acid inhibits proliferation and stimulates apoptosis in HT29 cells following activation of alkaline sphingomyelinase. | 2003 Jul-Aug | Anticancer Res. | pmid:12926069 |
| Elliott S et al. | The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes. | 2003 | Arthritis Res. Ther. | pmid:12932292 |
| Baglin I et al. | New ursolic and betulinic derivatives as potential cytotoxic agents. | 2003 | J Enzyme Inhib Med Chem | pmid:12943194 |
| Ryu JH et al. | The role of hydrogen peroxide produced by polychlorinated biphenyls in PMR1-deficient yeast cells. | 2003 | J. Biochem. | pmid:12944380 |
| pmid:12963155 | ||||
| Soo Lee Y et al. | Inhibition of ultraviolet-A-modulated signaling pathways by asiatic acid and ursolic acid in HaCaT human keratinocytes. | 2003 | Eur. J. Pharmacol. | pmid:12969763 |
| JANOT MM et al. | [Study of a deposit of crystals from a fluid extract of Salvia officinalis]. | 1952 | Ann Pharm Fr | pmid:12986502 |
| POURRAT H and LE MEN J | [Ursolic acid: distribution of ursolic acid in labiate plants]. | 1953 | Ann Pharm Fr | pmid:13058228 |
| BRIESKORN CH and EBERHARDT KH | [Oxytriterpenic acids of sage oil. 9. Constituents of Salvia officinalis L..]. | 1953 | Arch Pharm Ber Dtsch Pharm Ges | pmid:13081104 |
| LE MEN J and POURRAT H | [Distribution of ursolic acid in the Apocynaceae]. | 1953 | Ann Pharm Fr | pmid:13092702 |
| WU BY and PARKS LM | Oleanolic acid from cranberries. | 1953 | J Am Pharm Assoc Am Pharm Assoc (Baltim) | pmid:13096399 |
| WU BY and PARKS LM | Chemical studies on ursolic acid. | 1953 | J Am Pharm Assoc Am Pharm Assoc (Baltim) | pmid:13096400 |
| POURRAT H et al. | [Ursolic acid; distribution of ursolic acid in Oleaceae]. | 1954 | Ann Pharm Fr | pmid:13171723 |
| BRIESKORN CH and KESKIN M | [Triterpenes in the bark, peel and leaf of Punica granatum L. 5. Knowledge of biochemistry of triterpenes]. | 1954 | Pharm Acta Helv | pmid:13236480 |
| SCHINDLER H and HERB M | [Chemistry of Ilex aquifolium L. I. Isolation of ursolic acid and rutin from leaves]. | 1955 | Arch Pharm Ber Dtsch Pharm Ges | pmid:13303362 |
| Raphael TJ and Kuttan G | Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system. | 2003 | Phytomedicine | pmid:13678231 |
| LE MEN J and POURRAT H | [Distribution of ursolic acid in the leaves of various Rosaceae; ursolic acid. V..]. | 1955 | Ann Pharm Fr | pmid:14388439 |
| Tapondjou LA et al. | Saponins from Cussonia bancoensis and their inhibitory effects on nitric oxide production. | 2003 | J. Nat. Prod. | pmid:14510614 |