MeSH term | MeSH ID | Detail |
---|---|---|
Carcinogenesis | D063646 | 3 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Dermatitis, Contact | D003877 | 59 associated lipids |
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with ursolic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinogenesis | D063646 | 3 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Dermatitis, Contact | D003877 | 59 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Pavithra PS et al. | Antibacterial and antioxidant activity of methanol extract of Evolvulus nummularius. | 2009 | Indian J Pharmacol | pmid:20177496 |
Yasukawa K et al. | Anti-tumor promoters phenolics and triterpenoid from Hippophae rhamnoides. | 2009 | Fitoterapia | pmid:19535023 |
Allouche Y et al. | Triterpenic content and chemometric analysis of virgin olive oils from forty olive cultivars. | 2009 | J. Agric. Food Chem. | pmid:19326867 |
Liu M et al. | Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma. | 2009 | Fitoterapia | pmid:19446614 |
Tang C et al. | Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis. | 2009 | Anticancer Drugs | pmid:19174695 |
da Silva Filho AA et al. | In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae). | 2009 | Fitoterapia | pmid:19540316 |
Zhou XJ et al. | Preparation and body distribution of freeze-dried powder of ursolic acid phospholipid nanoparticles. | 2009 | Drug Dev Ind Pharm | pmid:18798089 |
Chen IH et al. | Cytotoxic triterpenoids from the stems of Microtropis japonica. | 2009 | J. Nat. Prod. | pmid:19534471 |
Wu PK et al. | Oleanolic acid isolated from Oldenlandia diffusa exhibits a unique growth inhibitory effect against ras-transformed fibroblasts. | 2009 | Life Sci. | pmid:19433096 |
Gautam R and Jachak SM | Recent developments in anti-inflammatory natural products. | 2009 | Med Res Rev | pmid:19378317 |
Li J et al. | Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. | 2009 | J. Nat. Prod. | pmid:19555121 |
Awang K et al. | Methyl 3-dehydr-oxy-3-oxoursolate. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21577528 |
Xavier CP et al. | Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells. | 2009 | Cancer Lett. | pmid:19344998 |
Ali S et al. | Mutiniside, new antioxidant phenolic glucoside from Abutilon muticum. | 2009 | J Asian Nat Prod Res | pmid:19504389 |
Dinda B et al. | Iridoid glucosides from leaves and stem barks of Parkia javanica. | 2009 | J Asian Nat Prod Res | pmid:19408146 |
Chen RJ et al. | Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+ -ATPase. | 2010 | Acta Pharmacol. Sin. | pmid:20523340 |
Hsu CL et al. | Antioxidant and anti-inflammatory effects of Orthosiphon aristatus and its bioactive compounds. | 2010 | J. Agric. Food Chem. | pmid:20095565 |
Wang P et al. | Synthesis and cytotoxic activity of the N-acetylglucosamine-bearing triterpenoid saponins. | 2010 | Carbohydr. Res. | pmid:20116049 |
Genet C et al. | Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. | 2010 | J. Med. Chem. | pmid:19911773 |
Zhou Y et al. | Ursolic acid inhibits early lesions of diabetic nephropathy. | 2010 | Int. J. Mol. Med. | pmid:20818497 |
Fang X et al. | Optimization of microwave-assisted extraction followed by RP-HPLC for the simultaneous determination of oleanolic acid and ursolic acid in the fruits of Chaenomeles sinensis. | 2010 | J Sep Sci | pmid:20183824 |
Yu YX et al. | Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway. | 2010 | Chin. Med. J. | pmid:20819578 |
Lee AW et al. | Ursolic acid induces allograft inflammatory factor-1 expression via a nitric oxide-related mechanism and increases neovascularization. | 2010 | J. Agric. Food Chem. | pmid:21070071 |
Ibarra A et al. | Effects of chronic administration of Melissa officinalis L. extract on anxiety-like reactivity and on circadian and exploratory activities in mice. | 2010 | Phytomedicine | pmid:20171069 |
Zhang HP and Tao L | [Studies on the chemical constituents of Buddleja albiflora (II)]. | 2010 | Zhong Yao Cai | pmid:21049618 |
De Angel RE et al. | Antitumor effects of ursolic acid in a mouse model of postmenopausal breast cancer. | 2010 | Nutr Cancer | pmid:21058195 |
Akak CM et al. | New coumarin glycosides from the leaves of Diospyros crassiflora (Hiern). | 2010 | Fitoterapia | pmid:20580922 |
Nabekura T | Overcoming multidrug resistance in human cancer cells by natural compounds. | 2010 | Toxins (Basel) | pmid:22069634 |
Purnima A et al. | Antiinflammatory, Analgesic and Antipyretic Activities of Mimusops elengi Linn. | 2010 | Indian J Pharm Sci | pmid:21218059 |
Ashok P et al. | Antiurolithiatic and antioxidant activity of Mimusops elengi on ethylene glycol-induced urolithiasis in rats. | 2010 | Indian J Pharmacol | pmid:21189910 |
Wu CR et al. | Triterpenoid contents and anti-inflammatory properties of the methanol extracts of ligustrum species leaves. | 2010 | Molecules | pmid:21187813 |
Nsonde Ntandou GF et al. | Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts. | 2010 | J Ethnopharmacol | pmid:19799981 |
Prajapati MS et al. | Leucas aspera: A review. | 2010 | Pharmacogn Rev | pmid:22228946 |
Lee J et al. | Ursolic acid ameliorates thymic atrophy and hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice. | 2010 | Chem. Biol. Interact. | pmid:20869956 |
Lu J et al. | Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-κB pathway activation. | 2010 | Cereb. Cortex | pmid:20133359 |
Yu LB et al. | [Inhibitive effect of ursolic acid on the invasion and metastasis of ovarian carcinoma cells HO-8910PM]. | 2010 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:21265099 |
Kwon SH et al. | Apoptotic action of ursolic acid isolated from Corni fructus in RC-58T/h/SA#4 primary human prostate cancer cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20943386 |
Singh SK et al. | Molluscicides from some common medicinal plants of eastern Uttar Pradesh, India. | 2010 | J Appl Toxicol | pmid:19943357 |
Lan K et al. | Simple quality assessment approach for herbal extracts using high performance liquid chromatography-UV based metabolomics platform. | 2010 | J Chromatogr A | pmid:20045112 |
Song FL et al. | Total phenolic contents and antioxidant capacities of selected chinese medicinal plants. | 2010 | Int J Mol Sci | pmid:20640157 |
Lee JY et al. | Effects of hydroxy pentacyclic triterpene acids from Forsythia viridissima on asthmatic responses to ovalbumin challenge in conscious guinea pigs. | 2010 | Biol. Pharm. Bull. | pmid:20118545 |
Uprety Y et al. | Indigenous use and bio-efficacy of medicinal plants in the Rasuwa District, Central Nepal. | 2010 | J Ethnobiol Ethnomed | pmid:20102631 |
Kazakova OB et al. | Betulin and ursolic acid synthetic derivatives as inhibitors of Papilloma virus. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20558062 |
Kunwar RM et al. | Traditional herbal medicine in far-west Nepal: a pharmacological appraisal. | 2010 | J Ethnobiol Ethnomed | pmid:21144003 |
Lee MS and Thuong PT | Stimulation of glucose uptake by triterpenoids from Weigela subsessilis. | 2010 | Phytother Res | pmid:19548274 |
Yeh CT et al. | Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling. | 2010 | Mol Nutr Food Res | pmid:20352621 |
Li Y et al. | Enhancement of chemotherapeutic agent-induced apoptosis by inhibition of NF-kappaB using ursolic acid. | 2010 | Int. J. Cancer | pmid:19908232 |
Jang SM et al. | Inhibitory effects of ursolic acid on hepatic polyol pathway and glucose production in streptozotocin-induced diabetic mice. | 2010 | Metab. Clin. Exp. | pmid:19846180 |
Wu Q et al. | Antiviral flavonoids from Mosla scabra. | 2010 | Fitoterapia | pmid:20006976 |
Li J et al. | A new dilactone from the seeds of Gaultheria yunnanensis. | 2010 | Fitoterapia | pmid:19628028 |
Bibi N et al. | In vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicum. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20542692 |
Kanjoormana M and Kuttan G | Antiangiogenic activity of ursolic acid. | 2010 | Integr Cancer Ther | pmid:20462855 |
Jung TY et al. | Ursolic acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFN-gamma by CD4+ naïve T cells. | 2010 | Eur. J. Pharmacol. | pmid:20599915 |
Ibarra A et al. | Importance of extract standardization and in vitro/ex vivo assay selection for the evaluation of antioxidant activity of botanicals: a case study on three Rosmarinus officinalis L. extracts. | 2010 | J Med Food | pmid:20626255 |
Yang L et al. | Ursolic acid induces doxorubicin-resistant HepG2 cell death via the release of apoptosis-inducing factor. | 2010 | Cancer Lett. | pmid:20630652 |
Yadav VR et al. | Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. | 2010 | Toxins (Basel) | pmid:22069560 |
Meng Y et al. | Synthesis and in vitro cytotoxicity of novel ursolic acid derivatives. | 2010 | Molecules | pmid:20657424 |
Bankeu JJ et al. | Ceramide and Cerebroside from the stem bark of Ficus mucuso (Moraceae). | 2010 | Chem. Pharm. Bull. | pmid:21139276 |
Li Y et al. | Ursolic acid stimulates lipolysis in primary-cultured rat adipocytes. | 2010 | Mol Nutr Food Res | pmid:20521271 |
Mandukhail SU et al. | Studies on antidyslipidemic effects of Morinda citrifolia (Noni) fruit, leaves and root extracts. | 2010 | Lipids Health Dis | pmid:20727145 |
Xia N et al. | Prunella vulgaris L. Upregulates eNOS expression in human endothelial cells. | 2010 | Am. J. Chin. Med. | pmid:20503475 |
Zhang Y et al. | Ursolic acid induces PC-3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro. | 2010 | Mol. Carcinog. | pmid:20146252 |
Wu B et al. | [Apoptosis of jurkat cells induced by ursolic acid and its mechanism]. | 2010 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:20137120 |
Ferreira Dda S et al. | Trypanocidal activity and acute toxicity assessment of triterpene acids. | 2010 | Parasitol. Res. | pmid:20140451 |
Stanojković TP et al. | Cytotoxic and cell cycle effects induced by two herbal extracts on human cervix carcinoma and human breast cancer cell lines. | 2010 | J Med Food | pmid:20170382 |
Rollinger JM et al. | 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches. | 2010 | Bioorg. Med. Chem. | pmid:20100662 |
Zhang YX et al. | Ursolic acid overcomes Bcl-2-mediated resistance to apoptosis in prostate cancer cells involving activation of JNK-induced Bcl-2 phosphorylation and degradation. | 2010 | J. Cell. Biochem. | pmid:20052671 |
Liu Y et al. | Evaluation of inhibition of fatty acid synthase by ursolic acid: positive cooperation mechanism. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20074555 |
Suanarunsawat T et al. | Antioxidant Activity and Lipid-Lowering Effect of Essential Oils Extracted from Ocimum sanctum L. Leaves in Rats Fed with a High Cholesterol Diet. | 2010 | J Clin Biochem Nutr | pmid:20104265 |
Mullié C et al. | Inhibitory effect of ursolic acid derivatives on hydrogen peroxide- and glutathione-mediated degradation of hemin: a possible additional mechanism of action for antimalarial activity. | 2010 | Exp. Parasitol. | pmid:20109452 |
Ramos AA et al. | Protective effects of ursolic acid and luteolin against oxidative DNA damage include enhancement of DNA repair in Caco-2 cells. | 2010 | Mutat. Res. | pmid:20659486 |
Ghosh P et al. | Triterpenoids from Psidium guajava with Biocidal Activity. | 2010 | Indian J Pharm Sci | pmid:21218065 |
Annegowda HV et al. | Influence of sonication on the phenolic content and antioxidant activity of Terminalia catappa L. leaves. | 2010 | Pharmacognosy Res | pmid:21713141 |
Bertoni BW et al. | Genetic diversity in natural populations of Jacaranda decurrens Cham. determined using RAPD and AFLP markers. | 2010 | Genet. Mol. Biol. | pmid:21637428 |
Wang ZH et al. | Anti-glycative effects of oleanolic acid and ursolic acid in kidney of diabetic mice. | 2010 | Eur. J. Pharmacol. | pmid:19917277 |
Kurek A et al. | Oleanolic acid and ursolic acid affect peptidoglycan metabolism in Listeria monocytogenes. | 2010 | Antonie Van Leeuwenhoek | pmid:19894138 |
Yan SL et al. | Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines. | 2010 | Toxicol In Vitro | pmid:20005942 |
Gui C et al. | Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. | 2010 | Curr Chem Genomics | pmid:20448812 |
Yang EJ et al. | Acanthopanax koreanum fruit waste inhibits lipopolysaccharide-induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages. | 2010 | J. Biomed. Biotechnol. | pmid:20368786 |
Zhou C et al. | Variation of oleanolic and ursolic acid in the flesh of persimmon fruit among different cultivars. | 2010 | Molecules | pmid:20877245 |
Azevedo MF et al. | Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3. | 2010 | Phytother Res | pmid:20127879 |
Kaur G et al. | Exploring the potential effect of Ocimum sanctum in vincristine-induced neuropathic pain in rats. | 2010 | J Brachial Plex Peripher Nerve Inj | pmid:20181005 |
Shyu MH et al. | Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP. | 2010 | J. Agric. Food Chem. | pmid:20415421 |
Dai Z et al. | Pomegranate extract inhibits the proliferation and viability of MMTV-Wnt-1 mouse mammary cancer stem cells in vitro. | 2010 | Oncol. Rep. | pmid:20811693 |
Yu Z et al. | Gas phase isomeric differentiation of oleanolic and ursolic acids associated with heptakis-(2,6-di-O-methyl)-beta-cyclodextrin by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. | 2010 | J Mass Spectrom | pmid:20306522 |
Nabekura T et al. | Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals. | 2010 | Pharmacol. Res. | pmid:19944162 |
Takada K et al. | Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-α-induced E-selectin expression by cultured umbilical vein endothelial cells. | 2010 | Phytomedicine | pmid:20579861 |
Cunha WR et al. | Evaluation of the antibacterial activity of the methylene chloride extract of Miconia ligustroides, isolated triterpene acids, and ursolic acid derivatives. | 2010 | Pharm Biol | pmid:20645834 |
Musabayane CT et al. | Synergistic antihyperglycemic effects between plant-derived oleanolic acid and insulin in streptozotocin-induced diabetic rats. | 2010 | Ren Fail | pmid:20662697 |
Kuigoua GM et al. | Minor secondary metabolic products from the stem bark of Plumeria rubra Linn. displaying antimicrobial activities. | 2010 | Planta Med. | pmid:19937550 |
Ganbold M et al. | Cytotoxicity and bioavailability studies on a decoction of Oldenlandia diffusa and its fractions separated by HPLC. | 2010 | J Ethnopharmacol | pmid:20633624 |
Singh M et al. | Anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. leaves. | 2010 | Pharmacognosy Res | pmid:21713140 |
Shen D et al. | LC-MS method for the simultaneous quantitation of the anti-inflammatory constituents in oregano (Origanum species). | 2010 | J. Agric. Food Chem. | pmid:20496910 |
Ko CH et al. | Osteoprotective effects of Fructus Ligustri Lucidi aqueous extract in aged ovariectomized rats. | 2010 | Chin Med | pmid:21114821 |
Feng L et al. | Combination of active components enhances the efficacy of Prunella in prevention and treatment of lung cancer. | 2010 | Molecules | pmid:21060297 |
Tang XH et al. | Preservation on calcium homeostasis is involved in mitochondrial protection of Limonium sinense against liver damage in mice. | 2010 | Pharmacogn Mag | pmid:20931078 |
Tian S et al. | Determination of oleanolic acid and ursolic acid contents in Ziziphora clinopodioides Lam. by HPLC method. | 2010 | Pharmacogn Mag | pmid:20668577 |
Liobikas J et al. | Uncoupling and antioxidant effects of ursolic acid in isolated rat heart mitochondria. | 2011 | J. Nat. Prod. | pmid:21648406 |
Chiou JF et al. | A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging. | 2011 | Evid Based Complement Alternat Med | pmid:21785640 |
Zhou C et al. | Herbaceous peony (Paeonia lactiflora Pall.) as an alternative source of oleanolic and ursolic acids. | 2011 | Int J Mol Sci | pmid:21340006 |