| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinogenesis | D063646 | 3 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ahmad SF et al. | Amelioration of adjuvant-induced arthritis by ursolic acid through altered Th1/Th2 cytokine production. | 2006 | Pharmacol. Res. | pmid:16406805 |
| Jayaprakasam B et al. | Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). | 2006 | J. Agric. Food Chem. | pmid:16390206 |
| Yim EK et al. | Proteomic analysis of ursolic acid-induced apoptosis in cervical carcinoma cells. | 2006 | Cancer Lett. | pmid:15925442 |
| Lee HK et al. | Phytocomponents of triterpenoids, oleanolic acid and ursolic acid, regulated differently the processing of epidermal keratinocytes via PPAR-alpha pathway. | 2006 | Exp. Dermatol. | pmid:16364033 |
| Qi S et al. | Novel and simple nonaqueous capillary electrophoresis separation and determination bioactive triterpenes in Chinese herbs. | 2006 | J Pharm Biomed Anal | pmid:16011887 |
| Zhang GP et al. | [Effect of ursolic acid on caspase-3 and PARP expression of human MCF-7 cells]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16570804 |
| Hu JF et al. | Bacterial biofilm inhibitors from Diospyros dendo. | 2006 | J. Nat. Prod. | pmid:16441080 |
| Cui T et al. | Quantification of the polyphenols and triterpene acids in chinese hawthorn fruit by high-performance liquid chromatography. | 2006 | J. Agric. Food Chem. | pmid:16787000 |
| Song LL et al. | [Determination of ursolic acid of Liuwei Dihuangwan simulation samples by NIR]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17165581 |
| Slamenová D et al. | Reduction of DNA-damaging effects of anti-HIV drug 3'-azido-3'-dideoxythymidine on human cells by ursolic acid and lignin biopolymer. | 2006 | Neoplasma | pmid:17167716 |
| Jang DS et al. | Beccaridiol, an unusual 28-nortriterpenoid from the leaves of Diplectria beccariana. | 2006 | Phytochemistry | pmid:16426647 |
| Tian Z et al. | Anti-hepatoma activity and mechanism of ursolic acid and its derivatives isolated from Aralia decaisneana. | 2006 | World J. Gastroenterol. | pmid:16521214 |
| Ikeda Y et al. | Ursolic acid enhances cyclooxygenases and tumor necrosis factor-alpha expression in mouse skin. | 2006 | Biosci. Biotechnol. Biochem. | pmid:16636478 |
| Aguirre-Crespo F et al. | Ursolic acid mediates the vasorelaxant activity of Lepechinia caulescens via NO release in isolated rat thoracic aorta. | 2006 | Life Sci. | pmid:16630635 |
| Zhang YY et al. | [Mechanisms of inhibiting proliferation and inducing apoptosis of human gastric cancer cell line SGC7901 by ursolic acid]. | 2006 | Ai Zheng | pmid:16613675 |
| Zhang W et al. | Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake. | 2006 | Biochim. Biophys. Acta | pmid:16828971 |
| Ma X et al. | [Determination of ursolic acid in Ledum palustre L. by RP-HPLC]. | 2006 | Se Pu | pmid:16830480 |
| Tan J et al. | [Ursolic acid induces apoptosis in colon cancer HT-29 cells]. | 2006 | Zhonghua Zhong Liu Za Zhi | pmid:16750011 |
| Wang MY et al. | [Studies on the chemical constituents from stem of Chirita longgangensis var. Hongyao]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16706021 |
| Saravanan R et al. | Protective effect of ursolic acid on ethanol-mediated experimental liver damage in rats. | 2006 | Life Sci. | pmid:16137716 |
| Ahmed Z et al. | Structure determination of ursene-type triterpenes by NMR techniques. | 2006 | Magn Reson Chem | pmid:16607673 |
| Lee WS et al. | Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus TURCZ. | 2006 | Biol. Pharm. Bull. | pmid:16462051 |
| Holy J et al. | Disruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarine. | 2006 | BMC Cell Biol. | pmid:16512916 |
| He X and Liu RH | Cranberry phytochemicals: Isolation, structure elucidation, and their antiproliferative and antioxidant activities. | 2006 | J. Agric. Food Chem. | pmid:16968064 |
| Guarrera PM et al. | Food, flavouring and feed plant traditions in the Tyrrhenian sector of Basilicata, Italy. | 2006 | J Ethnobiol Ethnomed | pmid:16959031 |
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| Leite JP et al. | Trypanocidal activity of triterpenes from Arrabidaea triplinervia and derivatives. | 2006 | Biol. Pharm. Bull. | pmid:17077535 |
| Ding L et al. | Determination of glycyrrhetic acid in human plasma by LC-ESI-MS. | 2006 | J Pharm Biomed Anal | pmid:16337769 |
| Thuong PT et al. | Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis. | 2006 | Biol. Pharm. Bull. | pmid:16595930 |
| Sagar SM et al. | Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 2. | 2006 | Curr Oncol | pmid:17576449 |
| Aparecida Resende F et al. | Antimutagenicity of ursolic acid and oleanolic acid against doxorubicin-induced clastogenesis in Balb/c mice. | 2006 | Life Sci. | pmid:16647723 |
| Schleich S et al. | Extracts from Pygeum africanum and other ethnobotanical species with antiandrogenic activity. | 2006 | Planta Med. | pmid:16783690 |
| Lans C et al. | Ethnoveterinary medicines used for horses in Trinidad and in British Columbia, Canada. | 2006 | J Ethnobiol Ethnomed | pmid:16893454 |
| Ovesná Z et al. | Protective effects of ursolic acid and oleanolic acid in leukemic cells. | 2006 | Mutat. Res. | pmid:16831451 |
| Satomi Y et al. | Glycyrrhetinic acid and related compounds induce G1 arrest and apoptosis in human hepatocellular carcinoma HepG2. | 2005 Nov-Dec | Anticancer Res. | pmid:16309197 |
| Klimek B and Modnicki D | Terpenoids and sterols from Nepeta cataria L. var. citriodora (Lamiaceae). | 2005 May-Jun | Acta Pol Pharm | pmid:16193817 |
| Miyazawa M et al. | Suppression of the SOS-inducing activity of mutagenic heterocyclic amine, Trp-P-1, by triterpenoid from Uncaria sinensis in the Salmonella typhimurium TA1535/pSK1002 Umu test. | 2005 | J. Agric. Food Chem. | pmid:15769173 |
| Achiwa Y et al. | Ursolic acid induces Bax-dependent apoptosis through the caspase-3 pathway in endometrial cancer SNG-II cells. | 2005 | Oncol. Rep. | pmid:15583801 |
| Wang P et al. | Synthesis of two bidesmosidic ursolic acid saponins bearing a 2,3-branched trisaccharide residue. | 2005 | Carbohydr. Res. | pmid:16043158 |
| Usia T et al. | Cytochrome P450 2D6 (CYP2D6) inhibitory constituents of Catharanthus roseus. | 2005 | Biol. Pharm. Bull. | pmid:15930738 |
| Zhang W et al. | [Experimental study on MCF-7 cell apoptosis induced by ursolic acid]. | 2005 | Zhong Yao Cai | pmid:16104504 |
| Chávez IO et al. | Cytotoxic activity and effect on nitric oxide production of tirucallane-type triterpenes. | 2005 | J. Pharm. Pharmacol. | pmid:16105229 |
| Jeong HG et al. | Involvement of cytokines in the hepatic expression of metallothionein by ursolic acid. | 2005 | Toxicol. Lett. | pmid:15649620 |
| Ma CM et al. | The cytotoxic activity of ursolic acid derivatives. | 2005 | Eur J Med Chem | pmid:15922841 |
| Chattopadhyay D et al. | A potent sperm motility-inhibiting activity of bioflavonoids from an ethnomedicine of Onge, Alstonia macrophylla Wall ex A. DC, leaf extract. | 2005 | Contraception | pmid:15854639 |
| Khanum SA et al. | Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15993585 |
| Ren D et al. | Differential gene expression for investigation of Escherichia coli biofilm inhibition by plant extract ursolic acid. | 2005 | Appl. Environ. Microbiol. | pmid:16000817 |
| Liao Q et al. | LC-MS determination and pharmacokinetic studies of ursolic acid in rat plasma after administration of the traditional chinese medicinal preparation Lu-Ying extract. | 2005 | Yakugaku Zasshi | pmid:15930819 |
| Yuan G and Yi Y | [Studies on chemical constituents of the roots of Salacia hainanensis]. | 2005 | Zhong Yao Cai | pmid:15934239 |
| Achiwa Y et al. | Molecular mechanism of ursolic acid induced apoptosis in poorly differentiated endometrial cancer HEC108 cells. | 2005 | Oncol. Rep. | pmid:16012738 |
| Qi X et al. | [Study on chemical constituents from stem of Mallotus apelta]. | 2005 | Zhong Yao Cai | pmid:16447866 |
| Chiang LC et al. | Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. | 2005 | Clin. Exp. Pharmacol. Physiol. | pmid:16173941 |
| Jo Y et al. | Jacaranone and related compounds from the fresh fruits of Ternstroemia japonica and their antioxidative activity. | 2005 | Arch. Pharm. Res. | pmid:16178411 |
| Tang X et al. | Inhibition by [corrected] ursolic acid of [corrected] calcium-induced mitochondrial permeability transition and release of two proapoptotic proteins. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16188235 |
| Ikeda Y et al. | Ursolic acid promotes the release of macrophage migration inhibitory factor via ERK2 activation in resting mouse macrophages. | 2005 | Biochem. Pharmacol. | pmid:16188240 |
| Wang B et al. | [Studies on the chemical constituents from herb of Rhodobryum roseum]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16124603 |
| Liu Z et al. | [Study on the extracting of ursolic acid by uniform design]. | 2005 | Zhong Yao Cai | pmid:16131040 |
| Urech K et al. | Apoptosis inducing activity of viscin, a lipophilic extract from Viscum album L. | 2005 | J. Pharm. Pharmacol. | pmid:15638998 |
| Feria-Romero I et al. | Induced accumulation of oleanolic acid and ursolic acid in cell suspension cultures of Uncaria tomentosa. | 2005 | Biotechnol. Lett. | pmid:16086245 |
| Zhang G et al. | Determination of oleanolic acid and ursolic acid in cornel by cyclodextrin-modified micellar electrokinetic chromatography. | 2005 | Biomed. Chromatogr. | pmid:15654724 |
| Fu L et al. | Three new triterpenes from Nerium oleander and biological activity of the isolated compounds. | 2005 | J. Nat. Prod. | pmid:15730243 |
| Liu J | Oleanolic acid and ursolic acid: research perspectives. | 2005 | J Ethnopharmacol | pmid:15994040 |
| Gören AC et al. | DNA damaging activities of methanol extract of Ajuga postii and iridoid glucoside reptoside. | 2005 | Nat. Prod. Res. | pmid:15938192 |
| Harmand PO et al. | Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and caspase-3 activation in M4Beu melanoma cells. | 2005 | Int. J. Cancer | pmid:15523687 |
| Zhang P et al. | Antibacterial constituents from fruit bodies of ascomyce Bulgaria inquinans. | 2005 | Arch. Pharm. Res. | pmid:16178412 |
| Jiménez A et al. | Secondary metabolites from Chamaedora tepejilote (Palmae) are active against Mycobacterium tuberculosis. | 2005 | Phytother Res | pmid:16041726 |
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| Basappa M et al. | Novel delta2-isoxazolines as group II phospholipase A2 inhibitors. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15203142 |
| Shih YH et al. | Ursolic acid protects hippocampal neurons against kainate-induced excitotoxicity in rats. | 2004 | Neurosci. Lett. | pmid:15193771 |
| Cárdenas C et al. | Effects of ursolic acid on different steps of the angiogenic process. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15219842 |
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| Kim KA et al. | Inhibition of cytochrome P450 activities by oleanolic acid and ursolic acid in human liver microsomes. | 2004 | Life Sci. | pmid:15043991 |
| Shin KM et al. | In vitro anti-inflammatory activity of 23-hydroxyursolic acid isolated from Cussonia bancoensis in murine macrophage RAW 264.7 cells. | 2004 | Planta Med. | pmid:15386188 |
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| Park JH et al. | Antiinflammatory activity of Synurus deltoides. | 2004 | Phytother Res | pmid:15597310 |
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