| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinogenesis | D063646 | 3 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jang SM et al. | Inhibitory effects of ursolic acid on hepatic polyol pathway and glucose production in streptozotocin-induced diabetic mice. | 2010 | Metab. Clin. Exp. | pmid:19846180 |
| Li R et al. | The influence of cosolvent on the complexation of HP-beta-cyclodextrins with oleanolic acid and ursolic acid. | 2009 | AAPS PharmSciTech | pmid:19834815 |
| Zheng RX et al. | Chemical constituents from the fruits of Hippophae rhamnoides. | 2009 | Nat. Prod. Res. | pmid:19809919 |
| Puangpraphant S and de Mejia EG | Saponins in yerba mate tea ( Ilex paraguariensis A. St.-Hil) and quercetin synergistically inhibit iNOS and COX-2 in lipopolysaccharide-induced macrophages through NFkappaB pathways. | 2009 | J. Agric. Food Chem. | pmid:19807157 |
| Nsonde Ntandou GF et al. | Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts. | 2010 | J Ethnopharmacol | pmid:19799981 |
| Tu HY et al. | Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species. | 2009 | Bioorg. Med. Chem. | pmid:19758808 |
| pmid:19754387 | ||||
| Shan JZ et al. | Ursolic acid inhibits proliferation and induces apoptosis of HT-29 colon cancer cells by inhibiting the EGFR/MAPK pathway. | 2009 | J Zhejiang Univ Sci B | pmid:19735099 |
| Ramadan MA et al. | Chemical composition of the stem bark and leaves of Ficus pandurata Hance. | 2009 | Nat. Prod. Res. | pmid:19731141 |
| pmid:19715334 | ||||
| pmid:19708767 | ||||
| pmid:19695573 | ||||
| Yu HH et al. | Protective effect of ursolic acid from Cornus officinalis on the hydrogen peroxide-induced damage of HEI-OC1 auditory cells. | 2009 | Am. J. Chin. Med. | pmid:19655411 |
| Zhang P et al. | Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. | 2009 | J. Nat. Prod. | pmid:19642687 |
| Kim J et al. | Anti-lipase and lipolytic activities of ursolic acid isolated from the roots of Actinidia arguta. | 2009 | Arch. Pharm. Res. | pmid:19641878 |
| Yao Z et al. | [Triterpenoids from leaves of Ilex cornuta]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19639785 |
| Grange PA et al. | Production of superoxide anions by keratinocytes initiates P. acnes-induced inflammation of the skin. | 2009 | PLoS Pathog. | pmid:19629174 |
| Li J et al. | A new dilactone from the seeds of Gaultheria yunnanensis. | 2010 | Fitoterapia | pmid:19628028 |
| pmid:19557361 | ||||
| Li J et al. | Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. | 2009 | J. Nat. Prod. | pmid:19555121 |
| Lee MS and Thuong PT | Stimulation of glucose uptake by triterpenoids from Weigela subsessilis. | 2010 | Phytother Res | pmid:19548274 |
| Zhang YX et al. | Phosphorylation of Bcl-2 and activation of caspase-3 via the c-Jun N-terminal kinase pathway in ursolic acid-induced DU145 cells apoptosis. | 2009 | Biochimie | pmid:19545597 |
| MartÃn R et al. | Natural triterpenic diols promote apoptosis in astrocytoma cells through ROS-mediated mitochondrial depolarization and JNK activation. | 2009 | PLoS ONE | pmid:19543395 |
| da Silva Filho AA et al. | In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae). | 2009 | Fitoterapia | pmid:19540316 |
| Yasukawa K et al. | Anti-tumor promoters phenolics and triterpenoid from Hippophae rhamnoides. | 2009 | Fitoterapia | pmid:19535023 |
| Chen IH et al. | Cytotoxic triterpenoids from the stems of Microtropis japonica. | 2009 | J. Nat. Prod. | pmid:19534471 |
| Jäger S et al. | Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts. | 2009 | Molecules | pmid:19513002 |
| Ali S et al. | Mutiniside, new antioxidant phenolic glucoside from Abutilon muticum. | 2009 | J Asian Nat Prod Res | pmid:19504389 |
| Pérez Gutiérrez RM et al. | Hypoglycemic activity of constituents from Astianthus viminalis in normal and streptozotocin-induced diabetic mice. | 2009 | J Nat Med | pmid:19484331 |
| Liu M et al. | Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma. | 2009 | Fitoterapia | pmid:19446614 |
| Kassi E et al. | Ursolic acid triggers apoptosis and Bcl-2 downregulation in MCF-7 breast cancer cells. | 2009 | Cancer Invest. | pmid:19440893 |
| Wu PK et al. | Oleanolic acid isolated from Oldenlandia diffusa exhibits a unique growth inhibitory effect against ras-transformed fibroblasts. | 2009 | Life Sci. | pmid:19433096 |
| Lee JH et al. | Gardenia jasminoides Ellis ethanol extract and its constituents reduce the risks of gastritis and reverse gastric lesions in rats. | 2009 | Food Chem. Toxicol. | pmid:19425231 |
| Dinda B et al. | Iridoid glucosides from leaves and stem barks of Parkia javanica. | 2009 | J Asian Nat Prod Res | pmid:19408146 |
| pmid:19402062 | ||||
| Lavhale MS et al. | A novel triterpenoid isolated from the root bark of Ailanthus excelsa Roxb (Tree of Heaven), AECHL-1 as a potential anti-cancer agent. | 2009 | PLoS ONE | pmid:19399188 |
| Gautam R and Jachak SM | Recent developments in anti-inflammatory natural products. | 2009 | Med Res Rev | pmid:19378317 |
| Seo C et al. | Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19362837 |
| Xavier CP et al. | Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells. | 2009 | Cancer Lett. | pmid:19344998 |
| pmid:19340849 | ||||
| Kowalczyk MC et al. | Differential effects of several phytochemicals and their derivatives on murine keratinocytes in vitro and in vivo: implications for skin cancer prevention. | 2009 | Carcinogenesis | pmid:19329757 |
| Allouche Y et al. | Triterpenic content and chemometric analysis of virgin olive oils from forty olive cultivars. | 2009 | J. Agric. Food Chem. | pmid:19326867 |
| Masuda M et al. | Inhibitory effects of constituents of Morinda citrifolia seeds on elastase and tyrosinase. | 2009 | J Nat Med | pmid:19308654 |
| Yu XH et al. | [Study on ursolic acid extraction rate by ultramicro smashing and conventional smashing from leaves of Paulownia fortunei]. | 2008 | Zhong Yao Cai | pmid:19230417 |
| Lin Y et al. | Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters. | 2011 | Evid Based Complement Alternat Med | pmid:19228775 |
| Kontogianni VG et al. | Rapid and novel discrimination and quantification of oleanolic and ursolic acids in complex plant extracts using two-dimensional nuclear magnetic resonance spectroscopy-Comparison with HPLC methods. | 2009 | Anal. Chim. Acta | pmid:19216877 |
| Tang C et al. | Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis. | 2009 | Anticancer Drugs | pmid:19174695 |
| pmid:19167274 | ||||
| pmid:19166733 | ||||
| Awad R et al. | Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity. | 2009 | Phytother Res | pmid:19165747 |
| Cristians S et al. | Hypoglycemic activity of extracts and compounds from the leaves of Hintonia standleyana and H. latiflora: potential alternatives to the use of the stem bark of these species. | 2009 | J. Nat. Prod. | pmid:19140696 |
| Meng YQ et al. | The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation of their preliminary mechanism of action. | 2009 | Bioorg. Med. Chem. | pmid:19091579 |
| pmid:19071206 | ||||
| Kawano M et al. | Anti-inflammatory and analgesic components from "hierba santa," a traditional medicine in Peru. | 2009 | J Nat Med | pmid:19067116 |
| pmid:19051345 | ||||
| pmid:19023532 | ||||
| Jang SM et al. | Ursolic acid enhances the cellular immune system and pancreatic beta-cell function in streptozotocin-induced diabetic mice fed a high-fat diet. | 2009 | Int. Immunopharmacol. | pmid:19013541 |
| Cheung HY and Zhang QF | Enhanced analysis of triterpenes, flavonoids and phenolic compounds in Prunella vulgaris L. by capillary zone electrophoresis with the addition of running buffer modifiers. | 2008 | J Chromatogr A | pmid:18980769 |
| Hassan EM et al. | A new monoterpene alkaloid and other constituents of Plumeria acutifolia. | 2008 | Planta Med. | pmid:18975263 |
| Huang HC et al. | Ursolic acid inhibits IL-1beta or TNF-alpha-induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC-zeta and downregulating the MMP-9 expression. | 2009 | Mol. Carcinog. | pmid:18973186 |
| Prediger RD et al. | Effects of acute administration of the hydroalcoholic extract of mate tea leaves (Ilex paraguariensis) in animal models of learning and memory. | 2008 | J Ethnopharmacol | pmid:18948179 |
| Shyu MH et al. | Hsian-tsao (Mesona procumbens Heml.) prevents against rat liver fibrosis induced by CCl(4) via inhibition of hepatic stellate cells activation. | 2008 | Food Chem. Toxicol. | pmid:18929613 |
| Silva MG et al. | Variation of ursolic acid content in eight Ocimum species from northeastern Brazil. | 2008 | Molecules | pmid:18923339 |
| Liu H et al. | Solid-phase extraction of ursolic acid from herb using beta-cyclodextrin-based molecularly imprinted microspheres. | 2008 | J Sep Sci | pmid:18844208 |
| Fontanay S et al. | Ursolic, oleanolic and betulinic acids: antibacterial spectra and selectivity indexes. | 2008 | J Ethnopharmacol | pmid:18835348 |
| Lee SU et al. | Anabolic activity of ursolic acid in bone: Stimulating osteoblast differentiation in vitro and inducing new bone formation in vivo. | 2008 Nov-Dec | Pharmacol. Res. | pmid:18822379 |
| Sekiguchi H et al. | Suppressive Effects of Selected Food Phytochemicals on CD74 Expression in NCI-N87 Gastric Carcinoma Cells. | 2008 | J Clin Biochem Nutr | pmid:18818744 |
| pmid:18816515 | ||||
| Kang SY et al. | The anti-arthritic effect of ursolic acid on zymosan-induced acute inflammation and adjuvant-induced chronic arthritis models. | 2008 | J. Pharm. Pharmacol. | pmid:18812028 |
| Tsai SJ and Yin MC | Antioxidative and anti-inflammatory protection of oleanolic acid and ursolic acid in PC12 cells. | 2008 | J. Food Sci. | pmid:18803714 |
| Jaki BU et al. | Purity-activity relationships of natural products: the case of anti-TB active ursolic acid. | 2008 | J. Nat. Prod. | pmid:18798682 |
| Zhou XJ et al. | Preparation and body distribution of freeze-dried powder of ursolic acid phospholipid nanoparticles. | 2009 | Drug Dev Ind Pharm | pmid:18798089 |
| Ramachandran S and Prasad NR | Effect of ursolic acid, a triterpenoid antioxidant, on ultraviolet-B radiation-induced cytotoxicity, lipid peroxidation and DNA damage in human lymphocytes. | 2008 | Chem. Biol. Interact. | pmid:18793624 |
| pmid:18787788 | ||||
| pmid:18780248 | ||||
| Ibrahim A et al. | Microbial metabolism of biologically active secondary metabolites from Nerium oleander L. | 2008 | Chem. Pharm. Bull. | pmid:18758096 |
| pmid:18713073 | ||||
| Hao J et al. | Efficient access to 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid. | 2008 | J. Org. Chem. | pmid:18710287 |
| pmid:18707854 | ||||
| pmid:18662765 | ||||
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| pmid:18608775 | ||||
| Gnoatto SC et al. | Synthesis and preliminary evaluation of new ursolic and oleanolic acids derivatives as antileishmanial agents. | 2008 | J Enzyme Inhib Med Chem | pmid:18608757 |
| Kantamreddi VS and Wright CW | Investigation of Indian diospyros species for antiplasmodial properties. | 2008 | Evid Based Complement Alternat Med | pmid:18604258 |
| Ma CM et al. | Triterpenes from Cynomorium songaricium--analysis of HCV protease inhibitory activity, quantification, and content change under the influence of heating. | 2009 | J Nat Med | pmid:18600299 |
| Ying QL et al. | Inhibition of human leucocyte elastase by ursolic acid. Evidence for a binding site for pentacyclic triterpenes. | 1991 | Biochem. J. | pmid:1859379 |
| pmid:18583075 | ||||
| Ahmad M et al. | Urease inhibitor from Datisca cannabina linn. | 2008 | J Enzyme Inhib Med Chem | pmid:18569344 |
| Raphael TJ and Kuttan G | Effect of naturally occurring triterpenoids ursolic acid and glycyrrhizic acid on the cell-mediated immune responses of metastatic tumor-bearing animals. | 2008 | Immunopharmacol Immunotoxicol | pmid:18569082 |
| Cunha WR et al. | Hypoglicemic effect of Leandra lacunosa in normal and alloxan-induced diabetic rats. | 2008 | Fitoterapia | pmid:18538949 |
| Ikeda Y et al. | Strain differences regarding susceptibility to ursolic acid-induced interleukin-1beta release in murine macrophages. | 2008 | Life Sci. | pmid:18538348 |
| pmid:18537075 | ||||
| Srinivasan GV et al. | Identification of chemical compounds from the leaves of Leea indica. | 2008 | Acta Pharm | pmid:18515230 |
| pmid:18498484 | ||||
| Manu KA and Kuttan G | Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cells. | 2008 | Int. Immunopharmacol. | pmid:18486908 |
| pmid:18481026 | ||||
| Tran TA et al. | The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection. | 2008 | J Neuroinflammation | pmid:18474101 |
| Furtado RA et al. | Ursolic acid and oleanolic acid suppress preneoplastic lesions induced by 1,2-dimethylhydrazine in rat colon. | 2008 | Toxicol Pathol | pmid:18467683 |
| Zhao WJ et al. | Determination of glycyrrhetic acid in human plasma by HPLC-MS method and investigation of its pharmacokinetics. | 2008 | J Clin Pharm Ther | pmid:18452416 |