| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinogenesis | D063646 | 3 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cui HZ et al. | Ursolic acid increases the secretion of atrial natriuretic peptide in isolated perfused beating rabbit atria. | 2011 | Eur. J. Pharmacol. | pmid:21122803 |
| Kunkel SD et al. | mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass. | 2011 | Cell Metab. | pmid:21641545 |
| Skariyachan S et al. | Computer aided screening and evaluation of herbal therapeutics against MRSA infections. | 2011 | Bioinformation | pmid:22125390 |
| Liobikas J et al. | Uncoupling and antioxidant effects of ursolic acid in isolated rat heart mitochondria. | 2011 | J. Nat. Prod. | pmid:21648406 |
| Lu J et al. | Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice. | 2011 | Brain Behav. Immun. | pmid:21708244 |
| Saaby L et al. | Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.). | 2011 | Phytother Res | pmid:20632303 |
| Messner B et al. | Ursolic acid causes DNA-damage, p53-mediated, mitochondria- and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo. | 2011 | Atherosclerosis | pmid:21703625 |
| Sun LP et al. | Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors. | 2011 | Eur J Med Chem | pmid:21680062 |
| Bai KK et al. | Synthesis of [3β-acetoxy-urs-12-en-28-oyl]-1-monoglyceride and investigation on its anti tumor effects against BGC-823. | 2011 | Bioorg. Med. Chem. | pmid:21664827 |
| Deoda RS et al. | Gastroprotective Effect of Rubia cordifolia Linn. on Aspirin Plus Pylorus-Ligated Ulcer. | 2011 | Evid Based Complement Alternat Med | pmid:21423635 |
| Liu Y et al. | Ursolic acid promotes robust tolerance to cardiac allografts in mice. | 2011 | Clin. Exp. Immunol. | pmid:21391985 |
| Sultana N | Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product. | 2011 | J Enzyme Inhib Med Chem | pmid:21417964 |
| Shanmugam MK et al. | Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model. | 2011 | Int. J. Cancer | pmid:21480220 |
| Wen KC et al. | Inhibitory Effects of Terminalia catappa on UVB-Induced Photodamage in Fibroblast Cell Line. | 2011 | Evid Based Complement Alternat Med | pmid:20981325 |
| Arora R et al. | Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud. | 2011 | Evid Based Complement Alternat Med | pmid:20976081 |
| Shen D et al. | A rapid LC/MS/MS method for the analysis of nonvolatile antiinflammatory agents from Mentha spp. | 2011 | J. Food Sci. | pmid:22417488 |
| Chen Q et al. | Development of a liquid chromatography-mass spectrometry method for the determination of ursolic acid in rat plasma and tissue: application to the pharmacokinetic and tissue distribution study. | 2011 | Anal Bioanal Chem | pmid:21249342 |
| Sporn MB et al. | New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. | 2011 | J. Nat. Prod. | pmid:21309592 |
| Limami Y et al. | HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death. | 2011 | Biochimie | pmid:21251952 |
| Patel DK et al. | Pedalium murex Linn.: an overview of its phytopharmacological aspects. | 2011 | Asian Pac J Trop Med | pmid:21967701 |
| Prasad S et al. | Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK. | 2011 | J. Biol. Chem. | pmid:21156789 |
| Fukushima EO et al. | CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis. | 2011 | Plant Cell Physiol. | pmid:22039103 |
| Wang X et al. | Ursolic acid ameliorates hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells. | 2011 | J. Hepatol. | pmid:21168456 |
| Xia Y et al. | Quantitation of ursolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry and its pharmacokinetic study. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21169069 |
| Xu T et al. | Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein. | 2011 | J. Biol. Chem. | pmid:21566134 |
| Minaiyan M et al. | Effects of extract and essential oil of Rosmarinus officinalis L. on TNBS-induced colitis in rats. | 2011 | Res Pharm Sci | pmid:22049274 |
| Filocamo A et al. | Norfloxacin and ursolic acid: in vitro association and postantibiotic effect against Staphylococcus aureus. | 2011 | Lett. Appl. Microbiol. | pmid:21609344 |
| Rao VS et al. | Ursolic acid, a pentacyclic triterpene from Sambucus australis, prevents abdominal adiposity in mice fed a high-fat diet. | 2011 | J Med Food | pmid:21612453 |
| Ali M and Chaudhary N | Ficus hispida Linn.: A review of its pharmacognostic and ethnomedicinal properties. | 2011 | Pharmacogn Rev | pmid:22096323 |
| Pinon A et al. | A novel form of melanoma apoptosis resistance: melanogenesis up-regulation in apoptotic B16-F0 cells delays ursolic acid-triggered cell death. | 2011 | Exp. Cell Res. | pmid:21565187 |
| Roth M et al. | Isolation of modulators of the liver-specific organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae). | 2011 | J. Pharmacol. Exp. Ther. | pmid:21846839 |
| Chiou JF et al. | A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging. | 2011 | Evid Based Complement Alternat Med | pmid:21785640 |
| Chung PY et al. | Synergistic antimicrobial activity between pentacyclic triterpenoids and antibiotics against Staphylococcus aureus strains. | 2011 | Ann. Clin. Microbiol. Antimicrob. | pmid:21658242 |
| Kikuchi T et al. | 3-O-(E)-p-coumaroyl tormentic acid from Eriobotrya japonica leaves induces caspase-dependent apoptotic cell death in human leukemia cell line. | 2011 | Chem. Pharm. Bull. | pmid:21372421 |
| Shan JZ et al. | Proliferation-inhibiting and apoptosis-inducing effects of ursolic acid and oleanolic acid on multi-drug resistance cancer cells in vitro. | 2011 | Chin J Integr Med | pmid:21826595 |
| Bitencourt MA et al. | Aqueous and methanolic extracts of Caulerpa mexicana suppress cell migration and ear edema induced by inflammatory agents. | 2011 | Mar Drugs | pmid:21892348 |
| Xu XY et al. | Two new triterpenoid glycosides from the leaves of Anthocephalus chinensis. | 2011 | J Asian Nat Prod Res | pmid:21985583 |
| Wang C et al. | Determination of oleanolic and ursolic acid in Chinese herbs using HPLC and γ-CD as mobile phase modifier. | 2011 | J Sep Sci | pmid:21994210 |
| Ullevig SL et al. | Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis. | 2011 | Atherosclerosis | pmid:21752377 |
| Walch SG et al. | Antioxidant Capacity and Polyphenolic Composition as Quality Indicators for Aqueous Infusions of Salvia officinalis L. (sage tea). | 2011 | Front Pharmacol | pmid:22194722 |
| Lin Y et al. | Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters. | 2011 | Evid Based Complement Alternat Med | pmid:19228775 |
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| Wójciak-Kosior M et al. | The effect of ursolic and oleanolic acids on human skin fibroblast cells. | 2011 | Folia Histochem. Cytobiol. | pmid:22252762 |
| Venkateswara Rao G et al. | Chemical constituents and biological studies of Origanum vulgare Linn. | 2011 | Pharmacognosy Res | pmid:21772760 |
| Tan W et al. | Anti-cancer natural products isolated from chinese medicinal herbs. | 2011 | Chin Med | pmid:21777476 |
| Xu X et al. | Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway. | 2011 | J. Exp. Clin. Cancer Res. | pmid:21447176 |
| Samadi N et al. | Comparative antibacterial efficacy of endemic satureja khuzistanica jamzad essential oil, sodium hypochlorite and chlorhexidine gluconate solutions as root canal irrigations. | 2011 | Dent Res J (Isfahan) | pmid:22132012 |
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| Yau Hsiung W and Abdul Kadir H | Leea indica Ethyl Acetate Fraction Induces Growth-Inhibitory Effect in Various Cancer Cell Lines and Apoptosis in Ca Ski Human Cervical Epidermoid Carcinoma Cells. | 2011 | Evid Based Complement Alternat Med | pmid:21423690 |
| Pieroni LG et al. | Antioxidant activity and total phenols from the methanolic extract of Miconia albicans (Sw.) Triana leaves. | 2011 | Molecules | pmid:22075573 |
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| Lúcio KA et al. | Oleanolic acid initiates apoptosis in non-small cell lung cancer cell lines and reduces metastasis of a B16F10 melanoma model in vivo. | 2011 | PLoS ONE | pmid:22174843 |
| Li G et al. | Highly sensitive and selective pre-column derivatization high-performance liquid chromatography approach for rapid determination of triterpenes oleanolic and ursolic acids and application to Swertia species: optimization of triterpenic acids extraction and pre-column derivatization using response surface methodology. | 2011 | Anal. Chim. Acta | pmid:21334488 |
| Xia EQ et al. | Microwave-assisted extraction of oleanolic acid and ursolic acid from Ligustrum lucidum Ait. | 2011 | Int J Mol Sci | pmid:21954361 |
| Jia Y et al. | Ursolic acid is a PPAR-α agonist that regulates hepatic lipid metabolism. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21855333 |
| Odonne G et al. | Antileishmanial sesquiterpene lactones from Pseudelephantopus spicatus, a traditional remedy from the Chayahuita Amerindians (Peru). Part III. | 2011 | J Ethnopharmacol | pmid:21771652 |
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| Fu SB et al. | Multihydroxylation of ursolic acid by Pestalotiopsis microspora isolated from the medicinal plant Huperzia serrata. | 2011 | Fitoterapia | pmid:21767617 |
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| Wu HY et al. | Suppression of hepatitis B virus x protein-mediated tumorigenic effects by ursolic Acid. | 2011 | J. Agric. Food Chem. | pmid:21314126 |
| Wang X et al. | Ursolic acid inhibits proliferation and induces apoptosis of cancer cells in vitro and in vivo. | 2011 | J. Biomed. Biotechnol. | pmid:21716649 |
| Wen JH and Xiong YQ | The effect of herbal medicine danshensu and ursolic acid on pharmacokinetics of rosuvastatin in rats. | 2011 | Eur J Drug Metab Pharmacokinet | pmid:21717139 |
| Grudniak AM et al. | Oleanolic and ursolic acids influence affect the expression of the cysteine regulon and the stress response in Escherichia coli. | 2011 | Curr. Microbiol. | pmid:21221969 |
| Yamaguchi H et al. | Ligand-receptor interaction between triterpenoids and the 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) enzyme predicts their toxic effects against tumorigenic r/m HM-SFME-1 cells. | 2011 | J. Biol. Chem. | pmid:21880714 |
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| Zhou C et al. | Herbaceous peony (Paeonia lactiflora Pall.) as an alternative source of oleanolic and ursolic acids. | 2011 | Int J Mol Sci | pmid:21340006 |
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