| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Khaliq S et al. | Phytochemical investigation of Perovskia abrotanoides. | 2007 | Planta Med. | pmid:17315312 |
| Shahat AA et al. | Antiviral and antioxidant activity of flavonoids and proanthocyanidins from Crataegus sinaica. | 2002 | Planta Med. | pmid:12094299 |
| Neto CC et al. | Cytotoxic triterpene acids from the Peruvian medicinal plant Polylepis racemosa. | 2000 | Planta Med. | pmid:10909276 |
| Cantrell CL et al. | Antimycobacterial plant terpenoids. | 2001 | Planta Med. | pmid:11731906 |
| Déciga-Campos M et al. | Isobolographic analysis of the antinociceptive interaction between ursolic acid and diclofenac or tramadol in mice. | 2014 | Planta Med. | pmid:24431012 |
| Gu JQ et al. | Antitubercular constituents of Valeriana laxiflora. | 2004 | Planta Med. | pmid:15229801 |
| Shin KM et al. | In vitro anti-inflammatory activity of 23-hydroxyursolic acid isolated from Cussonia bancoensis in murine macrophage RAW 264.7 cells. | 2004 | Planta Med. | pmid:15386188 |
| Lee KH et al. | The cytotoxic principles of Prunella vulgaris, Psychotria serpens, and Hyptis capitata: ursolic acid and related derivatives. | 1988 | Planta Med. | pmid:3222376 |
| Richards RM et al. | Antibacterial activity of compounds from Rubus pinfaensis. | 1994 | Planta Med. | pmid:7997480 |
| González-Trujano ME et al. | Spasmolytic and antinociceptive activities of ursolic acid and acacetin identified in Agastache mexicana. | 2012 | Planta Med. | pmid:22473340 |
| Kim YK et al. | Cytotoxic triterpenes from stem bark of Physocarpus intermedius. | 2000 | Planta Med. | pmid:10909277 |
| Min BS et al. | Inhibitory effect of triterpenes from Crataegus pinatifida on HIV-I protease. | 1999 | Planta Med. | pmid:10364847 |
| Jeong TS et al. | Chitin synthase II inhibitory activity of ursolic acid, isolated from Crataegus pinnatifida. | 1999 | Planta Med. | pmid:10232075 |
| Lee CJ et al. | Effects of ursolic acid, betulin and sulfur-containing compounds on mucin release from airway goblet cells. | 2004 | Planta Med. | pmid:15643543 |
| Rios MY et al. | Sterols, triterpenes and biflavonoids of Viburnum jucundum and cytotoxic activity of ursolic acid. | 2001 | Planta Med. | pmid:11582553 |
| Jiang B et al. | Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata. | 2002 | Planta Med. | pmid:12391557 |
| Kim E et al. | Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes. | 2011 | Planta Med. | pmid:20717876 |
| Yoshimura H et al. | In vitro TGF-beta1 antagonistic activity of ursolic and oleanolic acids isolated from Clerodendranthus spicatus. | 2003 | Planta Med. | pmid:12898427 |
| Chiang LC et al. | Immunomodulatory activities of flavonoids, monoterpenoids, triterpenoids, iridoid glycosides and phenolic compounds of Plantago species. | 2003 | Planta Med. | pmid:12898413 |
| Kuigoua GM et al. | Minor secondary metabolic products from the stem bark of Plumeria rubra Linn. displaying antimicrobial activities. | 2010 | Planta Med. | pmid:19937550 |
| Schleich S et al. | Extracts from Pygeum africanum and other ethnobotanical species with antiandrogenic activity. | 2006 | Planta Med. | pmid:16783690 |
| Lu X et al. | Ursolic acid attenuates diabetic mesangial cell injury through the up-regulation of autophagy via miRNA-21/PTEN/Akt/mTOR suppression. | 2015 | PLoS ONE | pmid:25689721 |
| Kalani K et al. | In vitro, in silico and in vivo studies of ursolic acid as an anti-filarial agent. | 2014 | PLoS ONE | pmid:25375886 |
| Hwang TL et al. | Ursolic acid inhibits superoxide production in activated neutrophils and attenuates trauma-hemorrhage shock-induced organ injury in rats. | 2014 | PLoS ONE | pmid:25360589 |
| He Y et al. | Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes. | 2014 | PLoS ONE | pmid:25329874 |
| Ou X et al. | Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome. | 2014 | PLoS ONE | pmid:24740400 |
| Arapitsas P et al. | A metabolomic approach to the study of wine micro-oxygenation. | 2012 | PLoS ONE | pmid:22662221 |
| Feng L et al. | Inhibition of human neutrophil elastase by pentacyclic triterpenes. | 2013 | PLoS ONE | pmid:24376583 |
| Li S et al. | Therapeutic role of ursolic acid on ameliorating hepatic steatosis and improving metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease rats. | 2014 | PLoS ONE | pmid:24489777 |
| Ichikawa T et al. | Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes. | 2009 | PLoS ONE | pmid:20027226 |
| Chen Y et al. | Optimisation of potassium chloride nutrition for proper growth, physiological development and bioactive component production in Prunella vulgaris L. | 2013 | PLoS ONE | pmid:23874390 |
| Wu L et al. | Processing technology investigation of loquat (Eriobotrya japonica) leaf by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry combined with chemometrics. | 2013 | PLoS ONE | pmid:23667702 |
| Liu YQ et al. | Retigeric acid B exhibits antitumor activity through suppression of nuclear factor-κB signaling in prostate cancer cells in vitro and in vivo. | 2012 | PLoS ONE | pmid:22666431 |
| Quave CL et al. | Ellagic acid derivatives from Rubus ulmifolius inhibit Staphylococcus aureus biofilm formation and improve response to antibiotics. | 2012 | PLoS ONE | pmid:22242149 |
| Yamamoto ES et al. | The Effect of Ursolic Acid on Leishmania (Leishmania) amazonensis Is Related to Programed Cell Death and Presents Therapeutic Potential in Experimental Cutaneous Leishmaniasis. | 2015 | PLoS ONE | pmid:26674781 |
| MartÃn R et al. | Natural triterpenic diols promote apoptosis in astrocytoma cells through ROS-mediated mitochondrial depolarization and JNK activation. | 2009 | PLoS ONE | pmid:19543395 |
| Kress CL et al. | Triterpenoids display single agent anti-tumor activity in a transgenic mouse model of chronic lymphocytic leukemia and small B cell lymphoma. | 2007 | PLoS ONE | pmid:17593960 |
| Lúcio KA et al. | Oleanolic acid initiates apoptosis in non-small cell lung cancer cell lines and reduces metastasis of a B16F10 melanoma model in vivo. | 2011 | PLoS ONE | pmid:22174843 |
| Kunkel SD et al. | Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease. | 2012 | PLoS ONE | pmid:22745735 |
| Massaoka MH et al. | Jacaranone induces apoptosis in melanoma cells via ROS-mediated downregulation of Akt and p38 MAPK activation and displays antitumor activity in vivo. | 2012 | PLoS ONE | pmid:22701695 |
| Ma T et al. | Human papillomavirus type 18 E6 and E7 genes integrate into human hepatoma derived cell line Hep G2. | 2012 | PLoS ONE | pmid:22655088 |
| Shanmugam MK et al. | Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways. | 2012 | PLoS ONE | pmid:22427843 |
| Lavhale MS et al. | A novel triterpenoid isolated from the root bark of Ailanthus excelsa Roxb (Tree of Heaven), AECHL-1 as a potential anti-cancer agent. | 2009 | PLoS ONE | pmid:19399188 |
| Kavitha CV et al. | Asiatic acid inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture models. | 2011 | PLoS ONE | pmid:21826202 |
| Checker R et al. | Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-κB, AP-1 and NF-AT. | 2012 | PLoS ONE | pmid:22363615 |
| Wang O et al. | Anticancer activity of 2α, 3α, 19β, 23β-Tetrahydroxyurs-12-en-28-oic acid (THA), a novel triterpenoid isolated from Sinojackia sarcocarpa. | 2011 | PLoS ONE | pmid:21695177 |
| Shabrova EV et al. | Insights into the molecular mechanisms of the anti-atherogenic actions of flavonoids in normal and obese mice. | 2011 | PLoS ONE | pmid:22016761 |
| Sifaoui I et al. | Programmed cell death in Acanthamoeba castellanii Neff induced by several molecules present in olive leaf extracts. | 2017 | PLoS ONE | pmid:28859105 |
| Cárdenas C et al. | Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene. | 2011 | PLoS ONE | pmid:21858104 |
| Dutra RC et al. | Preventive and therapeutic euphol treatment attenuates experimental colitis in mice. | 2011 | PLoS ONE | pmid:22073270 |
| Mishra T et al. | Isolation, Characterization and Anticancer Potential of Cytotoxic Triterpenes from Betula utilis Bark. | 2016 | PLoS ONE | pmid:27453990 |
| Villar VH et al. | Down-Regulation of AKT Signalling by Ursolic Acid Induces Intrinsic Apoptosis and Sensitization to Doxorubicin in Soft Tissue Sarcoma. | 2016 | PLoS ONE | pmid:27219337 |
| Wu P et al. | Synthesis and Evaluation of Novel Triterpene Analogues of Ursolic Acid as Potential Antidiabetic Agent. | 2015 | PLoS ONE | pmid:26406581 |
| Yang Y et al. | Enhancement of Radiation Effects by Ursolic Acid in BGC-823 Human Adenocarcinoma Gastric Cancer Cell Line. | 2015 | PLoS ONE | pmid:26177078 |
| Wang J et al. | Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells. | 2013 | PLoS ONE | pmid:23737956 |
| Kang SH et al. | Icariside II induces apoptosis in U937 acute myeloid leukemia cells: role of inactivation of STAT3-related signaling. | 2012 | PLoS ONE | pmid:22493659 |
| He Y et al. | Ursolic acid inhibits adipogenesis in 3T3-L1 adipocytes through LKB1/AMPK pathway. | 2013 | PLoS ONE | pmid:23922935 |
| Grange PA et al. | Production of superoxide anions by keratinocytes initiates P. acnes-induced inflammation of the skin. | 2009 | PLoS Pathog. | pmid:19629174 |
| Kurek A et al. | The effect of oleanolic and ursolic acids on the hemolytic properties and biofilm formation of Listeria monocytogenes. | 2014 | Pol. J. Microbiol. | pmid:25033658 |
| Crown PL et al. | Ritual Black Drink consumption at Cahokia. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22869743 |
| Bonkhoff H | Factors implicated in radiation therapy failure and radiosensitization of prostate cancer. | 2012 | Prostate Cancer | pmid:22229096 |
| Shan J et al. | Ursolic acid synergistically enhances the therapeutic effects of oxaliplatin in colorectal cancer. | 2016 | Protein Cell | pmid:27472952 |
| Liu Y et al. | Study on the noncovalent interactions of saikosaponins and cytochrome c by electrospray ionization mass spectrometry. | 2012 | Rapid Commun. Mass Spectrom. | pmid:22368050 |
| Ullevig SL et al. | Ursolic acid protects monocytes against metabolic stress-induced priming and dysfunction by preventing the induction of Nox4. | 2014 | Redox Biol | pmid:24494201 |
| Musabayane CT et al. | Synergistic antihyperglycemic effects between plant-derived oleanolic acid and insulin in streptozotocin-induced diabetic rats. | 2010 | Ren Fail | pmid:20662697 |
| Minaiyan M et al. | Effects of extract and essential oil of Rosmarinus officinalis L. on TNBS-induced colitis in rats. | 2011 | Res Pharm Sci | pmid:22049274 |
| Qin N et al. | RNA-Seq-based transcriptome analysis of methicillin-resistant Staphylococcus aureus biofilm inhibition by ursolic acid and resveratrol. | 2014 | Sci Rep | pmid:24970710 |
| Wang J et al. | Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis. | 2014 | Sci Rep | pmid:25833312 |
| Pareek TK et al. | Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis. | 2011 | Sci Rep | pmid:22355716 |
| Kim SH et al. | Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells. | 2015 | Sci Rep | pmid:26412148 |
| Tan X et al. | Transcriptome analysis of the biofilm formed by methicillin-susceptible Staphylococcus aureus. | 2015 | Sci Rep | pmid:26149474 |
| Gohari AR et al. | Evaluation of the cytotoxicity of Satureja spicigera and its main compounds. | 2012 | ScientificWorldJournal | pmid:22623883 |
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| Sun Z et al. | Identification and determination of carboxylic acids in food samples using 2-(2-(anthracen-10-yl)-1H-phenanthro[9,10-d]imidazol-1-yl)ethyl 4-methylbenzenesulfonate (APIETS) as labeling reagent by HPLC with FLD and APCI/MS. | 2011 | Talanta | pmid:21726743 |
| Huang CY et al. | Inhibition of cell proliferation, invasion and migration by ursolic acid in human lung cancer cell lines. | 2011 | Toxicol In Vitro | pmid:21539908 |
| Yan SL et al. | Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines. | 2010 | Toxicol In Vitro | pmid:20005942 |
| Furtado RA et al. | Ursolic acid and oleanolic acid suppress preneoplastic lesions induced by 1,2-dimethylhydrazine in rat colon. | 2008 | Toxicol Pathol | pmid:18467683 |
| Wu DM et al. | Ursolic acid improves domoic acid-induced cognitive deficits in mice. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23707761 |
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| Ramos AA et al. | Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells: evaluation by the comet assay. | 2008 | Toxicol. Lett. | pmid:18276086 |
| Senthil S et al. | Protective effect of ursolic Acid against myocardial ischemia induced by isoproterenol in rats. | 2007 | Toxicol. Mech. Methods | pmid:20020988 |
| Szuster-Ciesielska A et al. | Betulin and betulinic acid attenuate ethanol-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS), cytokine (TNF-α, TGF-β) production and by influencing intracellular signaling. | 2011 | Toxicology | pmid:21172400 |
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