MeSH term | MeSH ID | Detail |
---|---|---|
Dermatitis, Contact | D003877 | 59 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with ursolic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Dermatitis, Contact | D003877 | 59 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cui HZ et al. | Ursolic acid increases the secretion of atrial natriuretic peptide in isolated perfused beating rabbit atria. | 2011 | Eur. J. Pharmacol. | pmid:21122803 |
Kunkel SD et al. | mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass. | 2011 | Cell Metab. | pmid:21641545 |
Liobikas J et al. | Uncoupling and antioxidant effects of ursolic acid in isolated rat heart mitochondria. | 2011 | J. Nat. Prod. | pmid:21648406 |
Lu J et al. | Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice. | 2011 | Brain Behav. Immun. | pmid:21708244 |
Messner B et al. | Ursolic acid causes DNA-damage, p53-mediated, mitochondria- and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo. | 2011 | Atherosclerosis | pmid:21703625 |
Sun LP et al. | Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors. | 2011 | Eur J Med Chem | pmid:21680062 |
Deoda RS et al. | Gastroprotective Effect of Rubia cordifolia Linn. on Aspirin Plus Pylorus-Ligated Ulcer. | 2011 | Evid Based Complement Alternat Med | pmid:21423635 |
Wen KC et al. | Inhibitory Effects of Terminalia catappa on UVB-Induced Photodamage in Fibroblast Cell Line. | 2011 | Evid Based Complement Alternat Med | pmid:20981325 |
Arora R et al. | Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud. | 2011 | Evid Based Complement Alternat Med | pmid:20976081 |
Shen D et al. | A rapid LC/MS/MS method for the analysis of nonvolatile antiinflammatory agents from Mentha spp. | 2011 | J. Food Sci. | pmid:22417488 |
Abdureyim S et al. | Anti-inflammatory, immunomodulatory, and heme oxygenase-1 inhibitory activities of ravan napas, a formulation of uighur traditional medicine, in a rat model of allergic asthma. | 2011 | Evid Based Complement Alternat Med | pmid:20953388 |
Zhang T et al. | Ursolic acid induces HL60 monocytic differentiation and upregulates C/EBPβ expression by ERK pathway activation. | 2011 | Anticancer Drugs | pmid:20948428 |
Sonnet P and Mullié C | In vitro antimalarial activity of ICL670: a further proof of the correlation between inhibition of β-hematin formation and of peroxidative degradation of hemin. | 2011 | Exp. Parasitol. | pmid:21295029 |
Chen Q et al. | Development of a liquid chromatography-mass spectrometry method for the determination of ursolic acid in rat plasma and tissue: application to the pharmacokinetic and tissue distribution study. | 2011 | Anal Bioanal Chem | pmid:21249342 |
Sporn MB et al. | New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. | 2011 | J. Nat. Prod. | pmid:21309592 |
Limami Y et al. | HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death. | 2011 | Biochimie | pmid:21251952 |
Patel DK et al. | Pedalium murex Linn.: an overview of its phytopharmacological aspects. | 2011 | Asian Pac J Trop Med | pmid:21967701 |
Prasad S et al. | Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK. | 2011 | J. Biol. Chem. | pmid:21156789 |
Wang X et al. | Ursolic acid ameliorates hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells. | 2011 | J. Hepatol. | pmid:21168456 |
Xia Y et al. | Quantitation of ursolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry and its pharmacokinetic study. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21169069 |
Xu T et al. | Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein. | 2011 | J. Biol. Chem. | pmid:21566134 |
Minaiyan M et al. | Effects of extract and essential oil of Rosmarinus officinalis L. on TNBS-induced colitis in rats. | 2011 | Res Pharm Sci | pmid:22049274 |
Filocamo A et al. | Norfloxacin and ursolic acid: in vitro association and postantibiotic effect against Staphylococcus aureus. | 2011 | Lett. Appl. Microbiol. | pmid:21609344 |
Rao VS et al. | Ursolic acid, a pentacyclic triterpene from Sambucus australis, prevents abdominal adiposity in mice fed a high-fat diet. | 2011 | J Med Food | pmid:21612453 |
Pinon A et al. | A novel form of melanoma apoptosis resistance: melanogenesis up-regulation in apoptotic B16-F0 cells delays ursolic acid-triggered cell death. | 2011 | Exp. Cell Res. | pmid:21565187 |
Roth M et al. | Isolation of modulators of the liver-specific organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae). | 2011 | J. Pharmacol. Exp. Ther. | pmid:21846839 |
Chiou JF et al. | A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging. | 2011 | Evid Based Complement Alternat Med | pmid:21785640 |
Chung PY et al. | Synergistic antimicrobial activity between pentacyclic triterpenoids and antibiotics against Staphylococcus aureus strains. | 2011 | Ann. Clin. Microbiol. Antimicrob. | pmid:21658242 |
Reyes-Zurita FJ et al. | The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism. | 2011 | BMC Cancer | pmid:21524306 |
Kikuchi T et al. | 3-O-(E)-p-coumaroyl tormentic acid from Eriobotrya japonica leaves induces caspase-dependent apoptotic cell death in human leukemia cell line. | 2011 | Chem. Pharm. Bull. | pmid:21372421 |
Shan JZ et al. | Proliferation-inhibiting and apoptosis-inducing effects of ursolic acid and oleanolic acid on multi-drug resistance cancer cells in vitro. | 2011 | Chin J Integr Med | pmid:21826595 |
Bitencourt MA et al. | Aqueous and methanolic extracts of Caulerpa mexicana suppress cell migration and ear edema induced by inflammatory agents. | 2011 | Mar Drugs | pmid:21892348 |
Walch SG et al. | Antioxidant Capacity and Polyphenolic Composition as Quality Indicators for Aqueous Infusions of Salvia officinalis L. (sage tea). | 2011 | Front Pharmacol | pmid:22194722 |
Zhang XH and Zhu X | [The newest progress of the pharmacology of prunol]. | 2011 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:22013813 |
Wójciak-Kosior M et al. | The effect of ursolic and oleanolic acids on human skin fibroblast cells. | 2011 | Folia Histochem. Cytobiol. | pmid:22252762 |
Tannock LR | Ursolic acid effect on atherosclerosis: apples and apples, or apples and oranges? | 2011 | Atherosclerosis | pmid:21993411 |
Venkateswara Rao G et al. | Chemical constituents and biological studies of Origanum vulgare Linn. | 2011 | Pharmacognosy Res | pmid:21772760 |
Martin C et al. | How can research on plants contribute to promoting human health? | 2011 | Plant Cell | pmid:21586682 |
Tan W et al. | Anti-cancer natural products isolated from chinese medicinal herbs. | 2011 | Chin Med | pmid:21777476 |
Sun Z et al. | Identification and determination of carboxylic acids in food samples using 2-(2-(anthracen-10-yl)-1H-phenanthro[9,10-d]imidazol-1-yl)ethyl 4-methylbenzenesulfonate (APIETS) as labeling reagent by HPLC with FLD and APCI/MS. | 2011 | Talanta | pmid:21726743 |
Xu X et al. | Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway. | 2011 | J. Exp. Clin. Cancer Res. | pmid:21447176 |
Kang KS et al. | Effect of intraperitoneal injection of curcumin on food intake in a goldfish model. | 2011 | J. Mol. Neurosci. | pmid:20514526 |
Yau Hsiung W and Abdul Kadir H | Leea indica Ethyl Acetate Fraction Induces Growth-Inhibitory Effect in Various Cancer Cell Lines and Apoptosis in Ca Ski Human Cervical Epidermoid Carcinoma Cells. | 2011 | Evid Based Complement Alternat Med | pmid:21423690 |
Muñoz O et al. | Chemical study and anti-inflammatory, analgesic and antioxidant activities of the leaves of Aristotelia chilensis (Mol.) Stuntz, Elaeocarpaceae. | 2011 | J. Pharm. Pharmacol. | pmid:21585384 |
Rasoanaivo P et al. | Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. | 2011 | Malar. J. | pmid:21411015 |
Wang X et al. | Antifungal metabolites from the roots of Diospyros virginiana by overpressure layer chromatography. | 2011 | Chem. Biodivers. | pmid:22162171 |
Arbab AS et al. | MRI to assess chemoprevention in transgenic adenocarcinoma of mouse prostate (TRAMP). | 2011 | BMC Med Imaging | pmid:22165848 |
Lúcio KA et al. | Oleanolic acid initiates apoptosis in non-small cell lung cancer cell lines and reduces metastasis of a B16F10 melanoma model in vivo. | 2011 | PLoS ONE | pmid:22174843 |
Li G et al. | Highly sensitive and selective pre-column derivatization high-performance liquid chromatography approach for rapid determination of triterpenes oleanolic and ursolic acids and application to Swertia species: optimization of triterpenic acids extraction and pre-column derivatization using response surface methodology. | 2011 | Anal. Chim. Acta | pmid:21334488 |
Cho K et al. | Oleanolic acid and ursolic acid derived from Cornus officinalis Sieb. et Zucc. suppress epidermal growth factor- and phorbol ester-induced MUC5AC mucin production and gene expression from human airway epithelial cells. | 2011 | Phytother Res | pmid:21442679 |
Aslan M et al. | Effect of Gentiana olivieri on experimental epilepsy models. | 2011 | Pharmacogn Mag | pmid:22262939 |
Xia EQ et al. | Microwave-assisted extraction of oleanolic acid and ursolic acid from Ligustrum lucidum Ait. | 2011 | Int J Mol Sci | pmid:21954361 |
Yao L et al. | Protective effects of polysaccharides from soybean meal against X-ray radiation induced damage in mouse spleen lymphocytes. | 2011 | Int J Mol Sci | pmid:22174652 |
Alshawsh MA et al. | Hepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in Rats. | 2011 | Evid Based Complement Alternat Med | pmid:21647311 |
Wakchaure D et al. | Hepatoprotective activity of Symplocos racemosa bark on carbon tetrachloride-induced hepatic damage in rats. | 2011 | J Ayurveda Integr Med | pmid:22022156 |
Anusha M et al. | Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats. | 2011 | Indian J Pharmacol | pmid:22022001 |
Kavitha CV et al. | Asiatic acid inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture models. | 2011 | PLoS ONE | pmid:21826202 |
Zhang HE et al. | [Optimization of supercritical fluid extraction of ursolic acid from follum eriobotryae by response surface methodology]. | 2011 | Zhong Yao Cai | pmid:22372151 |
Ansarullah S et al. | Influence of Oreocnide integrifolia (Gaud.) Miq on IRS-1, Akt and Glut-4 in Fat-Fed C57BL/6J Type 2 Diabetes Mouse Model. | 2011 | Evid Based Complement Alternat Med | pmid:21785636 |
Zhong Y et al. | Carb-oxy-methyl ursolate monohydrate. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:21523096 |
Chen Q et al. | Identification and quantification of oleanolic acid and ursolic acid in Chinese herbs by liquid chromatography-ion trap mass spectrometry. | 2011 | Biomed. Chromatogr. | pmid:21465498 |
Moneriz C et al. | Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages. | 2011 | Malar. J. | pmid:21477369 |
Kiran MS et al. | Changes in expression of VE-cadherin and MMPs in endothelial cells: Implications for angiogenesis. | 2011 | pmid:21349163 | |
Truong NB et al. | Antituberculosis cycloartane triterpenoids from Radermachera boniana. | 2011 | J. Nat. Prod. | pmid:21469696 |
Mohan L et al. | Evaluation of the Anxiolytic Activity of NR-ANX-C (a Polyherbal Formulation) in Ethanol Withdrawal-Induced Anxiety Behavior in Rats. | 2011 | Evid Based Complement Alternat Med | pmid:20953426 |
Peixoto JA et al. | Antileishmanial activity of the hydroalcoholic extract of Miconia langsdorffii, isolated compounds, and semi-synthetic derivatives. | 2011 | Molecules | pmid:21343887 |
Kim E et al. | Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes. | 2011 | Planta Med. | pmid:20717876 |
Meng YQ et al. | [Synthesis and anti-tumor activity of ursolic acid derivatives]. | 2011 | Yao Xue Xue Bao | pmid:21800543 |
Kuete V et al. | Antimicrobial activities of the methanol extract, fractions and compounds from Ficus polita Vahl. (Moraceae). | 2011 | BMC Complement Altern Med | pmid:21269424 |
Szuster-Ciesielska A et al. | Betulin and betulinic acid attenuate ethanol-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS), cytokine (TNF-α, TGF-β) production and by influencing intracellular signaling. | 2011 | Toxicology | pmid:21172400 |
Fu SB et al. | Multihydroxylation of ursolic acid by Pestalotiopsis microspora isolated from the medicinal plant Huperzia serrata. | 2011 | Fitoterapia | pmid:21767617 |
Chen Y et al. | [Preparation and transdermal diffusion of ursolic acid ethosomes]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21809568 |
Annan K et al. | Acaricidal effect of an isolate from Hoslundia opposita vahl against Amblyomma variegatum (Acari: Ixodidae). | 2011 | Pharmacognosy Res | pmid:22022167 |
Passero LF et al. | Anti-leishmanial effects of purified compounds from aerial parts of Baccharis uncinella C. DC. (Asteraceae). | 2011 | Parasitol. Res. | pmid:20886232 |
Li GL et al. | Development of a new HPLC method with precolumn fluorescent derivatization for rapid, selective and sensitive detection of triterpenic acids in fruits. | 2011 | J. Agric. Food Chem. | pmid:21388126 |
Wilkinson K et al. | A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36. | 2011 | J. Biol. Chem. | pmid:21835916 |
Shabrova EV et al. | Insights into the molecular mechanisms of the anti-atherogenic actions of flavonoids in normal and obese mice. | 2011 | PLoS ONE | pmid:22016761 |
Wu HY et al. | Suppression of hepatitis B virus x protein-mediated tumorigenic effects by ursolic Acid. | 2011 | J. Agric. Food Chem. | pmid:21314126 |
Fu SB et al. | Biotransformation of ursolic acid by an endophytic fungus from medicinal plant Huperzia serrata. | 2011 | Chem. Pharm. Bull. | pmid:21881267 |
Kim KH et al. | Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells. | 2011 | Arch. Pharm. Res. | pmid:21910059 |
Jilani K et al. | Triggering of erythrocyte cell membrane scrambling by ursolic acid. | 2011 | J. Nat. Prod. | pmid:21923134 |
Wang X et al. | Ursolic acid inhibits proliferation and induces apoptosis of cancer cells in vitro and in vivo. | 2011 | J. Biomed. Biotechnol. | pmid:21716649 |
Frontana-Uribe BA et al. | A new languidulane diterpenoid from Salvia mexicana var. mexicana. | 2011 | Molecules | pmid:22019574 |
Wen JH and Xiong YQ | The effect of herbal medicine danshensu and ursolic acid on pharmacokinetics of rosuvastatin in rats. | 2011 | Eur J Drug Metab Pharmacokinet | pmid:21717139 |
Grudniak AM et al. | Oleanolic and ursolic acids influence affect the expression of the cysteine regulon and the stress response in Escherichia coli. | 2011 | Curr. Microbiol. | pmid:21221969 |
Yamaguchi H et al. | Ligand-receptor interaction between triterpenoids and the 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) enzyme predicts their toxic effects against tumorigenic r/m HM-SFME-1 cells. | 2011 | J. Biol. Chem. | pmid:21880714 |
Cárdenas C et al. | Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene. | 2011 | PLoS ONE | pmid:21858104 |
Lin CC et al. | Antiangiogenic potential of three triterpenic acids in human liver cancer cells. | 2011 | J. Agric. Food Chem. | pmid:21175131 |
Pareek TK et al. | Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis. | 2011 | Sci Rep | pmid:22355716 |
Lee HZ et al. | Clarification of the phenotypic characteristics and anti-tumor activity of Hedyotis diffusa. | 2011 | Am. J. Chin. Med. | pmid:21213409 |
Sasaki T et al. | Chemical constituents from Sambucus adnata and their protein-tyrosine phosphatase 1B inhibitory activities. | 2011 | Chem. Pharm. Bull. | pmid:22041077 |
Brendolise C et al. | An unusual plant triterpene synthase with predominant α-amyrin-producing activity identified by characterizing oxidosqualene cyclases from Malus × domestica. | 2011 | FEBS J. | pmid:21575133 |
Akiyama M | The roles of ABCA12 in keratinocyte differentiation and lipid barrier formation in the epidermis. | 2011 | Dermatoendocrinol | pmid:21695020 |
Zhou C et al. | Flavonoids, phenolics, and antioxidant capacity in the flower of Eriobotrya japonica Lindl. | 2011 | Int J Mol Sci | pmid:21686159 |
Assob JC et al. | Antimicrobial and toxicological activities of five medicinal plant species from Cameroon traditional medicine. | 2011 | BMC Complement Altern Med | pmid:21867554 |
Zhou C et al. | Herbaceous peony (Paeonia lactiflora Pall.) as an alternative source of oleanolic and ursolic acids. | 2011 | Int J Mol Sci | pmid:21340006 |
Huang SS et al. | Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice. | 2011 | Evid Based Complement Alternat Med | pmid:21584194 |
Gasnier C et al. | Defined plant extracts can protect human cells against combined xenobiotic effects. | 2011 | J Occup Med Toxicol | pmid:21251308 |
Beg S et al. | Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives. | 2011 | Pharmacogn Rev | pmid:22279370 |
Bayer M et al. | Photoprotection against UVAR: effective triterpenoids require a lipid raft stabilizing chemical structure. | 2011 | Exp. Dermatol. | pmid:21824200 |