MeSH term | MeSH ID | Detail |
---|---|---|
Dermatitis, Contact | D003877 | 59 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with ursolic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Dermatitis, Contact | D003877 | 59 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Steele JC et al. | In vitro and in vivo evaluation of betulinic acid as an antimalarial. | 1999 | Phytother Res | pmid:10190183 |
Haraguchi H et al. | Antimicrobial triterpenes from Ilex integra and the mechanism of antifungal action. | 1999 | Phytother Res | pmid:10190191 |
Jeong TS et al. | Chitin synthase II inhibitory activity of ursolic acid, isolated from Crataegus pinnatifida. | 1999 | Planta Med. | pmid:10232075 |
Min BS et al. | Inhibitory effect of triterpenes from Crataegus pinatifida on HIV-I protease. | 1999 | Planta Med. | pmid:10364847 |
Pérez-Camino MC and Cert A | Quantitative determination of hydroxy pentacyclic triterpene acids in vegetable oils. | 1999 | J. Agric. Food Chem. | pmid:10564016 |
PokrovskiÄ AG et al. | [Immunomodulating activity of ursolic acid derivatives]. | 1999 | Dokl. Akad. Nauk. | pmid:10613250 |
Kitani K et al. | Pharmacological modifications of endogenous antioxidant enzymes with special reference to the effects of deprenyl: a possible antioxidant strategy. | 1999 | Mech. Ageing Dev. | pmid:10656538 |
Choi BM et al. | Cyclic adenosine monophosphate inhibits ursolic acid-induced apoptosis via activation of protein kinase A in human leukaemic HL-60 cells. | 2000 | Pharmacol. Toxicol. | pmid:10728914 |
Subbaramaiah K et al. | Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. | 2000 | Cancer Res. | pmid:10811116 |