| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Steele JC et al. | In vitro and in vivo evaluation of betulinic acid as an antimalarial. | 1999 | Phytother Res | pmid:10190183 |
| Haraguchi H et al. | Antimicrobial triterpenes from Ilex integra and the mechanism of antifungal action. | 1999 | Phytother Res | pmid:10190191 |
| Jeong TS et al. | Chitin synthase II inhibitory activity of ursolic acid, isolated from Crataegus pinnatifida. | 1999 | Planta Med. | pmid:10232075 |
| Min BS et al. | Inhibitory effect of triterpenes from Crataegus pinatifida on HIV-I protease. | 1999 | Planta Med. | pmid:10364847 |
| Pérez-Camino MC and Cert A | Quantitative determination of hydroxy pentacyclic triterpene acids in vegetable oils. | 1999 | J. Agric. Food Chem. | pmid:10564016 |
| PokrovskiÄ AG et al. | [Immunomodulating activity of ursolic acid derivatives]. | 1999 | Dokl. Akad. Nauk. | pmid:10613250 |
| Kitani K et al. | Pharmacological modifications of endogenous antioxidant enzymes with special reference to the effects of deprenyl: a possible antioxidant strategy. | 1999 | Mech. Ageing Dev. | pmid:10656538 |
| Choi BM et al. | Cyclic adenosine monophosphate inhibits ursolic acid-induced apoptosis via activation of protein kinase A in human leukaemic HL-60 cells. | 2000 | Pharmacol. Toxicol. | pmid:10728914 |
| Subbaramaiah K et al. | Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. | 2000 | Cancer Res. | pmid:10811116 |
| Saraswat B et al. | Ursolic acid isolated from Eucalyptus tereticornis protects against ethanol toxicity in isolated rat hepatocytes. | 2000 | Phytother Res | pmid:10815008 |
| Min BS et al. | Cytotoxic triterpenes from Crataegus pinnatifida. | 2000 | Arch. Pharm. Res. | pmid:10836742 |
| Syrovets T et al. | Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIalpha. | 2000 | Mol. Pharmacol. | pmid:10860928 |
| Neto CC et al. | Cytotoxic triterpene acids from the Peruvian medicinal plant Polylepis racemosa. | 2000 | Planta Med. | pmid:10909276 |
| Kim YK et al. | Cytotoxic triterpenes from stem bark of Physocarpus intermedius. | 2000 | Planta Med. | pmid:10909277 |
| Kim DK et al. | Apoptotic activity of ursolic acid may correlate with the inhibition of initiation of DNA replication. | 2000 | Int. J. Cancer | pmid:10925354 |
| Choi YH et al. | Induction of apoptosis by ursolic acid through activation of caspases and down-regulation of c-IAPs in human prostate epithelial cells. | 2000 | Int. J. Oncol. | pmid:10938399 |
| Tu P et al. | [Fat soluble constituents of the leaves of Vaccinium bracteatum Thunb]. | 1997 | Zhongguo Zhong Yao Za Zhi | pmid:11038902 |
| Akbarsha MA et al. | Retention of cytoplasmic droplet by rat cauda epididymal spermatozoa after treatment with cytotoxic and xenobiotic agents. | 2000 | J. Reprod. Fertil. | pmid:11058454 |
| Lauthier F et al. | Ursolic acid triggers calcium-dependent apoptosis in human Daudi cells. | 2000 | Anticancer Drugs | pmid:11129737 |
| Kashiwada Y et al. | Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives. | 2000 | J. Nat. Prod. | pmid:11141100 |
| Hollósy F et al. | Cytostatic, cytotoxic and protein tyrosine kinase inhibitory activity of ursolic acid in A431 human tumor cells. | 2000 Nov-Dec | Anticancer Res. | pmid:11205305 |
| Huang H et al. | [Chemical constituents in the stem and leaf of Isodon oresbius]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11243153 |
| Baricevic D et al. | Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid. | 2001 | J Ethnopharmacol | pmid:11297842 |
| Chung YK et al. | Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase. | 2001 | Mol. Cells | pmid:11355692 |
| pmid:11483378 | ||||
| Martin-Aragón S et al. | Pharmacological modification of endogenous antioxidant enzymes by ursolic acid on tetrachloride-induced liver damage in rats and primary cultures of rat hepatocytes. | 2001 | Exp. Toxicol. Pathol. | pmid:11484840 |
| Upadhyay RK et al. | Eclalbatin, a triterpene saponin from Eclipta alba. | 2001 | J Asian Nat Prod Res | pmid:11491397 |
| Rios MY et al. | Sterols, triterpenes and biflavonoids of Viburnum jucundum and cytotoxic activity of ursolic acid. | 2001 | Planta Med. | pmid:11582553 |
| Yarosh DB et al. | Liposomal ursolic acid (merotaine) increases ceramides and collagen in human skin. | 2000 | Horm. Res. | pmid:11595826 |
| Zhou F et al. | [Chemical constituents of the stem and root of Syzygium buxifolium Hook. Et Arn]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11596235 |
| Ding H et al. | [Quantitative determination of ursolic acid in Herba cynomorii by ultraviolet spectrophotometry]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11596256 |
| Zheng X et al. | [Chemical studies on Pyrrosia gralla (Gies.) Ching]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11596269 |
| Martinet A et al. | NMR and LC-MSn characterisation of two minor saponins from Ilex paraguariensis. | 2001 Jan-Feb | Phytochem Anal | pmid:11704961 |
| Novotný L et al. | Ursolic acid: an anti-tumorigenic and chemopreventive activity. Minireview. | 2001 | Neoplasma | pmid:11712672 |
| Lee I et al. | Ursolic acid-induced changes in tumor growth, O2 consumption, and tumor interstitial fluid pressure. | 2001 Jul-Aug | Anticancer Res. | pmid:11724362 |
| Cantrell CL et al. | Antimycobacterial plant terpenoids. | 2001 | Planta Med. | pmid:11731906 |
| You HJ et al. | Ursolic acid enhances nitric oxide and tumor necrosis factor-alpha production via nuclear factor-kappaB activation in the resting macrophages. | 2001 | FEBS Lett. | pmid:11741581 |
| Huang J et al. | [Experimental study on apoptosis induced by ursolic acid isolated from asparagus in HL-60 cells]. | 1999 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11783246 |
| Ismaili H et al. | Topical anti-inflammatory activity of Thymus willdenowii. | 2001 | J. Pharm. Pharmacol. | pmid:11804395 |
| Sang S et al. | New prenylated benzoic acid and other constituents from almond hulls (Prunus amygdalus Batsch). | 2002 | J. Agric. Food Chem. | pmid:11804537 |
| pmid:11830140 | ||||
| Ahumada C et al. | Influence of the parasite Viscum cruciatum Sieber on the chemical constituents of Crataegus monogyna Jacq. | 2001 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:11837662 |
| Hollósy F et al. | Activation of caspase-3 protease during the process of ursolic acid and its derivative-induced apoptosis. | 2001 Sep-Oct | Anticancer Res. | pmid:11848513 |
| pmid:11853742 | ||||
| Xiang W et al. | Constituents of Gnetum montanum. | 2002 | Fitoterapia | pmid:11864762 |
| Both DM et al. | Liposome-encapsulated ursolic acid increases ceramides and collagen in human skin cells. | 2002 | Arch. Dermatol. Res. | pmid:11876525 |
| Heo HJ et al. | Ursolic acid of Origanum majorana L. reduces Abeta-induced oxidative injury. | 2002 | Mol. Cells | pmid:11911474 |
| Pathak A et al. | Synthesis of combinatorial libraries based on terpenoid scaffolds. | 2002 | Comb. Chem. High Throughput Screen. | pmid:11966432 |
| Jeon BW et al. | Phosphoinositide 3-OH kinase/protein kinase B inhibits apoptotic cell death induced by reactive oxygen species in Saccharomyces cerevisiae. | 2002 | J. Biochem. | pmid:11983076 |
| pmid:11983195 | ||||
| Dzhambazov B et al. | In vitro screening for antitumour activity of Clinopodium vulgare L. (Lamiaceae) extracts. | 2002 | Biol. Pharm. Bull. | pmid:11995932 |
| Li J et al. | Effects of ursolic acid and oleanolic acid on human colon carcinoma cell line HCT15. | 2002 | World J. Gastroenterol. | pmid:12046077 |
| Chiang LC et al. | Antiviral activity of Plantago major extracts and related compounds in vitro. | 2002 | Antiviral Res. | pmid:12076751 |
| Shahat AA et al. | Antiviral and antioxidant activity of flavonoids and proanthocyanidins from Crataegus sinaica. | 2002 | Planta Med. | pmid:12094299 |
| pmid:12135095 | ||||
| Lee S et al. | Phytochemical constituents from the fruits of Acanthopanax sessiliflorus. | 2002 | Arch. Pharm. Res. | pmid:12135097 |
| Ismaili H et al. | Topical anti-inflammatory activity of extracts and compounds from Thymus broussonettii. | 2002 | J. Pharm. Pharmacol. | pmid:12195830 |
| WolbiÅ› M et al. | Triterpenes and sterols in the flowers and leaves of Prunus spinosa L. (Rosaceae). | 2001 Nov-Dec | Acta Pol Pharm | pmid:12197619 |
| Wen D et al. | [Studies on chemical constituents of Ilex Merr]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12205946 |
| pmid:12242000 | ||||
| Jiang B et al. | Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata. | 2002 | Planta Med. | pmid:12391557 |
| pmid:12391559 | ||||
| Lee S et al. | Sessiline, a new nitrogenous compound from the fruits of Acanthopanax sessiliflorus. | 2002 | Planta Med. | pmid:12391563 |
| Abe F et al. | Ursolic acid as a trypanocidal constituent in rosemary. | 2002 | Biol. Pharm. Bull. | pmid:12419966 |
| Wang Q et al. | Extract and identify ingredient from Ligustrum Lucidum Ait and study its effect to periodontal pathogen. | 2002 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:12425858 |
| pmid:12433200 | ||||
| Huss U et al. | Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. | 2002 | J. Nat. Prod. | pmid:12444669 |
| pmid:12453510 | ||||
| Pires VS et al. | Triterpenes and saponins from Ilex psammophila. | 2002 | Nat Prod Lett | pmid:12462345 |
| pmid:12482456 | ||||
| Goun E et al. | Antithrombin activity of some constituents from Origanum vulgare. | 2002 | Fitoterapia | pmid:12490231 |
| Andrikopoulos NK et al. | Inhibitory activity of minor polyphenolic and nonpolyphenolic constituents of olive oil against in vitro low-density lipoprotein oxidation. | 2002 | J Med Food | pmid:12511107 |
| Xu XZ and Tian X | [Studies on chemical components of Gentiana tizuensis Franch. (I)]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12512438 |
| Flores-Sánchez IJ et al. | Biosynthesis of sterols and triterpenes in cell suspension cultures of Uncaria tomentosa. | 2002 | Plant Cell Physiol. | pmid:12514247 |
| Yang J et al. | [Studies on constituents in Uncaria macrophylla Wall]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12515211 |
| Wu ZJ | [Lipid chemical constituents of Salvia sochifolia C. Y. Wu]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12525052 |
| Wen ZM and Xu LX | [Isolation and elucidation of chemical constituents of Shandanshaoyao Decoction(I)]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12528509 |
| pmid:12576208 | ||||
| Chandramu C et al. | Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L. | 2003 | Phytother Res | pmid:12601674 |
| Zhang HJ et al. | Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea. | 2003 | J. Nat. Prod. | pmid:12608862 |
| Tapondjou LA et al. | In vivo anti-nociceptive and anti-inflammatory effect of the two triterpenes, ursolic acid and 23-hydroxyursolic acid, from Cussonia bancoensis. | 2003 | Arch. Pharm. Res. | pmid:12643591 |
| Mallavadhani UV et al. | Antifeedant activity of some pentacyclic triterpene acids and their fatty acid ester analogues. | 2003 | J. Agric. Food Chem. | pmid:12643657 |
| Somova LI et al. | Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves. | 2003 | J Ethnopharmacol | pmid:12648829 |
| Hossain CF et al. | Genipatriol, a new cycloartane triterpene from Genipa spruceana. | 2003 | J. Nat. Prod. | pmid:12662099 |
| Prakash Chaturvedula VS et al. | New cytotoxic lupane triterpenoids from the twigs of Coussarea paniculata. | 2003 | J. Nat. Prod. | pmid:12662105 |
| Novotny L et al. | Development of LC-MS method for determination of ursolic acid: application to the analysis of ursolic acid in Staphylea holocarpa Hemsl. | 2003 | J Pharm Biomed Anal | pmid:12684108 |
| pmid:12709899 | ||||
| pmid:12709904 | ||||
| Chiang LC et al. | Antileukemic activity of selected natural products in Taiwan. | 2003 | Am. J. Chin. Med. | pmid:12723753 |
| Somova LO et al. | Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension. | 2003 | Phytomedicine | pmid:12725563 |
| pmid:12748987 | ||||
| Li Y et al. | Sterol and triterpenoid constituents of Verbena littoralis with NGF-potentiating activity. | 2003 | J. Nat. Prod. | pmid:12762811 |
| Liu CH and Liu Y | [Determination of ursolic acid in herba of Verbena officinalis by HPLC]. | 2002 | Zhongguo Zhong Yao Za Zhi | pmid:12776531 |
| Harmand PO et al. | Ursolic acid induces apoptosis through caspase-3 activation and cell cycle arrest in HaCat cells. | 2003 | Int. J. Oncol. | pmid:12792782 |
| Baglin I et al. | A review of natural and modified betulinic, ursolic and echinocystic acid derivatives as potential antitumor and anti-HIV agents. | 2003 | Mini Rev Med Chem | pmid:12871156 |
| Bolta Z et al. | Biomass segregation in sage cell suspension culture. | 2003 | Biotechnol. Lett. | pmid:12882308 |
| Chiang LC et al. | Immunomodulatory activities of flavonoids, monoterpenoids, triterpenoids, iridoid glycosides and phenolic compounds of Plantago species. | 2003 | Planta Med. | pmid:12898413 |
| Yoshimura H et al. | In vitro TGF-beta1 antagonistic activity of ursolic and oleanolic acids isolated from Clerodendranthus spicatus. | 2003 | Planta Med. | pmid:12898427 |
| pmid:12907261 |