MeSH term | MeSH ID | Detail |
---|---|---|
Dermatitis, Contact | D003877 | 59 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with ursolic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Dermatitis, Contact | D003877 | 59 associated lipids |
Tongue Neoplasms | D014062 | 15 associated lipids |
Carcinogenesis | D063646 | 3 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Paik KJ et al. | Induction of differentiation of the cultured rat mammary epithelial cells by triterpene acids. | 1998 | Arch. Pharm. Res. | pmid:9875466 |
Kim DW et al. | Growth inhibitory activities of kalopanaxsaponins A and I against human pathogenic fungi. | 1998 | Arch. Pharm. Res. | pmid:9868538 |
Ringbom T et al. | Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis. | 1998 | J. Nat. Prod. | pmid:9784154 |
Kashiwada Y et al. | Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids. | 1998 | J. Nat. Prod. | pmid:9748372 |
Farina C et al. | Synthesis and anti-ulcer activity of new derivatives of glycyrrhetic, oleanolic and ursolic acids. | 1998 | Farmaco | pmid:9543723 |
Cha HJ et al. | Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells. | 1998 | Oncogene | pmid:9488041 |
Suh N et al. | Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages. | 1998 | Cancer Res. | pmid:9485026 |
Baek JH et al. | Intracellular Ca2+ release mediates ursolic acid-induced apoptosis in human leukemic HL-60 cells. | 1997 | Int. J. Cancer | pmid:9398053 |
Máñez S et al. | Effect of selected triterpenoids on chronic dermal inflammation. | 1997 | Eur. J. Pharmacol. | pmid:9346335 |
Hsu HY et al. | Effects of oleanolic acid and ursolic acid on inhibiting tumor growth and enhancing the recovery of hematopoietic system postirradiation in mice. | 1997 | Cancer Lett. | pmid:9022122 |
Quéré L et al. | Triterpenes as potential dimerization inhibitors of HIV-1 protease. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8967903 |
Liu J | Pharmacology of oleanolic acid and ursolic acid. | 1995 | J Ethnopharmacol | pmid:8847885 |
Es-saady D et al. | Inhibitory effect of ursolic acid on B16 proliferation through cell cycle arrest. | 1996 | Cancer Lett. | pmid:8844972 |
Xu HX et al. | Anti-HIV triterpene acids from Geum japonicum. | 1996 | J. Nat. Prod. | pmid:8759159 |
Guo Y et al. | [Quantitative determination of ursolic acid in folium Ilicis cornutae (gouguye) gathered in different and periods]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8679072 |
Singletary K et al. | Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. | 1996 | Cancer Lett. | pmid:8640744 |
Cha HJ et al. | Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells. | 1996 | Cancer Res. | pmid:8625299 |
Tan GT et al. | Natural-product inhibitors of human DNA ligase I. | 1996 | Biochem. J. | pmid:8615799 |
Es-Saady D et al. | MCF-7 cell cycle arrested at G1 through ursolic acid, and increased reduction of tetrazolium salts. | 1996 Jan-Feb | Anticancer Res. | pmid:8615658 |
Huang MT et al. | Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. | 1994 | Cancer Res. | pmid:8306331 |
Richards RM et al. | Antibacterial activity of compounds from Rubus pinfaensis. | 1994 | Planta Med. | pmid:7997480 |
Takechi M and Tanaka Y | Structure-activity relationships of synthetic methyl ursolate glycosides. | 1993 | Phytochemistry | pmid:7764145 |
Niikawa M et al. | Isolation of substances from glossy privet (Ligustrum lucidum Ait.) inhibiting the mutagenicity of benzo[a]pyrene in bacteria. | 1993 | Mutat. Res. | pmid:7690454 |
Sohn KH et al. | Anti-angiogenic activity of triterpene acids. | 1995 | Cancer Lett. | pmid:7543366 |
Parfent'eva EP et al. | [Effect of ursolic acid on lipid metabolism indices in experimental atherosclerosis]. | 1980 Mar-Apr | Vopr. Med. Khim. | pmid:7456347 |
Tokuda H et al. | Inhibitory effects of ursolic and oleanolic acid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. | 1986 | Cancer Lett. | pmid:3802058 |
Ma XH et al. | [Studies on the preventive and therapeutic effects of ursolic acid (UA) on acute hepatic injury in rats]. | 1986 | Yao Xue Xue Bao | pmid:3776541 |
Schun Y and Cordell GA | Cytotoxic steroids of Gelsemium sempervirens. | 1987 Mar-Apr | J. Nat. Prod. | pmid:3655795 |
Chung MI et al. | Studies on the constituents of Formosan gentianaceous plants. Part VII. Constituents of Swertia randaiensis Hayata and pharmacological activity of norswertianolin. | 1986 | Gaoxiong Yi Xue Ke Xue Za Zhi | pmid:3482877 |
Lee KH et al. | The cytotoxic principles of Prunella vulgaris, Psychotria serpens, and Hyptis capitata: ursolic acid and related derivatives. | 1988 | Planta Med. | pmid:3222376 |
Ohigashi H et al. | Search for possible antitumor promoters by inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation; ursolic acid and oleanolic acid from an anti-inflammatory Chinese medicinal plant, Glechoma hederaceae L. | 1986 | Cancer Lett. | pmid:3006912 |
Zhao QC | [Chemical constituents of Rabdosia japonica var. glaucocalyx]. | 1987 | Zhong Yao Tong Bao | pmid:2964305 |
Kozai K et al. | Inhibition of glucosyltransferase from Streptococcus mutans by oleanolic acid and ursolic acid. | 1987 | Caries Res. | pmid:2949844 |
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Sifaoui I et al. | Programmed cell death in Acanthamoeba castellanii Neff induced by several molecules present in olive leaf extracts. | 2017 | PLoS ONE | pmid:28859105 |
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Sohn EJ et al. | Blockage of epithelial to mesenchymal transition and upregulation of let 7b are critically involved in ursolic acid induced apoptosis in malignant mesothelioma cell. | 2016 | Int. J. Biol. Sci. | pmid:28090191 |
Zhang CY et al. | Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets. | 2016 | World J. Gastroenterol. | pmid:28082803 |
Hamza M et al. | In vitro effectiveness of triterpenoids and their synergistic effect with antibiotics against Staphylococcus aureus strains. | 2016 Nov-Dec | Indian J Pharmacol | pmid:28066112 |
Srivedavyasasri R et al. | Phytochemical and biological evaluation of Salvia apiana. | 2017 | Nat. Prod. Res. | pmid:28025900 |
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Jesus JA et al. | Therapeutic effect of ursolic acid in experimental visceral leishmaniasis. | 2017 | Int J Parasitol Drugs Drug Resist | pmid:27984757 |
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Wu CC et al. | Combined Use of Zoledronic Acid Augments Ursolic Acid-Induced Apoptosis in Human Osteosarcoma Cells through Enhanced Oxidative Stress and Autophagy. | 2016 | Molecules | pmid:27916903 |
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Wu S et al. | Ursolic acid sensitizes cisplatin-resistant HepG2/DDP cells to cisplatin via inhibiting Nrf2/ARE pathway. | 2016 | Drug Des Devel Ther | pmid:27822011 |
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