| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tan J et al. | [Ursolic acid induces apoptosis in colon cancer HT-29 cells]. | 2006 | Zhonghua Zhong Liu Za Zhi | pmid:16750011 |
| Wang Q et al. | Extract and identify ingredient from Ligustrum Lucidum Ait and study its effect to periodontal pathogen. | 2002 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:12425858 |
| Shen YM et al. | [Effect of ursolic acid on proliferation and apoptosis of hepatic stellate cells in vitro]. | 2008 | Zhonghua Gan Zang Bing Za Zhi | pmid:18423155 |
| Jia YY et al. | [Comparative analysis of ursolic acid in Crataegus pinnatifida Bge. var. major N.E. Br. before and after processing]. | 1989 | Zhongguo Zhong Yao Za Zhi | pmid:2508668 |
| Guo Y et al. | [Quantitative determination of ursolic acid in folium Ilicis cornutae (gouguye) gathered in different and periods]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8679072 |
| Huang H et al. | [Chemical constituents in the stem and leaf of Isodon oresbius]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11243153 |
| Zhou F et al. | [Chemical constituents of the stem and root of Syzygium buxifolium Hook. Et Arn]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11596235 |
| Ding H et al. | [Quantitative determination of ursolic acid in Herba cynomorii by ultraviolet spectrophotometry]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11596256 |
| Zheng X et al. | [Chemical studies on Pyrrosia gralla (Gies.) Ching]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11596269 |
| Wen D et al. | [Studies on chemical constituents of Ilex Merr]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12205946 |
| Liu CH and Liu Y | [Determination of ursolic acid in herba of Verbena officinalis by HPLC]. | 2002 | Zhongguo Zhong Yao Za Zhi | pmid:12776531 |
| Wen ZM and Xu LX | [Isolation and elucidation of chemical constituents of Shandanshaoyao Decoction(I)]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12528509 |
| Xu XZ and Tian X | [Studies on chemical components of Gentiana tizuensis Franch. (I)]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12512438 |
| Yang J et al. | [Studies on constituents in Uncaria macrophylla Wall]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12515211 |
| Wu ZJ | [Lipid chemical constituents of Salvia sochifolia C. Y. Wu]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12525052 |
| Tu P et al. | [Fat soluble constituents of the leaves of Vaccinium bracteatum Thunb]. | 1997 | Zhongguo Zhong Yao Za Zhi | pmid:11038902 |
| Yao Z et al. | [Triterpenoids from leaves of Ilex cornuta]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19639785 |
| Chen Y et al. | [Preparation and transdermal diffusion of ursolic acid ethosomes]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21809568 |
| Li YL et al. | [Studies on chemical constituents from Serissa serissoides]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17583202 |
| Sun M et al. | [Experimental study on treating hyperlipidemic fatty liver with Taizhi'an capsule]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17583205 |
| Guo J et al. | [Studies on chemical constituents from the stems of Schisandra sphaerandra]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015287 |
| Zhang GP et al. | [Effect of ursolic acid on caspase-3 and PARP expression of human MCF-7 cells]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16570804 |
| Song LL et al. | [Determination of ursolic acid of Liuwei Dihuangwan simulation samples by NIR]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17165581 |
| Wang MY et al. | [Studies on the chemical constituents from stem of Chirita longgangensis var. Hongyao]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16706021 |
| Wang B et al. | [Studies on the chemical constituents from herb of Rhodobryum roseum]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16124603 |
| Yan H et al. | [Optimization of biotransformation of ursolic acid by alternaria longipes]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23189734 |
| Xue YM et al. | [Determination of ursolic acid of Sambucus adnata]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:24010309 |
| Huang J et al. | [Experimental study on apoptosis induced by ursolic acid isolated from asparagus in HL-60 cells]. | 1999 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11783246 |
| Zhang XH and Zhu X | [The newest progress of the pharmacology of prunol]. | 2011 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:22013813 |
| Yang JJ et al. | [Study on the effect of ursolic acid (UA) on the myocardial fibrosis of experimental diabetic mice]. | 2013 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:24175562 |
| Wu B et al. | [Apoptosis of jurkat cells induced by ursolic acid and its mechanism]. | 2010 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:20137120 |
| Jia WW et al. | [Inducing effects of ursolic acid on Jurkat cell apoptosis and its mechanisms]. | 2014 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:24762997 |
| Huang W et al. | [Study on anti-invasive effect and apoptosis induction of pentacyclic triterpenoid in human lung cancer cells]. | 2003 | Zhongguo Fei Ai Za Zhi | pmid:21272475 |
| Zhao QC | [Chemical constituents of Rabdosia japonica var. glaucocalyx]. | 1987 | Zhong Yao Tong Bao | pmid:2964305 |
| Xiong X et al. | [Effects of ursolic acid on liver-protection and bile secretion]. | 2003 | Zhong Yao Cai | pmid:14649204 |
| Zhang HP and Tao L | [Studies on the chemical constituents of Buddleja albiflora (II)]. | 2010 | Zhong Yao Cai | pmid:21049618 |
| Yu XH et al. | [Study on ursolic acid extraction rate by ultramicro smashing and conventional smashing from leaves of Paulownia fortunei]. | 2008 | Zhong Yao Cai | pmid:19230417 |
| Duan WD et al. | [Chemical constituents from the flower of Paulownia fortunei( seem. ) Hemsl]. | 2007 | Zhong Yao Cai | pmid:17571764 |
| Huang L et al. | [Studies on chemical constituents of Patrinia villosa]. | 2007 | Zhong Yao Cai | pmid:17674792 |
| Tang LY et al. | [Studies on chemical constituents of Sambucus adnata]. | 2007 | Zhong Yao Cai | pmid:17727059 |
| Lin YL et al. | [Study on fingerprint spectrum of loquat leaf by HPLC]. | 2007 | Zhong Yao Cai | pmid:18300490 |
| Zhang W et al. | [Experimental study on MCF-7 cell apoptosis induced by ursolic acid]. | 2005 | Zhong Yao Cai | pmid:16104504 |
| Yuan G and Yi Y | [Studies on chemical constituents of the roots of Salacia hainanensis]. | 2005 | Zhong Yao Cai | pmid:15934239 |
| Qi X et al. | [Study on chemical constituents from stem of Mallotus apelta]. | 2005 | Zhong Yao Cai | pmid:16447866 |
| Liu Z et al. | [Study on the extracting of ursolic acid by uniform design]. | 2005 | Zhong Yao Cai | pmid:16131040 |
| Zhang YP et al. | [Studies on the chemical constituents of Salvia miltiorrhiz of Lijiang]. | 2008 | Zhong Yao Cai | pmid:18619267 |
| Zhang HE et al. | [Optimization of supercritical fluid extraction of ursolic acid from follum eriobotryae by response surface methodology]. | 2011 | Zhong Yao Cai | pmid:22372151 |
| Liu CS et al. | [Chemical constituents from Gentiana striata]. | 2012 | Zhong Yao Cai | pmid:23236825 |
| Zhou BJ et al. | [The quality standard study on Hugan qingzhi tablets]. | 2012 | Zhong Yao Cai | pmid:23019914 |
| Li D et al. | [Effects of ursolic acid on c-Cbl-associated protein expression in 3T3-L1 adipocytes with insulin resistance]. | 2012 | Zhong Xi Yi Jie He Xue Bao | pmid:22883405 |