| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wojnicz D et al. | Anti-enterococcal activities of pentacyclic triterpenes. | 2017 May-Jun | Adv Clin Exp Med | pmid:28791824 |
| Bacanlı M et al. | The antioxidant, cytotoxic, and antigenotoxic effects of galangin, puerarin, and ursolic acid in mammalian cells. | 2017 | Drug Chem Toxicol | pmid:27461151 |
| Srivedavyasasri R et al. | Phytochemical and biological evaluation of Salvia apiana. | 2017 | Nat. Prod. Res. | pmid:28025900 |
| González-Chávez MM et al. | Anti-inflammatory activity of standardized dichloromethane extract of Salvia connivens on macrophages stimulated by LPS. | 2017 | Pharm Biol | pmid:28347190 |
| Sifaoui I et al. | Programmed cell death in Acanthamoeba castellanii Neff induced by several molecules present in olive leaf extracts. | 2017 | PLoS ONE | pmid:28859105 |
| Ray C et al. | Killing of Serratia marcescens biofilms with chloramphenicol. | 2017 | Ann. Clin. Microbiol. Antimicrob. | pmid:28356113 |
| Jesus JA et al. | Therapeutic effect of ursolic acid in experimental visceral leishmaniasis. | 2017 | Int J Parasitol Drugs Drug Resist | pmid:27984757 |
| Hamza M et al. | In vitro effectiveness of triterpenoids and their synergistic effect with antibiotics against Staphylococcus aureus strains. | 2016 Nov-Dec | Indian J Pharmacol | pmid:28066112 |
| Gao YS et al. | Inhibitory effect of ursolic acid and oleanolic acid from Eriobotrya fragrans on A549 cell viability in vivo. | 2016 | Genet. Mol. Res. | pmid:27323036 |
| Hassan L et al. | Resistance to ursolic acid-induced apoptosis through involvement of melanogenesis and COX-2/PGE2 pathways in human M4Beu melanoma cancer cells. | 2016 | Exp. Cell Res. | pmid:27262506 |
| Blanchaert B et al. | Bioanalytical LC/MS study of potential bacterial transglycosylation inhibitors. | 2016 | J Pharm Biomed Anal | pmid:26782294 |
| Miao J et al. | Chemical Composition and Bioactivities of Two Common Chaenomeles Fruits in China: Chaenomeles speciosa and Chaenomeles sinensis. | 2016 | J. Food Sci. | pmid:27384225 |
| Sohn EJ et al. | Blockage of epithelial to mesenchymal transition and upregulation of let 7b are critically involved in ursolic acid induced apoptosis in malignant mesothelioma cell. | 2016 | Int. J. Biol. Sci. | pmid:28090191 |
| Zhang CY et al. | Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets. | 2016 | World J. Gastroenterol. | pmid:28082803 |
| Wu CC et al. | Combined Use of Zoledronic Acid Augments Ursolic Acid-Induced Apoptosis in Human Osteosarcoma Cells through Enhanced Oxidative Stress and Autophagy. | 2016 | Molecules | pmid:27916903 |
| Wu S et al. | Ursolic acid sensitizes cisplatin-resistant HepG2/DDP cells to cisplatin via inhibiting Nrf2/ARE pathway. | 2016 | Drug Des Devel Ther | pmid:27822011 |
| Shan JZ et al. | Ursolic acid sensitized colon cancer cells to chemotherapy under hypoxia by inhibiting MDR1 through HIF-1α. | 2016 | J Zhejiang Univ Sci B | pmid:27604859 |
| Mendes VIS et al. | Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells. | 2016 | Eur J Med Chem | pmid:27484517 |
| Shan J et al. | Ursolic acid synergistically enhances the therapeutic effects of oxaliplatin in colorectal cancer. | 2016 | Protein Cell | pmid:27472952 |
| Mishra T et al. | Isolation, Characterization and Anticancer Potential of Cytotoxic Triterpenes from Betula utilis Bark. | 2016 | PLoS ONE | pmid:27453990 |
| Yealland G et al. | Rescue of mitochondrial function in parkin-mutant fibroblasts using drug loaded PMPC-PDPA polymersomes and tubular polymersomes. | 2016 | Neurosci. Lett. | pmid:27412236 |
| Wang CM et al. | The Pleiotropic Antibacterial Mechanisms of Ursolic Acid against Methicillin-Resistant Staphylococcus aureus (MRSA). | 2016 | Molecules | pmid:27399657 |
| Liang W et al. | Ursolic acid attenuates beta-amyloid-induced memory impairment in mice. | 2016 | Arq Neuropsiquiatr | pmid:27332074 |
| Wang Y et al. | Ursolic acid reduces the metalloprotease/anti-metalloprotease imbalance in cerebral ischemia and reperfusion injury. | 2016 | Drug Des Devel Ther | pmid:27274199 |
| Villar VH et al. | Down-Regulation of AKT Signalling by Ursolic Acid Induces Intrinsic Apoptosis and Sensitization to Doxorubicin in Soft Tissue Sarcoma. | 2016 | PLoS ONE | pmid:27219337 |
| Chuang WL et al. | The Apoptotic Effect of Ursolic Acid on SK-Hep-1 Cells is Regulated by the PI3K/Akt, p38 and JNK MAPK Signaling Pathways. | 2016 | Molecules | pmid:27104510 |
| Leng S et al. | Ursolic acid enhances macrophage autophagy and attenuates atherogenesis. | 2016 | J. Lipid Res. | pmid:27063951 |
| Yang LJ et al. | Inter-regulation of IGFBP1 and FOXO3a unveils novel mechanism in ursolic acid-inhibited growth of hepatocellular carcinoma cells. | 2016 | J. Exp. Clin. Cancer Res. | pmid:27036874 |
| Feuillolay C et al. | A Myrtus communis extract enriched in myrtucummulones and ursolic acid reduces resistance of Propionibacterium acnes biofilms to antibiotics used in acne vulgaris. | 2016 | Phytomedicine | pmid:26969384 |
| Abdullah NH et al. | Hyaluronidase Inhibitory Activity of Pentacylic Triterpenoids from Prismatomeris tetrandra (Roxb.) K. Schum: Isolation, Synthesis and QSAR Study. | 2016 | Int J Mol Sci | pmid:26907251 |
| Luna-Vázquez FJ et al. | Role of Nitric Oxide and Hydrogen Sulfide in the Vasodilator Effect of Ursolic Acid and Uvaol from Black Cherry Prunus serotina Fruits. | 2016 | Molecules | pmid:26771591 |
| Zhang X et al. | p21 induction plays a dual role in anti-cancer activity of ursolic acid. | 2016 | Exp. Biol. Med. (Maywood) | pmid:26582056 |
| Ding YJ et al. | Nephroprotective role of resveratrol and ursolic Acid in aristolochic Acid intoxicated zebrafish. | 2015 | Toxins (Basel) | pmid:25590276 |
| Podder B et al. | Ursolic Acid Activates Intracellular Killing Effect of Macrophages During Mycobacterium tuberculosis Infection. | 2015 | J. Microbiol. Biotechnol. | pmid:25406534 |
| Castro AJ et al. | The mechanism of action of ursolic acid as insulin secretagogue and insulinomimetic is mediated by cross-talk between calcium and kinases to regulate glucose balance. | 2015 | Biochim. Biophys. Acta | pmid:25312987 |
| Junco JJ et al. | Ursolic acid and resveratrol synergize with chloroquine to reduce melanoma cell viability. | 2015 | Melanoma Res. | pmid:25647735 |
| Broniatowski M et al. | Studies of the interactions of ursane-type bioactive terpenes with the model of Escherichia coli inner membrane-Langmuir monolayer approach. | 2015 | Biochim. Biophys. Acta | pmid:25450351 |
| Gao R et al. | Simultaneous determination of oleanolic acid, ursolic acid, quercetin and apigenin in Swertia mussotii Franch by capillary zone electrophoresis with running buffer modifier. | 2015 | Biomed. Chromatogr. | pmid:25042239 |
| Yamamoto ES et al. | The Effect of Ursolic Acid on Leishmania (Leishmania) amazonensis Is Related to Programed Cell Death and Presents Therapeutic Potential in Experimental Cutaneous Leishmaniasis. | 2015 | PLoS ONE | pmid:26674781 |
| López-GarcÃa S et al. | Macrophage Activation by Ursolic and Oleanolic Acids during Mycobacterial Infection. | 2015 | Molecules | pmid:26287131 |
| Park SN et al. | Oleanolic acid and ursolic acid inhibit peptidoglycan biosynthesis in Streptococcus mutans UA159. | 2015 | Braz. J. Microbiol. | pmid:26273281 |
| Cho J et al. | Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate. | 2015 | Cancer Prev Res (Phila) | pmid:26100520 |
| Flores-Bocanegra L et al. | α-Glucosidase Inhibitors from Vauquelinia corymbosa. | 2015 | Molecules | pmid:26307962 |
| Cho J et al. | Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. | 2015 | Oncotarget | pmid:26513295 |
| Woźniak Šet al. | Ursolic Acid--A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities. | 2015 | Molecules | pmid:26610440 |
| Kim SH et al. | Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells. | 2015 | Sci Rep | pmid:26412148 |
| Wu P et al. | Synthesis and Evaluation of Novel Triterpene Analogues of Ursolic Acid as Potential Antidiabetic Agent. | 2015 | PLoS ONE | pmid:26406581 |
| Wu J et al. | Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells. | 2015 | J. Exp. Clin. Cancer Res. | pmid:26362062 |
| He W et al. | A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver. | 2015 | Drug Des Devel Ther | pmid:26347199 |
| Ebert SM et al. | Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. | 2015 | J. Biol. Chem. | pmid:26338703 |