| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu YW et al. | Bioactive diterpenes from Callicarpa longissima. | 2012 | J. Nat. Prod. | pmid:22429052 |
| Shanmugam MK et al. | Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways. | 2012 | PLoS ONE | pmid:22427843 |
| Shen D et al. | A rapid LC/MS/MS method for the analysis of nonvolatile antiinflammatory agents from Mentha spp. | 2011 | J. Food Sci. | pmid:22417488 |
| Figueiredo VC and Nader GA | Ursolic acid directly promotes protein accretion in myotubes but does not affect myoblast proliferation. | 2012 | Cell Biochem. Funct. | pmid:22411156 |
| Ni Q et al. | Seasonal variations of the antioxidant composition in ground bamboo Sasa argenteastriatus leaves. | 2012 | Int J Mol Sci | pmid:22408451 |
| Youn K and Jun M | Inhibitory effects of key compounds isolated from Corni fructus on BACE1 Activity. | 2012 | Phytother Res | pmid:22407769 |
| Gao J et al. | Facile synthesis of triterpenoid saponins bearing β-Glu/Gal-(1→3)-β-GluA methyl ester and their cytotoxic activities. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22406153 |
| Mullié C et al. | Differences in anti-malarial activity of 4-aminoalcohol quinoline enantiomers and investigation of the presumed underlying mechanism of action. | 2012 | Malar. J. | pmid:22401346 |
| Zheng QY et al. | Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22387548 |
| Murakami A and Ohnishi K | Target molecules of food phytochemicals: food science bound for the next dimension. | 2012 | Food Funct | pmid:22377900 |
| Zhang HE et al. | [Optimization of supercritical fluid extraction of ursolic acid from follum eriobotryae by response surface methodology]. | 2011 | Zhong Yao Cai | pmid:22372151 |
| Bai KK et al. | Synthesis and evaluation of ursolic acid derivatives as potent cytotoxic agents. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22370266 |
| Liu Y et al. | Study on the noncovalent interactions of saikosaponins and cytochrome c by electrospray ionization mass spectrometry. | 2012 | Rapid Commun. Mass Spectrom. | pmid:22368050 |
| Checker R et al. | Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-κB, AP-1 and NF-AT. | 2012 | PLoS ONE | pmid:22363615 |
| Pareek TK et al. | Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis. | 2011 | Sci Rep | pmid:22355716 |
| Wang J et al. | Ursolic acid inhibits proliferation and induces apoptosis in human glioblastoma cell lines U251 by suppressing TGF-β1/miR-21/PDCD4 pathway. | 2012 | Basic Clin. Pharmacol. Toxicol. | pmid:22353043 |
| Kurek A et al. | Modulation of antibiotic resistance in bacterial pathogens by oleanolic acid and ursolic acid. | 2012 | Phytomedicine | pmid:22341643 |
| Lee EH et al. | Inhibitory effect of ursolic acid derivatives on recombinant human aldose reductase. | 2011 Sep-Oct | Bioorg. Khim. | pmid:22332359 |
| Zhang YH et al. | A new inositol derivative from Prenanthes macrophylla. | 2012 | J Asian Nat Prod Res | pmid:22296160 |
| Masuda M et al. | Matrix metalloproteinase-1 inhibitory activities of Morinda citrifolia seed extract and its constituents in UVA-irradiated human dermal fibroblasts. | 2012 | Biol. Pharm. Bull. | pmid:22293351 |
| Radhiga T et al. | Effect of ursolic acid treatment on apoptosis and DNA damage in isoproterenol-induced myocardial infarction. | 2012 | Biochimie | pmid:22289617 |
| Beg S et al. | Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives. | 2011 | Pharmacogn Rev | pmid:22279370 |
| Kalani K et al. | Pharmacophore, QSAR, and ADME based semisynthesis and in vitro evaluation of ursolic acid analogs for anticancer activity. | 2012 | J Mol Model | pmid:22271093 |
| Shin IS et al. | Ursolic acid reduces prostate size and dihydrotestosterone level in a rat model of benign prostatic hyperplasia. | 2012 | Food Chem. Toxicol. | pmid:22266360 |
| Aslan M et al. | Effect of Gentiana olivieri on experimental epilepsy models. | 2011 | Pharmacogn Mag | pmid:22262939 |
| Matsumoto RL et al. | Effects of maté tea intake on ex vivo LDL peroxidation induced by three different pathways. | 2009 | Nutrients | pmid:22253965 |
| Wang J et al. | 55-week treatment of mice with the unani and ayurvedic medicine pomegranate flower ameliorates ageing-associated insulin resistance and skin abnormalities. | 2012 | Evid Based Complement Alternat Med | pmid:22253646 |
| Wójciak-Kosior M et al. | The effect of ursolic and oleanolic acids on human skin fibroblast cells. | 2011 | Folia Histochem. Cytobiol. | pmid:22252762 |
| Feldman M et al. | Cranberry proanthocyanidins inhibit the adherence properties of Candida albicans and cytokine secretion by oral epithelial cells. | 2012 | BMC Complement Altern Med | pmid:22248145 |
| Katsuyama M et al. | Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme. | 2012 | J Clin Biochem Nutr | pmid:22247596 |
| Tang LI et al. | Screening of anti-dengue activity in methanolic extracts of medicinal plants. | 2012 | BMC Complement Altern Med | pmid:22244370 |
| Quave CL et al. | Ellagic acid derivatives from Rubus ulmifolius inhibit Staphylococcus aureus biofilm formation and improve response to antibiotics. | 2012 | PLoS ONE | pmid:22242149 |
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| Koh SJ et al. | Sensitization of ionizing radiation-induced apoptosis by ursolic acid. | 2012 | Free Radic. Res. | pmid:22239065 |
| Baliga MS and Kurian PJ | Ixora coccinea Linn.: traditional uses, phytochemistry and pharmacology. | 2012 | Chin J Integr Med | pmid:22231708 |
| Bonkhoff H | Factors implicated in radiation therapy failure and radiosensitization of prostate cancer. | 2012 | Prostate Cancer | pmid:22229096 |
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| Sun G et al. | A new triterpene from the plant of uncaria macrophylla. | 2012 | Molecules | pmid:22222909 |
| Gu G et al. | Oldenlandia diffusa extracts exert antiproliferative and apoptotic effects on human breast cancer cells through ERα/Sp1-mediated p53 activation. | 2012 | J. Cell. Physiol. | pmid:22213398 |
| Xia EQ et al. | Ultrasound-assisted extraction of oleanolic acid and ursolic acid from Ligustrum lucidum Ait. | 2012 | Ultrason Sonochem | pmid:22197019 |
| Walch SG et al. | Antioxidant Capacity and Polyphenolic Composition as Quality Indicators for Aqueous Infusions of Salvia officinalis L. (sage tea). | 2011 | Front Pharmacol | pmid:22194722 |
| Shin SW et al. | Autophagy inhibition enhances ursolic acid-induced apoptosis in PC3 cells. | 2012 | Biochim. Biophys. Acta | pmid:22178132 |
| Lúcio KA et al. | Oleanolic acid initiates apoptosis in non-small cell lung cancer cell lines and reduces metastasis of a B16F10 melanoma model in vivo. | 2011 | PLoS ONE | pmid:22174843 |
| Yao L et al. | Protective effects of polysaccharides from soybean meal against X-ray radiation induced damage in mouse spleen lymphocytes. | 2011 | Int J Mol Sci | pmid:22174652 |
| Saaby L and Nielsen CH | Triterpene acids from rose hip powder inhibit self-antigen- and LPS-induced cytokine production and CD4⺠T-cell proliferation in human mononuclear cell cultures. | 2012 | Phytother Res | pmid:22170858 |
| Teixeira T et al. | Molluscicidal activity of crude water and hexane extracts of Hypericum species to snails (Radix peregra). | 2012 | Environ. Toxicol. Chem. | pmid:22170085 |
| Arbab AS et al. | MRI to assess chemoprevention in transgenic adenocarcinoma of mouse prostate (TRAMP). | 2011 | BMC Med Imaging | pmid:22165848 |
| Wang X et al. | Antifungal metabolites from the roots of Diospyros virginiana by overpressure layer chromatography. | 2011 | Chem. Biodivers. | pmid:22162171 |
| Rodrigues MR et al. | Antinociceptive and anti-inflammatory potential of extract and isolated compounds from the leaves of Salvia officinalis in mice. | 2012 | J Ethnopharmacol | pmid:22154965 |
| Sung B et al. | Cancer cell signaling pathways targeted by spice-derived nutraceuticals. | 2012 | Nutr Cancer | pmid:22149093 |