| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
Total
3
ursolic acid
Ursolic acid is a lipid of Prenol Lipids (PR) class. Ursolic acid is associated with abnormalities such as Aortic Valve Insufficiency, Marles Greenberg Persaud syndrome, Infection, Arthritis and Dermatitis. The involved functions are known as Transcription, Genetic, Metabolic Inhibition, Cell physiology, Cell Differentiation process and Apoptosis. Ursolic acid often locates in Blood, Bacterial Fimbria, soluble, Extracellular and Microglial. The associated genes with ursolic acid are STAT3 gene, Genes, Reporter, IMPACT gene, ITSN2 gene and casamino acids. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Steroids, cholanic acid and 1-palmitoyl-2-oleoylphosphatidylethanolamine. The related experimental models are Mouse Model, Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of ursolic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ursolic acid?
ursolic acid is suspected in Aortic Valve Insufficiency, Dermatitis, Muscular Atrophy, Bury, Marles Greenberg Persaud syndrome, Obesity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ursolic acid
PubChem Associated disorders and diseases
What pathways are associated with ursolic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ursolic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with ursolic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with ursolic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with ursolic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with ursolic acid?
Mouse Model
Mouse Model are used in the study 'Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.' (Prasad S et al., 2012) and Mouse Model are used in the study 'A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.' (Wilkinson K et al., 2011).
Knock-out
Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Cancer Model
Cancer Model are used in the study 'Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.' (Cho J et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with ursolic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cui HZ et al. | Ursolic acid increases the secretion of atrial natriuretic peptide in isolated perfused beating rabbit atria. | 2011 | Eur. J. Pharmacol. | pmid:21122803 |
| Bankeu JJ et al. | Ceramide and Cerebroside from the stem bark of Ficus mucuso (Moraceae). | 2010 | Chem. Pharm. Bull. | pmid:21139276 |
| Kunwar RM et al. | Traditional herbal medicine in far-west Nepal: a pharmacological appraisal. | 2010 | J Ethnobiol Ethnomed | pmid:21144003 |
| Prasad S et al. | Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK. | 2011 | J. Biol. Chem. | pmid:21156789 |
| pmid:21162002 | ||||
| Wang X et al. | Ursolic acid ameliorates hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells. | 2011 | J. Hepatol. | pmid:21168456 |
| Xia Y et al. | Quantitation of ursolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry and its pharmacokinetic study. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21169069 |
| Szuster-Ciesielska A et al. | Betulin and betulinic acid attenuate ethanol-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS), cytokine (TNF-α, TGF-β) production and by influencing intracellular signaling. | 2011 | Toxicology | pmid:21172400 |
| Lin CC et al. | Antiangiogenic potential of three triterpenic acids in human liver cancer cells. | 2011 | J. Agric. Food Chem. | pmid:21175131 |
| Wu CR et al. | Triterpenoid contents and anti-inflammatory properties of the methanol extracts of ligustrum species leaves. | 2010 | Molecules | pmid:21187813 |
| Ashok P et al. | Antiurolithiatic and antioxidant activity of Mimusops elengi on ethylene glycol-induced urolithiasis in rats. | 2010 | Indian J Pharmacol | pmid:21189910 |
| Wang JS et al. | Ursolic acid induces apoptosis by suppressing the expression of FoxM1 in MCF-7 human breast cancer cells. | 2012 | Med. Oncol. | pmid:21191671 |
| Bishayee A et al. | Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer. | 2011 | Front Biosci (Landmark Ed) | pmid:21196213 |
| Lee HZ et al. | Clarification of the phenotypic characteristics and anti-tumor activity of Hedyotis diffusa. | 2011 | Am. J. Chin. Med. | pmid:21213409 |
| Purnima A et al. | Antiinflammatory, Analgesic and Antipyretic Activities of Mimusops elengi Linn. | 2010 | Indian J Pharm Sci | pmid:21218059 |
| Ghosh P et al. | Triterpenoids from Psidium guajava with Biocidal Activity. | 2010 | Indian J Pharm Sci | pmid:21218065 |
| Grudniak AM et al. | Oleanolic and ursolic acids influence affect the expression of the cysteine regulon and the stress response in Escherichia coli. | 2011 | Curr. Microbiol. | pmid:21221969 |
| Chen Q et al. | Development of a liquid chromatography-mass spectrometry method for the determination of ursolic acid in rat plasma and tissue: application to the pharmacokinetic and tissue distribution study. | 2011 | Anal Bioanal Chem | pmid:21249342 |
| Gasnier C et al. | Defined plant extracts can protect human cells against combined xenobiotic effects. | 2011 | J Occup Med Toxicol | pmid:21251308 |
| Limami Y et al. | HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death. | 2011 | Biochimie | pmid:21251952 |
| Yu LB et al. | [Inhibitive effect of ursolic acid on the invasion and metastasis of ovarian carcinoma cells HO-8910PM]. | 2010 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:21265099 |
| Kuete V et al. | Antimicrobial activities of the methanol extract, fractions and compounds from Ficus polita Vahl. (Moraceae). | 2011 | BMC Complement Altern Med | pmid:21269424 |
| Huang W et al. | [Study on anti-invasive effect and apoptosis induction of pentacyclic triterpenoid in human lung cancer cells]. | 2003 | Zhongguo Fei Ai Za Zhi | pmid:21272475 |
| Sonnet P and Mullié C | In vitro antimalarial activity of ICL670: a further proof of the correlation between inhibition of β-hematin formation and of peroxidative degradation of hemin. | 2011 | Exp. Parasitol. | pmid:21295029 |
| Sporn MB et al. | New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. | 2011 | J. Nat. Prod. | pmid:21309592 |
| Wu HY et al. | Suppression of hepatitis B virus x protein-mediated tumorigenic effects by ursolic Acid. | 2011 | J. Agric. Food Chem. | pmid:21314126 |
| Li G et al. | Highly sensitive and selective pre-column derivatization high-performance liquid chromatography approach for rapid determination of triterpenes oleanolic and ursolic acids and application to Swertia species: optimization of triterpenic acids extraction and pre-column derivatization using response surface methodology. | 2011 | Anal. Chim. Acta | pmid:21334488 |
| Zhou C et al. | Herbaceous peony (Paeonia lactiflora Pall.) as an alternative source of oleanolic and ursolic acids. | 2011 | Int J Mol Sci | pmid:21340006 |
| Peixoto JA et al. | Antileishmanial activity of the hydroalcoholic extract of Miconia langsdorffii, isolated compounds, and semi-synthetic derivatives. | 2011 | Molecules | pmid:21343887 |
| Kiran MS et al. | Changes in expression of VE-cadherin and MMPs in endothelial cells: Implications for angiogenesis. | 2011 | pmid:21349163 | |
| Kondo M et al. | Ursolic acid and its esters: occurrence in cranberries and other Vaccinium fruit and effects on matrix metalloproteinase activity in DU145 prostate tumor cells. | 2011 | J. Sci. Food Agric. | pmid:21351105 |
| Kikuchi T et al. | 3-O-(E)-p-coumaroyl tormentic acid from Eriobotrya japonica leaves induces caspase-dependent apoptotic cell death in human leukemia cell line. | 2011 | Chem. Pharm. Bull. | pmid:21372421 |
| Li GL et al. | Development of a new HPLC method with precolumn fluorescent derivatization for rapid, selective and sensitive detection of triterpenic acids in fruits. | 2011 | J. Agric. Food Chem. | pmid:21388126 |
| Liu Y et al. | Ursolic acid promotes robust tolerance to cardiac allografts in mice. | 2011 | Clin. Exp. Immunol. | pmid:21391985 |
| Rasoanaivo P et al. | Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. | 2011 | Malar. J. | pmid:21411015 |
| Sultana N | Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product. | 2011 | J Enzyme Inhib Med Chem | pmid:21417964 |
| Deoda RS et al. | Gastroprotective Effect of Rubia cordifolia Linn. on Aspirin Plus Pylorus-Ligated Ulcer. | 2011 | Evid Based Complement Alternat Med | pmid:21423635 |
| Yau Hsiung W and Abdul Kadir H | Leea indica Ethyl Acetate Fraction Induces Growth-Inhibitory Effect in Various Cancer Cell Lines and Apoptosis in Ca Ski Human Cervical Epidermoid Carcinoma Cells. | 2011 | Evid Based Complement Alternat Med | pmid:21423690 |
| pmid:21432926 | ||||
| Cho K et al. | Oleanolic acid and ursolic acid derived from Cornus officinalis Sieb. et Zucc. suppress epidermal growth factor- and phorbol ester-induced MUC5AC mucin production and gene expression from human airway epithelial cells. | 2011 | Phytother Res | pmid:21442679 |
| Xu X et al. | Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway. | 2011 | J. Exp. Clin. Cancer Res. | pmid:21447176 |
| Shanmugam MK et al. | Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice. | 2011 | J. Mol. Med. | pmid:21465181 |
| Chen Q et al. | Identification and quantification of oleanolic acid and ursolic acid in Chinese herbs by liquid chromatography-ion trap mass spectrometry. | 2011 | Biomed. Chromatogr. | pmid:21465498 |
| Truong NB et al. | Antituberculosis cycloartane triterpenoids from Radermachera boniana. | 2011 | J. Nat. Prod. | pmid:21469696 |
| Moneriz C et al. | Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages. | 2011 | Malar. J. | pmid:21477369 |
| Shanmugam MK et al. | Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model. | 2011 | Int. J. Cancer | pmid:21480220 |
| Wang YJ et al. | Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways. | 2011 | Neurobiol Learn Mem | pmid:21496491 |
| Shao JW et al. | In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives. | 2011 | Eur J Med Chem | pmid:21514015 |
| Zhong Y et al. | Carb-oxy-methyl ursolate monohydrate. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:21523096 |
| Reyes-Zurita FJ et al. | The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism. | 2011 | BMC Cancer | pmid:21524306 |